Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 20590-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20590-1-AP, RRID:AB_10694420
- Product name
- AIM2 antibody
- Antibody type
- Polyclonal
- Description
- AIM2 antibody (Cat. #20590-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references AIM2 participates in house dust mite (HDM)-induced epithelial dysfunctions and ovalbumin (OVA)-induced allergic asthma in infant mice.
Absent in Melanoma 2 Mediates Inflammasome Signaling Activation against Clostridium perfringens Infection.
Identification of key pyroptosis-related genes and microimmune environment among peripheral arterial beds in atherosclerotic arteries.
Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage.
Blockade of Notch1 Signaling Alleviated Podocyte Injury in Lupus Nephritis Via Inhibition of NLRP3 Inflammasome Activation.
Absent in melanoma 2 (AIM2) positive profile identifies a poor prognosis of lung adenocarcinoma patients.
The Comparative Effects of Schwann Cells and Wharton's Jelly Mesenchymal Stem Cells on the AIM2 Inflammasome Activity in an Experimental Model of Spinal Cord Injury.
Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke.
Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma.
Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.
Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema.
Exosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis.
Autophagy-Based Unconventional Secretory for AIM2 Inflammasome Drives DNA Damage Resistance During Intervertebral Disc Degeneration.
Caspase-11 and AIM2 inflammasome are involved in smoking-induced COPD and lung adenocarcinoma.
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation.
Expression and localization of absent in melanoma 2 in the injured spinal cord.
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Analysis of the expression of NLRP3 and AIM2 in periapical lesions with apical periodontitis and microbial analysis outside the apical segment of teeth.
AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection.
Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B.
Yang S, Guo R, Meng X, Zhang Y
The Journal of asthma : official journal of the Association for the Care of Asthma 2024 May;61(5):479-490
The Journal of asthma : official journal of the Association for the Care of Asthma 2024 May;61(5):479-490
Absent in Melanoma 2 Mediates Inflammasome Signaling Activation against Clostridium perfringens Infection.
Ma Z, Lou Y, Wang N, Zhao Y, Zhang S, Zhang M, Li J, Xu Q, He A, Yu S
International journal of molecular sciences 2024 Jun 14;25(12)
International journal of molecular sciences 2024 Jun 14;25(12)
Identification of key pyroptosis-related genes and microimmune environment among peripheral arterial beds in atherosclerotic arteries.
Liu JW, Zhang ZH, Lv XS, Xu MY, Ni B, He B, Wang F, Chen J, Zhang JB, Ye ZD, Liu P, Wen JY
Scientific reports 2024 Jan 2;14(1):233
Scientific reports 2024 Jan 2;14(1):233
Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage.
Tang S, Lai N, Xu L
Brain research 2024 Jan 1;1822:148666
Brain research 2024 Jan 1;1822:148666
Blockade of Notch1 Signaling Alleviated Podocyte Injury in Lupus Nephritis Via Inhibition of NLRP3 Inflammasome Activation.
Wu D, Jiang T, Zhang S, Huang M, Zhu Y, Chen L, Zheng Y, Zhang D, Yu H, Yao G, Sun L
Inflammation 2024 Apr;47(2):649-663
Inflammation 2024 Apr;47(2):649-663
Absent in melanoma 2 (AIM2) positive profile identifies a poor prognosis of lung adenocarcinoma patients.
Colarusso C, Terlizzi M, Falanga A, Stathopoulos G, De Lucia L, Hansbro PM, Pinto A, Sorrentino R
International immunopharmacology 2023 Nov;124(Pt B):110990
International immunopharmacology 2023 Nov;124(Pt B):110990
The Comparative Effects of Schwann Cells and Wharton's Jelly Mesenchymal Stem Cells on the AIM2 Inflammasome Activity in an Experimental Model of Spinal Cord Injury.
Kharazinejad E, Hassanzadeh G, Sahebkar A, Yousefi B, Reza Sameni H, Majidpoor J, Golchini E, Taghdiri Nooshabadi V, Mousavi M
Neuroscience 2023 Dec 15;535:1-12
Neuroscience 2023 Dec 15;535:1-12
Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke.
Liu L, Cai Y, Deng C
European journal of medical research 2023 Dec 15;28(1):596
European journal of medical research 2023 Dec 15;28(1):596
Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma.
Fu L, Bao J, Li J, Li Q, Lin H, Zhou Y, Li J, Yan Y, Langston ME, Sun T, Guo S, Zhou X, Chen Y, Liu Y, Zhao Y, Lu J, Huang Y, Chen W, Chung BI, Luo J
Frontiers in immunology 2022;13:1021935
Frontiers in immunology 2022;13:1021935
Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.
Yu J, Tang R, Li J
Frontiers in oncology 2022;12:991165
Frontiers in oncology 2022;12:991165
Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema.
Ruwanpura SM, McLeod L, Dousha LF, Seow HJ, West AC, West AJ, Weng T, Alanazi M, MacDonald M, King PT, Bardin PG, Gabay C, Klinman DM, Bozinovski S, Vlahos R, Anderson GP, Rose-John S, Saad MI, Jenkins BJ
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 6;119(36):e2201494119
Proceedings of the National Academy of Sciences of the United States of America 2022 Sep 6;119(36):e2201494119
Exosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis.
Zhou Z, Li C, Bao T, Zhao X, Xiong W, Luo C, Yin G, Fan J
Journal of neurotrauma 2022 Aug;39(15-16):1057-1074
Journal of neurotrauma 2022 Aug;39(15-16):1057-1074
Autophagy-Based Unconventional Secretory for AIM2 Inflammasome Drives DNA Damage Resistance During Intervertebral Disc Degeneration.
Li S, Liao Z, Luo R, Song Y, Wang K, Feng X, Ou Y, Wu X, Zhang Y, Gao Y, Yin H, Yang C
Frontiers in cell and developmental biology 2021;9:672847
Frontiers in cell and developmental biology 2021;9:672847
Caspase-11 and AIM2 inflammasome are involved in smoking-induced COPD and lung adenocarcinoma.
Colarusso C, Terlizzi M, Lamort AS, Cerqua I, Roviezzo F, Stathopoulos G, Pinto A, Sorrentino R
Oncotarget 2021 May 25;12(11):1057-1071
Oncotarget 2021 May 25;12(11):1057-1071
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.
Ji Q, Wang L, Liu J, Wu Y, Lv H, Wen Y, Shi L, Qu B, Szentmáry N
Inflammation 2021 Apr;44(2):682-692
Inflammation 2021 Apr;44(2):682-692
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, Gong Z, Liu L, Zhang H, Li Y, Yang S, Hu T, Wu L, Masliah E, Huang S, Cao H
Cellular & molecular immunology 2020 Mar;17(3):283-299
Cellular & molecular immunology 2020 Mar;17(3):283-299
Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation.
Liao Y, Hussain T, Liu C, Cui Y, Wang J, Yao J, Chen H, Song Y, Sabir N, Hussain M, Zhao D, Zhou X
Frontiers in immunology 2019;10:268
Frontiers in immunology 2019;10:268
Expression and localization of absent in melanoma 2 in the injured spinal cord.
Wang SN, Guo XY, Tang J, Ding SQ, Shen L, Wang R, Ma SF, Hu JG, Lü HZ
Neural regeneration research 2019 Mar;14(3):542-552
Neural regeneration research 2019 Mar;14(3):542-552
Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.
Guo Q, Wu Y, Hou Y, Liu Y, Liu T, Zhang H, Fan C, Guan H, Li Y, Shan Z, Teng W
Frontiers in immunology 2018;9:1197
Frontiers in immunology 2018;9:1197
Analysis of the expression of NLRP3 and AIM2 in periapical lesions with apical periodontitis and microbial analysis outside the apical segment of teeth.
Ran S, Liu B, Gu S, Sun Z, Liang J
Archives of oral biology 2017 Jun;78:39-47
Archives of oral biology 2017 Jun;78:39-47
AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection.
Hu GQ, Song PX, Li N, Chen W, Lei QQ, Yu SX, Zhang XJ, Du CT, Deng XM, Han WY, Yang YJ
Mucosal immunology 2016 Sep;9(5):1330-9
Mucosal immunology 2016 Sep;9(5):1330-9
Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B.
Wu DL, Xu GH, Lu SM, Ma BL, Miao NZ, Liu XB, Cheng YP, Feng JH, Liu ZG, Feng-Ding, Na-Liu, Li WQ, Zhao YR
Human immunology 2013 May;74(5):514-21
Human immunology 2013 May;74(5):514-21
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 20590-1-AP(AIM2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AIM2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human AIM2. This antibody recognizes human antigen. The AIM2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
