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- Antibody Data
- Antigen structure
- References [38]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 60300-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- PTEN antibody
- Antibody type
- Monoclonal
- Description
- PTEN antibody (Cat. #60300-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 5C10B6
- Vial size
- 20ul, 150ul
Submitted references TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
The mechanisms of MicroRNA 21 in premature ovarian insufficiency mice with mesenchymal stem cells transplantation : The involved molecular and immunological mechanisms.
SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53.
CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling.
HNRNPA2B1-mediated m(6)A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p/PTEN axis.
DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway.
Qilan preparation inhibits proliferation and induces apoptosis by down-regulating microRNA-21 in human Tca8113 tongue squamous cell carcinoma cells.
Hsa_circ_0000345 inhibits cell proliferation, migration and invasion of nasopharyngeal carcinoma cells via miR-513a-3p/PTEN axis.
Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease.
Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.
The Janus-faced role of TRPM2-S in retroperitoneal liposarcoma via increasing ROS levels.
Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma.
Pediatric Giant Cell Glioblastoma Presenting with Intracranial Dissemination at Diagnosis: A Case Report.
The Association of microRNA-34a With High Incidence and Metastasis of Lung Cancer in Gejiu and Xuanwei Yunnan.
PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.
PTEN alleviates maladaptive repair of renal tubular epithelial cells by restoring CHMP2A-mediated phagosome closure.
Effects and mechanism of microRNA‑218 against lung cancer.
β-catenin regulates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice by modulating PTEN pathways.
Inhibition of TRPA1 Promotes Cardiac Repair in Mice After Myocardial Infarction.
MicroRNA‑28 promotes the proliferation of non‑small‑cell lung cancer cells by targeting PTEN.
MicroRNA-221 promotes breast cancer resistance to adriamycin via modulation of PTEN/Akt/mTOR signaling.
LSD1 negatively regulates autophagy in myoblast cells by driving PTEN degradation.
Overcoming cisplatin resistance by targeting the MTDH-PTEN interaction in ovarian cancer with sera derived from rats exposed to Guizhi Fuling wan extract.
Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling.
PTEN downregulates WD repeat‑containing protein 66 in salivary adenoid cystic carcinoma.
The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis.
Comprehensive assessment the expression of core elements related to IGFIR/PI3K pathway in granulosa cells of women with polycystic ovary syndrome.
Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.
Targeting USP7 Identifies a Metastasis-Competent State within Bone Marrow-Resident Melanoma CTCs.
Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway.
Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin-6/STAT3 signaling pathway.
MTDH promotes glioma invasion through regulating miR-130b-ceRNAs.
DHPAC, a novel synthetic microtubule destabilizing agent, possess high anti-tumor activity in vincristine-resistant oral epidermoid carcinoma in vitro and in vivo.
Chemoresistance is associated with Beclin-1 and PTEN expression in epithelial ovarian cancers.
LPS induced miR-181a promotes pancreatic cancer cell migration via targeting PTEN and MAP2K4.
Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia.
Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression.
The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells.
Hao XL, Lv YF, Li DF, Bai FH, Gong J, Pan GQ, Su LX, Wang YL, Fu WL, Liu B, Huang L, Yan D, Tan QL, Liu JY, Guo QN
Journal of translational medicine 2024 Jan 2;22(1):6
Journal of translational medicine 2024 Jan 2;22(1):6
The mechanisms of MicroRNA 21 in premature ovarian insufficiency mice with mesenchymal stem cells transplantation : The involved molecular and immunological mechanisms.
Yin N, Luo C, Wei L, Yang G, Bo L, Mao C
Journal of ovarian research 2024 Apr 4;17(1):75
Journal of ovarian research 2024 Apr 4;17(1):75
SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53.
Zou F, Chen W, Song T, Xing J, Zhang Y, Chen K, Hu W, Li L, Ning J, Li C, Yu W, Cheng F
Cancer cell international 2023 Sep 28;23(1):221
Cancer cell international 2023 Sep 28;23(1):221
CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling.
Tan HJ, Deng ZH, Zhang C, Deng HW, Xiao HM
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2436-2448
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2436-2448
HNRNPA2B1-mediated m(6)A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p/PTEN axis.
Li K, Gong Q, Xiang XD, Guo G, Liu J, Zhao L, Li J, Chen N, Li H, Zhang LJ, Zhou CY, Wang ZY, Zhuang L
Journal of translational medicine 2023 Jun 12;21(1):382
Journal of translational medicine 2023 Jun 12;21(1):382
DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway.
Sun C, Wen K, Zhang B, Dong Y, Chen C, Neo SY, Leng B, Gao TT, Wu J
Aging 2023 Jul 8;15(13):6380-6399
Aging 2023 Jul 8;15(13):6380-6399
Qilan preparation inhibits proliferation and induces apoptosis by down-regulating microRNA-21 in human Tca8113 tongue squamous cell carcinoma cells.
Jiamin D, Yifeng X, Zuoliang C, Wanlu C, Zhongxiong MA, Yunde X, Lin Z
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):693-700
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):693-700
Hsa_circ_0000345 inhibits cell proliferation, migration and invasion of nasopharyngeal carcinoma cells via miR-513a-3p/PTEN axis.
Jiang C, Li H, Liu F, Shi L, Liu J, Li Y
The journal of physiological sciences : JPS 2022 May 12;72(1):10
The journal of physiological sciences : JPS 2022 May 12;72(1):10
Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease.
Zeng L, Jiang H, Ashraf GM, Liu J, Wang L, Zhao K, Liu M, Li Z, Liu R
Molecular therapy. Nucleic acids 2022 Mar 8;27:256-275
Molecular therapy. Nucleic acids 2022 Mar 8;27:256-275
Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.
Peng T, He Y, Wang T, Yu J, Ma X, Zhou Z, Sheng Y, Li L, Peng H, Li S, Zou J, Yuan Y, Zhao Y, Shi H, Li F, Liu W, Hu K, Lu X, Zhang G, Wang F
Journal of medicinal chemistry 2022 Aug 25;65(16):11010-11033
Journal of medicinal chemistry 2022 Aug 25;65(16):11010-11033
The Janus-faced role of TRPM2-S in retroperitoneal liposarcoma via increasing ROS levels.
Li X, Bu F, Ma S, Cananzi F, Zhao Y, Xiao M, Min L, Luo C
Cell communication and signaling : CCS 2022 Aug 25;20(1):128
Cell communication and signaling : CCS 2022 Aug 25;20(1):128
Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma.
Ge X, Li M, Yin J, Shi Z, Fu Y, Zhao N, Chen H, Meng L, Li X, Hu Z, Zhao X, Guo H, Qian X
Molecular cell 2022 Apr 7;82(7):1249-1260.e7
Molecular cell 2022 Apr 7;82(7):1249-1260.e7
Pediatric Giant Cell Glioblastoma Presenting with Intracranial Dissemination at Diagnosis: A Case Report.
Kinoshita T, Yano H, Nakayama N, Suzui N, Iida T, Endo S, Yasue S, Ozeki M, Kobayashi K, Miyazaki T, Iwama T
NMC case report journal 2021;8(1):151-157
NMC case report journal 2021;8(1):151-157
The Association of microRNA-34a With High Incidence and Metastasis of Lung Cancer in Gejiu and Xuanwei Yunnan.
Chen Y, Hou C, Zhao LX, Cai QC, Zhang Y, Li DL, Tang Y, Liu HY, Liu YY, Zhang YY, Yang YK, Gao CW, Yao Q, Zhu QS, Cao CH
Frontiers in oncology 2021;11:619346
Frontiers in oncology 2021;11:619346
PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.
Ma D, Liu P, Wang P, Zhou Z, Fang Q, Wang J
Journal of cellular physiology 2021 Sep;236(9):6312-6327
Journal of cellular physiology 2021 Sep;236(9):6312-6327
PTEN alleviates maladaptive repair of renal tubular epithelial cells by restoring CHMP2A-mediated phagosome closure.
Wang H, Wang Y, Wang X, Huang H, Bao J, Zhong W, Li A
Cell death & disease 2021 Nov 16;12(12):1087
Cell death & disease 2021 Nov 16;12(12):1087
Effects and mechanism of microRNA‑218 against lung cancer.
Chen Y, Yang JL, Xue ZZ, Cai QC, Hou C, Li HJ, Zhao LX, Zhang Y, Gao CW, Cong L, Wang TZ, Chen DM, Li GS, Luo SQ, Yao Q, Yang CJ, Zhu QS, Cao CH
Molecular medicine reports 2021 Jan;23(1)
Molecular medicine reports 2021 Jan;23(1)
β-catenin regulates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice by modulating PTEN pathways.
Ban Q, Qiao L, Xia H, Xie B, Liu J, Ma Y, Zhang L, Zhang M, Liu LG, Jiao W, Yang S, Li Z, Zheng S, Liu D, Xia J, Qi Z
American journal of translational research 2020;12(8):4757-4771
American journal of translational research 2020;12(8):4757-4771
Inhibition of TRPA1 Promotes Cardiac Repair in Mice After Myocardial Infarction.
Li R, Liu R, Yan F, Zhuang X, Shi H, Gao X
Journal of cardiovascular pharmacology 2020 Mar;75(3):240-249
Journal of cardiovascular pharmacology 2020 Mar;75(3):240-249
MicroRNA‑28 promotes the proliferation of non‑small‑cell lung cancer cells by targeting PTEN.
Cui F, Zhou Q, Xiao K, Qian H
Molecular medicine reports 2020 Jun;21(6):2589-2596
Molecular medicine reports 2020 Jun;21(6):2589-2596
MicroRNA-221 promotes breast cancer resistance to adriamycin via modulation of PTEN/Akt/mTOR signaling.
Yin Y, Wang X, Li T, Ren Q, Li L, Sun X, Zhang B, Wang X, Han H, He Y, Cao Z, Sun X, Zhou Z
Cancer medicine 2020 Feb;9(4):1544-1552
Cancer medicine 2020 Feb;9(4):1544-1552
LSD1 negatively regulates autophagy in myoblast cells by driving PTEN degradation.
Shi YX, He YJ, Zhou Y, Li HK, Yang D, Li RY, Deng ZL, Gao YF
Biochemical and biophysical research communications 2020 Feb 19;522(4):924-930
Biochemical and biophysical research communications 2020 Feb 19;522(4):924-930
Overcoming cisplatin resistance by targeting the MTDH-PTEN interaction in ovarian cancer with sera derived from rats exposed to Guizhi Fuling wan extract.
Han L, Cao X, Chen Z, Guo X, Yang L, Zhou Y, Bian H
BMC complementary medicine and therapies 2020 Feb 17;20(1):57
BMC complementary medicine and therapies 2020 Feb 17;20(1):57
Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling.
Guo Y, Pei X
Evidence-based complementary and alternative medicine : eCAM 2019;2019:7517431
Evidence-based complementary and alternative medicine : eCAM 2019;2019:7517431
PTEN downregulates WD repeat‑containing protein 66 in salivary adenoid cystic carcinoma.
Cao Y, Liu H, Xia SL, Zhang X, Bai H, Yang Q, Li J, Gao L, Jin F, Wei MJ, Lu SL, Xiao J
Oncology reports 2019 Mar;41(3):1827-1836
Oncology reports 2019 Mar;41(3):1827-1836
The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis.
Du T, Li H, Fan Y, Yuan L, Guo X, Zhu Q, Yao Y, Li X, Liu C, Yu X, Liu Z, Cui CP, Han C, Zhang L
Nature communications 2019 Jul 2;10(1):2914
Nature communications 2019 Jul 2;10(1):2914
Comprehensive assessment the expression of core elements related to IGFIR/PI3K pathway in granulosa cells of women with polycystic ovary syndrome.
He T, Liu Y, Zhao S, Liu H, Wang Z, Shi Y
European journal of obstetrics, gynecology, and reproductive biology 2019 Feb;233:134-140
European journal of obstetrics, gynecology, and reproductive biology 2019 Feb;233:134-140
Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.
Sun B, Zhao X, Ming J, Liu X, Liu D, Jiang C
Oncogene 2019 Aug;38(33):6142-6157
Oncogene 2019 Aug;38(33):6142-6157
Targeting USP7 Identifies a Metastasis-Competent State within Bone Marrow-Resident Melanoma CTCs.
Vishnoi M, Boral D, Liu H, Sprouse ML, Yin W, Goswami-Sewell D, Tetzlaff MT, Davies MA, Oliva ICG, Marchetti D
Cancer research 2018 Sep 15;78(18):5349-5362
Cancer research 2018 Sep 15;78(18):5349-5362
Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway.
Zhou BG, Wei CS, Zhang S, Zhang Z, Gao HM
Journal of cellular biochemistry 2018 May;119(5):3885-3891
Journal of cellular biochemistry 2018 May;119(5):3885-3891
Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin-6/STAT3 signaling pathway.
Zhang J, Li Z, Liu L, Wang Q, Li S, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Huang S, Zhao Y, He X
Hepatology (Baltimore, Md.) 2018 Jan;67(1):171-187
Hepatology (Baltimore, Md.) 2018 Jan;67(1):171-187
MTDH promotes glioma invasion through regulating miR-130b-ceRNAs.
Tong L, Chu M, Yan B, Zhao W, Liu S, Wei W, Lou H, Zhang S, Ma S, Xu J, Wei L
Oncotarget 2017 Mar 14;8(11):17738-17749
Oncotarget 2017 Mar 14;8(11):17738-17749
DHPAC, a novel synthetic microtubule destabilizing agent, possess high anti-tumor activity in vincristine-resistant oral epidermoid carcinoma in vitro and in vivo.
Zhang Y, Gong FL, Lu ZN, Wang HY, Cheng YN, Liu ZP, Yu LG, Zhang HH, Guo XL
The international journal of biochemistry & cell biology 2017 Dec;93:1-11
The international journal of biochemistry & cell biology 2017 Dec;93:1-11
Chemoresistance is associated with Beclin-1 and PTEN expression in epithelial ovarian cancers.
Ying H, Qu D, Liu C, Ying T, Lv J, Jin S, Xu H
Oncology letters 2015 Apr;9(4):1759-1763
Oncology letters 2015 Apr;9(4):1759-1763
LPS induced miR-181a promotes pancreatic cancer cell migration via targeting PTEN and MAP2K4.
Liu J, Xu D, Wang Q, Zheng D, Jiang X, Xu L
Digestive diseases and sciences 2014 Jul;59(7):1452-60
Digestive diseases and sciences 2014 Jul;59(7):1452-60
Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia.
Wu Q, He J, Mei W, Zhang Z, Wu X, Sun F
Metallomics : integrated biometal science 2014 Dec;6(12):2204-12
Metallomics : integrated biometal science 2014 Dec;6(12):2204-12
Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression.
Wen W, Ding J, Sun W, Fu J, Chen Y, Wu K, Ning B, Han T, Huang L, Chen C, Xie D, Li Z, Feng G, Wu M, Xie W, Wang H
Hepatology (Baltimore, Md.) 2012 Jun;55(6):1787-98
Hepatology (Baltimore, Md.) 2012 Jun;55(6):1787-98
The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells.
Liu S, Li L, Zhang Y, Zhang Y, Zhao Y, You X, Lin Z, Zhang X, Ye L
The Journal of biological chemistry 2012 Aug 31;287(36):30228-39
The Journal of biological chemistry 2012 Aug 31;287(36):30228-39
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- DU 145 cells were subjected to SDS PAGE followed by western blot with 60300-1-Ig( PTEN Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PTEN antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human PTEN. This antibody recognizes human antigen. The PTEN antibody has been validated for the following applications: ELISA, IHC, WB, IF analysis.
