Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- H00009447-B01P - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#H00009447-B01P, RRID:AB_2224851
- Product name
- Mouse Polyclonal AIM2 Antibody
- Antibody type
- Polyclonal
- Description
- Protein A purified. AIM2 - absent in melanoma 2,
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.05 mg
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells.
Interactome-wide analysis identifies end-binding protein 1 as a crucial component for the speck-like particle formation of activated absence in melanoma 2 (AIM2) inflammasomes.
Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers.
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.
Ansari MA, Singh VV, Dutta S, Veettil MV, Dutta D, Chikoti L, Lu J, Everly D, Chandran B
Journal of virology 2013 Aug;87(15):8606-23
Journal of virology 2013 Aug;87(15):8606-23
Interactome-wide analysis identifies end-binding protein 1 as a crucial component for the speck-like particle formation of activated absence in melanoma 2 (AIM2) inflammasomes.
Wang LJ, Hsu CW, Chen CC, Liang Y, Chen LC, Ojcius DM, Tsang NM, Hsueh C, Wu CC, Chang YS
Molecular & cellular proteomics : MCP 2012 Nov;11(11):1230-44
Molecular & cellular proteomics : MCP 2012 Nov;11(11):1230-44
Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers.
Lee J, Li L, Gretz N, Gebert J, Dihlmann S
Oncogene 2012 Mar 8;31(10):1242-53
Oncogene 2012 Mar 8;31(10):1242-53
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.
Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES
Nature 2009 Mar 26;458(7237):509-13
Nature 2009 Mar 26;458(7237):509-13
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: AIM2 Antibody [H00009447-B01P] - Analysis of AIM2 expression in transfected 293T cell line by AIM2 polyclonal antibody. Lane 1: AIM2 transfected lysate(37.73 KDa). Lane 2: Non-transfected lysate.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunocytochemistry/Immunofluorescence: AIM2 Antibody [H00009447-B01P] - Analysis of purified antibody to AIM2 on HeLa cell. (antibody concentration 10 ug/ml)