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- Antigen structure
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- Immunohistochemistry [1]
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- Product number
- HPA043618 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA043618, RRID:AB_10959305
- Product name
- Anti-CFAP45
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human CFAP45, Gene description: cilia and flagella associated protein 45, Alternative Gene Names: CCDC19, NESG1, Validated applications: WB, IHC, ICC, Uniprot ID: Q9UL16, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.1 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references The cilia and flagella associated protein CFAP52 orchestrated with CFAP45 is required for sperm motility in mice.
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.
Wu B, Li R, Ma S, Ma Y, Fan L, Gong C, Liu C, Sun L, Yuan L
The Journal of biological chemistry 2023 Jul;299(7):104858
The Journal of biological chemistry 2023 Jul;299(7):104858
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.
Dougherty GW, Mizuno K, Nöthe-Menchen T, Ikawa Y, Boldt K, Ta-Shma A, Aprea I, Minegishi K, Pang YP, Pennekamp P, Loges NT, Raidt J, Hjeij R, Wallmeier J, Mussaffi H, Perles Z, Elpeleg O, Rabert F, Shiratori H, Letteboer SJ, Horn N, Young S, Strünker T, Stumme F, Werner C, Olbrich H, Takaoka K, Ide T, Twan WK, Biebach L, Große-Onnebrink J, Klinkenbusch JA, Praveen K, Bracht DC, Höben IM, Junger K, Gützlaff J, Cindrić S, Aviram M, Kaiser T, Memari Y, Dzeja PP, Dworniczak B, Ueffing M, Roepman R, Bartscherer K, Katsanis N, Davis EE, Amirav I, Hamada H, Omran H
Nature communications 2020 Nov 2;11(1):5520
Nature communications 2020 Nov 2;11(1):5520
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human fallopian tube and skeletal muscle tissues using HPA043618 antibody. Corresponding CFAP45 RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
