Antibody data

Product number
Ab098106 - Provider product page
Provider
Aladdin Scientific
Product name
CTNNA1 Antibody
Antibody type
Polyclonal
Description
Rabbit anti Human CTNNA1 Antibody, Polyclonal, could be used for WB, IHC, ICC/IF and so on. Application WB: 0.5-2 µg/mL IHC: 5-20 µg/mL ICC/IF: 5-20 _g/mL Protein Function Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Reactivity
Human, Porcine
Host
Human
Conjugate
Unconjugated
Antigen sequence
AA 2-228
Vial size
100_l,10_l,1ml,20_l,50_l
Concentration
Lot by Lot
Storage
Store at 4_ short term (1-2 weeks). Store at -20_ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
CTNNA1 protein structure - Ab098106 shown in red.