17178-1-AP

antibody from Proteintech Group

Targeting: TNP1

Provider product page for 17178-1-AP

Western blot

ELISA

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [27]
Comments [0]
Validations
Western blot [1]

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Product number: 17178-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#17178-1-AP, RRID:AB_2206757
Product name: TNP1 antibody
Antibody type: Polyclonal
Description: TNP1 antibody (Cat. #17178-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TNP1 protein structure - 17178-1-AP shown in red.

Submitted references Optimization of oxygen concentration and glycosphingolipid effects on spermatogenesis in mouse testicular culture†.

Nagata S, Ishikawa-Yamauchi Y, Katagiri K, Sato T, Ikawa M, Ogawa T
Biology of reproduction 2026 Mar 16;114(3):1079-1090

Dissecting the development of bovine testicular tissue using spatial transcriptomics.

Jin H, Ma Y, Xie Y, Yang S, Chen X, Wang N, Zhang L, Ma Y
Journal of animal science and biotechnology 2026 Feb 5;17(1):21

Generation of functionally competent testicular somatic cells from pluripotent stem cells.

Sato T, Yoshino T, Ohtsuka M, Suzuki T, Matsumura T, Matsudaira Y, Ishikawa-Yamauchi Y, Maeda S, Yabukami H, Kanai Y, Inoue M, Shima Y, Tachibana M, Matoba S, Inoue K, Ogonuki N, Ogura A, Hayashi K, Ogawa T
Science advances 2026 Feb 27;12(9):eadz0269

EP300-interacting inhibitor of differentiation 3 is required for spermatogenesis in mice.

Zhang P, Zhang L, Yu L, Zhou X, Chen X, Zhou Y, Wang N, Zhu H
Andrology 2025 Oct;13(7):1901-1912

PRKCQ Is Dispensable for Spermatogenesis in Mice.

Chen Y, Chen H, Han Z, Cui Y, Situ C, Qi Y, Cheng Q, Li Y
Cell biology international 2025 May;49(5):522-533

Homozygous deleterious variants in the C-terminal of TDRD5 impair spermiogenesis, causing severe oligoasthenoteratozoospermia in humans.

Guo R, Ding B, Hu K, Wang K, Tang D, Wang X, Sun J, Li K, Cheng H, Xu C, Sun M, Lu L, Liu M, Cao Y, Yang X, He X
Andrology 2025 Jul;13(5):1270-1284

CFAP65 is essential for C2a projection integrity in axonemes: implications for organ-specific ciliary dysfunction and infertility.

Chen J, Ren C, Zhao S, Wu H, Wang J, Dong Y, Liu S, Pan Y, Xiao Z, Yang S, Zhang J, Liu M
Cellular and molecular life sciences : CMLS 2025 Jan 24;82(1):61

Multi-omics analysis and experimental verification reveal testicular fatty acid metabolism disorder in non-obstructive azoospermia.

Li Z, Xiang YJ, Zou ZC, Feng YM, Wang H, Chen WQ, Ge X, Ma JZ, Jing J, Yao B
Zoological research 2025 Jan 18;46(1):177-192

Bazi Bushen alleviates reproductive aging in aged male mice.

Ma K, Li M, Song Y, Mao X, Zhang S, Zhang Y, Jiang Y, Ji C, Niu K, Li H, Hou Y, Wei C
Chinese journal of natural medicines 2024 May;22(5):416-425

5- methylcytidine effectively improves spermatogenesis recovery in busulfan-induced oligoasthenospermia mice.

Wang C, Ye T, Bao J, Dong J, Wang W, Li C, Ding H, Chen H, Wang X, Shi J
European journal of pharmacology 2024 Mar 15;967:176405

Disrupted intercellular bridges and spermatogenesis in fatty acyl-CoA reductase 1 knockout mice: A new model of ether lipid deficiency.

Pan B, Yuan S, Mayernik L, Yap YT, Moin K, Chung CS, Maddipati K, Krawetz SA, Zhang Z, Hess RA, Chen X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22908

Absence of CEP78 causes photoreceptor and sperm flagella impairments in mice and a human individual.

Zhu T, Zhang Y, Sheng X, Zhang X, Chen Y, Zhu H, Guo Y, Qi Y, Zhao Y, Zhou Q, Chen X, Guo X, Zhao C
eLife 2023 Feb 9;12

Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway.

Zhou J, Zeng L, Zhang Y, Wang M, Li Y, Jia Y, Wu L, Su P
The Science of the total environment 2022 Nov 15;847:157500

Multi-omics analyses reveal the mechanisms of Arsenic-induced male reproductive toxicity in mice.

Peng Z, Yang Q, Yeerken R, Chen J, Liu X, Li X
Journal of hazardous materials 2022 Feb 15;424(Pt C):127548

CDKN2AIP is critical for spermiogenesis and germ cell development.

Cao Y, Sun Q, Chen Z, Lu J, Geng T, Ma L, Zhang Y
Cell & bioscience 2022 Aug 21;12(1):136

Silica nanoparticles inhibiting the differentiation of round spermatid and chromatin remodeling of haploid period via MIWI in mice.

Liu J, Li X, Zhou G, Zhang Y, Sang Y, Wang J, Li Y, Ge W, Sun Z, Zhou X
Environmental pollution (Barking, Essex : 1987) 2021 Sep 1;284:117446

CFAP43-mediated intra-manchette transport is required for sperm head shaping and flagella formation.

Yu Y, Wang J, Zhou L, Li H, Zheng B, Yang S
Zygote (Cambridge, England) 2021 Feb;29(1):75-81

Silica nanoparticles induce spermatogenesis disorders via L3MBTL2-DNA damage-p53 apoptosis and RNF8-ubH2A/ubH2B pathway in mice.

Liu J, Li X, Zhou G, Sang Y, Zhang Y, Zhao Y, Ge W, Sun Z, Zhou X
Environmental pollution (Barking, Essex : 1987) 2020 Oct;265(Pt A):114974

PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis.

Kim CR, Noda T, Kim H, Kim G, Park S, Na Y, Oura S, Shimada K, Bang I, Ahn JY, Kim YR, Oh SK, Choi HJ, Kim JS, Jung I, Lee H, Okada Y, Ikawa M, Baek SH
Cell reports 2020 Jul 28;32(4):107950

Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice†.

Devlin DJ, Nozawa K, Ikawa M, Matzuk MM
Biology of reproduction 2020 Aug 4;103(2):205-222

PHF7 is a novel histone H2A E3 ligase prior to histone-to-protamine exchange during spermiogenesis.

Wang X, Kang JY, Wei L, Yang X, Sun H, Yang S, Lu L, Yan M, Bai M, Chen Y, Long J, Li N, Li D, Huang J, Lei M, Shao Z, Yuan W, Zuo E, Lu K, Liu MF, Li J
Development (Cambridge, England) 2019 Jul 10;146(13)

The ubiquitin ligase subunit β-TrCP in Sertoli cells is essential for spermatogenesis in mice.

Morohoshi A, Nakagawa T, Nakano S, Nagasawa Y, Nakayama K
Developmental biology 2019 Jan 15;445(2):178-188

Raptor directs Sertoli cell cytoskeletal organization and polarity in the mouse testis.

Xiong Z, Wang C, Wang Z, Dai H, Song Q, Zou Z, Xiao B, Zhao AZ, Bai X, Chen Z
Biology of reproduction 2018 Dec 1;99(6):1289-1302

Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis.

Liu S, Yu H, Liu Y, Liu X, Zhang Y, Bu C, Yuan S, Chen Z, Xie G, Li W, Xu B, Yang J, He L, Jin T, Xiong Y, Sun L, Liu X, Han C, Cheng Z, Liang J, Shang Y
Molecular cell 2017 Sep 7;67(5):853-866.e5

TSSK6 is required for γH2AX formation and the histone-to-protamine transition during spermiogenesis.

Jha KN, Tripurani SK, Johnson GR
Journal of cell science 2017 May 15;130(10):1835-1844

Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis.

Gou LT, Kang JY, Dai P, Wang X, Li F, Zhao S, Zhang M, Hua MM, Lu Y, Zhu Y, Li Z, Chen H, Wu LG, Li D, Fu XD, Li J, Shi HJ, Liu MF
Cell 2017 Jun 1;169(6):1090-1104.e13

Molecular analysis of cell type-specific gene expression profile during mouse spermatogenesis by laser microdissection and qRT-PCR.

Esakky P, Hansen DA, Drury AM, Moley KH
Reproductive sciences (Thousand Oaks, Calif.) 2013 Mar;20(3):238-52

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TNP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TNP1. This antibody recognizes human, mouse, rat antigen. The TNP1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 17178-1-AP.pdf

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