844801

antibody from BioLegend
Targeting: CTNNA1 CAP102
Provider product page for 844801
Western blot
Immunocytochemistry
Immunoprecipitation
Immunoelectron microscopy

Antibody data

Product number
844801 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#844801, RRID:AB_2565821
Product name
Purified anti-α-E-Catenin
Antibody type
Monoclonal
Antigen
Recombinant human MBP-alpha catenin fusion protein.
Description
α-catenin associates with the cytoplasmic domain of a variety of plasma membrane spanning cadherins that mediate cell-cell adhesion. The association of catenins to cadherins produces a complex that is linked to the actin filament network, which seems to be of primary importance for their cell-adhesion properties. Catenin can associate with both E- and N-cadherins. It was originally thought to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and α-catenin was shown not to bind to F-actin when assembled in the complex suggesting a more complex, dynamic linkage between actin and these adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments.
Reactivity
Human, Mouse, Rat
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
1G5
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
CTNNA1 protein structure - 844801 shown in red.