17856-1-AP

antibody from Proteintech Group

Targeting: USP21 USP16, USP23

Provider product page for 17856-1-AP

Western blot

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Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [17]
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Validations
Western blot [1]

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Product number: 17856-1-AP - Provider product page
Provider: Proteintech Group
Product name: USP21 antibody
Antibody type: Polyclonal
Description: KD/KO validated USP21 antibody (Cat. #17856-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

USP21 protein structure - 17856-1-AP shown in red.

Submitted references USP21 deubiquitinates DPYSL2 and enhances its centrosomal abundance to promote cilium formation.

Song T, Zhou P, Zhang F, Liu C, Han X, Yue Y, Hu M, Yan S, Li Q, Liu M, Zhou J, Zhao H
Journal of genetics and genomics = Yi chuan xue bao 2026 Feb;53(2):256-268

Targeting USP21 to inhibit abdominal aortic aneurysm progression by suppressing the phenotypic transition of vascular smooth muscle cells.

Zhang H, Yue H, Sun Y, Sun G, Yang K, Jiang T, Cui S, Liu Y, Guo Y, Zhang W, Zhang C, Chen Y, Xu F
Cell reports. Medicine 2025 Sep 16;6(9):102328

GTF3C2 Promotes the Proliferation of Hepatocellular Carcinoma Cells through the USP21/MEK2/ERK1/2 Pathway.

Wu Y, Yang Y, Zhang Y, Xu Q, Huang D, Tu K
Journal of clinical and translational hepatology 2025 May 28;13(5):374-384

Ubiquitin-specific protease 21 aggravates enterovirus 71 (EV71) infection by restricting Lys48-linked ubiquitination of EV71-2A protease.

Yang X, Tang M, Zang L, Hao P, Chen Y, Yuan Y, Miao Y, Zuo Y, Wu Z, Che Z, Ren T, Wu Q, Peng Y, Zhou W, Zheng H, Shi W
International journal of biological macromolecules 2025 Jun;314:144202

Adipose stem cell exosomes, stimulated by pro-inflammatory factors, enhance immune evasion in triple-negative breast cancer by modulating the HDAC6/STAT3/PD-L1 pathway through the transporter UCHL1.

Zhu Q, Zhang K, Cao Y, Hu Y
Cancer cell international 2024 Nov 20;24(1):385

TET2 stabilized by deubiquitinase USP21 ameliorates cigarette smoke-induced apoptosis in airway epithelial cells.

Luo L, Zeng Z, Li T, Liu X, Cui Y, Tao Y, Li Y, Chen Y
iScience 2024 Mar 15;27(3):109252

Comprehensive analysis of the relationship between ubiquitin-specific protease 21 (USP21) and prognosis, tumor microenvironment infiltration, and therapy response in colorectal cancer.

Nie H, Yu Y, Wang F, Huang X, Wang H, Wang J, Tao M, Ning Y, Zhou J, Zhao Q, Xu F, Fang J
Cancer immunology, immunotherapy : CII 2024 Jun 4;73(8):156

Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer.

Ding JH, Xiao Y, Yang F, Song XQ, Xu Y, Ding XH, Ding R, Shao ZM, Di GH, Jiang YZ
Science translational medicine 2024 Jan 3;16(728):eadg7740

Construction and validation of a prognostic signature based on necroptosis-related genes in hepatocellular carcinoma.

Peng YL, Wang LX, Li MY, Liu LP, Li RS
PloS one 2023;18(2):e0279744

Anti-tumor effects of deubiquitinating enzyme inhibitor PR-619 in human chondrosarcoma through reduced cell proliferation and endoplasmic reticulum stress-related apoptosis.

Lin WC, Chiu YL, Kuo KL, Chow PM, Hsu CH, Liao SM, Dong JR, Chang SC, Liu SH, Liu TJ, Hsu FS, Wang KC, Lin YC, Chang CC, Huang KY
American journal of cancer research 2023;13(7):3055-3066

Salt-like transcription factor 4 promotes laryngeal cancer progression through transcriptional activation of ubiquitin-specific protease 21 to stabilize Yin Yang 1.

Wang QD, Liu LL, Li D, Gao L, Zhang MJ
Pathology international 2023 Mar;73(3):109-119

USP21 contributes to the aggressiveness of laryngeal cancer cells by deubiquitinating and stabilizing AURKA.

Wang QD, Shi T, Xu Y, Liu Y, Zhang MJ
The Kaohsiung journal of medical sciences 2023 Apr;39(4):354-363

RBM47/SNHG5/FOXO3 axis activates autophagy and inhibits cell proliferation in papillary thyroid carcinoma.

Qin Y, Sun W, Wang Z, Dong W, He L, Zhang T, Lv C, Zhang H
Cell death & disease 2022 Mar 25;13(3):270

PR-619, a General Inhibitor of Deubiquitylating Enzymes, Diminishes Cisplatin Resistance in Urothelial Carcinoma Cells through the Suppression of c-Myc: An In Vitro and In Vivo Study.

Hsu FS, Lin WC, Kuo KL, Chiu YL, Hsu CH, Liao SM, Dong JR, Liu SH, Chang SC, Yang SP, Chen YT, Chang RJ, Huang KH
International journal of molecular sciences 2021 Oct 28;22(21)

Deubiquitinating Enzyme USP21 Inhibits HIV-1 Replication by Downregulating Tat Expression.

Gao W, Li G, Zhao S, Wang H, Huan C, Zheng B, Jiang C, Zhang W
Journal of virology 2021 Jun 10;95(13):e0046021

Oligomerization-driven MLKL ubiquitylation antagonizes necroptosis.

Liu Z, Dagley LF, Shield-Artin K, Young SN, Bankovacki A, Wang X, Tang M, Howitt J, Stafford CA, Nachbur U, Fitzgibbon C, Garnish SE, Webb AI, Komander D, Murphy JM, Hildebrand JM, Silke J
The EMBO journal 2021 Dec 1;40(23):e103718

The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth.

Li W, Cui K, Prochownik EV, Li Y
Cell death & disease 2018 May 1;9(5):482

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The USP21 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human USP21. This antibody recognizes human antigen. The USP21 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 17856-1-AP.pdf

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