Antibody data
- Antibody Data
- Antigen structure
- References [54]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- AF743 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse VEGFR3/Flt-4 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse VEGFR3/Flt-4 in direct ELISAs and Western blots. In direct ELISAs, approximately 30% cross-reactivity with recombinant human (rh) VEGFR3 is observed and less than 5% cross-reactivity with recombinant mouse VEGFR2 is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
P35917
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation.
Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling.
HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.
Expression of the Atypical Chemokine Receptor ACKR4 Identifies a Novel Population of Intestinal Submucosal Fibroblasts That Preferentially Expresses Endothelial Cell Regulators.
Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread.
Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms.
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program.
Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma.
FGF-dependent metabolic control of vascular development.
Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.
Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms.
VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis.
Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.
Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction.
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1.
Basophil-derived IL-6 regulates TH17 cell differentiation and CD4 T cell immunity.
Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43.
VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling.
Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1.
Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves.
Delayed Healing of Sickle Cell Ulcers Is due to Impaired Angiogenesis and CXCL12 Secretion in Skin Wounds.
G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling.
Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina.
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.
Structural and functional features of central nervous system lymphatic vessels.
Quantitative assessment of angiogenesis, perfused blood vessels and endothelial tip cells in the postnatal mouse brain.
EphB4 forward signalling regulates lymphatic valve development.
Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice.
The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel.
Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
Fusing VE-cadherin to α-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation.
Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation.
Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals.
Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.
Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process.
Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions.
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy.
Lenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphoma.
Proteinuria triggers renal lymphangiogenesis prior to the development of interstitial fibrosis.
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.
Remodeling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli.
Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development.
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.
Vascular endothelial growth factor-C induces lymphangitic carcinomatosis, an extremely aggressive form of lung metastases.
Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.
Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues.
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.
Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth.
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.
Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.
Desmoplakin and Plakoglobin--specific markers of lymphatic vessels in the skin?
B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis.
Norman TA Jr, Gower AC, Chen F, Fine A
PloS one 2019;14(5):e0216795
PloS one 2019;14(5):e0216795
Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling.
Cha B, Geng X, Mahamud MR, Zhang JY, Chen L, Kim W, Jho EH, Kim Y, Choi D, Dixon JB, Chen H, Hong YK, Olson L, Kim TH, Merrill BJ, Davis MJ, Srinivasan RS
Cell reports 2018 Oct 16;25(3):571-584.e5
Cell reports 2018 Oct 16;25(3):571-584.e5
HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.
Gauvrit S, Villasenor A, Strilic B, Kitchen P, Collins MM, Marín-Juez R, Guenther S, Maischein HM, Fukuda N, Canham MA, Brickman JM, Bogue CW, Jayaraman PS, Stainier DYR
Nature communications 2018 Jul 13;9(1):2704
Nature communications 2018 Jul 13;9(1):2704
Expression of the Atypical Chemokine Receptor ACKR4 Identifies a Novel Population of Intestinal Submucosal Fibroblasts That Preferentially Expresses Endothelial Cell Regulators.
Thomson CA, van de Pavert SA, Stakenborg M, Labeeuw E, Matteoli G, Mowat AM, Nibbs RJB
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 1;201(1):215-229
Journal of immunology (Baltimore, Md. : 1950) 2018 Jul 1;201(1):215-229
Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread.
Ma Q, Dieterich LC, Ikenberg K, Bachmann SB, Mangana J, Proulx ST, Amann VC, Levesque MP, Dummer R, Baluk P, McDonald DM, Detmar M
Science advances 2018 Aug;4(8):eaat4758
Science advances 2018 Aug;4(8):eaat4758
Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms.
Zhang Y, Ulvmar MH, Stanczuk L, Martinez-Corral I, Frye M, Alitalo K, Mäkinen T
Nature communications 2018 Apr 3;9(1):1296
Nature communications 2018 Apr 3;9(1):1296
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program.
Frye M, Taddei A, Dierkes C, Martinez-Corral I, Fielden M, Ortsäter H, Kazenwadel J, Calado DP, Ostergaard P, Salminen M, He L, Harvey NL, Kiefer F, Mäkinen T
Nature communications 2018 Apr 17;9(1):1511
Nature communications 2018 Apr 17;9(1):1511
Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma.
Kim J, Park DY, Bae H, Park DY, Kim D, Lee CK, Song S, Chung TY, Lim DH, Kubota Y, Hong YK, He Y, Augustin HG, Oliver G, Koh GY
The Journal of clinical investigation 2017 Oct 2;127(10):3877-3896
The Journal of clinical investigation 2017 Oct 2;127(10):3877-3896
FGF-dependent metabolic control of vascular development.
Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M
Nature 2017 May 11;545(7653):224-228
Nature 2017 May 11;545(7653):224-228
Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.
Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH
Nature cell biology 2017 Mar;19(3):189-201
Nature cell biology 2017 Mar;19(3):189-201
Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms.
Yazdani S, Poosti F, Toro L, Wedel J, Mencke R, Mirković K, de Borst MH, Alexander JS, Navis G, van Goor H, van den Born J, Hillebrands JL
Scientific reports 2017 Mar 17;7:44403
Scientific reports 2017 Mar 17;7:44403
VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis.
Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, Lee BJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, Shong M, Koh GY
EMBO molecular medicine 2017 Jun;9(6):750-769
EMBO molecular medicine 2017 Jun;9(6):750-769
Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine.
Olmeda D, Cerezo-Wallis D, Riveiro-Falkenbach E, Pennacchi PC, Contreras-Alcalde M, Ibarz N, Cifdaloz M, Catena X, Calvo TG, Cañón E, Alonso-Curbelo D, Suarez J, Osterloh L, Graña O, Mulero F, Megías D, Cañamero M, Martínez-Torrecuadrada JL, Mondal C, Di Martino J, Lora D, Martinez-Corral I, Bravo-Cordero JJ, Muñoz J, Puig S, Ortiz-Romero P, Rodriguez-Peralto JL, Ortega S, Soengas MS
Nature 2017 Jun 28;546(7660):676-680
Nature 2017 Jun 28;546(7660):676-680
Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction.
Tatin F, Renaud-Gabardos E, Godet AC, Hantelys F, Pujol F, Morfoisse F, Calise D, Viars F, Valet P, Masri B, Prats AC, Garmy-Susini B
JCI insight 2017 Jun 15;2(12)
JCI insight 2017 Jun 15;2(12)
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1.
Jha SK, Rauniyar K, Karpanen T, Leppänen VM, Brouillard P, Vikkula M, Alitalo K, Jeltsch M
Scientific reports 2017 Jul 7;7(1):4916
Scientific reports 2017 Jul 7;7(1):4916
Basophil-derived IL-6 regulates TH17 cell differentiation and CD4 T cell immunity.
Yuk CM, Park HJ, Kwon BI, Lah SJ, Chang J, Kim JY, Lee KM, Park SH, Hong S, Lee SH
Scientific reports 2017 Jan 30;7:41744
Scientific reports 2017 Jan 30;7:41744
Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43.
Munger SJ, Davis MJ, Simon AM
Developmental biology 2017 Jan 15;421(2):204-218
Developmental biology 2017 Jan 15;421(2):204-218
VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling.
Heinolainen K, Karaman S, D'Amico G, Tammela T, Sormunen R, Eklund L, Alitalo K, Zarkada G
Circulation research 2017 Apr 28;120(9):1414-1425
Circulation research 2017 Apr 28;120(9):1414-1425
Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1.
Liu X, Uemura A, Fukushima Y, Yoshida Y, Hirashima M
Cell reports 2016 Nov 22;17(9):2299-2311
Cell reports 2016 Nov 22;17(9):2299-2311
Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves.
Cha B, Geng X, Mahamud MR, Fu J, Mukherjee A, Kim Y, Jho EH, Kim TH, Kahn ML, Xia L, Dixon JB, Chen H, Srinivasan RS
Genes & development 2016 Jun 15;30(12):1454-69
Genes & development 2016 Jun 15;30(12):1454-69
Delayed Healing of Sickle Cell Ulcers Is due to Impaired Angiogenesis and CXCL12 Secretion in Skin Wounds.
Nguyen VT, Nassar D, Batteux F, Raymond K, Tharaux PL, Aractingi S
The Journal of investigative dermatology 2016 Feb;136(2):497-506
The Journal of investigative dermatology 2016 Feb;136(2):497-506
G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling.
Majumder S, Zhu G, Xu X, Senchanthisai S, Jiang D, Liu H, Xue C, Wang X, Coia H, Cui Z, Smolock EM, Libby RT, Berk BC, Pang J
Cell reports 2016 Dec 6;17(10):2532-2541
Cell reports 2016 Dec 6;17(10):2532-2541
Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina.
Zhou Y, Williams J, Smallwood PM, Nathans J
PloS one 2015;10(12):e0143650
PloS one 2015;10(12):e0143650
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.
Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K
The Journal of experimental medicine 2015 Jun 29;212(7):991-9
The Journal of experimental medicine 2015 Jun 29;212(7):991-9
Structural and functional features of central nervous system lymphatic vessels.
Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J
Nature 2015 Jul 16;523(7560):337-41
Nature 2015 Jul 16;523(7560):337-41
Quantitative assessment of angiogenesis, perfused blood vessels and endothelial tip cells in the postnatal mouse brain.
Wälchli T, Mateos JM, Weinman O, Babic D, Regli L, Hoerstrup SP, Gerhardt H, Schwab ME, Vogel J
Nature protocols 2015 Jan;10(1):53-74
Nature protocols 2015 Jan;10(1):53-74
EphB4 forward signalling regulates lymphatic valve development.
Zhang G, Brady J, Liang WC, Wu Y, Henkemeyer M, Yan M
Nature communications 2015 Apr 13;6:6625
Nature communications 2015 Apr 13;6:6625
Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice.
Huang Y, Caputo CR, Noordmans GA, Yazdani S, Monteiro LH, van den Born J, van Goor H, Heeringa P, Korstanje R, Hillebrands JL
PloS one 2014;9(3):e91850
PloS one 2014;9(3):e91850
The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel.
Aspelund A, Tammela T, Antila S, Nurmi H, Leppänen VM, Zarkada G, Stanczuk L, Francois M, Mäkinen T, Saharinen P, Immonen I, Alitalo K
The Journal of clinical investigation 2014 Sep;124(9):3975-86
The Journal of clinical investigation 2014 Sep;124(9):3975-86
Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
Park DY, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong KY, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong YK, Koh GY
The Journal of clinical investigation 2014 Sep;124(9):3960-74
The Journal of clinical investigation 2014 Sep;124(9):3960-74
Fusing VE-cadherin to α-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation.
Dartsch N, Schulte D, Hägerling R, Kiefer F, Vestweber D
Molecular and cellular biology 2014 May;34(9):1634-48
Molecular and cellular biology 2014 May;34(9):1634-48
Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation.
Baluk P, Adams A, Phillips K, Feng J, Hong YK, Brown MB, McDonald DM
The American journal of pathology 2014 May;184(5):1577-92
The American journal of pathology 2014 May;184(5):1577-92
Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals.
Lindskog H, Kim YH, Jelin EB, Kong Y, Guevara-Gallardo S, Kim TN, Wang RA
Development (Cambridge, England) 2014 Mar;141(5):1120-8
Development (Cambridge, England) 2014 Mar;141(5):1120-8
Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.
Ramasamy SK, Kusumbe AP, Wang L, Adams RH
Nature 2014 Mar 20;507(7492):376-380
Nature 2014 Mar 20;507(7492):376-380
Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process.
Kizhatil K, Ryan M, Marchant JK, Henrich S, John SW
PLoS biology 2014 Jul;12(7):e1001912
PLoS biology 2014 Jul;12(7):e1001912
Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions.
Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen EA, Orsenigo F, Lohela M, D'Amico G, Holopainen T, Leow CC, Dejana E, Petrova TV, Augustin HG, Alitalo K
Genes & development 2014 Jul 15;28(14):1592-603
Genes & development 2014 Jul 15;28(14):1592-603
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy.
Hägerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams RH, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F
The EMBO journal 2013 Mar 6;32(5):629-44
The EMBO journal 2013 Mar 6;32(5):629-44
Lenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphoma.
Song K, Herzog BH, Sheng M, Fu J, McDaniel JM, Chen H, Ruan J, Xia L
Cancer research 2013 Dec 15;73(24):7254-64
Cancer research 2013 Dec 15;73(24):7254-64
Proteinuria triggers renal lymphangiogenesis prior to the development of interstitial fibrosis.
Yazdani S, Poosti F, Kramer AB, Mirković K, Kwakernaak AJ, Hovingh M, Slagman MC, Sjollema KA, de Borst MH, Navis G, van Goor H, van den Born J
PloS one 2012;7(11):e50209
PloS one 2012;7(11):e50209
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.
Benedito R, Rocha SF, Woeste M, Zamykal M, Radtke F, Casanovas O, Duarte A, Pytowski B, Adams RH
Nature 2012 Mar 18;484(7392):110-4
Nature 2012 Mar 18;484(7392):110-4
Remodeling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli.
Betterman KL, Paquet-Fifield S, Asselin-Labat ML, Visvader JE, Butler LM, Stacker SA, Achen MG, Harvey NL
The American journal of pathology 2012 Dec;181(6):2225-38
The American journal of pathology 2012 Dec;181(6):2225-38
Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development.
Lin FJ, Chen X, Qin J, Hong YK, Tsai MJ, Tsai SY
The Journal of clinical investigation 2010 May;120(5):1694-707
The Journal of clinical investigation 2010 May;120(5):1694-707
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.
Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Lüthi U, Barberis A, Benjamin LE, Mäkinen T, Nobes CD, Adams RH
Nature 2010 May 27;465(7297):483-6
Nature 2010 May 27;465(7297):483-6
Vascular endothelial growth factor-C induces lymphangitic carcinomatosis, an extremely aggressive form of lung metastases.
Das S, Ladell DS, Podgrabinska S, Ponomarev V, Nagi C, Fallon JT, Skobe M
Cancer research 2010 Mar 1;70(5):1814-24
Cancer research 2010 Mar 1;70(5):1814-24
Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.
Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivée B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A
The Journal of cell biology 2010 Jan 11;188(1):115-30
The Journal of cell biology 2010 Jan 11;188(1):115-30
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.
Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, Waltari M, Hellström M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Ylä-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K
Nature 2008 Jul 31;454(7204):656-60
Nature 2008 Jul 31;454(7204):656-60
Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues.
Lohela M, Heloterä H, Haiko P, Dumont DJ, Alitalo K
The American journal of pathology 2008 Dec;173(6):1891-901
The American journal of pathology 2008 Dec;173(6):1891-901
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.
Wirzenius M, Tammela T, Uutela M, He Y, Odorisio T, Zambruno G, Nagy JA, Dvorak HF, Ylä-Herttuala S, Shibuya M, Alitalo K
The Journal of experimental medicine 2007 Jun 11;204(6):1431-40
The Journal of experimental medicine 2007 Jun 11;204(6):1431-40
Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth.
Laakkonen P, Waltari M, Holopainen T, Takahashi T, Pytowski B, Steiner P, Hicklin D, Persaud K, Tonra JR, Witte L, Alitalo K
Cancer research 2007 Jan 15;67(2):593-9
Cancer research 2007 Jan 15;67(2):593-9
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Bréant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL
Nature neuroscience 2006 Mar;9(3):340-8
Nature neuroscience 2006 Mar;9(3):340-8
Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.
Reinhardt RL, Hong S, Kang SJ, Wang ZE, Locksley RM
Journal of immunology (Baltimore, Md. : 1950) 2006 Aug 1;177(3):1618-27
Journal of immunology (Baltimore, Md. : 1950) 2006 Aug 1;177(3):1618-27
Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.
Reinhardt RL, Hong S, Kang SJ, Wang ZE, Locksley RM
Journal of immunology (Baltimore, Md. : 1950) 2006 Aug 1;177(3):1618-27
Journal of immunology (Baltimore, Md. : 1950) 2006 Aug 1;177(3):1618-27
Desmoplakin and Plakoglobin--specific markers of lymphatic vessels in the skin?
Fedele C, Berens D, Rautenfeld V, Pabst R
Anatomia, histologia, embryologia 2004 Jun;33(3):168-71
Anatomia, histologia, embryologia 2004 Jun;33(3):168-71
B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis.
Ruddell A, Mezquita P, Brandvold KA, Farr A, Iritani BM
The American journal of pathology 2003 Dec;163(6):2233-45
The American journal of pathology 2003 Dec;163(6):2233-45
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of VEGFR3/Flt-4 in bEnd.3 Mouse Cell Line by Flow Cytometry. bEnd.3 cells, a mouse endothelioma cell line, was stained with Goat Anti-Mouse VEGFR3/Flt-4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF743, filled histogram) or isotype control antibody (Catalog # AB-108-C, open histogram), followed by PE-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0107).