Explore
Validate
Learn21492-1-AP
antibody from Proteintech Group
Targeting: VANGL2
KIAA1215, LPP1, LTAP, MGC119403, MGC119404, STB1, STBM, STBM1
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 21492-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21492-1-AP, RRID:AB_11182263
- Product name
- VANGL2 antibody
- Antibody type
- Polyclonal
- Description
- VANGL2 antibody (Cat. #21492-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Epithelial-Mesenchymal Wnt Crosstalk Directs Planar Cell Polarity in the Developing Cochlea.
CRB2 Facilitates Epithelial Ovarian Cancer Progression by Inducing Polarity Changes via Activation of the Wnt/PCP Signalling Pathway.
Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation.
Tryptophan in the mouse diet is essential for embryo implantation and decidualization.
Folate regulation of planar cell polarity pathway and F-actin through folate receptor alpha.
SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP.
Isolation and Comprehensive Analysis of Cochlear Tissue-Derived Small Extracellular Vesicles.
Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis.
A complex of Wnt/planar cell polarity signaling components Vangl1 and Fzd7 drives glioblastoma multiforme malignant properties.
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells.
An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.
Vangl2 participates in the primary ciliary assembly under low fluid shear stress in hUVECs.
CIC missense variants contribute to susceptibility for spina bifida.
Dihydroartemisinin Attenuates Hypoxic Pulmonary Hypertension via the Downregulation of miR-335 Targeting Vangl2.
Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells.
Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.
VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.
Kishimoto I, David AP, Rose KP, Narasimhan B, Efron B, Billings SE, Su EL, Dong W, Jan TA, Hertzano R, Cheng AG
bioRxiv : the preprint server for biology 2026 Mar 27;
bioRxiv : the preprint server for biology 2026 Mar 27;
CRB2 Facilitates Epithelial Ovarian Cancer Progression by Inducing Polarity Changes via Activation of the Wnt/PCP Signalling Pathway.
Tao C, Li S, Sun D, Zhou J, Chen Y, Zhang R, Ni X
Journal of cellular and molecular medicine 2026 Apr;30(7):e71124
Journal of cellular and molecular medicine 2026 Apr;30(7):e71124
Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation.
Alhashmi M, Gremida AME, Maharana SK, Antonaci M, Kerr A, Fu S, Lunn S, Turner DA, Al-Maslamani NA, Liu K, Meschis MM, Sutherland H, Wilson P, Clegg P, Wheeler GN, van 't Hof RJ, Bou-Gharios G, Yamamoto K
Bone research 2025 Jan 26;13(1):17
Bone research 2025 Jan 26;13(1):17
Tryptophan in the mouse diet is essential for embryo implantation and decidualization.
Chen ST, Ran F, Shi WW, Liu CK, Wang PC, Luo HN, Yang ZM
Frontiers in endocrinology 2024;15:1356914
Frontiers in endocrinology 2024;15:1356914
Folate regulation of planar cell polarity pathway and F-actin through folate receptor alpha.
Han X, Cao X, Cabrera RM, Ramirez PAP, Lin YL, Wlodarczyk BJ, Zhang C, Finnell RH, Lei Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23346
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23346
SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP.
Rehmani T, Dias AP, Applin BD, Salih M, Tuana BS
Life science alliance 2024 Dec;7(12)
Life science alliance 2024 Dec;7(12)
Isolation and Comprehensive Analysis of Cochlear Tissue-Derived Small Extracellular Vesicles.
Jiang P, Ma X, Wang X, Huang J, Wang Y, Ai J, Xiao H, Dai M, Lin Y, Shao B, Tang X, Tong W, Ye Z, Chai R, Zhang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2408964
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(48):e2408964
Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis.
VanderVorst K, Dreyer CA, Hatakeyama J, Bell GRR, Learn JA, Berg AL, Hernandez M, Lee H, Collins SR, Carraway KL 3rd
Breast cancer research : BCR 2023 May 5;25(1):52
Breast cancer research : BCR 2023 May 5;25(1):52
A complex of Wnt/planar cell polarity signaling components Vangl1 and Fzd7 drives glioblastoma multiforme malignant properties.
Dreyer CA, VanderVorst K, Natwick D, Bell G, Sood P, Hernandez M, Angelastro JM, Collins SR, Carraway KL 3rd
Cancer letters 2023 Jul 28;567:216280
Cancer letters 2023 Jul 28;567:216280
The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells.
Takahashi-Kanemitsu A, Lu M, Knight CT, Yamamoto T, Hayashi T, Mii Y, Ooki T, Kikuchi I, Kikuchi A, Barker N, Susaki EA, Taira M, Hatakeyama M
Science signaling 2023 Jul 18;16(794):eabp9020
Science signaling 2023 Jul 18;16(794):eabp9020
An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity.
Almeida SM, Ivantsiv S, Niibori R, Dunham WH, Green BA, Zhao L, Gingras AC, Cordes SP
Disease models & mechanisms 2023 Aug 1;16(8)
Disease models & mechanisms 2023 Aug 1;16(8)
Vangl2 participates in the primary ciliary assembly under low fluid shear stress in hUVECs.
Sheng X, Gao S, Sheng Y, Xie X, Wang J, He Y
Cell and tissue research 2022 Jan;387(1):95-109
Cell and tissue research 2022 Jan;387(1):95-109
CIC missense variants contribute to susceptibility for spina bifida.
Han X, Cao X, Aguiar-Pulido V, Yang W, Karki M, Ramirez PAP, Cabrera RM, Lin YL, Wlodarczyk BJ, Shaw GM, Ross ME, Zhang C, Finnell RH, Lei Y
Human mutation 2022 Dec;43(12):2021-2032
Human mutation 2022 Dec;43(12):2021-2032
Dihydroartemisinin Attenuates Hypoxic Pulmonary Hypertension via the Downregulation of miR-335 Targeting Vangl2.
Li Y, Cai H, Wei J, Zhu L, Yao Y, Xie M, Song L, Zhang C, Huang X, Wang L
DNA and cell biology 2022 Aug;41(8):750-767
DNA and cell biology 2022 Aug;41(8):750-767
Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells.
Gong Y, Li Z, Zou S, Deng D, Lai P, Hu H, Yao Y, Hu L, Zhang S, Li K, Wei T, Zhao X, Xiao G, Chen Z, Jiang Y, Bai X, Zou Z
Developmental cell 2021 Jul 26;56(14):2103-2120.e9
Developmental cell 2021 Jul 26;56(14):2103-2120.e9
Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.
Duan HY, Zhou KY, Wang T, Zhang Y, Li YF, Hua YM, Wang C
Chinese medical journal 2018 Sep 5;131(17):2080-2088
Chinese medical journal 2018 Sep 5;131(17):2080-2088
VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.
Jessen TN, Jessen JR
Experimental cell research 2017 Dec 15;361(2):265-276
Experimental cell research 2017 Dec 15;361(2):265-276
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 21492-1-AP(VANGL2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The VANGL2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human VANGL2. This antibody recognizes human,mouse,rat antigen. The VANGL2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
