Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
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- Product number
- 340201 - Provider product page
- Provider
- BioLegend
- Product name
- Purified anti-human CD307d (FcRL4)
- Antibody type
- Monoclonal
- Antigen
- P815 cells transfected with FcRL4
- Description
- FcRL4 (Fc receptor-like 4) is a 57 kD single pass type I transmembrane protein that exhibits 4 Ig like C2 domains. Also known as ITRA1, IGFP2, and FcRH4, FcRL4 is predominately found on a subset of memory B cells. Activation of FcRL4 contributes to B cell receptor inhibition through activation of the tyrosine kinases SHP-1 and 2. FcRL4's nascent loci is 1q23.1; however, breakpoint mutations are associated with multiple myeloma and non-Hodgkins lymphoma. Increased FcRL4 expression on memory B cells has also been observed in HIV viremic patients. FcRL4 predominately binds aggregated IgA, binds weakly with IgG3 and IgG4, and does not bind IgG1 and IgG2.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling.
Sohn HW, Krueger PD, Davis RS, Pierce SK
Blood 2011 Dec 8;118(24):6332-41
Blood 2011 Dec 8;118(24):6332-41
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