CABT-BL8420

antibody from Creative Diagnostics

Targeting: FLT4 PCL, VEGFR-3, VEGFR3

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL8420

Provider

Creative Diagnostics

Product name

Anti-VEGFA Monoclonal antibody, clone BGM5 [Biotin]

Antibody type

Monoclonal

Description

Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.

Reactivity

Mouse

Host

Rat

Conjugate

Biotin

Isotype

IgG