Explore
Validate
Learn
Immunoprecipitation
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 313512 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#313512, RRID:AB_416335
- Product name
- LEAF™ Purified anti-Human/Mouse/Rat CD278 (ICOS) [C398.4A]
- Antibody type
- Monoclonal
- Antigen
- Mouse T cell clone D10.G4.1
- Description
- ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Hamster
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 500 µg
- Concentration
- 1 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C.This LEAF™ solution contains no preservative; handle under aseptic conditions.
No comments: Submit comment
Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- PHA-stimulated human peripheral blood lymphocytes (3 days) stained with LEAF™ purified C398.4A, followed by anti-Armenian hamster IgG FITC
- Conjugate
- Unconjugated
