20590-1-AP

antibody from Proteintech Group

Targeting: AIM2 PYHIN4

Provider product page for 20590-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [59]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 20590-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20590-1-AP, RRID:AB_10694420
Product name: AIM2 antibody
Antibody type: Polyclonal
Description: AIM2 antibody (Cat. #20590-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

AIM2 protein structure - 20590-1-AP shown in red.

Submitted references Integrated Multi-Omics Analysis Reveals IRF1-Driven Microglial PANoptosis via ZBP1 in Spinal Cord Injury.

Xu X, Chen S, Liu S, Wang Y, Wang C, Liang R
Journal of inflammation research 2026;19:574990

H3K18 lactylation-mediated SPHK1-SIRT1 feedback loop accelerates pyroptosis of tubular epithelial cells in sepsis-associated acute kidney injury.

Huang Y, Zhao E, Zhao G, Zhuo W, Zhao Y, Wang H, Lv G, Hu R, Zeng Z, Han S, Hu Y, Zhao G
Theranostics 2026;16(9):4768-4786

Dual-targeting nuclear and mitochondrial DNA damage drives immunogenic activation via PANoptosis for synergistic magneto-thermodynamic-chemotherapy.

Wu L, Su J, Cao Y, Yuan H, Li Z, Ren J, Xiao M, Yu K, Liang B
Biomaterials 2026 Jun;329:123924

Gambogic acid inhibits tumor growth and induces HMGB1-mediated pyroptosis in AML models in vitro and in vivo.

Yang Y, Liu H, Zou M, Jiang M, Chen H, Wang Y, Zhang J, Qiu C, Xia F, Wang J, Jiang L, Pang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158105

Single-Nucleus Transcriptomics Uncovers Xaf1-Driven PANoptosis as a Therapeutic Target in Aminoglycoside-Induced Hearing Loss.

Wang X, Xiao H, Wu J, Lin Y, Ao Y, Ye Z, Tan X, Kong F, Chen X, Chai R, Zhang S
Cell proliferation 2026 Jan;59(1):e70081

S100A4 triggeres the pyroptosis of vsmcs: association with mitochondrial damage, impaired mitophagy, and Ca(2+) dysregulation.

Huang J, Zhou B, Wang L, Huang Q, Lin X, Zhao H, Xia Y
Biology direct 2026 Jan 12;21(1):18

PHGDH-dependent serine metabolism in astrocytes: A key regulator of oxidative stress and pyroptosis in cerebral ischemia-reperfusion injury.

Zhang J, Luo Y, Xie C, Zhang M, Qin H, Zhou Y, Wu X, Hu C, Hu F, Fei X, Zhang H, Li J, Fu Y, Yuan Y, Yang S, Gao D
Redox biology 2026 Feb;89:103954

Prussian blue nanoparticles targeting multiple PANoptosome-mediated PANoptosis for myocardial ischemia-reperfusion injury therapy.

Xu L, Jiang L, Wu R, Yan H, Li B, Cai X, Zheng Y
Nature communications 2026 Feb 27;17(1)

Targeting G9a Exerts Pleiotropic Suppression in Triple-Negative Breast Cancer Cells: Cooperatively Inducing Pyroptosis and Apoptosis.

Li J, Zhang G, Liu T, Yan X, Ma M
Biomolecules 2026 Feb 25;16(3)

Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer's disease risk factors.

Xie X, Liu J, Liang W, Zhang Y, Gong X, Yuan S, Qi C, Huang M, Shi L, Hou M, Zhang M, Liu W, Sun W, Wu Y, Li C, Cao Z, Jing H, Qian L, Liu J, Yuan S, Wang Q, Shen Y, Liu Z, Li Y, Pan H, Zhu B, Shan B, He K, Wang W, Zou C, Li Y, Chou JJ, Yuan J
Immunity 2026 Feb 10;59(2):419-437.e11

Metformin Attenuates Myocardial Ischemia-Reperfusion Injury in Rats by Modulating JNK Pathway and Inhibiting PANoptosis Mechanisms.

Hou B, Hou X, Zhang L, Liu T, Li Y, Dong R
Cardiovascular therapeutics 2025;2025:4642838

G Protein-Coupled Receptor 30 Attenuates Neuronal Pyroptosis Induced by Subarachnoid Hemorrhage.

Peng J, Hu X, He J, Xia Y
Mediators of inflammation 2025;2025:3585885

Compound Tinglizi Decoction-Containing Serum Is Associated with Inhibition of PANoptosis in Cardiomyocytes via SIRT3-Related Chaperone-Mediated Autophagy of AIM2.

Huang R, Tang J, Huang W, Shang Y, Liu W, Long H, Wan R
International journal of general medicine 2025;18:6975-6987

Integrated Single-Cell and Transcriptome Analysis with Experimental Validation Reveals PANoptosis-Related Gene Signatures in the Immune Microenvironment of Autoimmune Thyroiditis.

Zhao Z, Liu Z, Wang Q, Gao H, Song N, Yang X
Journal of inflammation research 2025;18:12123-12143

Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-κB/AIM2 pathways in cerebral ischemia/reperfusion injury.

Zhang H, Zhu C, Zhou X, Wang L, Deng L, He B, Li J
Frontiers in pharmacology 2025;16:1581320

An AIM2 inflammasome biomimetic mineralization inhibitor for vascular dementia therapy.

Zhang Y, Jiang L, Wu R, Gao W, Zhang X, Liu L, Zhang Y, Lu J, Zheng Y, Cai X, Fu J
Theranostics 2025;15(13):6347-6368

The viral BCL2 protein BHRF1 of Epstein-Barr virus promotes AIM2 inflammasome activation to facilitate lytic replication.

Lan Q, Zhang X, Sun Y, Yang J, Li X, Kuang E
PLoS pathogens 2025 Sep;21(9):e1013509

LPS-Induced Mitochondrial Damage via SLC41A1-Mediated Magnesium Ion Efflux Leads to the Pyroptosis of Dental Stem Cells.

Liu Y, Song C, Zhang L, Han X, Li C, Yan Y, Xing L, Si M, Yang B, Cheng L, Muramatsu A, Jiang B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e05666

Fusobacterium nucleatum-derived extracellular vesicles carrying virulence factor DNA trigger AIM2 inflammasome activation to facilitate UC progression.

Zhao Y, Wu R, Duan Y, Kong X, Zhang Y, You Y, Zhang J, Wang Y, Zhou L, Duan L
Cellular & molecular biology letters 2025 Nov 17;30(1):138

MiR-193b-3p Regulates Gasdermin-D/NLRP3 by Targeting the Signaling Axis Inhibition of Pyroptosis Attenuates Myocardial Ischemia-Reperfusion Injury.

Yu C, Zhu QP, Xie W, Xu WS, Liu JL, Wang W, Zhang YF, Zhang T, Shao G
Journal of physiological investigation 2025 Nov 1;68(6):349-357

AIM2 exacerbates hypoxic-ischemic brain damage in neonatal rats via promoting neuronal pyroptosis.

Li Q, Wang Z, Li F, Liu S, Ding Y, Yan J, Feng X, Li M
Brain research bulletin 2025 May;224:111305

Hydroxysafflor Yellow A Ameliorates Ischemic Stroke by Inhibiting NLRP3, AIM2, and Pyrin Inflammasome-Mediated Pyroptosis.

Ding YL, Qiao LJ, Fang H, Fan LL, Wu D, Xu JP, Lv QH, Deng MZ, Qiu YH, Zhou ZY, Huang Y, Zheng JY, Zhang SJ, Cai YF
Neurochemical research 2025 Jun 13;50(3):201

Circular RNA-OGDH promotes PANoptosis in diabetic cardiomyopathy: A novel mechanistic insight.

Guan J, Shi X, Ma J, Yin Y, Song G, Li Y, Chen X, Yan Y, Wang D, Liu S, Liu G, Zheng M, Ma F
The Journal of biological chemistry 2025 Jul;301(7):110280

Neutrophil CD11b is a pivotal PANoptosis marker correlated with disease activity in antineutrophil cytoplasmic antibody-associated vasculitis.

Han XY, Zhao YY, Chen SF, Li ZY, Zhao MH, Chen M
Apoptosis : an international journal on programmed cell death 2025 Dec;30(11-12):3115-3128

Tetrahydromagnolol targets TRIM38 to mediate PANoptosis in cancer cells and has the potential for synergistic cancer therapy.

Gu X, Li L, Duan T, Jin L, Sheng Q, Gao Q, Chen M, Sui X
Experimental hematology & oncology 2025 Dec 31;15(1):2

Card9 deficiency exacerbates vulvovaginal candidiasis by impairing the IL-17 production and vaginal epithelial barrier.

Liu W, Song Y, Wang R, Wan Z, Li R, Wang X
Medical mycology 2025 Apr 2;63(4)

DNA damage-induced AIM2 pyroptosis in high glucose-induced proximal tubular epithelial cell.

Li L, Zhang L, Cai Y, Li J, Zheng S, Wang W, Chen Y, Luo J, Li R, Liang X
Frontiers in cell and developmental biology 2024;12:1457369

Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome.

Li Y, Tian L, Li S, Chen X, Lei F, Bao J, Wu Q, Wen Y, Jie Y
Free radical biology & medicine 2024 Sep;222:106-121

Caspase-8 promotes NLRP3 inflammasome activation mediates eye development defects in zebrafish larvae exposed to perfulorooctane sulfonate (PFOS).

Wu LY, Zhang JL, Zeeshan M, Zhou Y, Zhang YT, He WT, Jin N, Dai Y, Chi W, Ou Z, Dong GH, Lin LZ
Environmental pollution (Barking, Essex : 1987) 2024 Sep 1;356:124252

Exosomes Derived from Rejuvenated Stem Cells Inactivate NLRP3 Inflammasome and Pyroptosis of Nucleus Pulposus Cells via the Transfer of Antioxidants.

Peng S, Liu X, Chang L, Liu B, Zhang M, Mao Y, Shen X
Tissue engineering and regenerative medicine 2024 Oct;21(7):1061-1077

Angiopoietin 1 Relieves Osteolysis by Promoting Macrophage Mitophagy Through the TBK1-SQSTM1 Pathway to Inhibit AIM2 Inflammasome-Mediated Pyroptosis.

Yin J, Lai P, Zhu L, Ma J
Applied biochemistry and biotechnology 2024 Nov;196(11):7908-7927

Bimetallic peroxide nanoparticles induce PANoptosis by disrupting ion homeostasis for enhanced immunotherapy.

Hou G, Chen Y, Lei H, Lu Y, Liu L, Han Z, Sun S, Li J, Cheng L
Science advances 2024 Nov 8;10(45):eadp7160

High-intensity interval training and moderate-intensity continuous training alleviate vascular dysfunction in spontaneously hypertensive rats through the inhibition of pyroptosis.

Li Y, Luo M, Chang Q, Cao S, Wang Y, Chen Z, Yang J, Liu G
Heliyon 2024 Nov 15;10(21):e39505

Integrative Gut Microbiota and Metabolomic Analyses Reveal the PANoptosis- and Ferroptosis-Related Mechanisms of Chrysoeriol in Inhibiting Melanoma.

Liu Y, Wang L, Huang T, Li Y, Zhang H
Journal of agricultural and food chemistry 2024 Nov 13;72(45):25173-25185

Hexavalent chromium exposure induces lung injury via activation of NLRP3 and AIM2 inflammasomes in rats.

Li N, Li S, Yu Y, Zhang X, Wu H, Li X, Jia G, Yu S
Ecotoxicology and environmental safety 2024 Nov 1;286:117181

AIM2 participates in house dust mite (HDM)-induced epithelial dysfunctions and ovalbumin (OVA)-induced allergic asthma in infant mice.

Yang S, Guo R, Meng X, Zhang Y
The Journal of asthma : official journal of the Association for the Care of Asthma 2024 May;61(5):479-490

Absent in Melanoma 2 Mediates Inflammasome Signaling Activation against Clostridium perfringens Infection.

Ma Z, Lou Y, Wang N, Zhao Y, Zhang S, Zhang M, Li J, Xu Q, He A, Yu S
International journal of molecular sciences 2024 Jun 14;25(12)

CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation.

Xu N, Jiang J, Jiang F, Dong G, Meng L, Wang M, Chen J, Li C, Shi Y, He S, Li R
Nature communications 2024 Jul 8;15(1):5730

Identification of key pyroptosis-related genes and microimmune environment among peripheral arterial beds in atherosclerotic arteries.

Liu JW, Zhang ZH, Lv XS, Xu MY, Ni B, He B, Wang F, Chen J, Zhang JB, Ye ZD, Liu P, Wen JY
Scientific reports 2024 Jan 2;14(1):233

Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage.

Tang S, Lai N, Xu L
Brain research 2024 Jan 1;1822:148666

FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.

Li L, Kong L, Xu S, Wang C, Gu J, Luo H, Meng Q
Hepatology international 2024 Feb;18(1):188-205

Blockade of Notch1 Signaling Alleviated Podocyte Injury in Lupus Nephritis Via Inhibition of NLRP3 Inflammasome Activation.

Wu D, Jiang T, Zhang S, Huang M, Zhu Y, Chen L, Zheng Y, Zhang D, Yu H, Yao G, Sun L
Inflammation 2024 Apr;47(2):649-663

Absent in melanoma 2 (AIM2) positive profile identifies a poor prognosis of lung adenocarcinoma patients.

Colarusso C, Terlizzi M, Falanga A, Stathopoulos G, De Lucia L, Hansbro PM, Pinto A, Sorrentino R
International immunopharmacology 2023 Nov;124(Pt B):110990

The Comparative Effects of Schwann Cells and Wharton's Jelly Mesenchymal Stem Cells on the AIM2 Inflammasome Activity in an Experimental Model of Spinal Cord Injury.

Kharazinejad E, Hassanzadeh G, Sahebkar A, Yousefi B, Reza Sameni H, Majidpoor J, Golchini E, Taghdiri Nooshabadi V, Mousavi M
Neuroscience 2023 Dec 15;535:1-12

Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke.

Liu L, Cai Y, Deng C
European journal of medical research 2023 Dec 15;28(1):596

Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma.

Fu L, Bao J, Li J, Li Q, Lin H, Zhou Y, Li J, Yan Y, Langston ME, Sun T, Guo S, Zhou X, Chen Y, Liu Y, Zhao Y, Lu J, Huang Y, Chen W, Chung BI, Luo J
Frontiers in immunology 2022;13:1021935

Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.

Yu J, Tang R, Li J
Frontiers in oncology 2022;12:991165

Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema.

Ruwanpura SM, McLeod L, Dousha LF, Seow HJ, West AC, West AJ, Weng T, Alanazi M, MacDonald M, King PT, Bardin PG, Gabay C, Klinman DM, Bozinovski S, Vlahos R, Anderson GP, Rose-John S, Saad MI, Jenkins BJ
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 6;119(36):e2201494119

Exosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis.

Zhou Z, Li C, Bao T, Zhao X, Xiong W, Luo C, Yin G, Fan J
Journal of neurotrauma 2022 Aug;39(15-16):1057-1074

Autophagy-Based Unconventional Secretory for AIM2 Inflammasome Drives DNA Damage Resistance During Intervertebral Disc Degeneration.

Li S, Liao Z, Luo R, Song Y, Wang K, Feng X, Ou Y, Wu X, Zhang Y, Gao Y, Yin H, Yang C
Frontiers in cell and developmental biology 2021;9:672847

Caspase-11 and AIM2 inflammasome are involved in smoking-induced COPD and lung adenocarcinoma.

Colarusso C, Terlizzi M, Lamort AS, Cerqua I, Roviezzo F, Stathopoulos G, Pinto A, Sorrentino R
Oncotarget 2021 May 25;12(11):1057-1071

Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.

Ji Q, Wang L, Liu J, Wu Y, Lv H, Wen Y, Shi L, Qu B, Szentmáry N
Inflammation 2021 Apr;44(2):682-692

NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.

He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, Gong Z, Liu L, Zhang H, Li Y, Yang S, Hu T, Wu L, Masliah E, Huang S, Cao H
Cellular & molecular immunology 2020 Mar;17(3):283-299

Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation.

Liao Y, Hussain T, Liu C, Cui Y, Wang J, Yao J, Chen H, Song Y, Sabir N, Hussain M, Zhao D, Zhou X
Frontiers in immunology 2019;10:268

Expression and localization of absent in melanoma 2 in the injured spinal cord.

Wang SN, Guo XY, Tang J, Ding SQ, Shen L, Wang R, Ma SF, Hu JG, Lü HZ
Neural regeneration research 2019 Mar;14(3):542-552

Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.

Guo Q, Wu Y, Hou Y, Liu Y, Liu T, Zhang H, Fan C, Guan H, Li Y, Shan Z, Teng W
Frontiers in immunology 2018;9:1197

Analysis of the expression of NLRP3 and AIM2 in periapical lesions with apical periodontitis and microbial analysis outside the apical segment of teeth.

Ran S, Liu B, Gu S, Sun Z, Liang J
Archives of oral biology 2017 Jun;78:39-47

AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection.

Hu GQ, Song PX, Li N, Chen W, Lei QQ, Yu SX, Zhang XJ, Du CT, Deng XM, Han WY, Yang YJ
Mucosal immunology 2016 Sep;9(5):1330-9

Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B.

Wu DL, Xu GH, Lu SM, Ma BL, Miao NZ, Liu XB, Cheng YP, Feng JH, Liu ZG, Feng-Ding, Na-Liu, Li WQ, Zhao YR
Human immunology 2013 May;74(5):514-21

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: K-562 cells were subjected to SDS PAGE followed by western blot with 20590-1-AP(AIM2 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The AIM2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human AIM2. This antibody recognizes human antigen. The AIM2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 20590-1-AP.pdf

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