Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 340204 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#340204, RRID:AB_2104578
- Product name
- PE anti-human CD307d (FcRL4)
- Antibody type
- Monoclonal
- Antigen
- P815 cells transfected with FcRL4
- Description
- FcRL4 (Fc receptor-like 4) is a 57 kD single pass type I transmembrane protein that exhibits 4 Ig like C2 domains. Also known as ITRA1, IGFP2, and FcRH4, FcRL4 is predominately found on a subset of memory B cells. Activation of FcRL4 contributes to B cell receptor inhibition through activation of the tyrosine kinases SHP-1 and 2. FcRL4's nascent loci is 1q23.1; however, breakpoint mutations are associated with multiple myeloma and non-Hodgkins lymphoma. Increased FcRL4 expression on memory B cells has also been observed in HIV viremic patients. FcRL4 predominately binds aggregated IgA, binds weakly with IgG3 and IgG4, and does not bind IgG1 and IgG2.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Yellow dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling.
Sohn HW, Krueger PD, Davis RS, Pierce SK
Blood 2011 Dec 8;118(24):6332-41
Blood 2011 Dec 8;118(24):6332-41
No comments: Submit comment
Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- FcRL4 transfected P815 cells stained with 413D12 PE
- Conjugate
- Yellow dye