Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 633902 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#633902, RRID:AB_2064706
- Product name
- Purified anti-Bcl-XS/L
- Antibody type
- Monoclonal
- Antigen
- Amino acids: 3-14 common to human and mouse Bcl-X
- Description
- Bcl-X is one of the members of Bcl-2 family proteins, and exists in several isoforms generated by alternative splicing and plays a critical role in the control of apoptosis. The large isoform Bcl-XL (30KD)contains the highly conserved BH1 and BH2 amino acid domains and protects cells against apoptosis, whereas the short isoform, Bcl-XS(18KD) which deletes the conserved BH1/BH2 domain by alternative mRNA splicing, promotes apoptosisby interacting with Bcl-XL and Bcl-2.Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.Clone 2H12 has been shown to be useful for western blotting and immunoprecipitation, immunohistochemistry, and immunofluorescence of the Human, Mouse and Rat Bcl-XL and Bcl-XS proteins.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Upon receipt, store undiluted at 4°C.
No comments: Submit comment
No validations: Submit validation data