60300-1-Ig

antibody from Proteintech Group

Targeting: PTEN BZS, MHAM, MMAC1, PTEN1, TEP1

Provider product page for 60300-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [75]
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Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 60300-1-Ig - Provider product page
Provider: Proteintech Group
Product name: PTEN antibody
Antibody type: Monoclonal
Description: PTEN antibody (Cat. #60300-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 5C10B6
Vial size: 20ul, 150ul

PTEN protein structure - 60300-1-Ig shown in red.

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SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53.

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HNRNPA2B1-mediated m(6)A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p/PTEN axis.

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DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway.

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O-GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance.

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Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease.

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The Janus-faced role of TRPM2-S in retroperitoneal liposarcoma via increasing ROS levels.

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Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma.

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The Association of microRNA-34a With High Incidence and Metastasis of Lung Cancer in Gejiu and Xuanwei Yunnan.

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PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.

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PTEN alleviates maladaptive repair of renal tubular epithelial cells by restoring CHMP2A-mediated phagosome closure.

Wang H, Wang Y, Wang X, Huang H, Bao J, Zhong W, Li A
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ND‑09 inhibits chronic myeloid leukemia K562 cell growth by regulating BCR‑ABL signaling.

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β-catenin regulates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice by modulating PTEN pathways.

Ban Q, Qiao L, Xia H, Xie B, Liu J, Ma Y, Zhang L, Zhang M, Liu LG, Jiao W, Yang S, Li Z, Zheng S, Liu D, Xia J, Qi Z
American journal of translational research 2020;12(8):4757-4771

Inhibition of TRPA1 Promotes Cardiac Repair in Mice After Myocardial Infarction.

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MicroRNA‑28 promotes the proliferation of non‑small‑cell lung cancer cells by targeting PTEN.

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Molecular medicine reports 2020 Jun;21(6):2589-2596

MicroRNA-221 promotes breast cancer resistance to adriamycin via modulation of PTEN/Akt/mTOR signaling.

Yin Y, Wang X, Li T, Ren Q, Li L, Sun X, Zhang B, Wang X, Han H, He Y, Cao Z, Sun X, Zhou Z
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LSD1 negatively regulates autophagy in myoblast cells by driving PTEN degradation.

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Cao Y, Liu H, Xia SL, Zhang X, Bai H, Yang Q, Li J, Gao L, Jin F, Wei MJ, Lu SL, Xiao J
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Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway.

Zhou BG, Wei CS, Zhang S, Zhang Z, Gao HM
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Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin-6/STAT3 signaling pathway.

Zhang J, Li Z, Liu L, Wang Q, Li S, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Huang S, Zhao Y, He X
Hepatology (Baltimore, Md.) 2018 Jan;67(1):171-187

MTDH promotes glioma invasion through regulating miR-130b-ceRNAs.

Tong L, Chu M, Yan B, Zhao W, Liu S, Wei W, Lou H, Zhang S, Ma S, Xu J, Wei L
Oncotarget 2017 Mar 14;8(11):17738-17749

DHPAC, a novel synthetic microtubule destabilizing agent, possess high anti-tumor activity in vincristine-resistant oral epidermoid carcinoma in vitro and in vivo.

Zhang Y, Gong FL, Lu ZN, Wang HY, Cheng YN, Liu ZP, Yu LG, Zhang HH, Guo XL
The international journal of biochemistry & cell biology 2017 Dec;93:1-11

Chemoresistance is associated with Beclin-1 and PTEN expression in epithelial ovarian cancers.

Ying H, Qu D, Liu C, Ying T, Lv J, Jin S, Xu H
Oncology letters 2015 Apr;9(4):1759-1763

LPS induced miR-181a promotes pancreatic cancer cell migration via targeting PTEN and MAP2K4.

Liu J, Xu D, Wang Q, Zheng D, Jiang X, Xu L
Digestive diseases and sciences 2014 Jul;59(7):1452-60

Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia.

Wu Q, He J, Mei W, Zhang Z, Wu X, Sun F
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Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression.

Wen W, Ding J, Sun W, Fu J, Chen Y, Wu K, Ning B, Han T, Huang L, Chen C, Xie D, Li Z, Feng G, Wu M, Xie W, Wang H
Hepatology (Baltimore, Md.) 2012 Jun;55(6):1787-98

The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells.

Liu S, Li L, Zhang Y, Zhang Y, Zhao Y, You X, Lin Z, Zhang X, Ye L
The Journal of biological chemistry 2012 Aug 31;287(36):30228-39

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: DU 145 cells were subjected to SDS PAGE followed by western blot with 60300-1-Ig( PTEN Antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PTEN antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human PTEN. This antibody recognizes human antigen. The PTEN antibody has been validated for the following applications: ELISA, IHC, WB, IF analysis.
Appendix: 60300-1-Ig.pdf

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