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- References [14]
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- Product number
- 10511-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10511-1-AP, RRID:AB_2241182
- Product name
- UCK2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated UCK2 antibody (Cat. #10511-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Reprogramming of pyrimidine nucleotide metabolism supports vigorous cell proliferation of normal and malignant T cells.
Immune- and metabolism-related gene signature analysis uncovers the prognostic and immune microenvironments of hepatocellular carcinoma.
A prognostic and immune related risk model based on zinc homeostasis in hepatocellular carcinoma.
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions.
Oncogene-like addiction to aneuploidy in human cancers.
Uridine-cytidine kinase 2 potentiates the mutagenic influence of the antiviral β-d-N4-hydroxycytidine.
Oncogene-like addiction to aneuploidy in human cancers.
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma.
A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer.
Adult T-cell leukemia-lymphoma acquires resistance to DNA demethylating agents through dysregulation of enzymes involved in pyrimidine metabolism.
Prognostic and predictive role of a metabolic rate-limiting enzyme signature in hepatocellular carcinoma.
Uridine-cytidine kinase 2 promotes metastasis of hepatocellular carcinoma cells via the Stat3 pathway.
Lack of cross-resistance to FF-10501, an inhibitor of inosine-5'-monophosphate dehydrogenase, in azacitidine-resistant cell lines selected from SKM-1 and MOLM-13 leukemia cell lines.
Mechanisms of resistance to azacitidine in human leukemia cell lines.
Watanabe T, Yamamoto Y, Kurahashi Y, Kawasoe K, Kidoguchi K, Ureshino H, Kamachi K, Yoshida-Sakai N, Fukuda-Kurahashi Y, Nakamura H, Okada S, Sueoka E, Kimura S
Blood advances 2024 Mar 26;8(6):1345-1358
Blood advances 2024 Mar 26;8(6):1345-1358
Immune- and metabolism-related gene signature analysis uncovers the prognostic and immune microenvironments of hepatocellular carcinoma.
Gu Y, Ma E, Jiang S, Shan Z, Xia G, Ma R, Fu J, Wang Z
Journal of cancer research and clinical oncology 2024 Jun 19;150(6):311
Journal of cancer research and clinical oncology 2024 Jun 19;150(6):311
A prognostic and immune related risk model based on zinc homeostasis in hepatocellular carcinoma.
Shi Y, Ye R, Gao Y, Xia F, Yu XF
iScience 2024 Apr 19;27(4):109389
iScience 2024 Apr 19;27(4):109389
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions.
Skinner OS, Blanco-Fernández J, Goodman RP, Kawakami A, Shen H, Kemény LV, Joesch-Cohen L, Rees MG, Roth JA, Fisher DE, Mootha VK, Jourdain AA
Nature metabolism 2023 May;5(5):765-776
Nature metabolism 2023 May;5(5):765-776
Oncogene-like addiction to aneuploidy in human cancers.
Girish V, Lakhani AA, Scaduto CM, Thompson SL, Brown LM, Hagenson RA, Sausville EL, Mendelson BE, Lukow DA, Yuan ML, Kandikuppa PK, Stevens EC, Lee SN, Salovska B, Li W, Smith JC, Taylor AM, Martienssen RA, Liu Y, Sun R, Sheltzer JM
bioRxiv : the preprint server for biology 2023 Jan 10;
bioRxiv : the preprint server for biology 2023 Jan 10;
Uridine-cytidine kinase 2 potentiates the mutagenic influence of the antiviral β-d-N4-hydroxycytidine.
Xu Z, Flensburg C, Bilardi RA, Majewski IJ
Nucleic acids research 2023 Dec 11;51(22):12031-12042
Nucleic acids research 2023 Dec 11;51(22):12031-12042
Oncogene-like addiction to aneuploidy in human cancers.
Girish V, Lakhani AA, Thompson SL, Scaduto CM, Brown LM, Hagenson RA, Sausville EL, Mendelson BE, Kandikuppa PK, Lukow DA, Yuan ML, Stevens EC, Lee SN, Schukken KM, Akalu SM, Vasudevan A, Zou C, Salovska B, Li W, Smith JC, Taylor AM, Martienssen RA, Liu Y, Sun R, Sheltzer JM
Science (New York, N.Y.) 2023 Aug 25;381(6660):eadg4521
Science (New York, N.Y.) 2023 Aug 25;381(6660):eadg4521
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma.
Pal S, Kaplan JP, Nguyen H, Stopka SA, Savani MR, Regan MS, Nguyen QD, Jones KL, Moreau LA, Peng J, Dipiazza MG, Perciaccante AJ, Zhu X, Hunsel BR, Liu KX, Alexandrescu S, Drissi R, Filbin MG, McBrayer SK, Agar NYR, Chowdhury D, Haas-Kogan DA
Cancer cell 2022 Sep 12;40(9):957-972.e10
Cancer cell 2022 Sep 12;40(9):957-972.e10
A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer.
Boukouris AE, Zhang Y, Saleme B, Kinnaird A, Zhao YY, Liu Y, Zervopoulos SD, Das SK, Mittal RD, Haromy A, Lorenzana-Carrillo MA, Krysler AR, Cromwell CR, Hubbard BP, Sutendra G, Michelakis ED
Cell reports 2022 Mar 15;38(11):110511
Cell reports 2022 Mar 15;38(11):110511
Adult T-cell leukemia-lymphoma acquires resistance to DNA demethylating agents through dysregulation of enzymes involved in pyrimidine metabolism.
Yoshida-Sakai N, Watanabe T, Yamamoto Y, Ureshino H, Kamachi K, Kurahashi Y, Fukuda-Kurahashi Y, Kimura S
International journal of cancer 2022 Apr 1;150(7):1184-1197
International journal of cancer 2022 Apr 1;150(7):1184-1197
Prognostic and predictive role of a metabolic rate-limiting enzyme signature in hepatocellular carcinoma.
Wang Z, Fu Y, Xia A, Chen C, Qu J, Xu G, Zou X, Wang Q, Wang S
Cell proliferation 2021 Oct;54(10):e13117
Cell proliferation 2021 Oct;54(10):e13117
Uridine-cytidine kinase 2 promotes metastasis of hepatocellular carcinoma cells via the Stat3 pathway.
Zhou Q, Jiang H, Zhang J, Yu W, Zhou Z, Huang P, Wang J, Xiao Z
Cancer management and research 2018;10:6339-6355
Cancer management and research 2018;10:6339-6355
Lack of cross-resistance to FF-10501, an inhibitor of inosine-5'-monophosphate dehydrogenase, in azacitidine-resistant cell lines selected from SKM-1 and MOLM-13 leukemia cell lines.
Murase M, Iwamura H, Komatsu K, Saito M, Maekawa T, Nakamura T, Yokokawa T, Shimada Y
Pharmacology research & perspectives 2016 Feb;4(1):e00206
Pharmacology research & perspectives 2016 Feb;4(1):e00206
Mechanisms of resistance to azacitidine in human leukemia cell lines.
Sripayap P, Nagai T, Uesawa M, Kobayashi H, Tsukahara T, Ohmine K, Muroi K, Ozawa K
Experimental hematology 2014 Apr;42(4):294-306.e2
Experimental hematology 2014 Apr;42(4):294-306.e2
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UCK2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UCK2. This antibody recognizes human, mouse, rat antigen. The UCK2 antibody has been validated for the following applications: ELISA, WB analysis.
