Tissue expression
Cell line expression
Protein structure
ALS2
Alsin Rho guanine nucleotide exchange factor ALS2ALS2CR6
The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Top validated antibodies |
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Invitrogen Antibodies | 13998-1-AP | Polyclonal |
WB
ICC
IP
IHC
OA
|
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Novus Biologicals | NB100-885 | 2 references | Polyclonal |
WB
EL
ICC
IHC |
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Proteintech Group | 13998-1-AP | Polyclonal |
WB
EL
ICC
IP
IHC
|
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NovoPro Bioscience Inc. | 107884 | Polyclonal |
WB
EL
ICC
IP
IHC
|
||
antibodies-online | ABIN257842 | 2 references | Polyclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
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Recommended by provider