66902-1-Ig

antibody from Proteintech Group

Targeting: AIM2 PYHIN4

Provider product page for 66902-1-Ig

Western blot

ELISA

Antibody data

Antibody Data
Antigen structure
References [23]
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Product number: 66902-1-Ig - Provider product page
Provider: Proteintech Group
Product name: AIM2 antibody
Antibody type: Monoclonal
Description: AIM2 antibody (Cat. #66902-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat, rabbit and has been validated for the following applications: WB,ELISA.
Reactivity: Human, Mouse, Rat, Rabbit
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 3E12A8
Vial size: 20ul, 150ul

AIM2 protein structure - 66902-1-Ig shown in red.

Submitted references AIM2 inflammasome deficiency mitigates cardiac senescence by suppressing GSDMD-executed pyroptosis.

Bao Y, Wang G, Ainiwaer D, Li H, Wang K, Anwaier G, Sun Z
Tissue & cell 2026 Apr 19;102:103541

Methamphetamine and HIV-1 Tat Synergistically Induce Microglial Pyroptosis Via Activation of the AIM2 Inflammasome.

Miao L, Wang H, Yang X, Xu L, Xu R, Teng H, Zhang Y, Zhao Y, Yang G, Zeng X
Inflammation 2025 Oct;48(5):3300-3313

FlaA N/C attenuates radiation-induced lung injury by promoting NAIP/NLRC4/ASC inflammasome autophagy and inhibiting pyroptosis.

Deng S, Yang Y, He S, Chen Z, Xia X, Zhang T, Yin Q, Liu T, Wu D, Pan K, Xu Y
Journal of translational medicine 2025 Feb 27;23(1):237

Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death.

Sun B, Wu J, Li Z, Zhang Y, Lu X, Wang J, Xu X
International immunopharmacology 2025 Dec 3;166:115639

ZIKV infection causes placental inflammation through activating PANoptosis.

Zhang S, Chen D, Zhang K, Liu M, Liang H, Liang L, Liang J, Liang M, An S, Lyu M, Zhu J, Li S, Hu D, Zhu X, Wu J, He Z, Li M
Journal of virology 2025 Dec 23;99(12):e0175925

Zn(2+) regulates mitochondrial DNA efflux to inhibit AIM2-mediated ZBP1-PANoptosome pathway and alleviate septic myocardial injury.

Guo J, Meng S, Zhang J, Wang N, Guo F
Chemico-biological interactions 2025 Aug 25;417:111525

(+)-Catechin ameliorates diabetic nephropathy injury by inhibiting endoplasmic reticulum stress-related NLRP3-mediated inflammation.

Zhang X, Huo Z, Jia X, Xiong Y, Li B, Zhang L, Li X, Li X, Fang Y, Dong X, Chen G
Food & function 2024 May 20;15(10):5450-5465

Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-γ and TNF-α to PANoptosis.

Li H, Ni H, Li Y, Zhou A, Qin X, Li Y, Che L, Mo H, Qin C, Li J
Cell death discovery 2024 May 13;10(1):227

Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis.

Zheng Z, Li K, Yang Z, Wang X, Shen C, Zhang Y, Lu H, Yin Z, Sha M, Ye J, Zhu L
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jun;73(6):961-978

Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions.

Hou Y, Chu X, Park JH, Zhu Q, Hussain M, Li Z, Madsen HB, Yang B, Wei Y, Wang Y, Fang EF, Croteau DL, Bohr VA
Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Jun;20(6):4212-4233

m6A-methylated Lonp1 drives mitochondrial proteostasis stress to induce testicular pyroptosis upon environmental cadmium exposure.

Ouyang KW, Wang TT, Wang H, Luo YX, Hu YF, Zheng XM, Ling Q, Wang KW, Xiong YW, Zhang J, Chang W, Zhang YF, Yuan Z, Li H, Gao L, Xu DX, Zhu HL, Yang L, Wang H
The Science of the total environment 2024 Jun 25;931:172938

Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR.

Li L, Xu S, Wang W, Li X, Wang H, Yang Q, Wang C, Gu J, Luo H, Meng Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155693

Cadmium exposure induces pyroptosis of TM4 cells through oxidative stress damage and inflammasome activation.

Zhou J, Zhang Y, Zeng L, Wang X, Xiang W, Su P
Ecotoxicology and environmental safety 2024 Jan 15;270:115930

Tangeretin Attenuates Cerebral Ischemia-Reperfusion-Induced Neuronal Pyroptosis by Inhibiting AIM2 Inflammasome Activation via Regulating NRF2.

You G, Zheng L, Zhang Y, Zhang Y, Wang Y, Guo W, Liu H, Tatiana P, Vladimir K, Zan J
Inflammation 2024 Feb;47(1):145-158

Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease.

Xu S, Kong L, Li L, Wang C, Gu J, Luo H, Meng Q
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166930

FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease.

Li L, Kong L, Xu S, Wang C, Gu J, Luo H, Meng Q
Hepatology international 2024 Feb;18(1):188-205

AIM2 promotes excitatory glutamate receptor expression by inhibiting STING and contributes to bone cancer pain in male mice.

Wang L, Xu X, Su S, Li B, Zhang K, Yu X, Xiao Y, Lu S, Lu Z, Wu Y, Ke C
Scientific reports 2024 Dec 30;14(1):31851

PKIB involved in the metastasis and survival of osteosarcoma.

Wan R, Yang G, Liu Q, Fu X, Liu Z, Miao H, Liu H, Huang W
Frontiers in oncology 2022;12:965838

Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway.

Zhou J, Zeng L, Zhang Y, Wang M, Li Y, Jia Y, Wu L, Su P
The Science of the total environment 2022 Nov 15;847:157500

Increased susceptibility of irradiated mice to Aspergillus fumigatus infection via NLRP3/GSDMD pathway in pulmonary bronchial epithelia.

Wu DM, He M, Zhao YY, Deng SH, Liu T, Zhang T, Zhang F, Wang YY, Xu Y
Cell communication and signaling : CCS 2022 Jun 27;20(1):98

Prohibitin 1 regulates mtDNA release and downstream inflammatory responses.

Liu H, Fan H, He P, Zhuang H, Liu X, Chen M, Zhong W, Zhang Y, Zhen C, Li Y, Jiang H, Meng T, Xu Y, Zhao G, Feng D
The EMBO journal 2022 Dec 15;41(24):e111173

STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis.

Dawson RE, Deswaerte V, West AC, Tang K, West AJ, Balic JJ, Gearing LJ, Saad MI, Yu L, Wu Y, Bhathal PS, Kumar B, Chakrabarti JT, Zavros Y, Oshima H, Klinman DM, Oshima M, Tan P, Jenkins BJ
Gut 2022 Aug;71(8):1515-1531

Establishment of tumor inflammasome clusters with distinct immunogenomic landscape aids immunotherapy.

Liang Q, Wu J, Zhao X, Shen S, Zhu C, Liu T, Cui X, Chen L, Wei C, Cheng P, Cheng W, Wu A
Theranostics 2021;11(20):9884-9903

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