GTX61089

antibody from GeneTex

Targeting: CTNNB1 armadillo, beta-catenin, CTNNB

Western blot (Supportive data in Antibodypedia)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

GTX61089

Provider

GeneTex

Proper citation

GeneTex Cat#GTX61089, RRID:AB_10619670

Product name

beta Catenin antibody [E247]

Antibody type

Monoclonal

Reactivity

Human, Mouse, Rat, Bovine, Hamster, Sheep, Simian, Zebrafish

Host

Rabbit

References

Submitted references

Ribose-5-phosphate isomerase A overexpression promotes liver cancer development in transgenic zebrafish via activation of ERK and β-catenin pathways.

Chou YT, Chen LY, Tsai SL, Tu HC, Lu JW, Ciou SC, Wang HD, Yuh CH
Carcinogenesis 2019 May 14;40(3):461-473

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GSK3β negatively regulates TRAX, a scaffold protein implicated in mental disorders, for NHEJ-mediated DNA repair in neurons.

Chien T, Weng YT, Chang SY, Lai HL, Chiu FL, Kuo HC, Chuang DM, Chern Y
Molecular psychiatry 2018 Dec;23(12):2375-2390

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YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.

Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 14;114(7):1643-1648

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Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation.

Chang LC, Chen TC, Chen SJ, Chen CL, Lee CC, Wu SH, Yen Y, Huang HS, Lin JJ
Oncotarget 2016 Oct 18;7(42):67986-68001

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Inhibition of cancer cell migration and invasion through suppressing the Wnt1-mediating signal pathway by G-quadruplex structure stabilizers.

Wang JM, Huang FC, Kuo MH, Wang ZF, Tseng TY, Chang LC, Yen SJ, Chang TC, Lin JJ
The Journal of biological chemistry 2014 May 23;289(21):14612-23

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Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.

Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M
Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 28;109(35):14007-12

Western blot

Supportive validation

Submitted by

GeneTex (provider)

Main image

Experimental details

A. Western blot analysis on A431 cell lysate using anti-Beta-catenin RabMAb (cat. #GTX61089); dilution 1:10000.

Validation comment

WB

Supportive validation

Submitted by

GeneTex (provider)

Main image

Experimental details

WB analysis of U2OS lysate using beta Catenin antibody [E247] at a dilution of 1:5,000.

Validation comment

WB

Immunocytochemistry

Supportive validation

Submitted by

GeneTex (provider)

Main image

Experimental details

ICC/IF analysis of A431 cells using beta Catenin antibody [E247] at a dilution of 1:250.

Immunohistochemistry

Supportive validation

Submitted by

GeneTex (provider)

Main image

Experimental details

IHC analysis of kidney carcinoma tissue using beta Catenin antibody [E247].

Supportive validation

Submitted by

GeneTex (provider)

Main image

Experimental details

IHC-P analysis of IHC analysis of human colon adenocarcinoma tissue using beta Catenin antibody [E247] at a dilution of 1:500.