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- Antigen structure
- References [14]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 11266-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11266-1-AP, RRID:AB_2263720
- Product name
- HAX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HAX1 antibody (Cat. #11266-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression.
Gentianella acuta-derived Gen-miR-1 suppresses myocardial fibrosis by targeting HAX1/HMG20A/Smads axis to attenuate inflammation in cardiac fibroblasts.
African swine fever virus MGF360-9L promotes viral replication by degrading the host protein HAX1.
Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins.
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
The RNA-Binding Landscape of HAX1 Protein Indicates Its Involvement in Translation and Ribosome Assembly.
Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1.
The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice.
HAX1 maintains the glioma progression in hypoxia through promoting mitochondrial fission.
Lamprey PHB2 maintains mitochondrial stability by tanslocation to the mitochondria under oxidative stress.
HAX1 enhances the survival and metastasis of non-small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway.
Immunoblotting validation of research antibodies generated against HS1-associated protein X-1 in the human neutrophil model cell line PLB-985.
Hax1 regulates neutrophil adhesion and motility through RhoA.
Jin H, Huang X, Pan Q, Ma N, Xie X, Wei Y, Yu F, Wen W, Zhang B, Zhang P, Chen X, Wang J, Liu RY, Lin J, Meng X, Lee MH
Nature communications 2024 Mar 21;15(1):2551
Nature communications 2024 Mar 21;15(1):2551
Gentianella acuta-derived Gen-miR-1 suppresses myocardial fibrosis by targeting HAX1/HMG20A/Smads axis to attenuate inflammation in cardiac fibroblasts.
Zhang T, Zhang Y, Li S, Ge H, Song Q, Zhang Y, Yang G, Li A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154923
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154923
African swine fever virus MGF360-9L promotes viral replication by degrading the host protein HAX1.
Yang J, Yang B, Hao Y, Shi X, Yang X, Zhang D, Zhao D, Yan W, Chen L, Bie X, Chen G, Zhu Z, Li D, Shen C, Li G, Liu X, Zheng H, Zhang K
Virus research 2023 Oct 15;336:199198
Virus research 2023 Oct 15;336:199198
Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins.
Dai S, Min YQ, Li Q, Feng K, Jiang Z, Wang Z, Zhang C, Ren F, Fang Y, Zhang J, Zhu Q, Wang M, Wang H, Deng F, Ning YJ
Nature communications 2023 Nov 14;14(1):7365
Nature communications 2023 Nov 14;14(1):7365
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
Wang S, Tan J, Chen L, Wang J
Journal of oncology 2022;2022:2956888
Journal of oncology 2022;2022:2956888
The RNA-Binding Landscape of HAX1 Protein Indicates Its Involvement in Translation and Ribosome Assembly.
Balcerak A, Macech-Klicka E, Wakula M, Tomecki R, Goryca K, Rydzanicz M, Chmielarczyk M, Szostakowska-Rodzos M, Wisniewska M, Lyczek F, Helwak A, Tollervey D, Kudla G, Grzybowska EA
Cells 2022 Sep 20;11(19)
Cells 2022 Sep 20;11(19)
Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1.
Zhang Y, Varela L, Szigeti-Buck K, Williams A, Stoiljkovic M, Šestan-Peša M, Henao-Mejia J, D'Acunzo P, Levy E, Flavell RA, Horvath TL, Kaczmarek LK
Nature communications 2021 Mar 19;12(1):1731
Nature communications 2021 Mar 19;12(1):1731
The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, Lawatscheck J, Baek K, Garz AK, Rudelius M, Deuschle FC, Keller U, Lemeer S, Verbeek M, Götze KS, Skerra A, Weber WA, Buchner J, Schulman BA, Kuster B, Fernández-Sáiz V, Bassermann F
Molecular cell 2021 Mar 18;81(6):1170-1186.e10
Molecular cell 2021 Mar 18;81(6):1170-1186.e10
Suppression of Kv3.3 channels by antisense oligonucleotides reverses biochemical effects and motor impairment in spinocerebellar ataxia type 13 mice.
Zhang Y, Quraishi IH, McClure H, Williams LA, Cheng Y, Kale S, Dempsey GT, Agrawal S, Gerber DJ, McManus OB, Kaczmarek LK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Dec;35(12):e22053
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Dec;35(12):e22053
HAX1 maintains the glioma progression in hypoxia through promoting mitochondrial fission.
Lin J, Wang Y, Lin Z
Journal of cellular and molecular medicine 2021 Dec;25(24):11170-11184
Journal of cellular and molecular medicine 2021 Dec;25(24):11170-11184
Lamprey PHB2 maintains mitochondrial stability by tanslocation to the mitochondria under oxidative stress.
Shi Y, Li Q, Sun F, Zhu C, Ma S, Qin D, Li Q, Li T
Fish & shellfish immunology 2020 Sep;104:613-621
Fish & shellfish immunology 2020 Sep;104:613-621
HAX1 enhances the survival and metastasis of non-small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway.
Liang Z, Zhong Y, Meng L, Chen Y, Liu Y, Wu A, Li X, Wang M
Thoracic cancer 2020 Nov;11(11):3155-3167
Thoracic cancer 2020 Nov;11(11):3155-3167
Immunoblotting validation of research antibodies generated against HS1-associated protein X-1 in the human neutrophil model cell line PLB-985.
Cavnar P, Inman K
F1000Research 2015;4:148
F1000Research 2015;4:148
Hax1 regulates neutrophil adhesion and motility through RhoA.
Cavnar PJ, Berthier E, Beebe DJ, Huttenlocher A
The Journal of cell biology 2011 May 2;193(3):465-73
The Journal of cell biology 2011 May 2;193(3):465-73
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human heart tissue were subjected to SDS PAGE followed by western blot with 11266-1-AP(HAX1 antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HAX1 (IP:11266-1-AP, 3ug; Detection:11266-1-AP 1:300) with mouse brain tissue lysate 6000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HAX1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HAX1. This antibody recognizes human, mouse antigen. The HAX1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
