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- References [13]
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- Product number
- 20049-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20049-1-AP, RRID:AB_10665371
- Product name
- MPC2 antibody
- Antibody type
- Polyclonal
- Description
- MPC2 antibody (Cat. #20049-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.
Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission.
A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.
Systemic Proteome Phenotypes Reveal Defective Metabolic Flexibility in Mecp2 Mutants.
Beta-Hydroxybutyrate Augments Oxaliplatin-Induced Cytotoxicity by Altering Energy Metabolism in Colorectal Cancer Organoids.
Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants.
Mitochondrial pyruvate carrier blockade results in decreased osteoclastogenesis and bone resorption via regulating mitochondrial energy production.
Downregulation of mitochondrial pyruvate carrier 2 aggravates neuronal injury in the cortex following cerebral ischemia in rat.
Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytes†.
Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos.
Mitochondrial pyruvate carrier 2 mediates mitochondrial dysfunction and apoptosis in high glucose-treated podocytes.
Function of mitochondrial pyruvate carriers in hepatocellular carcinoma patients.
3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants.
Weng W, Shen L, Yu X, Yuan R, Shao M, Han P, Sun H
American journal of translational research 2024;16(1):27-38
American journal of translational research 2024;16(1):27-38
Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission.
Tiwari A, Myeong J, Hashemiaghdam A, Zhang H, Niu X, Laramie MA, Stunault MI, Sponagel J, Patti G, Shriver L, Klyachko V, Ashrafi G
bioRxiv : the preprint server for biology 2024 Mar 20;
bioRxiv : the preprint server for biology 2024 Mar 20;
A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.
Allen SP, Al Sultan A, Kabucho Kibirige E, Tonkiss E, Hamer KJ, Castelli LM, Lin YH, Roscoe S, Stefanidis N, Mead RJ, Highley JR, Cooper-Knock J, Hautbergue GM, Heath PR, Kirby J, Shaw PJ
Frontiers in aging neuroscience 2023;15:1151848
Frontiers in aging neuroscience 2023;15:1151848
Systemic Proteome Phenotypes Reveal Defective Metabolic Flexibility in Mecp2 Mutants.
Zlatic SA, Werner E, Surapaneni V, Lee CE, Gokhale A, Singleton K, Duong D, Crocker A, Gentile K, Middleton F, Dalloul JM, Liu WL, Patgiri A, Tarquinio D, Carpenter R, Faundez V
bioRxiv : the preprint server for biology 2023 Sep 1;
bioRxiv : the preprint server for biology 2023 Sep 1;
Beta-Hydroxybutyrate Augments Oxaliplatin-Induced Cytotoxicity by Altering Energy Metabolism in Colorectal Cancer Organoids.
Sever T, Ellidokuz EB, Basbinar Y, Ellidokuz H, Yilmaz ÖH, Calibasi-Kocal G
Cancers 2023 Dec 6;15(24)
Cancers 2023 Dec 6;15(24)
Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants.
Zlatic SA, Werner E, Surapaneni V, Lee CE, Gokhale A, Singleton K, Duong D, Crocker A, Gentile K, Middleton F, Dalloul JM, Liu WL, Patgiri A, Tarquinio D, Carpenter R, Faundez V
Human molecular genetics 2023 Dec 12;33(1):12-32
Human molecular genetics 2023 Dec 12;33(1):12-32
Mitochondrial pyruvate carrier blockade results in decreased osteoclastogenesis and bone resorption via regulating mitochondrial energy production.
Guo Q, Zhao H, Cheng H, Kang H, Dong Y, Peng R, Zhu M, Fang Z, Li F
The Journal of biological chemistry 2022 Mar 4;:101775
The Journal of biological chemistry 2022 Mar 4;:101775
Downregulation of mitochondrial pyruvate carrier 2 aggravates neuronal injury in the cortex following cerebral ischemia in rat.
Wang Y, Liu Y, Yuan Y, Zhang Y, Luo Y, Han S, Yan Y, Wang Z, Liu X, Zhao L
Brain research bulletin 2022 Jul;185:193-202
Brain research bulletin 2022 Jul;185:193-202
Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytes†.
Tanaka K, Hayashi Y, Takehara A, Ito-Matsuoka Y, Tachibana M, Yaegashi N, Matsui Y
Biology of reproduction 2021 Jul 2;105(1):64-75
Biology of reproduction 2021 Jul 2;105(1):64-75
Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos.
Gomkale R, Cruz-Zaragoza LD, Suppanz I, Guiard B, Montoya J, Callegari S, Pacheu-Grau D, Warscheid B, Rehling P
Current biology : CB 2020 Mar 23;30(6):1119-1127.e5
Current biology : CB 2020 Mar 23;30(6):1119-1127.e5
Mitochondrial pyruvate carrier 2 mediates mitochondrial dysfunction and apoptosis in high glucose-treated podocytes.
Feng J, Ma Y, Chen Z, Hu J, Yang Q, Ding G
Life sciences 2019 Nov 15;237:116941
Life sciences 2019 Nov 15;237:116941
Function of mitochondrial pyruvate carriers in hepatocellular carcinoma patients.
Ma X, Cui Y, Zhou H, Li Q
Oncology letters 2018 Jun;15(6):9110-9116
Oncology letters 2018 Jun;15(6):9110-9116
3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants.
Konstantakou EG, Voutsinas GE, Velentzas AD, Basogianni AS, Paronis E, Balafas E, Kostomitsopoulos N, Syrigos KN, Anastasiadou E, Stravopodis DJ
Molecular cancer 2015 Jul 22;14:135
Molecular cancer 2015 Jul 22;14:135
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MPC2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human MPC2. This antibody recognizes human,mouse,rat antigen. The MPC2 antibody has been validated for the following applications: ELISA, WB analysis.
