Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 16129-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16129-1-AP, RRID:AB_2104749
- Product name
- FDPS antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FDPS antibody (Cat. #16129-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lipin1-dependent transcriptional inactivation of SREBPs contributes to selinexor sensitivity in multiple myeloma.
The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism.
Tylophora yunnanensis extract inhibits cholesterol biosynthesis to suppress triple negative breast cancer.
Isorhapontigenin suppresses inflammation, proliferation and aggressiveness of rheumatoid arthritis fibroblast-like synoviocytes by targeting farnesyl diphosphate synthase.
Periodontal ligament fibroblasts utilize isoprenoid intermediate farnesyl diphosphate for maintaining osteo/cementogenic differentiation abilities.
Modulation of the RAC1/MAPK/ERK signalling pathway by farnesyl diphosphate synthase regulates granulosa cells proliferation in polycystic ovary syndrome.
TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves.
miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway.
Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism.
Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis.
Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer.
Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord.
Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling.
Transcriptomic Analysis Reveals the Protective Effects of Empagliflozin on Lipid Metabolism in Nonalcoholic Fatty Liver Disease.
Simvastatin accelerated motoneurons death in SOD1(G93A) mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles.
Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP/PS1 mouse.
Overexpression of farnesyl pyrophosphate synthase increases myocardial ischemia/reperfusion injury in mice.
Does Viperin Function as a Radical S-Adenosyl-l-methionine-dependent Enzyme in Regulating Farnesylpyrophosphate Synthase Expression and Activity?
Lentiviral-mediated silencing of farnesyl pyrophosphate synthase through RNA interference in mice.
Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo.
Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.
Wang JY, Chen MP, Jiang JX, Wan YK, Li X, Zhang YW, Fang Y, Huang HH, Qin ZY, Hou J
Acta pharmacologica Sinica 2025 Sep;46(9):2496-2508
Acta pharmacologica Sinica 2025 Sep;46(9):2496-2508
The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism.
Rattani A, Anderson C, Trim WV, Garita E, Imada S, Khawaled S, Shin H, Zhang J, Yilmaz ÖH, Kirschner M
bioRxiv : the preprint server for biology 2025 Nov 18;
bioRxiv : the preprint server for biology 2025 Nov 18;
Tylophora yunnanensis extract inhibits cholesterol biosynthesis to suppress triple negative breast cancer.
Feng ZH, Li WY, Li QZ, Zhao FB, Zhang HJ, Zhang L, Zhang H
Journal of ethnopharmacology 2025 May 28;348:119877
Journal of ethnopharmacology 2025 May 28;348:119877
Isorhapontigenin suppresses inflammation, proliferation and aggressiveness of rheumatoid arthritis fibroblast-like synoviocytes by targeting farnesyl diphosphate synthase.
Liu Y, Su F, Qiu Q, Shen C, Chen S, Lin W, Liu D, Li R, Kuang Y, Liu T, Xiao Y, Li H, Xu H, Liang L
International immunopharmacology 2025 Jun 26;159:114894
International immunopharmacology 2025 Jun 26;159:114894
Periodontal ligament fibroblasts utilize isoprenoid intermediate farnesyl diphosphate for maintaining osteo/cementogenic differentiation abilities.
Wang X, Suzuki S, Yuan H, Hirata-Tsuchiya S, Fahreza RR, Nemoto E, Shiba H, Yamada S
Journal of dental sciences 2025 Jan;20(1):560-568
Journal of dental sciences 2025 Jan;20(1):560-568
Modulation of the RAC1/MAPK/ERK signalling pathway by farnesyl diphosphate synthase regulates granulosa cells proliferation in polycystic ovary syndrome.
Guo X, Cao Y, He Q, Chen L, Wang Q, Zhang J, Lv W, Zhang B, Zhou X
Human cell 2024 May;37(3):689-703
Human cell 2024 May;37(3):689-703
TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves.
Grove M, Kim H, Pang S, Amaya JP, Hu G, Zhou J, Lemay M, Son YJ
eLife 2024 Mar 8;13
eLife 2024 Mar 8;13
miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway.
Xing K, Bian X, Shi D, Dong S, Zhou H, Xiao S, Bai J, Wu W
Journal of hepatocellular carcinoma 2023;10:2173-2185
Journal of hepatocellular carcinoma 2023;10:2173-2185
Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism.
Yang X, Wang Z, Zandkarimi F, Liu Y, Duan S, Li Z, Kon N, Zhang Z, Jiang X, Stockwell BR, Gu W
Cell metabolism 2023 Aug 8;35(8):1474-1490.e8
Cell metabolism 2023 Aug 8;35(8):1474-1490.e8
Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis.
Zhou W, Liu H, Yuan Z, Zundell J, Towers M, Lin J, Lombardi S, Nie H, Murphy B, Yang T, Wang C, Liao L, Goldman AR, Kannan T, Kossenkov AV, Drapkin R, Montaner LJ, Claiborne DT, Zhang N, Wu S, Zhang R
Cancer cell 2023 Apr 10;41(4):740-756.e10
Cancer cell 2023 Apr 10;41(4):740-756.e10
Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer.
Guo C, Wan R, He Y, Lin SH, Cao J, Qiu Y, Zhang T, Zhao Q, Niu Y, Jin Y, Huang HY, Wang X, Tan L, Thomas RK, Zhang H, Chen L, Wong KK, Hu L, Ji H
Nature cancer 2022 May;3(5):614-628
Nature cancer 2022 May;3(5):614-628
Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord.
Khandker L, Jeffries MA, Chang YJ, Mather ML, Evangelou AV, Bourne JN, Tafreshi AK, Ornelas IM, Bozdagi-Gunal O, Macklin WB, Wood TL
Cell reports 2022 Mar 1;38(9):110423
Cell reports 2022 Mar 1;38(9):110423
Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling.
Seshacharyulu P, Halder S, Nimmakayala R, Rachagani S, Chaudhary S, Atri P, Chirravuri-Venkata R, Ouellette MM, Carmicheal J, Gautam SK, Vengoji R, Wang S, Li S, Smith L, Talmon GA, Klute K, Ly Q, Reames BN, Grem JL, Berim L, Padussis JC, Kaur S, Kumar S, Ponnusamy MP, Jain M, Lin C, Batra SK
EBioMedicine 2022 Jan;75:103772
EBioMedicine 2022 Jan;75:103772
Transcriptomic Analysis Reveals the Protective Effects of Empagliflozin on Lipid Metabolism in Nonalcoholic Fatty Liver Disease.
Ma Y, Kan C, Qiu H, Liu Y, Hou N, Han F, Shi J, Sun X
Frontiers in pharmacology 2021;12:793586
Frontiers in pharmacology 2021;12:793586
Simvastatin accelerated motoneurons death in SOD1(G93A) mice through inhibiting Rab7-mediated maturation of late autophagic vacuoles.
Bai L, Wang Y, Huo J, Li S, Wen Y, Liu Q, Yang J, Liu Y, Li R
Cell death & disease 2021 Apr 12;12(4):392
Cell death & disease 2021 Apr 12;12(4):392
Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP/PS1 mouse.
Wang X, Xia W, Li K, Zhang Y, Ge W, Ma C
Journal of the neurological sciences 2019 Apr 15;399:125-139
Journal of the neurological sciences 2019 Apr 15;399:125-139
Overexpression of farnesyl pyrophosphate synthase increases myocardial ischemia/reperfusion injury in mice.
Dai D, Sun X, Ding J, Chen Y, Hu S
Gene 2018 Sep 25;672:72-78
Gene 2018 Sep 25;672:72-78
Does Viperin Function as a Radical S-Adenosyl-l-methionine-dependent Enzyme in Regulating Farnesylpyrophosphate Synthase Expression and Activity?
Makins C, Ghosh S, Román-Meléndez GD, Malec PA, Kennedy RT, Marsh EN
The Journal of biological chemistry 2016 Dec 23;291(52):26806-26815
The Journal of biological chemistry 2016 Dec 23;291(52):26806-26815
Lentiviral-mediated silencing of farnesyl pyrophosphate synthase through RNA interference in mice.
Yang J, Zhao CZ, Chen B, Chen F, Han J, Hu SJ
BioMed research international 2015;2015:914026
BioMed research international 2015;2015:914026
Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced cardiac hypertrophy and fibrosis in vivo.
Yang J, Zhu HH, Chen GP, Ye Y, Zhao CZ, Mou Y, Hu SJ
The international journal of biochemistry & cell biology 2013 Mar;45(3):657-66
The international journal of biochemistry & cell biology 2013 Mar;45(3):657-66
Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.
Yang J, Mou Y, Wu T, Ye Y, Jiang JC, Zhao CZ, Zhu HH, Du CQ, Zhou L, Hu SJ
Cardiovascular research 2013 Mar 1;97(3):490-9
Cardiovascular research 2013 Mar 1;97(3):490-9
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FDPS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FDPS. This antibody recognizes human, mouse, rat antigen. The FDPS antibody has been validated for the following applications: ELISA, WB analysis.
