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- References [167]
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- Product number
- 10849-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10849-1-AP, RRID:AB_2247214
- Product name
- FOXO3A antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FOXO3A antibody (Cat. #10849-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references FOXO3 upregulates and activates GSDME to trigger myeloma cell pyroptosis.
Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3-Mediated Mitophagy.
Aerobic exercise improve physical endurance and muscle function by ameliorating oxidative stress and modulating mitochondrial dynamics in aged skeletal muscle.
Overexpression of As3mt Attenuates Sodium Arsenite Induced Ferritinophagy and Hepatic Lipid Accumulation in Mice.
Hyperacetylation escalates myocardial susceptibility to ischemia reperfusion injury by mediating mitochondrial supercomplexes assembly in T2DM.
Astragaloside IV alleviates post-traumatic cytotoxic edema via inhibition of AQP4 expression and subcellular localization.
Tibetan medicine Bawei Chenxiang Wan attenuates chronic mountain sickness by targeting the AKT/FOXO3a/CAT axis to inhibit oxidative stress.
Resistance exercise alleviates skeletal muscle atrophy through reduction of oxidative stress via Sestrin1 in C57BL/6J mice.
Sesamin exerts protective effects against diquat-induced acute kidney injury by inhibiting oxidative stress, apoptosis and autophagy: A key role for the SIRT5/FOXO3a signaling pathway.
Safranal accelerates diabetic wound healing by suppressing ferroptosis through modulation of transcription factor Forkhead Box O3.
SERPINE1-Driven MAPK Activation Enhances Cuproptosis Resistance and Angiogenic Potential in Colorectal Cancer.
Metformin Suppresses Glioblastoma Tumor Growth and Progression Through the AMPK/FoxO3a/Survivin Axis.
Epigenetic reprogramming periosteum promotes aging critical segmental bone defect repair via methylation remodeling.
Kaempferol Mitigates Liver Injury Induced by Copper Toxicity Through the Activation of the Sirt1/Nrf2/FOXO3 Signaling Pathway.
Alendronic acid modified PLGA drug delivery system loaded with 17β-Estradiol and vitamin D3 has anti-osteoporotic effect.
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy.
An anti-FAP-scFv-functionalized exosome-carrying hydrogel delivers SKI mRNA to fibrotic nucleus pulposus cells to alleviate intervertebral disc degeneration by regulating FOXO3.
Energy metabolism disturbance induced by atorvastatin exposure on yellowstripe goby (Mugilogobius chulae) larvae based on transcriptome and metabolome analysis.
Slow-Release Prostacyclin Agonist-Immersed Sheet Implantation Suppresses Liver Fibrosis via Hippo Signaling Pathway Activation.
From Molecular Docking to Rat Models: Butyrate From a High-Fiber Diet Inhibits HDAC1 and NLRP3 Inflammasome to Alleviate Oxidative Stress and Inflammation After Spinal Cord Injury.
LncRNA FTX/OCT4/miR-122-5p orchestrates self-renewal and lineage commitment of human dental pulp stem cells by directly targeting FOXO3.
H3K18 lactylation in cancer-associated fibroblasts drives malignant pleural effusion progression via TNFR2(+) T(reg) recruitment.
FSH-Induced Nuclear Exclusion of FOXO1 Mediated by PI3K/Akt Signaling Pathway in Granulosa Cells Is Associated with Follicle Selection and Growth of the Hen Ovary.
Effective compound combination of Bufei Yishen formula ameliorates PM2.5-induced COPD by inhibiting mitochondrial oxidative stress through SIRT3-mediated FOXO3 deacetylation.
Porphyromonas gingivalis aggravates atherosclerotic plaque instability by promoting lipid-laden macrophage necroptosis.
Senescent cartilage endplate stem cells-derived exosomes induce oxidative stress injury in nucleus pulposus cells and aggravate intervertebral disc degeneration by regulating FOXO3.
Mitochondrial oxidative stress inhibited Sirt3/Foxo3/PPARα pathway and aggravated copper and zinc co-deficiency-induced hepatic lipotoxicity in a fish model.
Study on the role of miR-10b-3p as SASP in exosomes of premature senescent hepatocytes induced by hexavalent chromium.
Role of the USP7/FOXO3A axis in environmentally relevant doses of arsenic-induced lung carcinogenesis: Insights from bioinformatics analysis and model of human epithelial cell malignant transformation.
Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy.
MSCs regulate oxidative stress through the Nrf2 pathway to treat chronic obstructive pulmonary disease.
Transferrin receptor knockdown attenuates atrial fibrillation by inhibiting cardiomyocyte ferroptosis and atrial fibrosis.
Core fucosylation regulates the ovarian response via FSH receptor during follicular development.
Gengnianchun Against H(2)O(2)-Induced Oxidative Damage in KGN Cells via miR-548m/FOXO3 Signaling.
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring.
NCAPD3-mediated AKT activation regulates prostate cancer progression.
Inhibition of DNA Methyltransferase DNMT1 Reverses Th2 Response Polarisation and Alleviates Allergic Rhinitis.
Regulation of Smad2/3 Nuclear Exclusion by Follicle-Stimulating Hormone (FSH) in Chicken Follicular Granulosa Cells and Its Effect on FOXO3/4.
Matrix stiffness-sensitive LDHA drives autophagy of pancreatic ductal adenocarcinoma via inducing FOXO3 expression and lactylation.
Astaxanthin suppress ferroptosis through the Akt1-FoxO3a signaling pathway to alleviates brain injury after intracerebral hemorrhage.
N2 neutrophils induce cell stemness reprogramming to promote gastric cancer progression via exosomal miRNAs.
Pectin Polysaccharides from Cascara Prevent Metabolic Dysfunction-Associated Fatty Liver Disease Development by Regulating Gut Microbiota and Liver Metabolism.
Interleukin 13 alleviates traumatic brain injury by promoting pericyte autophagy.
A Decoy Oligodeoxynucleotides Disturbing Forkhead Box O3 Mediated ctnna2 Transcriptional Repression Prevents Postoperative Neurocognitive Disorder in Mice.
Tumor-derived exosomal tsRNA 3'tiRNA-AlaCGC in promoting fibroblast senescence and Galectin-9 secretion to induce immune tolerance in lung adenocarcinoma.
Environmentally relevant concentrations lithium exposure induces neurotoxicity in yellowstripe goby (Mugilogobius chulae): Responses of BDNF/AKT/FoxOs in regulating glutamate excitotoxicity and mitochondrial function.
The Effect of FSH-Induced Nuclear Exclusion of FOXO3/4 on Granulosa Cell Proliferation and Apoptosis of Hen Ovarian Follicles.
Nobiletin Enhances Skeletal Muscle Mass and Modulates Bile Acid Composition in Diet-Induced Obese Mice.
Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway.
Circ-ITCH inhibits bladder cancer progression through miR-184/FOXO3 axis.
MMP9 drives ferroptosis by regulating GPX4 and iron signaling.
A novel mesenchymal stem cell-targeting dual-miRNA delivery system based on aptamer-functionalized tetrahedral framework nucleic acids: Application to endogenous regeneration of articular cartilage.
Diarylpropionitrile-stimulated ERβ nuclear accumulation promotes MyoD-induced muscle regeneration in mdx mice by interacting with FOXO3A.
Discovery of Potent Covalent CRM1 Inhibitors Via a Customized Structure-Based Virtual Screening Pipeline and Bioassays.
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate muscle atrophy via the miR-132-3p/FoxO3 axis.
Procyanidin C1 ameliorates acidic pH stress induced nucleus pulposus degeneration through SIRT3/FOXO3-mediated mitochondrial dynamics.
Gastrodin against oxidative stress-inflammation crosstalk via inhibiting mtDNA/TLR9 and JAK2/STAT3 signaling to ameliorate ischemic stroke injury.
EMX2 inhibits clear cell renal cell carcinoma progress via modulating Akt/FOXO3a pathway.
Indole-3-carbinol ameliorates ovarian damage in female old mice through Nrf2/HO-1 pathway activation.
d-galactose causes embryonic development arrest and placental development disorders in mice by increasing ROS and inhibiting SIRT1/FOXO3a axis.
Lysophosphatidic Acid Stimulates Mitogenic Activity and Signaling in Human Neuroblastoma Cells through a Crosstalk with Anaplastic Lymphoma Kinase.
IL-1β promotes esophageal squamous cell carcinoma growth and metastasis through FOXO3A by activating the PI3K/AKT pathway.
The role of microRNA-142a in Toxoplasma gondii infection-induced downregulation of Foxp3: implications for adverse pregnancy outcomes.
Neuroprotective effects of polyphyllin VI against rotenone-induced toxicity in SH-SY5Y cells.
Fangji Fuling Decoction Alleviates Sepsis by Blocking MAPK14/FOXO3A Signaling Pathway.
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning.
Interferon-Alpha Induces Psoriatic Inflammation in Mice by Phosphorylating FOXO3.
Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor.
Taraxerone exerts antipulmonary fibrosis effect through Smad signaling pathway and antioxidant stress response in a Sirtuin1-dependent manner.
Dental pulp mesenchymal stem cell-derived exosomes inhibit neuroinflammation and microglial pyroptosis in subarachnoid hemorrhage via the miRNA-197-3p/FOXO3 axis.
20( S )-Protopanaxatriol Improves Atherosclerosis by Inhibiting Low-Density Lipoprotein Receptor Degradation in ApoE KO Mice.
Berberine alleviates contrast-induced nephropathy by activating Akt/Foxo3a/Nrf2 signalling pathway.
Maimendong decoction regulates M2 macrophage polarization to suppress pulmonary fibrosis via PI3K/Akt/FOXO3a signalling pathway-mediated fibroblast activation.
Response of lipid metabolism, energy supply, and cell fate in yellowstripe goby (Mugilogobius chulae) exposed to environmentally relevant concentrations atorvastatin.
A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice.
Dendrobium officinale Polysaccharides as a Natural Functional Component for Acetic-Acid-Induced Gastric Ulcers in Rats.
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Cepharanthine sensitizes gastric cancer cells to chemotherapy by targeting TRIB3-FOXO3-FOXM1 axis to inhibit autophagy.
Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis.
Acetyl-11-keto-β-boswellia acid attenuates Ti particle-induced osteoblastic oxidative stress and osteolysis through the Foxo3 signaling pathway.
Berberine ameliorates contrast-induced acute kidney injury by regulating HDAC4-FoxO3a axis-induced autophagy: In vivo and in vitro.
Low-dose deoxynivalenol exposure inhibits hepatic mitophagy and hesperidin reverses this phenomenon by activating SIRT1.
Combined therapy of dabrafenib and an anti-HER2 antibody-drug conjugate for advanced BRAF-mutant melanoma.
The role of miR-222-2p in exosomes secreted by hexavalent chromium-induced premature senescent hepatocytes as a SASP component.
Triamcinolone acetonide induces the autophagy of Ag85B-treated WI-38 cells via SIRT1/FOXO3 pathway.
Luteolin inhibits triple-negative breast cancer by inducing apoptosis and autophagy through SGK1-FOXO3a-BNIP3 signaling.
Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retina.
Proteomic analysis of uterine lavage fluid of dairy cows at different time after delivery by mass spectrometry.
3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis.
Zigui-Yichong-Fang protects against cyclophosphamide-induced premature ovarian insufficiency via the SIRT1/Foxo3a pathway.
Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway.
Metformin Suppresses Stemness of Non-Small-Cell Lung Cancer Induced by Paclitaxel through FOXO3a.
Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.
Resistance exercise alleviates dexamethasone-induced muscle atrophy via Sestrin2/MSTN pathway in C57BL/6J mice.
Exercise mitigates Dapagliflozin-induced skeletal muscle atrophy in STZ-induced diabetic rats.
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.
The Investigation of the Molecular Mechanism of Morinda officinalis How in the Treatment of Heart Failure.
Toxicity assessment of organophosphate flame retardant triphenyl phosphate (TPHP) on intestines in mice.
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
miR-342-5p promotes vascular smooth muscle cell phenotypic transition through a negative-feedback regulation of Notch signaling via targeting FOXO3.
Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.
Ursolic Acid Alleviates Cancer Cachexia and Prevents Muscle Wasting via Activating SIRT1.
Ketone Body β-Hydroxybutyrate Prevents Myocardial Oxidative Stress in Septic Cardiomyopathy.
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy.
Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway.
Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage.
Exercise attenuates angiotensinⅡ-induced muscle atrophy by targeting PPARγ/miR-29b.
Recombinant P40 protein of Schistosoma japonicum inhibits TREM-1 expression in RAW264.7 cells via FOXO3a.
Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1.
RBM47/SNHG5/FOXO3 axis activates autophagy and inhibits cell proliferation in papillary thyroid carcinoma.
Virus-induced FoxO factor facilitates replication of human cytomegalovirus.
Solasonine relieves sevoflurane-induced neurotoxicity via activating the AMP-activated protein kinase/FoxO3a pathway.
Cordycepin, a major bioactive component of Cordyceps militaris, ameliorates diabetes-induced testicular damage through the Sirt1/Foxo3a pathway.
A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.
MicroRNA-122-5p promotes renal fibrosis and injury in spontaneously hypertensive rats by targeting FOXO3.
Inhibition of cell proliferation by Tas of foamy viruses through cell cycle arrest or apoptosis underlines the different mechanisms of virus-host interactions.
A novel combination treatment of antiADAM17 antibody and erlotinib to overcome acquired drug resistance in non-small cell lung cancer through the FOXO3a/FOXM1 axis.
Danggui Buxue Tang Rescues Folliculogenesis and Ovarian Cell Apoptosis in Rats with Premature Ovarian Insufficiency.
β-hydroxybutyrate Alleviates Learning and Memory Impairment Through the SIRT1 Pathway in D-Galactose-Injured Mice.
Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G(0)/G(1) Cell Cycle Arrest and Antiproliferation in A549 Cells.
The protective effects of resveratrol pretreatment in cyclophosphamide-induced rat ovarian injury: an vivo study.
Adiponectin regulates osteocytic MLO-Y4 cell apoptosis in a high-glucose environment through the AMPK/FoxO3a signaling pathway.
Activation of angiotensin-converting enzyme 2/angiotensin (1-7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling.
MiR-223-3p targets FOXO3a to inhibit radiosensitivity in prostate cancer by activating glycolysis.
Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish.
RANKL Mediates Muscle Atrophy and Dysfunction in a Cigarette Smoke-induced Model of Chronic Obstructive Pulmonary Disease.
MiR-1290 promotes myoblast differentiation and protects against myotube atrophy via Akt/p70/FoxO3 pathway regulation.
PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis.
Early-senescent bone marrow mesenchymal stem cells promote C2C12 cell myogenic differentiation by preventing the nuclear translocation of FOXO3.
Syringin exerts neuroprotective effects in a rat model of cerebral ischemia through the FOXO3a/NF-κB pathway.
Xiaoyaosan decoction alleviated rat liver fibrosis via the TGFβ/Smad and Akt/FoxO3 signaling pathways based on network pharmacology analysis.
Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis.
WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute myeloid leukemia.
EGFR/FOXO3A/LXR-α Axis Promotes Prostate Cancer Proliferation and Metastasis and Dual-Targeting LXR-α/EGFR Shows Synthetic Lethality.
TNNC1 Reduced Gemcitabine Sensitivity of Nonsmall-Cell Lung Cancer by Increasing Autophagy.
MiR-23a-5p exacerbates intestinal ischemia-reperfusion injury by promoting oxidative stress via targeting PPAR alpha.
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
CDKL3 promotes osteosarcoma progression by activating Akt/PKB.
Linc00261 inhibits metastasis and the WNT signaling pathway of pancreatic cancer by regulating a miR‑552‑5p/FOXO3 axis.
LongShengZhi capsule inhibits doxorubicin-induced heart failure by anti-oxidative stress.
Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation.
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.
Carfilzomib inhibits the growth of lung adenocarcinoma via upregulation of Gadd45a expression.
FOXO3/TRIM22 axis abated the antitumor effect of gemcitabine in non-small cell lung cancer via autophagy induction.
Exogenous CGRP Regulates Apoptosis and Autophagy to Alleviate Traumatic Brain Injury Through Akt/mTOR Signalling Pathway.
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.
BH3 mimetic ABT-263 enhances the anticancer effects of apigenin in tumor cells with activating EGFR mutation.
circRNA_0025202 Regulates Tamoxifen Sensitivity and Tumor Progression via Regulating the miR-182-5p/FOXO3a Axis in Breast Cancer.
Doxorubicin obliterates mouse ovarian reserve through both primordial follicle atresia and overactivation.
Punicalagin Prevents Inflammation in LPS-Induced RAW264.7 Macrophages by Inhibiting FoxO3a/Autophagy Signaling Pathway.
A New Possible Mechanism by Which Punicalagin Protects against Liver Injury Induced by Type 2 Diabetes Mellitus: Upregulation of Autophagy via the Akt/FoxO3a Signaling Pathway.
Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation.
Resveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH-1) through p38 MAPK-FOXO3a pathway.
Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy.
Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF-κB pathway and ROS signaling.
Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.
Expression of PIM-1 in salivary gland adenoid cystic carcinoma: Association with tumor progression and patients' prognosis.
Nuclear forkhead box O3a accumulation contributing to the proliferative suppression in liver cancer cells by PI3K/Akt signaling pathway.
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways.
High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.
Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.
CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways.
Low-protein diet fed to crossbred sows during pregnancy and lactation enhances myostatin gene expression through epigenetic regulation in skeletal muscle of weaning piglets.
Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure.
miRNA-155 modulates the malignant biological characteristics of NK/T-cell lymphoma cells by targeting FOXO3a gene.
Wang Y, Wang Y, Cui Y, He Y, Yang Y, Zhou W, Liu L, Wang H, Liu M, Wei Y, Huang Z, Wei X, Mao X
International journal of biological sciences 2026;22(4):1793-1806
International journal of biological sciences 2026;22(4):1793-1806
Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3-Mediated Mitophagy.
Huang C, Zhang G, Ma YK, Ma XN, Lv SC
The Kaohsiung journal of medical sciences 2026 May;42(5):e70131
The Kaohsiung journal of medical sciences 2026 May;42(5):e70131
Aerobic exercise improve physical endurance and muscle function by ameliorating oxidative stress and modulating mitochondrial dynamics in aged skeletal muscle.
Zheng F, Zhou J, Cao Y, Lin L, Wang W, Zhang L, Li W, Li T, Wang L
Journal of physiology and biochemistry 2026 Mar 17;82(1)
Journal of physiology and biochemistry 2026 Mar 17;82(1)
Overexpression of As3mt Attenuates Sodium Arsenite Induced Ferritinophagy and Hepatic Lipid Accumulation in Mice.
Bao JC, Yang Y, Wang Y, Xie FS
Biological trace element research 2026 Mar 17;
Biological trace element research 2026 Mar 17;
Hyperacetylation escalates myocardial susceptibility to ischemia reperfusion injury by mediating mitochondrial supercomplexes assembly in T2DM.
Deng Y, Yang W, Yang J, Ji L, Xie M, Tang K, He Q, Hu G, Shangguan W, Jiang C, Li T
Redox biology 2026 Jun;93:104163
Redox biology 2026 Jun;93:104163
Astragaloside IV alleviates post-traumatic cytotoxic edema via inhibition of AQP4 expression and subcellular localization.
Shen W, Jiang C, Liu X, Wang D, Li G, Hui Y, Ding Y, Li C, Shao B, Hou B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158096
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158096
Tibetan medicine Bawei Chenxiang Wan attenuates chronic mountain sickness by targeting the AKT/FOXO3a/CAT axis to inhibit oxidative stress.
Li X, Zhang S, Qiu Y, Wang Y, Hou J, Ji X, Ge F, Zhang X, Sun Q, Song H, Ciwang R, Luo Y, Tao X
Journal of ethnopharmacology 2026 Jun 12;364:121481
Journal of ethnopharmacology 2026 Jun 12;364:121481
Resistance exercise alleviates skeletal muscle atrophy through reduction of oxidative stress via Sestrin1 in C57BL/6J mice.
Yang X, Peng J, Huang Y, Liu S, Niu Y, Fu L
Sports medicine and health science 2026 Jan;8(1):50-60
Sports medicine and health science 2026 Jan;8(1):50-60
Sesamin exerts protective effects against diquat-induced acute kidney injury by inhibiting oxidative stress, apoptosis and autophagy: A key role for the SIRT5/FOXO3a signaling pathway.
Han S, Pu Y, Liu Z
Pesticide biochemistry and physiology 2026 Jan;216(Pt 1):106728
Pesticide biochemistry and physiology 2026 Jan;216(Pt 1):106728
Safranal accelerates diabetic wound healing by suppressing ferroptosis through modulation of transcription factor Forkhead Box O3.
Wang Z, Zhu Y, Chen L, Hu Z, Cheng B, Lin Z, Li K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157675
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157675
SERPINE1-Driven MAPK Activation Enhances Cuproptosis Resistance and Angiogenic Potential in Colorectal Cancer.
Gao P, Li H, Luo J, Zhang C, Wei J, Li X, Ma H
Digestive diseases and sciences 2026 Feb 9;
Digestive diseases and sciences 2026 Feb 9;
Metformin Suppresses Glioblastoma Tumor Growth and Progression Through the AMPK/FoxO3a/Survivin Axis.
Cavaliere F, Pellegrino M, Cormace A, Spadafora S, Fava M, Yang SH, Lee JE, Nocito MC, Sirianni R, Casaburi I, Garofalo C, Sisci D, Morelli C, Lanzino M
Cells 2026 Feb 6;15(3)
Cells 2026 Feb 6;15(3)
Epigenetic reprogramming periosteum promotes aging critical segmental bone defect repair via methylation remodeling.
Zheng J, Ke J, Wu S, Lan Y, Zhong Z, Yang S, Zhao N, Wang Z, Chai M, Shi X, Wang Y
Bioactive materials 2026 Aug;62:759-775
Bioactive materials 2026 Aug;62:759-775
Kaempferol Mitigates Liver Injury Induced by Copper Toxicity Through the Activation of the Sirt1/Nrf2/FOXO3 Signaling Pathway.
Xu J, Wan W, Mu H, Gong S, Liu Y, Deng T
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70813
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70813
Alendronic acid modified PLGA drug delivery system loaded with 17β-Estradiol and vitamin D3 has anti-osteoporotic effect.
Wang Y, Zhang S, Ma X, Hu D, Liu J, Wei L, Lei X, Hu Y, Li F, Gao Y
Materials today. Bio 2026 Apr;37:102789
Materials today. Bio 2026 Apr;37:102789
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy.
Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y, Ni Q, Ding X, Song G
Journal of diabetes 2026 Apr;18(4):e70209
Journal of diabetes 2026 Apr;18(4):e70209
An anti-FAP-scFv-functionalized exosome-carrying hydrogel delivers SKI mRNA to fibrotic nucleus pulposus cells to alleviate intervertebral disc degeneration by regulating FOXO3.
Li Y, Zhai Y, Wang T, Wang S, Tian Y, Bian Z, Zhang Y, Zhang C, Liu M, Li C
Theranostics 2025;15(9):3877-3899
Theranostics 2025;15(9):3877-3899
Energy metabolism disturbance induced by atorvastatin exposure on yellowstripe goby (Mugilogobius chulae) larvae based on transcriptome and metabolome analysis.
Zhao Y, Wang Y, Gong W, Duan C, Ren J, Zhang H, Nie X
Journal of environmental sciences (China) 2025 Sep;155:475-487
Journal of environmental sciences (China) 2025 Sep;155:475-487
Slow-Release Prostacyclin Agonist-Immersed Sheet Implantation Suppresses Liver Fibrosis via Hippo Signaling Pathway Activation.
Fujii W, Tomimaru Y, Kobayashi S, Torigata K, Hasegawa K, Harada A, Sasaki K, Hasegawa S, Yamada D, Akita H, Noda T, Takahashi H, Imamura H, Kodama T, Terai S, Sawa Y, Miyagawa S, Doki Y, Eguchi H
Hepatology research : the official journal of the Japan Society of Hepatology 2025 Oct;55(10):1353-1366
Hepatology research : the official journal of the Japan Society of Hepatology 2025 Oct;55(10):1353-1366
From Molecular Docking to Rat Models: Butyrate From a High-Fiber Diet Inhibits HDAC1 and NLRP3 Inflammasome to Alleviate Oxidative Stress and Inflammation After Spinal Cord Injury.
Ganggang K, Cheng G, Gang L, Wenwu Z, Di Z, Yan L, Baoshu X, Yiqin W
Journal of neurochemistry 2025 Oct;169(10):e70250
Journal of neurochemistry 2025 Oct;169(10):e70250
LncRNA FTX/OCT4/miR-122-5p orchestrates self-renewal and lineage commitment of human dental pulp stem cells by directly targeting FOXO3.
Zeng K, Wu L, Xin W, Cui C, Mai S, Hong H, Wei X
Stem cell research & therapy 2025 Oct 15;16(1):567
Stem cell research & therapy 2025 Oct 15;16(1):567
H3K18 lactylation in cancer-associated fibroblasts drives malignant pleural effusion progression via TNFR2(+) T(reg) recruitment.
Ye L, Xiang X, Wang Z, Zhang S, Xue Q, Wei X, Liu Y, Wang H, Ai J, Yang B, Chen L, Niu Y, Peng W, Zhou Q
Experimental & molecular medicine 2025 Nov;57(11):2671-2685
Experimental & molecular medicine 2025 Nov;57(11):2671-2685
FSH-Induced Nuclear Exclusion of FOXO1 Mediated by PI3K/Akt Signaling Pathway in Granulosa Cells Is Associated with Follicle Selection and Growth of the Hen Ovary.
Yan C, Ou Y, Sun X, Sun Y, Zhao J, Qin N, Xu R
Cells 2025 Nov 26;14(23)
Cells 2025 Nov 26;14(23)
Effective compound combination of Bufei Yishen formula ameliorates PM2.5-induced COPD by inhibiting mitochondrial oxidative stress through SIRT3-mediated FOXO3 deacetylation.
Wang J, Yue H, Dong Y, Liu T, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156568
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156568
Porphyromonas gingivalis aggravates atherosclerotic plaque instability by promoting lipid-laden macrophage necroptosis.
Huang X, Xie M, Wang Y, Lu X, Mei F, Zhang K, Yang X, Chen G, Yin Y, Feng G, Song W, Dong N, Deng X, Wang S, Chen L
Signal transduction and targeted therapy 2025 May 23;10(1):171
Signal transduction and targeted therapy 2025 May 23;10(1):171
Senescent cartilage endplate stem cells-derived exosomes induce oxidative stress injury in nucleus pulposus cells and aggravate intervertebral disc degeneration by regulating FOXO3.
Bian Z, Zhai Y, Zhang Y, Wang T, Li H, Ouyang J, Liu C, Wang S, Hu Z, Chang X, Zhang C, Liu M, Li C
Free radical biology & medicine 2025 Jun;233:39-54
Free radical biology & medicine 2025 Jun;233:39-54
Mitochondrial oxidative stress inhibited Sirt3/Foxo3/PPARα pathway and aggravated copper and zinc co-deficiency-induced hepatic lipotoxicity in a fish model.
Zhong CC, Zhang X, Pantopoulos K, Song CC, Yang H, Wei XL, Luo Z
Cellular and molecular life sciences : CMLS 2025 Jun 5;82(1):226
Cellular and molecular life sciences : CMLS 2025 Jun 5;82(1):226
Study on the role of miR-10b-3p as SASP in exosomes of premature senescent hepatocytes induced by hexavalent chromium.
Liang Q, Huang Z, Wang D, Xin F, Xu J, He J, Luo R, Zeng Y, Ma Y
Ecotoxicology and environmental safety 2025 Jun 15;298:118333
Ecotoxicology and environmental safety 2025 Jun 15;298:118333
Role of the USP7/FOXO3A axis in environmentally relevant doses of arsenic-induced lung carcinogenesis: Insights from bioinformatics analysis and model of human epithelial cell malignant transformation.
Chen X, Wang Y, Liu Z, He Y, Gao H, Guan X, Chen L, Chen S, Xing X, Chen W, Li D, Wang Q
Ecotoxicology and environmental safety 2025 Jun 1;297:118224
Ecotoxicology and environmental safety 2025 Jun 1;297:118224
Senescent macrophages induce ferroptosis in skeletal muscle and accelerate osteoarthritis-related muscle atrophy.
Xiang W, Zhang T, Li B, Li S, Zhang B, Fang S, Chen L, Gong Y, Huang B, Feng D, Wu J, Yuan J, Wu Y, Yan X, Jin R, Zhang X, Fang X, Lian J, Chen L, Zhou S, Ni Z
Nature aging 2025 Jul;5(7):1295-1316
Nature aging 2025 Jul;5(7):1295-1316
MSCs regulate oxidative stress through the Nrf2 pathway to treat chronic obstructive pulmonary disease.
Zhou Y, Zhou W, Li Y, Zhang J
BMC pulmonary medicine 2025 Jul 2;25(1):304
BMC pulmonary medicine 2025 Jul 2;25(1):304
Transferrin receptor knockdown attenuates atrial fibrillation by inhibiting cardiomyocyte ferroptosis and atrial fibrosis.
Zhan Y, Zhou Y, Zhang C, Zhai Z, Yang Y, Liu X
Experimental animals 2025 Jul 11;74(3):348-361
Experimental animals 2025 Jul 11;74(3):348-361
Core fucosylation regulates the ovarian response via FSH receptor during follicular development.
Wang T, Zhang Z, Qu C, Song W, Li M, Shao X, Fukuda T, Gu J, Taniguchi N, Li W
Journal of advanced research 2025 Jan;67:105-120
Journal of advanced research 2025 Jan;67:105-120
Gengnianchun Against H(2)O(2)-Induced Oxidative Damage in KGN Cells via miR-548m/FOXO3 Signaling.
Li J, Rao Y, Pu T, Xu T, Wang W
Journal of cellular biochemistry 2025 Jan;126(1):e30701
Journal of cellular biochemistry 2025 Jan;126(1):e30701
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring.
Cheng X, Xue Y, Wang H, Ma Z, Hu N, Zhang C, Gao Y, Fan R, Hu L, Li J, Zhang D, Huang J, Fang S, Xiao R, He Y, Luo T, Zheng L
Ecotoxicology and environmental safety 2025 Jan 1;289:117632
Ecotoxicology and environmental safety 2025 Jan 1;289:117632
NCAPD3-mediated AKT activation regulates prostate cancer progression.
Zhang Y, Xie W, Zong X, Fang Y, Ren J, Jing Z, Wei Y, Lu S, Zhu Q, Liu P
FASEB bioAdvances 2025 Feb;7(2):e1488
FASEB bioAdvances 2025 Feb;7(2):e1488
Inhibition of DNA Methyltransferase DNMT1 Reverses Th2 Response Polarisation and Alleviates Allergic Rhinitis.
Zou P, Li J, Li J, Wang J
Clinical and experimental pharmacology & physiology 2025 Feb;52(2):e70015
Clinical and experimental pharmacology & physiology 2025 Feb;52(2):e70015
Regulation of Smad2/3 Nuclear Exclusion by Follicle-Stimulating Hormone (FSH) in Chicken Follicular Granulosa Cells and Its Effect on FOXO3/4.
Sun Y, Liswaniso S, Wu H, Sun X, Yan C, Qin N, Xu R
Genes 2025 Feb 26;16(3)
Genes 2025 Feb 26;16(3)
Matrix stiffness-sensitive LDHA drives autophagy of pancreatic ductal adenocarcinoma via inducing FOXO3 expression and lactylation.
Gong T, Han Q, Zhang Y, Zhu K, Chen Y, Tao Y, Xing H, Wu D, Ma Y, Zhang S
Biomaterials advances 2025 Dec;177:214401
Biomaterials advances 2025 Dec;177:214401
Astaxanthin suppress ferroptosis through the Akt1-FoxO3a signaling pathway to alleviates brain injury after intracerebral hemorrhage.
Zhang J, Hua Q, Gao L, Yang S, Lu M, Cai Q
Journal of pharmacological sciences 2025 Dec;159(4):310-321
Journal of pharmacological sciences 2025 Dec;159(4):310-321
N2 neutrophils induce cell stemness reprogramming to promote gastric cancer progression via exosomal miRNAs.
Tang H, Zhong Y, Wang J, Meng S, Yu D, Fan B, Dong X, Wang M, Fu M, Qian Y, Zhang X, Ji R, Zhang X, Fang X, Zhang J
Cellular signalling 2025 Dec;136:112085
Cellular signalling 2025 Dec;136:112085
Pectin Polysaccharides from Cascara Prevent Metabolic Dysfunction-Associated Fatty Liver Disease Development by Regulating Gut Microbiota and Liver Metabolism.
Jiang S, Lu C, Zhao C, Yuan F, Jin J, Wang Y, Wang X, Yan T, Gao T
Journal of agricultural and food chemistry 2025 Dec 24;73(51):32650-32660
Journal of agricultural and food chemistry 2025 Dec 24;73(51):32650-32660
Interleukin 13 alleviates traumatic brain injury by promoting pericyte autophagy.
Ya D, Guo B, Jiang Y, Deng J, Tian N, Li X, Chen W, Liao R
Free radical biology & medicine 2025 Dec 16;241:384-410
Free radical biology & medicine 2025 Dec 16;241:384-410
A Decoy Oligodeoxynucleotides Disturbing Forkhead Box O3 Mediated ctnna2 Transcriptional Repression Prevents Postoperative Neurocognitive Disorder in Mice.
Wu Z, Xie D, Zhao J, Zhao J, Liu H, Xing D, Gu T, Guo Y, Wang D, Lu Z, Dong H, Zhao J, Deng J
CNS neuroscience & therapeutics 2025 Aug;31(8):e70454
CNS neuroscience & therapeutics 2025 Aug;31(8):e70454
Tumor-derived exosomal tsRNA 3'tiRNA-AlaCGC in promoting fibroblast senescence and Galectin-9 secretion to induce immune tolerance in lung adenocarcinoma.
Zhao G, Zhang Y, Zhang H, Guo Y, Xu C, Ge D, Gu J
Cell death discovery 2025 Aug 25;11(1):403
Cell death discovery 2025 Aug 25;11(1):403
Environmentally relevant concentrations lithium exposure induces neurotoxicity in yellowstripe goby (Mugilogobius chulae): Responses of BDNF/AKT/FoxOs in regulating glutamate excitotoxicity and mitochondrial function.
Gong W, Zhao Y, Zhang H, Duan C, Xiao Y, Wang Y, Wang C, Nie X
Aquatic toxicology (Amsterdam, Netherlands) 2025 Apr;281:107294
Aquatic toxicology (Amsterdam, Netherlands) 2025 Apr;281:107294
The Effect of FSH-Induced Nuclear Exclusion of FOXO3/4 on Granulosa Cell Proliferation and Apoptosis of Hen Ovarian Follicles.
Zhao J, Sun Y, Liswaniso S, Wu H, Sun X, Yan C, Qin N, Xu R
Genes 2025 Apr 27;16(5)
Genes 2025 Apr 27;16(5)
Nobiletin Enhances Skeletal Muscle Mass and Modulates Bile Acid Composition in Diet-Induced Obese Mice.
Koh YC, Liu CP, Leung SY, Lin WS, Ho PY, Ho CT, Pan MH
Journal of agricultural and food chemistry 2025 Apr 16;73(15):9076-9087
Journal of agricultural and food chemistry 2025 Apr 16;73(15):9076-9087
Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway.
Wang D, Wang J, Yin Z, Gong K, Zhang S, Zha Z, Duan Y
International journal of nanomedicine 2024;19:10839-10856
International journal of nanomedicine 2024;19:10839-10856
Circ-ITCH inhibits bladder cancer progression through miR-184/FOXO3 axis.
Yang F, Guo Z, Wu J, Lu X
American journal of translational research 2024;16(12):7911-7923
American journal of translational research 2024;16(12):7911-7923
MMP9 drives ferroptosis by regulating GPX4 and iron signaling.
Gawargi FI, Mishra PK
iScience 2024 Sep 20;27(9):110622
iScience 2024 Sep 20;27(9):110622
A novel mesenchymal stem cell-targeting dual-miRNA delivery system based on aptamer-functionalized tetrahedral framework nucleic acids: Application to endogenous regeneration of articular cartilage.
Fu L, Wu J, Li P, Zheng Y, Zhang Z, Yuan X, Ding Z, Ning C, Sui X, Liu S, Shi S, Guo Q, Lin Y
Bioactive materials 2024 Oct;40:634-648
Bioactive materials 2024 Oct;40:634-648
Diarylpropionitrile-stimulated ERβ nuclear accumulation promotes MyoD-induced muscle regeneration in mdx mice by interacting with FOXO3A.
Tong H, Fan S, Hu W, Wang H, Guo G, Huang X, Zhao L, Li X, Zhang L, Jiang Z, Yu Q
Pharmacological research 2024 Oct;208:107376
Pharmacological research 2024 Oct;208:107376
Discovery of Potent Covalent CRM1 Inhibitors Via a Customized Structure-Based Virtual Screening Pipeline and Bioassays.
Liu H, Shen C, Li H, Hou T, Yang Y
Journal of chemical information and modeling 2024 Oct 14;64(19):7422-7431
Journal of chemical information and modeling 2024 Oct 14;64(19):7422-7431
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate muscle atrophy via the miR-132-3p/FoxO3 axis.
Ma H, Jing Y, Zeng J, Ge J, Sun S, Cui R, Qian C, Qu S, Sheng H
Journal of orthopaedic translation 2024 Nov;49:23-36
Journal of orthopaedic translation 2024 Nov;49:23-36
Procyanidin C1 ameliorates acidic pH stress induced nucleus pulposus degeneration through SIRT3/FOXO3-mediated mitochondrial dynamics.
Hua W, Xie L, Dong C, Yang G, Chi S, Xu Z, Yang C, Wang H, Wu X
Journal of translational medicine 2024 Nov 27;22(1):1071
Journal of translational medicine 2024 Nov 27;22(1):1071
Gastrodin against oxidative stress-inflammation crosstalk via inhibiting mtDNA/TLR9 and JAK2/STAT3 signaling to ameliorate ischemic stroke injury.
Zhang M, Zhang Y, Peng J, Huang Y, Gong Z, Lu H, Han L, Wang D
International immunopharmacology 2024 Nov 15;141:113012
International immunopharmacology 2024 Nov 15;141:113012
EMX2 inhibits clear cell renal cell carcinoma progress via modulating Akt/FOXO3a pathway.
Zhou X, Dong S, Zhou Y, He Z, Zhang Z, Liao L, Zou B, Zheng X, Peng K, Duan X
Molecular carcinogenesis 2024 May;63(5):951-961
Molecular carcinogenesis 2024 May;63(5):951-961
Indole-3-carbinol ameliorates ovarian damage in female old mice through Nrf2/HO-1 pathway activation.
Hu H, Li F, Zhu F, Li J, Wang S, He Z, Chen J, Cheng L, Zhong F
Biochemical pharmacology 2024 May;223:116193
Biochemical pharmacology 2024 May;223:116193
d-galactose causes embryonic development arrest and placental development disorders in mice by increasing ROS and inhibiting SIRT1/FOXO3a axis.
Yin L, Niu Y, Zheng X, Chu J, Ma T
Placenta 2024 May;150:52-61
Placenta 2024 May;150:52-61
Lysophosphatidic Acid Stimulates Mitogenic Activity and Signaling in Human Neuroblastoma Cells through a Crosstalk with Anaplastic Lymphoma Kinase.
Dedoni S, Olianas MC, Onali P
Biomolecules 2024 May 28;14(6)
Biomolecules 2024 May 28;14(6)
IL-1β promotes esophageal squamous cell carcinoma growth and metastasis through FOXO3A by activating the PI3K/AKT pathway.
Chen S, Yang Y, Zheng Z, Zhang M, Chen X, Xiao N, Liu H
Cell death discovery 2024 May 18;10(1):238
Cell death discovery 2024 May 18;10(1):238
The role of microRNA-142a in Toxoplasma gondii infection-induced downregulation of Foxp3: implications for adverse pregnancy outcomes.
Zhong Y, Cao Y, Geng X, Yang S, Qian T, Liu C, Chen J
BMC infectious diseases 2024 May 13;24(1):490
BMC infectious diseases 2024 May 13;24(1):490
Neuroprotective effects of polyphyllin VI against rotenone-induced toxicity in SH-SY5Y cells.
Li L, Chen Z, Hao C
Brain research 2024 May 1;1830:148824
Brain research 2024 May 1;1830:148824
Fangji Fuling Decoction Alleviates Sepsis by Blocking MAPK14/FOXO3A Signaling Pathway.
Wang Y, Chen MQ, Dai LF, Zhang HD, Wang X
Chinese journal of integrative medicine 2024 Mar;30(3):230-242
Chinese journal of integrative medicine 2024 Mar;30(3):230-242
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning.
Shi L, Yang J, Tao Z, Zheng L, Bui TF, Alonso RL, Yue F, Cheng Z
Clinical science (London, England : 1979) 2024 Mar 20;138(6):371-385
Clinical science (London, England : 1979) 2024 Mar 20;138(6):371-385
Interferon-Alpha Induces Psoriatic Inflammation in Mice by Phosphorylating FOXO3.
Gu H, Wang X, Lu M, Wang Y, Ren K, Zhang Y, Liu W, Hu G, Zeng W, Xia Y
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2024 Jun;44(6):260-270
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2024 Jun;44(6):260-270
Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor.
Chen J, Hu J, Guo X, Yang Y, Qin D, Tang X, Huang Z, Wang F, Hu D, Peng D, Yu B
Cell death & disease 2024 Jun 3;15(6):389
Cell death & disease 2024 Jun 3;15(6):389
Taraxerone exerts antipulmonary fibrosis effect through Smad signaling pathway and antioxidant stress response in a Sirtuin1-dependent manner.
Chen Z, Xie W, Tang S, Lin M, Ren L, Huang X, Deng L, Qian R, Wang Z, Xiong D, Xie P, Liu W
Phytotherapy research : PTR 2024 Jul;38(7):3720-3735
Phytotherapy research : PTR 2024 Jul;38(7):3720-3735
Dental pulp mesenchymal stem cell-derived exosomes inhibit neuroinflammation and microglial pyroptosis in subarachnoid hemorrhage via the miRNA-197-3p/FOXO3 axis.
Liang X, Miao Y, Tong X, Chen J, Liu H, He Z, Liu A, Hu Z
Journal of nanobiotechnology 2024 Jul 19;22(1):426
Journal of nanobiotechnology 2024 Jul 19;22(1):426
20( S )-Protopanaxatriol Improves Atherosclerosis by Inhibiting Low-Density Lipoprotein Receptor Degradation in ApoE KO Mice.
Huang YW, Luo F, Zhang M, Wang L, Meng W, Hu D, Yang J, Sheng J, Wang X
Journal of cardiovascular pharmacology 2024 Jul 1;84(1):45-57
Journal of cardiovascular pharmacology 2024 Jul 1;84(1):45-57
Berberine alleviates contrast-induced nephropathy by activating Akt/Foxo3a/Nrf2 signalling pathway.
Wang W, Yu R, Wu C, Li Q, Chen J, Xiao Y, Chen H, Song J, Ji M, Zuo Z
Journal of cellular and molecular medicine 2024 Jan;28(1):e18016
Journal of cellular and molecular medicine 2024 Jan;28(1):e18016
Maimendong decoction regulates M2 macrophage polarization to suppress pulmonary fibrosis via PI3K/Akt/FOXO3a signalling pathway-mediated fibroblast activation.
Shuangshuang H, Mengmeng S, Lan Z, Fang Z, Yu L
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117308
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117308
Response of lipid metabolism, energy supply, and cell fate in yellowstripe goby (Mugilogobius chulae) exposed to environmentally relevant concentrations atorvastatin.
Zhao Y, Duan C, Zhang H, Gong W, Wang Y, Ren J, Nie X, Li J
Environmental pollution (Barking, Essex : 1987) 2024 Jan 15;341:122991
Environmental pollution (Barking, Essex : 1987) 2024 Jan 15;341:122991
A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice.
Zhou Y, Zhao Q, Zhang Y, Di L, Xue F, Xu W, Gao W, Guo Y, He Y, Kou J, Qin Y, Xie X, Du L, Han G, Pang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155298
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155298
Dendrobium officinale Polysaccharides as a Natural Functional Component for Acetic-Acid-Induced Gastric Ulcers in Rats.
Zhang M, Xu L, Chen L, Wu H, Jia L, Zhu H
Molecules (Basel, Switzerland) 2024 Feb 16;29(4)
Molecules (Basel, Switzerland) 2024 Feb 16;29(4)
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Han YL, Yan TT, Li HX, Chen SS, Zhang ZZ, Wang MY, Chen MJ, Chen YL, Yang XX, Wei LL, Duan YJ, Zhang S
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Cepharanthine sensitizes gastric cancer cells to chemotherapy by targeting TRIB3-FOXO3-FOXM1 axis to inhibit autophagy.
Lu YY, Fang YY, Wang SS, Guo J, Song JL, Zhu L, Lin ZK, Wang R, Zhang SY, Qiu WS, Qi WW
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156161
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156161
Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis.
Wang K, Zeng H, Yang H
Chinese medicine 2024 Dec 31;19(1):180
Chinese medicine 2024 Dec 31;19(1):180
Acetyl-11-keto-β-boswellia acid attenuates Ti particle-induced osteoblastic oxidative stress and osteolysis through the Foxo3 signaling pathway.
Gu Y, Wu Z, Xie H, Qian Z, Li Z, Tang Y, Wang Q, Fang T, Tao H, Chen K, Zhu P, Ding Y, Xu Y, Peng Y, Ye H, Guo X, Tao Y, Gu Y
International immunopharmacology 2024 Dec 25;143(Pt 3):113547
International immunopharmacology 2024 Dec 25;143(Pt 3):113547
Berberine ameliorates contrast-induced acute kidney injury by regulating HDAC4-FoxO3a axis-induced autophagy: In vivo and in vitro.
Zuo Z, Li Q, Zhou S, Yu R, Wu C, Chen J, Xiao Y, Chen H, Song J, Pan Y, Wang W
Phytotherapy research : PTR 2024 Apr;38(4):1761-1780
Phytotherapy research : PTR 2024 Apr;38(4):1761-1780
Low-dose deoxynivalenol exposure inhibits hepatic mitophagy and hesperidin reverses this phenomenon by activating SIRT1.
Chen H, Xin W, Jiang J, Shan A, Ma J
Journal of hazardous materials 2024 Apr 15;468:133854
Journal of hazardous materials 2024 Apr 15;468:133854
Combined therapy of dabrafenib and an anti-HER2 antibody-drug conjugate for advanced BRAF-mutant melanoma.
Li W, Zheng C, Xu X, Xia Y, Zhang K, Huang A, Zhang X, Zheng Y, Chen G, Zhang S
Cellular & molecular biology letters 2024 Apr 10;29(1):50
Cellular & molecular biology letters 2024 Apr 10;29(1):50
The role of miR-222-2p in exosomes secreted by hexavalent chromium-induced premature senescent hepatocytes as a SASP component.
Ma Y, Li S, Ye S, Luo S, Wei L, Su Y, Zeng Y, Shi Y, Bian H, Xiao F
Environmental pollution (Barking, Essex : 1987) 2024 Apr 1;346:123535
Environmental pollution (Barking, Essex : 1987) 2024 Apr 1;346:123535
Triamcinolone acetonide induces the autophagy of Ag85B-treated WI-38 cells via SIRT1/FOXO3 pathway.
Luo L, Zhou L, Luo L, Feng D, Ding Y, Lu Z, Nie G, Bai L, Xiao Y
Allergologia et immunopathologia 2023;51(2):27-35
Allergologia et immunopathologia 2023;51(2):27-35
Luteolin inhibits triple-negative breast cancer by inducing apoptosis and autophagy through SGK1-FOXO3a-BNIP3 signaling.
Wu L, Lin Y, Gao S, Wang Y, Pan H, Wang Z, Pozzolini M, Yang F, Zhang H, Yang Y, Xiao L, Xu Y
Frontiers in pharmacology 2023;14:1200843
Frontiers in pharmacology 2023;14:1200843
Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retina.
Tan LX, Germer CJ, Thamban T, La Cunza N, Lakkaraju A
Current biology : CB 2023 Sep 25;33(18):3805-3820.e7
Current biology : CB 2023 Sep 25;33(18):3805-3820.e7
Proteomic analysis of uterine lavage fluid of dairy cows at different time after delivery by mass spectrometry.
Jiang X, Li Z, Chang X, Huang C, Qiu R, Wang A, Lin P, Tang K, Chen H, Zhou D, Jin Y
Theriogenology 2023 Sep 1;207:31-48
Theriogenology 2023 Sep 1;207:31-48
3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis.
Mu M, Zhang Q, Zhao C, Li X, Chen Z, Sun X, Yu J
Cancer gene therapy 2023 Oct;30(10):1414-1425
Cancer gene therapy 2023 Oct;30(10):1414-1425
Zigui-Yichong-Fang protects against cyclophosphamide-induced premature ovarian insufficiency via the SIRT1/Foxo3a pathway.
Xiu Z, Tang S, Kong P, Yan M, Tong X, Liu X, Liang X, Li R, Duan Y
Journal of ethnopharmacology 2023 Oct 5;314:116608
Journal of ethnopharmacology 2023 Oct 5;314:116608
Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway.
Wang X, Shen T, Lian J, Deng K, Qu C, Li E, Li G, Ren Y, Wang Z, Jiang Z, Sun X, Li X
Molecular medicine (Cambridge, Mass.) 2023 Oct 19;29(1):137
Molecular medicine (Cambridge, Mass.) 2023 Oct 19;29(1):137
Metformin Suppresses Stemness of Non-Small-Cell Lung Cancer Induced by Paclitaxel through FOXO3a.
Tang Z, Zhang Y, Yu Z, Luo Z
International journal of molecular sciences 2023 Nov 22;24(23)
International journal of molecular sciences 2023 Nov 22;24(23)
Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.
Zhang X, Dong Z, Yang Y, Liu C, Li J, Sun W, Zhu Y, Shen Y, Wang Z, Lü M, Cui H
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031
Resistance exercise alleviates dexamethasone-induced muscle atrophy via Sestrin2/MSTN pathway in C57BL/6J mice.
Yang Y, Yang X, Huang Y, Liu S, Niu Y, Fu L
Experimental cell research 2023 Nov 1;432(1):113779
Experimental cell research 2023 Nov 1;432(1):113779
Exercise mitigates Dapagliflozin-induced skeletal muscle atrophy in STZ-induced diabetic rats.
Yang X, Wang L, Zhang L, Zhai X, Sheng X, Quan H, Lin H
Diabetology & metabolic syndrome 2023 Jul 12;15(1):154
Diabetology & metabolic syndrome 2023 Jul 12;15(1):154
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
Cheng L, He Q, Liu B, Chen L, Lv F, Li X, Li Y, Liu C, Song Y, Xing Y
Cell death & disease 2023 Jan 31;14(1):74
Cell death & disease 2023 Jan 31;14(1):74
The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.
Du P, Meng L, Liao X, Liu Y, Mo X, Gong M, Liao Y
Acta biochimica et biophysica Sinica 2023 Jan 25;55(1):103-116
Acta biochimica et biophysica Sinica 2023 Jan 25;55(1):103-116
The Investigation of the Molecular Mechanism of Morinda officinalis How in the Treatment of Heart Failure.
Wang A, Guo Y, Ding S, Yu Y, Yuan Z, Zhang H, Liu Y
Frontiers in bioscience (Landmark edition) 2023 Feb 24;28(2):34
Frontiers in bioscience (Landmark edition) 2023 Feb 24;28(2):34
Toxicity assessment of organophosphate flame retardant triphenyl phosphate (TPHP) on intestines in mice.
Peng C, Zhang X, Chen Y, Wang L
Ecotoxicology and environmental safety 2023 Dec;268:115685
Ecotoxicology and environmental safety 2023 Dec;268:115685
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression.
Cong L, Liu X, Bai Y, Qin Q, Zhao L, Shi Y, Bai Y, Guo Z
Biological research 2023 Dec 2;56(1):62
Biological research 2023 Dec 2;56(1):62
miR-342-5p promotes vascular smooth muscle cell phenotypic transition through a negative-feedback regulation of Notch signaling via targeting FOXO3.
Wen T, Duan Y, Gao D, Zhang X, Zhang X, Liang L, Yang Z, Zhang P, Zhang J, Sun J, Feng Y, Zheng Q, Han H, Yan X
Life sciences 2023 Aug 1;326:121828
Life sciences 2023 Aug 1;326:121828
Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.
Wang Y, Chen X, Baker JS, Davison GW, Xu S, Zhou Y, Bao X
European journal of nutrition 2023 Apr;62(3):1453-1466
European journal of nutrition 2023 Apr;62(3):1453-1466
Ursolic Acid Alleviates Cancer Cachexia and Prevents Muscle Wasting via Activating SIRT1.
Tao W, Ouyang Z, Liao Z, Li L, Zhang Y, Gao J, Ma L, Yu S
Cancers 2023 Apr 20;15(8)
Cancers 2023 Apr 20;15(8)
Ketone Body β-Hydroxybutyrate Prevents Myocardial Oxidative Stress in Septic Cardiomyopathy.
Ji L, He Q, Liu Y, Deng Y, Xie M, Luo K, Cai X, Zuo Y, Wu W, Li Q, Zhou R, Li T
Oxidative medicine and cellular longevity 2022;2022:2513837
Oxidative medicine and cellular longevity 2022;2022:2513837
FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy.
Guan S, Chen X, Chen Y, Wan G, Su Q, Liang H, Yang Y, Fang W, Huang Y, Zhao H, Zhuang W, Liu S, Wang F, Feng W, Zhang X, Huang M, Wang X, Zhang L
Acta pharmaceutica Sinica. B 2022 Sep;12(9):3639-3649
Acta pharmaceutica Sinica. B 2022 Sep;12(9):3639-3649
Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway.
Li H, Zhang M, Wang Y, Gong K, Yan T, Wang D, Meng X, Yang X, Chen Y, Han J, Duan Y, Zhang S
Food & function 2022 Sep 22;13(18):9576-9588
Food & function 2022 Sep 22;13(18):9576-9588
Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage.
Zhao Y, Guo Y, Sun M, Hussion S, Zheng Y, Huang H, Huo X, Zhao Y, Zhang F, Han Y, Ning Q, Xu P, Sun J, Lu S
Journal of bone and mineral metabolism 2022 Nov;40(6):914-926
Journal of bone and mineral metabolism 2022 Nov;40(6):914-926
Exercise attenuates angiotensinⅡ-induced muscle atrophy by targeting PPARγ/miR-29b.
Liu Q, Chen L, Liang X, Cao Y, Zhu X, Wang S, Li J, Gao J, Xiao J
Journal of sport and health science 2022 Nov;11(6):696-707
Journal of sport and health science 2022 Nov;11(6):696-707
Recombinant P40 protein of Schistosoma japonicum inhibits TREM-1 expression in RAW264.7 cells via FOXO3a.
Shen P, Zhang T, Chen G, Zhang B, Huang A, Duan L, Zhu D, Chen J, Wang J, Duan Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 May;149:112826
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 May;149:112826
Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1.
Xu C, Zhang Z, Liu N, Li L, Zhong H, Wang R, Shi Q, Zhang Z, Wei L, Hu B, Zhang H, Shen X, Wang Y, Liu Y, Yuan W
Nature communications 2022 May 5;13(1):2467
Nature communications 2022 May 5;13(1):2467
RBM47/SNHG5/FOXO3 axis activates autophagy and inhibits cell proliferation in papillary thyroid carcinoma.
Qin Y, Sun W, Wang Z, Dong W, He L, Zhang T, Lv C, Zhang H
Cell death & disease 2022 Mar 25;13(3):270
Cell death & disease 2022 Mar 25;13(3):270
Virus-induced FoxO factor facilitates replication of human cytomegalovirus.
Sleman S
Archives of virology 2022 Jan;167(1):109-121
Archives of virology 2022 Jan;167(1):109-121
Solasonine relieves sevoflurane-induced neurotoxicity via activating the AMP-activated protein kinase/FoxO3a pathway.
Zhang H, Yan L
Human & experimental toxicology 2022 Jan-Dec;41:9603271211069984
Human & experimental toxicology 2022 Jan-Dec;41:9603271211069984
Cordycepin, a major bioactive component of Cordyceps militaris, ameliorates diabetes-induced testicular damage through the Sirt1/Foxo3a pathway.
Huang T, Zhou Y, Lu X, Tang C, Ren C, Bao X, Deng Z, Cao X, Zou J, Zhang Q, Ma B
Andrologia 2022 Feb;54(1):e14294
Andrologia 2022 Feb;54(1):e14294
A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.
Deng Q, Yang S, Sun L, Huang K, Dong K, Zhu Y, Cao Y, Li Y, Wu S, Huang R
Redox biology 2022 Feb;49:102217
Redox biology 2022 Feb;49:102217
MicroRNA-122-5p promotes renal fibrosis and injury in spontaneously hypertensive rats by targeting FOXO3.
Liu Y, Dong ZJ, Song JW, Liang LR, Sun LL, Liu XY, Miao R, Xu YL, Li XT, Zhang MW, Zhang ZZ, Zhong JC
Experimental cell research 2022 Feb 15;411(2):113017
Experimental cell research 2022 Feb 15;411(2):113017
Inhibition of cell proliferation by Tas of foamy viruses through cell cycle arrest or apoptosis underlines the different mechanisms of virus-host interactions.
Jie W, Rui-Fen Z, Zhong-Xiang H, Yan W, Wei-Na L, Yong-Ping M, Jing S, Jing-Yi C, Wan-Hong L, Xiao-Hua H, Zhi L, Yan S
Virulence 2022 Dec;13(1):342-354
Virulence 2022 Dec;13(1):342-354
A novel combination treatment of antiADAM17 antibody and erlotinib to overcome acquired drug resistance in non-small cell lung cancer through the FOXO3a/FOXM1 axis.
Li J, Chen P, Wu Q, Guo L, Leong KW, Chan KI, Kwok HF
Cellular and molecular life sciences : CMLS 2022 Dec 2;79(12):614
Cellular and molecular life sciences : CMLS 2022 Dec 2;79(12):614
Danggui Buxue Tang Rescues Folliculogenesis and Ovarian Cell Apoptosis in Rats with Premature Ovarian Insufficiency.
Wang L, Liu J, Nie G, Li Y, Yang H
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6614302
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6614302
β-hydroxybutyrate Alleviates Learning and Memory Impairment Through the SIRT1 Pathway in D-Galactose-Injured Mice.
Yang X, Wang R, Zhou H, Wang L, Wang R, Li H, Tan B, Wu Q, Xu X, Cui L, Li Z, Li H
Frontiers in pharmacology 2021;12:751028
Frontiers in pharmacology 2021;12:751028
Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G(0)/G(1) Cell Cycle Arrest and Antiproliferation in A549 Cells.
Zhang YL, Chen GL, Liu Y, Zhuang XC, Guo MQ
Antioxidants (Basel, Switzerland) 2021 Sep 30;10(10)
Antioxidants (Basel, Switzerland) 2021 Sep 30;10(10)
The protective effects of resveratrol pretreatment in cyclophosphamide-induced rat ovarian injury: an vivo study.
Nie Z, Zhang L, Chen W, Zhang Y, Wang W, Hua R, Zhang T, Zhao C, Gong M, Wu H
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2021 Oct;37(10):914-919
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2021 Oct;37(10):914-919
Adiponectin regulates osteocytic MLO-Y4 cell apoptosis in a high-glucose environment through the AMPK/FoxO3a signaling pathway.
Zeng Y, Liang H, Guo Y, Feng Y, Yao Q
Journal of cellular physiology 2021 Oct;236(10):7088-7096
Journal of cellular physiology 2021 Oct;236(10):7088-7096
Activation of angiotensin-converting enzyme 2/angiotensin (1-7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling.
Dang R, Yang M, Cui C, Wang C, Zhang W, Geng C, Han W, Jiang P
Aging cell 2021 Oct;20(10):e13480
Aging cell 2021 Oct;20(10):e13480
MiR-223-3p targets FOXO3a to inhibit radiosensitivity in prostate cancer by activating glycolysis.
Zhou K, Wei Y, Li X, Yang X
Life sciences 2021 Oct 1;282:119798
Life sciences 2021 Oct 1;282:119798
Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish.
Wu K, Chen GH, Hogstrand C, Ling SC, Wu LX, Luo Z
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2021 May;65:126732
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2021 May;65:126732
RANKL Mediates Muscle Atrophy and Dysfunction in a Cigarette Smoke-induced Model of Chronic Obstructive Pulmonary Disease.
Xiong J, Le Y, Rao Y, Zhou L, Hu Y, Guo S, Sun Y
American journal of respiratory cell and molecular biology 2021 May;64(5):617-628
American journal of respiratory cell and molecular biology 2021 May;64(5):617-628
MiR-1290 promotes myoblast differentiation and protects against myotube atrophy via Akt/p70/FoxO3 pathway regulation.
Che J, Xu C, Wu Y, Jia P, Han Q, Ma Y, Wang X, Zheng Y
Skeletal muscle 2021 Mar 15;11(1):6
Skeletal muscle 2021 Mar 15;11(1):6
PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis.
Yin S, Liu L, Brobbey C, Palanisamy V, Ball LE, Olsen SK, Ostrowski MC, Gan W
Nature communications 2021 Jun 8;12(1):3444
Nature communications 2021 Jun 8;12(1):3444
Early-senescent bone marrow mesenchymal stem cells promote C2C12 cell myogenic differentiation by preventing the nuclear translocation of FOXO3.
Che J, Xu C, Wu Y, Jia P, Han Q, Ma Y, Wang X, Du Y, Zheng Y
Life sciences 2021 Jul 15;277:119520
Life sciences 2021 Jul 15;277:119520
Syringin exerts neuroprotective effects in a rat model of cerebral ischemia through the FOXO3a/NF-κB pathway.
Tan J, Luo J, Meng C, Jiang N, Cao J, Zhao J
International immunopharmacology 2021 Jan;90:107268
International immunopharmacology 2021 Jan;90:107268
Xiaoyaosan decoction alleviated rat liver fibrosis via the TGFβ/Smad and Akt/FoxO3 signaling pathways based on network pharmacology analysis.
Zhou Y, Wu R, Cai FF, Zhou WJ, Lu YY, Zhang H, Chen QL, Su SB
Journal of ethnopharmacology 2021 Jan 10;264:113021
Journal of ethnopharmacology 2021 Jan 10;264:113021
Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis.
Zhou Y, Wu R, Cai FF, Zhou WJ, Lu YY, Zhang H, Chen QL, Sun MY, Su SB
Pharmaceutical biology 2021 Dec;59(1):1594-1606
Pharmaceutical biology 2021 Dec;59(1):1594-1606
WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute myeloid leukemia.
Zhu Y, Tong X, Wang Y, Lu X
Cell death & disease 2021 Dec 20;13(1):18
Cell death & disease 2021 Dec 20;13(1):18
EGFR/FOXO3A/LXR-α Axis Promotes Prostate Cancer Proliferation and Metastasis and Dual-Targeting LXR-α/EGFR Shows Synthetic Lethality.
Chen T, Xu J, Fu W
Frontiers in oncology 2020;10:1688
Frontiers in oncology 2020;10:1688
TNNC1 Reduced Gemcitabine Sensitivity of Nonsmall-Cell Lung Cancer by Increasing Autophagy.
Ye X, Xie G, Liu Z, Tang J, Cui M, Wang C, Guo C, Tang J
Medical science monitor : international medical journal of experimental and clinical research 2020 Sep 18;26:e922703
Medical science monitor : international medical journal of experimental and clinical research 2020 Sep 18;26:e922703
MiR-23a-5p exacerbates intestinal ischemia-reperfusion injury by promoting oxidative stress via targeting PPAR alpha.
Li LX, Yin LH, Gao M, Xu LN, Qi Y, Peng JY
Biochemical pharmacology 2020 Oct;180:114194
Biochemical pharmacology 2020 Oct;180:114194
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Wang D, Yang X, Chen Y, Gong K, Yu M, Gao Y, Wu X, Hu H, Liao C, Han J, Duan Y
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
CDKL3 promotes osteosarcoma progression by activating Akt/PKB.
He A, Ma L, Huang Y, Zhang H, Duan W, Li Z, Fei T, Yuan J, Wu H, Liu L, Bai Y, Dai W, Wang Y, Li H, Sun Y, Wang Y, Wang C, Yuan T, Yang Q, Tian S, Dong M, Sheng R, Xiang D
Life science alliance 2020 May;3(5)
Life science alliance 2020 May;3(5)
Linc00261 inhibits metastasis and the WNT signaling pathway of pancreatic cancer by regulating a miR‑552‑5p/FOXO3 axis.
Chen T, Lei S, Zeng Z, Zhang J, Xue Y, Sun Y, Lan J, Xu S, Mao D, Guo B
Oncology reports 2020 Mar;43(3):930-942
Oncology reports 2020 Mar;43(3):930-942
LongShengZhi capsule inhibits doxorubicin-induced heart failure by anti-oxidative stress.
Xu S, Wang Y, Yu M, Wang D, Liang Y, Chen Y, Liao C, Xie Z, Zhao B, Han J, Duan Y, Yang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109803
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109803
Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation.
Deng L, Li H, Su X, Zhang Y, Xu H, Fan L, Fan J, Han Q, Bai X, Zhao RC
Cell death & disease 2020 Mar 2;11(3):158
Cell death & disease 2020 Mar 2;11(3):158
Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.
Yang S, Zhao N, Sun B, Yang Y, Hu Y, Zhao R
Journal of the science of food and agriculture 2020 Mar 15;100(4):1486-1494
Journal of the science of food and agriculture 2020 Mar 15;100(4):1486-1494
Carfilzomib inhibits the growth of lung adenocarcinoma via upregulation of Gadd45a expression.
Yang F, Liu WW, Chen H, Zhu J, Huang AH, Zhou F, Gan Y, Zhang YH, Ma L
Journal of Zhejiang University. Science. B 2020 Jan.;21(1):64-76
Journal of Zhejiang University. Science. B 2020 Jan.;21(1):64-76
FOXO3/TRIM22 axis abated the antitumor effect of gemcitabine in non-small cell lung cancer via autophagy induction.
Wang Y, Liang HX, Zhang CM, Zou M, Zou BB, Wei W, Hu W
Translational cancer research 2020 Feb;9(2):937-948
Translational cancer research 2020 Feb;9(2):937-948
Exogenous CGRP Regulates Apoptosis and Autophagy to Alleviate Traumatic Brain Injury Through Akt/mTOR Signalling Pathway.
Tian J, Yang L, Wang P, Yang L, Fan Z
Neurochemical research 2020 Dec;45(12):2926-2938
Neurochemical research 2020 Dec;45(12):2926-2938
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Zhou H, Yuan D, Gao W, Tian J, Sun H, Yu S, Wang J, Sun L
IUBMB life 2020 Aug;72(8):1659-1679
IUBMB life 2020 Aug;72(8):1659-1679
FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy.
Wang Y, Yang Y, Zuo R, Wu J, Zhang C, Li C, Liu M, Zhou Y
Biochemical and biophysical research communications 2020 Apr 9;524(3):756-763
Biochemical and biophysical research communications 2020 Apr 9;524(3):756-763
BH3 mimetic ABT-263 enhances the anticancer effects of apigenin in tumor cells with activating EGFR mutation.
Zhan Y, Wang Y, Qi M, Liang P, Ma Y, Li T, Li H, Dai C, An Z, Qi Y, Wu H, Shao H
Cell & bioscience 2019;9:60
Cell & bioscience 2019;9:60
circRNA_0025202 Regulates Tamoxifen Sensitivity and Tumor Progression via Regulating the miR-182-5p/FOXO3a Axis in Breast Cancer.
Sang Y, Chen B, Song X, Li Y, Liang Y, Han D, Zhang N, Zhang H, Liu Y, Chen T, Li C, Wang L, Zhao W, Yang Q
Molecular therapy : the journal of the American Society of Gene Therapy 2019 Sep 4;27(9):1638-1652
Molecular therapy : the journal of the American Society of Gene Therapy 2019 Sep 4;27(9):1638-1652
Doxorubicin obliterates mouse ovarian reserve through both primordial follicle atresia and overactivation.
Wang Y, Liu M, Johnson SB, Yuan G, Arriba AK, Zubizarreta ME, Chatterjee S, Nagarkatti M, Nagarkatti P, Xiao S
Toxicology and applied pharmacology 2019 Oct 15;381:114714
Toxicology and applied pharmacology 2019 Oct 15;381:114714
Punicalagin Prevents Inflammation in LPS-Induced RAW264.7 Macrophages by Inhibiting FoxO3a/Autophagy Signaling Pathway.
Cao Y, Chen J, Ren G, Zhang Y, Tan X, Yang L
Nutrients 2019 Nov 15;11(11)
Nutrients 2019 Nov 15;11(11)
A New Possible Mechanism by Which Punicalagin Protects against Liver Injury Induced by Type 2 Diabetes Mellitus: Upregulation of Autophagy via the Akt/FoxO3a Signaling Pathway.
Zhang Y, Cao Y, Chen J, Qin H, Yang L
Journal of agricultural and food chemistry 2019 Dec 18;67(50):13948-13959
Journal of agricultural and food chemistry 2019 Dec 18;67(50):13948-13959
Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation.
Liu L, Chen H, Jin J, Tang Z, Yin P, Zhong D, Li G
Life sciences 2019 Dec 15;239:117036
Life sciences 2019 Dec 15;239:117036
Resveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH-1) through p38 MAPK-FOXO3a pathway.
Li C, Hu WL, Lu MX, Xiao GF
BMC complementary and alternative medicine 2019 Aug 29;19(1):233
BMC complementary and alternative medicine 2019 Aug 29;19(1):233
Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy.
Li YF, Ouyang SH, Tu LF, Wang X, Yuan WL, Wang GE, Wu YP, Duan WJ, Yu HM, Fang ZZ, Kurihara H, Zhang Y, He RR
Theranostics 2018;8(20):5713-5730
Theranostics 2018;8(20):5713-5730
Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF-κB pathway and ROS signaling.
Ma J, Yin G, Lu Z, Xie P, Zhou H, Liu J, Yu L
Phytotherapy research : PTR 2018 Sep;32(9):1770-1783
Phytotherapy research : PTR 2018 Sep;32(9):1770-1783
Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.
Yang S, Zhao N, Yang Y, Hu Y, Dong H, Zhao R
Journal of agricultural and food chemistry 2018 Mar 21;66(11):2704-2713
Journal of agricultural and food chemistry 2018 Mar 21;66(11):2704-2713
Expression of PIM-1 in salivary gland adenoid cystic carcinoma: Association with tumor progression and patients' prognosis.
Zhu X, Yu Y, Hou X, Xu J, Tan Z, Nie X, Ling Z, Ge M
Oncology letters 2018 Jan;15(1):1149-1156
Oncology letters 2018 Jan;15(1):1149-1156
Nuclear forkhead box O3a accumulation contributing to the proliferative suppression in liver cancer cells by PI3K/Akt signaling pathway.
Hou Y, Sun G, Jiang X, Zhu Z, Yang J
Journal of cancer research and therapeutics 2018 Dec;14(Supplement):S1124-S1128
Journal of cancer research and therapeutics 2018 Dec;14(Supplement):S1124-S1128
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways.
Zhang C, Li C, Chen S, Li Z, Ma L, Jia X, Wang K, Bao J, Liang Y, Chen M, Li P, Su H, Lee SM, Liu K, Wan JB, He C
Scientific reports 2017 Jan 23;7:41082
Scientific reports 2017 Jan 23;7:41082
High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.
Zhang XQ, Dong JJ, Cai T, Shen X, Zhou XJ, Liao L
Oncotarget 2017 Apr 11;8(15):24119-24129
Oncotarget 2017 Apr 11;8(15):24119-24129
Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.
Yang Y, Li X, Sun Q, He B, Jia Y, Cai D, Zhao R
The international journal of biochemistry & cell biology 2016 Oct;79:222-230
The international journal of biochemistry & cell biology 2016 Oct;79:222-230
CHIP promotes thyroid cancer proliferation via activation of the MAPK and AKT pathways.
Zhang L, Liu L, He X, Shen Y, Liu X, Wei J, Yu F, Tian J
Biochemical and biophysical research communications 2016 Aug 26;477(3):356-62
Biochemical and biophysical research communications 2016 Aug 26;477(3):356-62
Low-protein diet fed to crossbred sows during pregnancy and lactation enhances myostatin gene expression through epigenetic regulation in skeletal muscle of weaning piglets.
Jia Y, Gao G, Song H, Cai D, Yang X, Zhao R
European journal of nutrition 2016 Apr;55(3):1307-14
European journal of nutrition 2016 Apr;55(3):1307-14
Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure.
Chen Z, Kang X, Wang L, Dong H, Wang C, Xiong Z, Zhao W, Jia C, Lin J, Zhang W, Yuan W, Zhong M, Du H, Bai X
The Journal of biological chemistry 2015 Mar 6;290(10):6387-96
The Journal of biological chemistry 2015 Mar 6;290(10):6387-96
miRNA-155 modulates the malignant biological characteristics of NK/T-cell lymphoma cells by targeting FOXO3a gene.
Ji WG, Zhang XD, Sun XD, Wang XQ, Chang BP, Zhang MZ
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2014 Dec;34(6):882-888
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2014 Dec;34(6):882-888
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10849-1-AP(FOXO3A antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 10849-1-AP(FOXO3A antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FOXO3A antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FOXO3A. This antibody recognizes human,mouse,rat antigen. The FOXO3A antibody has been validated for the following applications: ELISA, WB, IHC analysis.
