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- Product number
- 20049-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20049-1-AP, RRID:AB_10665371
- Product name
- MPC2 antibody
- Antibody type
- Polyclonal
- Description
- MPC2 antibody (Cat. #20049-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Leonurine ameliorates experimental type 2 diabetes through gut microbiota remodeling, enhanced butyrate production, and MPC2 activation to restore GLP-1 secretion.
MPC-mediated lactate production drives histone lactylation in dendritic cells to affect tumor progression and immunotherapy.
SIRT3 deficiency aggravates mitochondrial metabolic disorder and podocyte injury in DKD via MPC2 acetylation.
LONP1 facilitates pulmonary artery smooth muscle cell glycolytic reprogramming by degrading MPC1 in pulmonary hypertension.
RB1 controls differentiation through positive regulation of phosphoglycerate mutases.
Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.
Glucose-1,6-bisphosphate: A new gatekeeper of cerebral mitochondrial pyruvate uptake.
Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission.
Inhibiting Glutaminase Exerts Opposite Effects on Ovariectomy-Induced and Age-Related Reductions in Murine Bone Mass.
Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models.
A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.
Systemic Proteome Phenotypes Reveal Defective Metabolic Flexibility in Mecp2 Mutants.
Beta-Hydroxybutyrate Augments Oxaliplatin-Induced Cytotoxicity by Altering Energy Metabolism in Colorectal Cancer Organoids.
Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants.
Mitochondrial pyruvate carrier blockade results in decreased osteoclastogenesis and bone resorption via regulating mitochondrial energy production.
Downregulation of mitochondrial pyruvate carrier 2 aggravates neuronal injury in the cortex following cerebral ischemia in rat.
Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytes†.
Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos.
Mitochondrial pyruvate carrier 2 mediates mitochondrial dysfunction and apoptosis in high glucose-treated podocytes.
Function of mitochondrial pyruvate carriers in hepatocellular carcinoma patients.
3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants.
Zhang Y, Chen W, Yu X, Feng J, Sammad A, Wang Z, Yin K
Frontiers in pharmacology 2026;17:1747267
Frontiers in pharmacology 2026;17:1747267
MPC-mediated lactate production drives histone lactylation in dendritic cells to affect tumor progression and immunotherapy.
Zhang B, Xu A, Wang H, Yan W, Zhang Q, Wang S
Cellular and molecular life sciences : CMLS 2025 Oct 28;82(1):371
Cellular and molecular life sciences : CMLS 2025 Oct 28;82(1):371
SIRT3 deficiency aggravates mitochondrial metabolic disorder and podocyte injury in DKD via MPC2 acetylation.
Feng J, Feng L, Yan Y, Ye H, Tang K, Guo X, Ma Y
Cellular signalling 2025 Nov;135:112029
Cellular signalling 2025 Nov;135:112029
LONP1 facilitates pulmonary artery smooth muscle cell glycolytic reprogramming by degrading MPC1 in pulmonary hypertension.
Li M, Zhang W, Zhang M, Li L, Yao Y, Qin Y, Wang D, Yan G, Qiao Y, Tang C
Clinical science (London, England : 1979) 2025 May 20;139(10):479-501
Clinical science (London, England : 1979) 2025 May 20;139(10):479-501
RB1 controls differentiation through positive regulation of phosphoglycerate mutases.
Kohno S, Okahashi N, Wan Y, Yu H, Takegami Y, Linn P, Nagatani N, Kitajima S, Kawada T, Matsuda F, Shimizu H, Takahashi C
Cell death & disease 2025 Jul 24;16(1):559
Cell death & disease 2025 Jul 24;16(1):559
Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.
Weng W, Shen L, Yu X, Yuan R, Shao M, Han P, Sun H
American journal of translational research 2024;16(1):27-38
American journal of translational research 2024;16(1):27-38
Glucose-1,6-bisphosphate: A new gatekeeper of cerebral mitochondrial pyruvate uptake.
Safari MS, Woerl P, Garmsiri C, Weber D, Kwiatkowski M, Hotze M, Kuenkel L, Lang L, Erlacher M, Gelpi E, Hainfellner JA, Baier G, Baier-Bitterlich G, Zur Nedden S
Molecular metabolism 2024 Oct;88:102018
Molecular metabolism 2024 Oct;88:102018
Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission.
Tiwari A, Myeong J, Hashemiaghdam A, Zhang H, Niu X, Laramie MA, Stunault MI, Sponagel J, Patti G, Shriver L, Klyachko V, Ashrafi G
bioRxiv : the preprint server for biology 2024 Mar 20;
bioRxiv : the preprint server for biology 2024 Mar 20;
Inhibiting Glutaminase Exerts Opposite Effects on Ovariectomy-Induced and Age-Related Reductions in Murine Bone Mass.
Guo Q, Zhao H, Dong Z, Cheng H, Zhu M, Fang Z
Aging and disease 2024 Feb 1;16(1):432-453
Aging and disease 2024 Feb 1;16(1):432-453
Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models.
Zur Nedden S, Safari MS, Weber D, Kuenkel L, Garmsiri C, Lang L, Orset C, Freret T, Haelewyn B, Hotze M, Kwiatkowski M, Sarg B, Faserl K, Savic D, Skvortsova II, Krogsdam A, Carollo S, Trajanoski Z, Oberacher H, Zlotek D, Ostermaier F, Cameron A, Baier G, Baier-Bitterlich G
Metabolism: clinical and experimental 2024 Dec;161:156039
Metabolism: clinical and experimental 2024 Dec;161:156039
A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.
Allen SP, Al Sultan A, Kabucho Kibirige E, Tonkiss E, Hamer KJ, Castelli LM, Lin YH, Roscoe S, Stefanidis N, Mead RJ, Highley JR, Cooper-Knock J, Hautbergue GM, Heath PR, Kirby J, Shaw PJ
Frontiers in aging neuroscience 2023;15:1151848
Frontiers in aging neuroscience 2023;15:1151848
Systemic Proteome Phenotypes Reveal Defective Metabolic Flexibility in Mecp2 Mutants.
Zlatic SA, Werner E, Surapaneni V, Lee CE, Gokhale A, Singleton K, Duong D, Crocker A, Gentile K, Middleton F, Dalloul JM, Liu WL, Patgiri A, Tarquinio D, Carpenter R, Faundez V
bioRxiv : the preprint server for biology 2023 Sep 1;
bioRxiv : the preprint server for biology 2023 Sep 1;
Beta-Hydroxybutyrate Augments Oxaliplatin-Induced Cytotoxicity by Altering Energy Metabolism in Colorectal Cancer Organoids.
Sever T, Ellidokuz EB, Basbinar Y, Ellidokuz H, Yilmaz ÖH, Calibasi-Kocal G
Cancers 2023 Dec 6;15(24)
Cancers 2023 Dec 6;15(24)
Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants.
Zlatic SA, Werner E, Surapaneni V, Lee CE, Gokhale A, Singleton K, Duong D, Crocker A, Gentile K, Middleton F, Dalloul JM, Liu WL, Patgiri A, Tarquinio D, Carpenter R, Faundez V
Human molecular genetics 2023 Dec 12;33(1):12-32
Human molecular genetics 2023 Dec 12;33(1):12-32
Mitochondrial pyruvate carrier blockade results in decreased osteoclastogenesis and bone resorption via regulating mitochondrial energy production.
Guo Q, Zhao H, Cheng H, Kang H, Dong Y, Peng R, Zhu M, Fang Z, Li F
The Journal of biological chemistry 2022 Mar 4;:101775
The Journal of biological chemistry 2022 Mar 4;:101775
Downregulation of mitochondrial pyruvate carrier 2 aggravates neuronal injury in the cortex following cerebral ischemia in rat.
Wang Y, Liu Y, Yuan Y, Zhang Y, Luo Y, Han S, Yan Y, Wang Z, Liu X, Zhao L
Brain research bulletin 2022 Jul;185:193-202
Brain research bulletin 2022 Jul;185:193-202
Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytes†.
Tanaka K, Hayashi Y, Takehara A, Ito-Matsuoka Y, Tachibana M, Yaegashi N, Matsui Y
Biology of reproduction 2021 Jul 2;105(1):64-75
Biology of reproduction 2021 Jul 2;105(1):64-75
Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos.
Gomkale R, Cruz-Zaragoza LD, Suppanz I, Guiard B, Montoya J, Callegari S, Pacheu-Grau D, Warscheid B, Rehling P
Current biology : CB 2020 Mar 23;30(6):1119-1127.e5
Current biology : CB 2020 Mar 23;30(6):1119-1127.e5
Mitochondrial pyruvate carrier 2 mediates mitochondrial dysfunction and apoptosis in high glucose-treated podocytes.
Feng J, Ma Y, Chen Z, Hu J, Yang Q, Ding G
Life sciences 2019 Nov 15;237:116941
Life sciences 2019 Nov 15;237:116941
Function of mitochondrial pyruvate carriers in hepatocellular carcinoma patients.
Ma X, Cui Y, Zhou H, Li Q
Oncology letters 2018 Jun;15(6):9110-9116
Oncology letters 2018 Jun;15(6):9110-9116
3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants.
Konstantakou EG, Voutsinas GE, Velentzas AD, Basogianni AS, Paronis E, Balafas E, Kostomitsopoulos N, Syrigos KN, Anastasiadou E, Stravopodis DJ
Molecular cancer 2015 Jul 22;14:135
Molecular cancer 2015 Jul 22;14:135
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- The MPC2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human MPC2. This antibody recognizes human,mouse,rat antigen. The MPC2 antibody has been validated for the following applications: ELISA, WB analysis.
