17514-1-AP

antibody from Proteintech Group

Targeting: KRT8 CARD2, CK8, CYK8, K2C8, K8, KO

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

17514-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#17514-1-AP, RRID:AB_2134726

Product name

Cytokeratin 8 antibody

Antibody type

Polyclonal

Description

Cytokeratin 8 antibody (Cat. #17514-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: FC, IHC, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Exosomal microRNAs of tuberculous pleural effusion orchestrating TGF-β signaling mediate pleural fibrosis.

Jiang LJ, Zheng YY, Liang LM, Jia ZH, Du RH, Huang H, Dai X, Cheng PP, Zhao LQ, Li Q, Jiang YH, Cui XL, Ye SY, Hu SH, Zhang HD, Lian CY, Feng X, Song LJ, Yu F, He XL, Xiong L, Xiang F, Wang X, Liu AD, Wang M, Ye H, Ma WL
Respiratory research 2026 Feb 3;27(1)

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Mammary organoid-based depot for post-surgical chemotherapy and gland regeneration.

Wang S, Yang Y, Wang Y, Han J, Hu T, Zhao S, Liu F, Yu X, Liang T, Zhang Y, Hu H, Yu J, Gu Z
Nature biomedical engineering 2026 Apr 17;

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Association between keratin 8 expression and immune-related pneumonitis: a case-control study in lung adenocarcinoma patients.

Wang X, Yang Y, Guo H, Li X, Sun Y, Mei Q, Ma Y
Frontiers in immunology 2025;16:1573943

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Effects of hyperhomocysteinemia on placental morphology and function.

Zhang Y, Lu R, Ma Y, Ma J, Song L, Zhou F, Guo J, Hu R
Placenta 2025 Sep;169:21-29

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Actomyosin forces trigger a conformational change in desmoplakin within desmosomes.

Dong Y, Elgerbi A, Xie B, Han Y, Kwiatkowski AV, Choy JS, Sivasankar S
Nature communications 2025 Oct 10;16(1):9052

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Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer.

Cheng Y, Liu B, Xin J, Wu X, Li W, Shang J, Wu J, Zhang Z, Xu B, Du M, Cheng G, Wang M
Nature aging 2025 May;5(5):909-928

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Dissecting the Single-Cell Diversity and Heterogeneity Underlying Cervical Precancerous Lesions and Cancer Tissues.

Han Y, Shi L, Jiang N, Huang J, Jia X, Zhu B
Reproductive sciences (Thousand Oaks, Calif.) 2025 May;32(5):1502-1519

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TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis.

Shi Y, Huang M, Zhou W, Zhao Y, Zhao J, Zhong B, French SW, Tang X, Liu H
Journal of translational medicine 2025 Jun 3;23(1):621

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A method for the identification of lactate metabolism-related prognostic biomarkers and its validations in non-small cell lung cancer.

Yang W, Gu M, Zhang Y, Zhang Y, Liu T, Wu D, Deng J, Liu M, Zhang Y
Scientific reports 2025 Feb 17;15(1):5812

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OPRK1 drives SLC9A3R1 progression to neuroendocrine prostate cancer.

Liang L, Shen Z, Zhang Y, Cheng Y, Yao B, Feng N, Zhao R
Cell death & disease 2025 Dec 7;17(1):68

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Exosome-mediated modulation of macrophage polarization and inflammation in early Klebsiella pneumoniae lung infections.

Liu Z, Ren P, Xue Y, Liu S, Li S, Li Y, Zhang Y
Clinical science (London, England : 1979) 2025 Dec 23;139(24):1691-1707

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Protective effects of Ganoderma lucidum spores on estradiol benzoate-induced TEC apoptosis and compromised double-positive thymocyte development.

Yang J, Pan H, Wang M, Li A, Zhang G, Fan X, Li Z
Frontiers in pharmacology 2024;15:1419881

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In-depth histological, lectin-histochemical, immunohistochemical and ultrastructural description of the olfactory rosettes and olfactory bulbs of turbot (Scophthalmus maximus).

Torres D, Villamayor PR, Román A, García P, Martínez P, Sanchez-Quinteiro P
Cell and tissue research 2024 Sep;397(3):215-239

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The expression spectrum of yak epididymal epithelial cells reveals the functional diversity of caput, corpus and cauda regions.

Pan M, Luo X, Zhang Z, Li J, Shahzad K, Danba Z, Caiwang G, Chilie W, Chen X, Zhao W
Genomics 2024 Sep;116(5):110912

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Dendrobium officinale polysaccharide promotes angiogenesis as well as follicle regeneration and hair growth through activation of the WNT signaling pathway.

Zhang Y, Tang Q, Zeng B, Wang F, Luo M, Huang P, Chen L, Wang H
Regenerative therapy 2024 Jun;26:114-123

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Skin as outermost immune organ of vertebrates that elicits robust early immune responses after immunization with glycoprotein of spring viraemia of carp virus.

Zhao Z, Zhao L, Wei XF, Jia YJ, Zhu B
PLoS pathogens 2024 Dec;20(12):e1012744

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Dexamethasone alleviates acute lung injury in a rat model with venovenous extracorporeal membrane oxygenation support.

Wei SL, Du JZ, Zhai KR, Yang JB, Zhang R, Wu XY, Li Y, Li B
BMJ open respiratory research 2024 Dec 4;11(1)

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Immunohistological study of the unexplored vomeronasal organ of an endangered mammal, the dama gazelle (Nanger dama).

Torres MV, Ortiz-Leal I, Ferreiro A, Rois JL, Sanchez-Quinteiro P
Microscopy research and technique 2023 Sep;86(9):1206-1233

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P53 Deficiency Accelerates Esophageal Epithelium Intestinal Metaplasia Malignancy.

Qiu Q, Guo G, Guo X, Hu X, Yu T, Liu G, Zhang H, Chen Y, She J
Biomedicines 2023 Mar 13;11(3)

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DPP4 Regulates the Th17/IL-17 Axis and Accelerates Epithelial Mesenchymal Transition to Promote Ovalbumin-Induced Asthma in Female C57BL/6J Mice.

Li L, Ling F, Li R, Jiang Y, Long H, Xiao B, Wu J, Long Z, Ma L
Frontiers in bioscience (Landmark edition) 2023 Dec 26;28(12):342

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An Integrated Proteomics and Metabolomics Strategy for the Mechanism of Calcium Oxalate Crystal-Induced Kidney Injury.

Gao S, Chao Y, Li N, Li H, Zhao H, Liu X, Chen W, Dong X
Frontiers in medicine 2022;9:805356

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The IL-33/ST2 Axis Promotes Primary Sjögren's Syndrome by Enhancing Salivary Epithelial Cell Activation and Type 1 Immune Response.

Dong Y, Ming B, Gao R, Mo Q, Wu X, Zheng F, Zhong J, Dong L
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The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer.

Li M, Rao X, Cui Y, Zhang L, Li X, Wang B, Zheng Y, Teng L, Zhou T, Zhuo W
Oncogene 2022 Feb;41(6):770-781

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Isolation, culture, and identification of ceruminous gland cells.

Wang J, He A, Zhu Y, Zhou G, Zhang T
Journal of molecular histology 2022 Apr;53(2):227-237

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Targeting cancer cell plasticity by HDAC inhibition to reverse EBV-induced dedifferentiation in nasopharyngeal carcinoma.

Xie J, Wang Z, Fan W, Liu Y, Liu F, Wan X, Liu M, Wang X, Zeng D, Wang Y, He B, Yan M, Zhang Z, Zhang M, Hou Z, Wang C, Kang Z, Fang W, Zhang L, Lam EW, Guo X, Yan J, Zeng Y, Chen M, Liu Q
Signal transduction and targeted therapy 2021 Sep 4;6(1):333

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Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.

Liu AD, Zhou J, Bi XY, Hou GQ, Li SS, Chen Q, Xu H, Cao X
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KLF4 transactivates TRIM29 expression and modulates keratin network.

Huang R, Fu Y, Deng Y
Biochemistry and biophysics reports 2021 Dec;28:101117

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Protective effects of miR-155-5p silencing on IFN-γ-induced apoptosis and inflammation in salivary gland epithelial cells.

Zhang J, Zhu L, Shi H, Zheng H
Experimental and therapeutic medicine 2021 Aug;22(2):882

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Cysteine Dioxygenase Regulates the Epithelial Morphogenesis of Mammary Gland via Cysteine Sulfinic Acid.

Zhao J, Han Y, Ma X, Zhou Y, Yuan S, Shen Q, Ye G, Liu H, Fu P, Zhang G, Qiao B, Liu A
iScience 2019 Mar 29;13:173-189

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Cytokeratin expression in epidermal stem cells in skin adnexal tumors.

Zhou X, Li G, Wang D, Sun X, Li X
Oncology letters 2019 Jan;17(1):927-932

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Wnt5a induces and maintains prostate cancer cells dormancy in bone.

Ren D, Dai Y, Yang Q, Zhang X, Guo W, Ye L, Huang S, Chen X, Lai Y, Du H, Lin C, Peng X, Song L
The Journal of experimental medicine 2019 Feb 4;216(2):428-449

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Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators.

Wei S, Zou Q, Lai S, Zhang Q, Li L, Yan Q, Zhou X, Zhong H, Lai L
Scientific reports 2016 Jan 19;6:19648

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Animal and cellular models of hepatocellular carcinoma bone metastasis: establishment and characterisation.

Hou R, Wang YW, Liang HF, Zhang ZG, Liu ZM, Zhang BH, Zhang BX, Chen XP
Journal of cancer research and clinical oncology 2015 Nov;141(11):1931-43

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Evaluation of apoptogenic adenovirus type 5 oncolytic vectors in a Syrian hamster head and neck cancer model.

Vijayalingam S, Kuppusamy M, Subramanian T, Strebeck FF, West CL, Varvares M, Chinnadurai G
Cancer gene therapy 2014 Jun;21(6):228-237

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

MCF7 cells were subjected to SDS PAGE followed by western blot with 17514-1-AP(KRT8 antibody) at dilution of 1:300

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human liver using 17514-1-AP(KRT8 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The Cytokeratin 8 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Cytokeratin 8. This antibody recognizes human antigen. The Cytokeratin 8 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

17514-1-AP.pdf

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