BS6976

antibody from Bioworld Technology, Inc

Targeting: CTNNA1 CAP102

Immunocytochemistry

Immunohistochemistry

Flow cytometry

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Validation data

Product number: BS6976 - Provider product page
Provider: Bioworld Technology, Inc
Product name: Catenin Ï«1 polyclonal antibody
Antibody type: Polyclonal
Antigen: Recombinant full length Human Catenin-Ï«1.
Description: Ï« E-catenin (also designated Ï«-catenin; cadherin-associated protein, alpha 1, 102kDa; and CAP102) plays a role in E-cadherin mediated cell-cell adhesion by linking E-cadherin to the cytoskeleton via ÉÇ- or ÎÛ-catenin and Actin. Ï« E-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and may provide a negative feedback loop controlling the size of developing cerebral cortex. It is abundant in neuroepithelial precursor cells in the developing cortical ventricular zone of the brain, with reduced expression in the cortical plate. Ï« E-catenin-vinculin interactions play a role in the assembly of the apical junction complex in epithelia. Catenins generally are thought to work as connectors that anchor E-cadherin to the cytoskeletal Actin bundle through the cadherin cytoplasmic domain. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, and is thus considered a contributing factor to metastasis.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

CTNNA1 protein structure - BS6976 shown in red.