BS6670

antibody from Bioworld Technology, Inc
Targeting: MPZ CMT1, CMT1B, CMT2I, CMT2J, HMSNIB, P0
Provider product page for BS6670
Western blot
Immunohistochemistry

Antibody data

Product number
BS6670 - Provider product page
Provider
Bioworld Technology, Inc
Product name
MPZ polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human MPZ.
Description
Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
MPZ protein structure - BS6670 shown in red.