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ELISAAntibody data
- Antibody Data
- Antigen structure
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- Validations
- ELISA [1]
- Flow cytometry [1]
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- Product number
- Ab175653 - Provider product page
- Provider
- Aladdin Scientific
- Product name
- Seribantumab (anti-ERBB3)
- Antibody type
- Recombinant
- Description
- Seribantumab (anti-ERBB3) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab (anti-ERBB3) blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab (anti-ERBB3) inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models.
- Reactivity
- Human, Mouse
- Conjugate
- Unconjugated
- Vial size
- 100_g,10mg,1mg,5mg
- Concentration
- Lot by Lot
- Storage
- Store at -80_ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
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Supportive validation
- Submitted by
- Aladdin Scientific (provider)
- Main image
- Experimental details
- Seribantumab (anti-ERBB3) (Ab175653) - ELISA Immobilized Recombinant Human ErbB3 / HER3 protein (rp170123) at 1.0 μg/mL can bind Seribantumab (anti-ERBB3) (Ab175653) with the EC₅₀ of 17.20 ng/mL.
Supportive validation
- Submitted by
- Aladdin Scientific (provider)
- Main image
- Experimental details
- Seribantumab (anti-ERBB3) (Ab175653) - Flow Cytometry Flow Cytometry analysis of MCF-7 cells labelling ERBB3 (red) with Seribantumab (anti-ERBB3) (Ab175653). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
