NBP1-42233

antibody from Novus Biologicals

Targeting: COL4A1

No application information provided.

Antibody Data

Product number

NBP1-42233

Provider

Novus Biologicals

Proper citation

Novus Cat#NBP1-42233, RRID:AB_2082506

Product name

Mouse Monoclonal Collagen IV alpha 1 Antibody

Antibody type

Monoclonal

Description

Unpurified. This monoclonal antibody reacts with native human collagen type IV, and with heat- denatured collagen IV form in ELISA and immunoblots. There is no cross-reactivity with human collagen I, II, III and V. It stains exclusively basement membranes on cryostat sections of human tissues such as kidney, liver and heart. The extent of expression of the basement membrane component type IV collagen may be correlated with the degree of differentiation of basement membrane producing neoplasms. Neoplastic cells of invasive carcinomas often lack a continuous basement membrane. In diagnostic histopathology antibodies to type IV collagen may help to distinguish between non-invasive (benign or in situ) and invasive lesions. Furthermore the antibody is important in the differential diagnosis of bullous lesions in dermatopathology. In in vitro studies with endothelial cells and smooth muscle cells the antibody is helpful in detection of production collagen type IV. This antibody reacts also with dog collagen IV on cryostate and paraffin sections.

Reactivity

Human

Host

Mouse

Isotype

IgM

Vial size

1 ml

Storage

Store at 4C. Do not freeze.