Ab091079

antibody from Aladdin Scientific

Targeting: CTNNB1 armadillo, beta-catenin, CTNNB

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Product number: Ab091079 - Provider product page
Provider: Aladdin Scientific
Product name: Recombinant beta Catenin Antibody
Antibody type: Recombinant
Description: Rabbit anti Human beta Catenin Antibody, Recombinant, could be used for WB, ICC/IF and so on.ApplicationWB: 1/500-1/1000ICC/IF: 1/50-1/200Protein FunctionKey dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: AA 663-681
Vial size: 100_l,10_l,1ml,50_l
Concentration: 0,3 mg/ml
Storage: Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

CTNNB1 protein structure - Ab091079 shown in red.