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- Product number
- 21115-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21115-1-AP, RRID:AB_10732845
- Product name
- ACE2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ACE2 antibody (Cat. #21115-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Potential Contribution of Cell Adhesion Molecule 1 to the Binding of SARS-CoV-2 Spike Protein to Mouse Nasal Mucosa.
Susceptibility to recombinant SARS-CoV-2 spike protein entry in the lungs of high-fat diet-induced obese mice.
MiR-145-5p reduced ANG II-induced ACE2 shedding and the inflammatory response in alveolar epithelial cells by targeting ADAM17 and inhibiting the AT1R/ADAM17 pathway.
Candesartan upregulates angiotensin-converting enzyme 2 in kidneys of male animals by decreased ubiquitination.
Design, synthesis and biological evaluation of novel 1,2,4a,5-tetrahydro-4H-benzo[b][1,4]oxazino[4,3-d][1,4]oxazine-based AAK1 inhibitors with anti-viral property against SARS-CoV-2.
SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion.
Hyperoxia-induced airflow restriction and Renin-Angiotensin System expression in a bronchopulmonary dysplasia mouse model.
Anti-hypertension effect of Wuwei Jiangya decoction via ACE2/Ang1-7/MAS signaling pathway in SHR based on network degree-distribution analysis.
A cardiotoxicity-eliminated ACE2 variant as a pan-inhibitor against coronavirus cell invasion.
Panax notoginseng saponin alleviates pulmonary fibrosis in rats by modulating the renin-angiotensin system.
ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression.
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes.
SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19.
miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding.
Angiotensin-converting enzyme - human amniotic mesenchymal stem cells improve pulmonary vascular remodeling in rats with pulmonary hypertension by promoting angiogenesis and counteracting inflammation.
Antrodia cinnamomea May Interfere with the Interaction Between ACE2 and SARS-CoV-2 Spike Protein in vitro and Reduces Lung Inflammation in a Hamster Model of COVID-19.
ACE2-EGFR-MAPK signaling contributes to SARS-CoV-2 infection.
Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion.
Lymphocytes regulate expression of the SARS-CoV-2 cell entry factor ACE2 in the pancreas of T2DM patients.
Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2.
Renin-angiotensin system inhibitors mitigate radiation pneumonitis by activating ACE2-angiotensin-(1-7) axis via NF-κB/MAPK pathway.
Azelaic Acid Regulates the Renin-Angiotensin System and Improves Colitis Based on Network Pharmacology and Experimentation.
Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.
SIRT6 attenuates LPS-induced inflammation and apoptosis of lung epithelial cells in acute lung injury through ACE2/STAT3/PIM1 signaling.
Synergistic effect of elevated glucose levels with SARS-CoV-2 spike protein induced NOX-dependent ROS production in endothelial cells.
Identification and characterization of 7-azaindole derivatives as inhibitors of the SARS-CoV-2 spike-hACE2 protein interaction.
Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2.
Smoking enhances the expression of angiotensin-converting enzyme 2 involved in the efficiency of severe acute respiratory syndrome coronavirus 2 infection.
Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells.
Angiotensin II Type 1 Receptor Blocker Prevents Abdominal Aortic Aneurysm Progression in Osteoprotegerin-Deficient Mice via Upregulation of Angiotensin (1-7).
High SARS-CoV-2 tropism and activation of immune cells in the testes of non-vaccinated deceased COVID-19 patients.
Identification and Screening of Potential ACE2 Activating Peptides from Soybean Protein Isolate Hydrolysate against Ang II-Induced Endothelial Dysfunction.
Renal CD81 interacts with sodium potassium 2 chloride cotransporter and sodium chloride cotransporter in rats with lipopolysaccharide-induced preeclampsia.
Synergistic effect of constituent drugs of Baibutang on improving Yin-deficiency pulmonary fibrosis in rats.
The dynamic nature of the coronavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia.
Propionate alleviates myocardial ischemia-reperfusion injury aggravated by Angiotensin II dependent on caveolin-1/ACE2 axis through GPR41.
Single-cell sequencing of brain tissues reveal the central nervous system's susceptibility to SARS-CoV-2 and the drug.
Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid Rafts.
Fusion assays for screening of fusion inhibitors targeting SARS-CoV-2 entry and syncytia formation.
Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.
Effects of growth hormone/estrogen/androgen on COVID-19-type proinflammatory responses in normal human lung epithelial BEAS-2B cells.
Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the host cells and spike-mediated cell fusion.
The Expression Levels of SARS-CoV-2 Infection-Mediating Molecules Promoted by Interferon-γ and Tumor Necrosis Factor-α Are Downregulated by Hydrogen Sulfide.
Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection.
The effects of angiotensin I-converting enzyme inhibitory peptide VGINYW and the hydrolysate of α-lactalbumin on blood pressure, oxidative stress and gut microbiota of spontaneously hypertensive rats.
The "LLQY" Motif on SARS-CoV-2 Spike Protein Affects S Incorporation into Virus Particles.
The accessible promoter-mediated supplementary effect of host factors provides new insight into the tropism of SARS-CoV-2.
Nanoantidote for repression of acidosis pH promoting COVID-19 infection.
SARS-CoV-2 recombinant proteins-induced degeneration of taste buds in rat circumvallate papillae.
Caveolin-1 Alleviates Acetaminophen-Induced Hepatotoxicity in Alcoholic Fatty Liver Disease by Regulating the Ang II/EGFR/ERK Axis.
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2.
SARS-CoV-2 spike engagement of ACE2 primes S2' site cleavage and fusion initiation.
Single Treatment of Vitamin D3 Ameliorates LPS-Induced Acute Lung Injury through Changing Lung Rodentibacter abundance.
Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.
Establishment of a pseudovirus neutralization assay based on SARS-CoV-2 S protein incorporated into lentiviral particles.
Broad antiviral and anti-inflammatory efficacy of nafamostat against SARS-CoV-2 and seasonal coronaviruses in primary human bronchiolar epithelia.
Carbohydrate Ligands for COVID-19 Spike Proteins.
Pandemic Influenza Infection Promotes Streptococcus pneumoniae Infiltration, Necrotic Damage, and Proteomic Remodeling in the Heart.
Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids.
ACE2 Affects the Expression and Function of IFITM3 During SARS-CoV-2 Pseudovirus Infection in Vero E6 Cells.
Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response.
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures.
SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response.
COVID-19-Related Chronic Bilateral Dacryoadenitis: A Clinicopathological Study.
Predicting the efficacy of COVID-19 convalescent plasma donor units with the Lumit Dx anti-receptor binding domain assay.
Dl-3-n-Butylphthalide Ameliorates Diabetic Nephropathy by Ameliorating Excessive Fibrosis and Podocyte Apoptosis.
A SCID mouse-human lung xenograft model of SARS-CoV-2 infection.
Effects of endurance training on the expression of host proteins involved in SARS-CoV-2 cell entry in C57BL/6J mouse.
COVID-19: a fatal case of acute liver failure associated with SARS-CoV-2 infection in pre-existing liver cirrhosis.
Activation of angiotensin-converting enzyme 2/angiotensin (1-7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling.
Jian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects.
Co-expression of the SARS-CoV-2 entry molecules ACE2 and TMPRSS2 in human ovaries: Identification of cell types and trends with age.
Kite-Shaped Molecules Block SARS-CoV-2 Cell Entry at a Post-Attachment Step.
Brief communication: Immunohistochemical detection of ACE2 in human salivary gland.
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.
Activation of STING Signaling Pathway Effectively Blocks Human Coronavirus Infection.
Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2.
Protective effect of recombinant Lactobacillus plantarum against H(2)O(2)-induced oxidative stress in HUVEC cells.
SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin system.
The potential effects of clinical antidiabetic agents on SARS-CoV-2.
ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes.
Landscape of SARS-CoV-2 spike protein-interacting cells in human tissues.
Parental PM(2) (.5) exposure changes Th17/Treg cells in offspring, is associated with the elevation of blood pressure.
JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells.
Male bias in ACE2 basic science research: missed opportunity for discovery in the time of COVID-19.
Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells.
Kidney injury molecule-1 is a potential receptor for SARS-CoV-2.
High Expression of ACE2 on Keratinocytes Reveals Skin as a Potential Target for SARS-CoV-2.
Biomimetic Human Disease Model of SARS-CoV-2-Induced Lung Injury and Immune Responses on Organ Chip System.
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide.
ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes.
Endomembrane targeting of human OAS1 p46 augments antiviral activity.
Oral Mucosa Could Be an Infectious Target of SARS-CoV-2.
Age and gender differences in ACE2 and TMPRSS2 expressions in oral epithelial cells.
A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants.
2019-nCoV may create complications in colon cancer patients with ACE2 expression.
Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model.
Clinicopathological Features and Outcomes of Acute Kidney Injury in Critically Ill COVID-19 with Prolonged Disease Course: A Retrospective Cohort.
Activation of the SARS-CoV-2 Receptor Ace2 through JAK/STAT-Dependent Enhancers during Pregnancy.
SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients.
Concomitant calciphylaxis and COVID-19 associated thrombotic retiform purpura.
MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes.
Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.
Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.
Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients.
HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry.
Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles.
Docked severe acute respiratory syndrome coronavirus 2 proteins within the cutaneous and subcutaneous microvasculature and their role in the pathogenesis of severe coronavirus disease 2019.
A cross-talk between epithelium and endothelium mediates human alveolar-capillary injury during SARS-CoV-2 infection.
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells.
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.
Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system.
Highly Porous Microcarriers for Minimally Invasive In Situ Skeletal Muscle Cell Delivery.
Anti-hypersensitive effect of angiotensin (1-7) on streptozotocin-induced diabetic neuropathic pain in mice.
A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway.
Takeuchi F, Sugano A, Yoneshige A, Hagiyama M, Inoue T, Wada A, Takaoka Y, Ito A
Cells, tissues, organs 2024;213(4):326-337
Cells, tissues, organs 2024;213(4):326-337
Susceptibility to recombinant SARS-CoV-2 spike protein entry in the lungs of high-fat diet-induced obese mice.
Gotoh K, Satoh F, Uesugi H, Noguchi T, Matsuda N, Sada K, Miyamoto S, Ozeki Y, Yoshida Y, Okamoto M, Masaki T, Kawabe T, Shibata H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23656
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23656
MiR-145-5p reduced ANG II-induced ACE2 shedding and the inflammatory response in alveolar epithelial cells by targeting ADAM17 and inhibiting the AT1R/ADAM17 pathway.
Wang X, Ma J, Lin D, Bai Y, Zhang D, Jia X, Gao J
European journal of pharmacology 2024 May 15;971:176392
European journal of pharmacology 2024 May 15;971:176392
Candesartan upregulates angiotensin-converting enzyme 2 in kidneys of male animals by decreased ubiquitination.
Wang P, Ren Z, Wang W, Liu M, Jia Y, Zhang M, Xue Y, Zhang C, Xu J, Wang C, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 31;38(6):e23537
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 31;38(6):e23537
Design, synthesis and biological evaluation of novel 1,2,4a,5-tetrahydro-4H-benzo[b][1,4]oxazino[4,3-d][1,4]oxazine-based AAK1 inhibitors with anti-viral property against SARS-CoV-2.
Mao ND, Xu Y, Che H, Yao X, Gao Y, Wang C, Deng H, Hui Z, Zhang H, Ye XY
European journal of medicinal chemistry 2024 Mar 15;268:116232
European journal of medicinal chemistry 2024 Mar 15;268:116232
SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion.
Zhang J, Kennedy A, de Melo Jorge DM, Xing L, Reid W, Bui S, Joppich J, Rose M, Ercan S, Tang Q, Tai AW, Wang Y
bioRxiv : the preprint server for biology 2024 Mar 15;
bioRxiv : the preprint server for biology 2024 Mar 15;
Hyperoxia-induced airflow restriction and Renin-Angiotensin System expression in a bronchopulmonary dysplasia mouse model.
Dowell J, Bice Z, Yan K, Konduri GG
Physiological reports 2024 Jan;12(1):e15895
Physiological reports 2024 Jan;12(1):e15895
Anti-hypertension effect of Wuwei Jiangya decoction via ACE2/Ang1-7/MAS signaling pathway in SHR based on network degree-distribution analysis.
Wang P, Hao D, Xiong X
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117121
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117121
A cardiotoxicity-eliminated ACE2 variant as a pan-inhibitor against coronavirus cell invasion.
Feng H, Yang L, Yang H, Cheng D, Li M, Song E, Xu T
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Jan 3;32(1):218-226
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Jan 3;32(1):218-226
Panax notoginseng saponin alleviates pulmonary fibrosis in rats by modulating the renin-angiotensin system.
Li H, Wang YG, Chen TF, Gao YH, Song L, Yang YF, Gao Y, Huo W, Zhang GP
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):116979
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):116979
ACE2 improves endothelial cell function and reduces acute lung injury by downregulating FAK expression.
He Y, Gang B, Zhang M, Bai Y, Wan Z, Pan J, Liu J, Liu G, Gu W
International immunopharmacology 2024 Feb 15;128:111535
International immunopharmacology 2024 Feb 15;128:111535
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes.
Yang X, Zheng X, Zhu Y, Zhao X, Liu J, Xun J, Yuan S, Chen J, Pan H, Yang J, Wang J, Liang Z, Shen X, Liang Y, Lin Q, Liang H, Li M, Peng F, Lu D, Xu J, Lu H, Jiang S, Zhao P, Zhu H
Signal transduction and targeted therapy 2024 Feb 14;9(1):42
Signal transduction and targeted therapy 2024 Feb 14;9(1):42
SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19.
Ma X, Liang J, Zhu G, Bhoria P, Shoara AA, MacKeigan DT, Khoury CJ, Slavkovic S, Lin L, Karakas D, Chen Z, Prifti V, Liu Z, Shen C, Li Y, Zhang C, Dou J, Rousseau Z, Zhang J, Ni T, Lei X, Chen P, Wu X, Shaykhalishahi H, Mubareka S, Connelly KA, Zhang H, Rotstein O, Ni H
Research (Washington, D.C.) 2023;6:0124
Research (Washington, D.C.) 2023;6:0124
miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding.
Wen J, Tang B, Guo L, Chen W, Tang X
International journal of hypertension 2023;2023:9497716
International journal of hypertension 2023;2023:9497716
Angiotensin-converting enzyme - human amniotic mesenchymal stem cells improve pulmonary vascular remodeling in rats with pulmonary hypertension by promoting angiogenesis and counteracting inflammation.
Wu C, Liu H, Ba M, Zha J, Gao Z, Li L, Xu P, Li M, Cai F, Chen M, Wu X, Guo L, Zhang H
International journal of clinical and experimental pathology 2023;16(10):282-293
International journal of clinical and experimental pathology 2023;16(10):282-293
Antrodia cinnamomea May Interfere with the Interaction Between ACE2 and SARS-CoV-2 Spike Protein in vitro and Reduces Lung Inflammation in a Hamster Model of COVID-19.
Li LH, Chiu HW, Wong WT, Huang KC, Lin TW, Chen ST, Hua KF
Journal of inflammation research 2023;16:4867-4884
Journal of inflammation research 2023;16:4867-4884
ACE2-EGFR-MAPK signaling contributes to SARS-CoV-2 infection.
Engler M, Albers D, Von Maltitz P, Groß R, Münch J, Cirstea IC
Life science alliance 2023 Sep;6(9)
Life science alliance 2023 Sep;6(9)
Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion.
Gao J, Cao C, Shi M, Hong S, Guo S, Li J, Liang T, Song P, Xu R, Li N
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154942
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154942
Lymphocytes regulate expression of the SARS-CoV-2 cell entry factor ACE2 in the pancreas of T2DM patients.
Zhang P, Zheng CB, Liu XY, Zhang X, Huang L, Zeng X
Diabetic medicine : a journal of the British Diabetic Association 2023 Oct;40(10):e15106
Diabetic medicine : a journal of the British Diabetic Association 2023 Oct;40(10):e15106
Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2.
Yu S, Zheng X, Zhou Y, Gao Y, Zhou B, Zhao Y, Li T, Li Y, Mou J, Cui X, Yang Y, Li D, Chen M, Lavillette D, Meng G
PLoS pathogens 2023 Nov;19(11):e1011789
PLoS pathogens 2023 Nov;19(11):e1011789
Renin-angiotensin system inhibitors mitigate radiation pneumonitis by activating ACE2-angiotensin-(1-7) axis via NF-κB/MAPK pathway.
Cong C, Niu S, Jiang Y, Zhang X, Jing W, Zheng Y, Zhang X, Su G, Zhang Y, Sun M
Scientific reports 2023 May 23;13(1):8324
Scientific reports 2023 May 23;13(1):8324
Azelaic Acid Regulates the Renin-Angiotensin System and Improves Colitis Based on Network Pharmacology and Experimentation.
Liao Y, Wu X, Luo W, Chen J, Huang Y, Ma K, Zhang C, Wang J, Yang Y, Deng M, Wang X
ACS omega 2023 May 2;8(17):15217-15228
ACS omega 2023 May 2;8(17):15217-15228
Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.
Oh CK, Nakamura T, Beutler N, Zhang X, Piña-Crespo J, Talantova M, Ghatak S, Trudler D, Carnevale LN, McKercher SR, Bakowski MA, Diedrich JK, Roberts AJ, Woods AK, Chi V, Gupta AK, Rosenfeld MA, Kearns FL, Casalino L, Shaabani N, Liu H, Wilson IA, Amaro RE, Burton DR, Yates JR 3rd, Becker C, Rogers TF, Chatterjee AK, Lipton SA
Nature chemical biology 2023 Mar;19(3):275-283
Nature chemical biology 2023 Mar;19(3):275-283
SIRT6 attenuates LPS-induced inflammation and apoptosis of lung epithelial cells in acute lung injury through ACE2/STAT3/PIM1 signaling.
Yang J, Chen X
Immunity, inflammation and disease 2023 Mar;11(3):e809
Immunity, inflammation and disease 2023 Mar;11(3):e809
Synergistic effect of elevated glucose levels with SARS-CoV-2 spike protein induced NOX-dependent ROS production in endothelial cells.
Zhang J, He L, Huang R, Alvarez JF, Yang DH, Sun Q, Wang F, Peng Z, Jiang N, Su L
Molecular biology reports 2023 Jul;50(7):6039-6047
Molecular biology reports 2023 Jul;50(7):6039-6047
Identification and characterization of 7-azaindole derivatives as inhibitors of the SARS-CoV-2 spike-hACE2 protein interaction.
Wang C, He F, Sun K, Guo K, Lu S, Wu T, Gao X, Fang M
International journal of biological macromolecules 2023 Jul 31;244:125182
International journal of biological macromolecules 2023 Jul 31;244:125182
Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2.
Prasad V, Cerikan B, Stahl Y, Kopp K, Magg V, Acosta-Rivero N, Kim H, Klein K, Funaya C, Haselmann U, Cortese M, Heigwer F, Bageritz J, Bitto D, Jargalsaikhan S, Neufeldt C, Pahmeier F, Boutros M, Yamauchi Y, Ruggieri A, Bartenschlager R
Molecular cell 2023 Jul 20;83(14):2559-2577.e8
Molecular cell 2023 Jul 20;83(14):2559-2577.e8
Smoking enhances the expression of angiotensin-converting enzyme 2 involved in the efficiency of severe acute respiratory syndrome coronavirus 2 infection.
Suzuki R, Ono Y, Noshita K, Kim KS, Ito H, Morioka Y, Tamura T, Okuzaki D, Tagawa T, Takenaka T, Yoshizumi T, Shimamura T, Iwami S, Fukuhara T
Microbiology and immunology 2023 Jan;67(1):22-31
Microbiology and immunology 2023 Jan;67(1):22-31
Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells.
Zhang B, Liu S, Sun Y, Xu D
Toxicology 2023 Jan 15;484:153392
Toxicology 2023 Jan 15;484:153392
Angiotensin II Type 1 Receptor Blocker Prevents Abdominal Aortic Aneurysm Progression in Osteoprotegerin-Deficient Mice via Upregulation of Angiotensin (1-7).
Karasaki K, Kokubo H, Bumdelger B, Kaji N, Sakai C, Ishida M, Yoshizumi M
Journal of the American Heart Association 2023 Feb 7;12(3):e027589
Journal of the American Heart Association 2023 Feb 7;12(3):e027589
High SARS-CoV-2 tropism and activation of immune cells in the testes of non-vaccinated deceased COVID-19 patients.
Costa GMJ, Lacerda SMSN, Figueiredo AFA, Wnuk NT, Brener MRG, Andrade LM, Campolina-Silva GH, Kauffmann-Zeh A, Pacifico LGG, Versiani AF, Antunes MM, Souza FR, Cassali GD, Caldeira-Brant AL, Chiarini-Garcia H, de Souza FG, Costa VV, da Fonseca FG, Nogueira ML, Campos GRF, Kangussu LM, Martins EMN, Antonio LM, Bittar C, Rahal P, Aguiar RS, Mendes BP, Procópio MS, Furtado TP, Guimaraes YL, Menezes GB, Martinez-Marchal A, Orwig KE, Brieño-Enríquez M, Furtado MH
BMC biology 2023 Feb 16;21(1):36
BMC biology 2023 Feb 16;21(1):36
Identification and Screening of Potential ACE2 Activating Peptides from Soybean Protein Isolate Hydrolysate against Ang II-Induced Endothelial Dysfunction.
Zhou M, Song T, Li W, Huang M, Zheng L, Zhao M
Journal of agricultural and food chemistry 2023 Aug 9;71(31):11957-11969
Journal of agricultural and food chemistry 2023 Aug 9;71(31):11957-11969
Renal CD81 interacts with sodium potassium 2 chloride cotransporter and sodium chloride cotransporter in rats with lipopolysaccharide-induced preeclampsia.
Wang P, Zhu G, Wu Q, Shen L, Liu D, Wang Z, Wang W, Ren Z, Jia Y, Liu M, Xue Y, Ji D, Hu Y, Yu Y, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22834
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22834
Synergistic effect of constituent drugs of Baibutang on improving Yin-deficiency pulmonary fibrosis in rats.
Fu S, Song X, Tang X, Qian X, Du Z, Hu Y, Xu X, Zhang M
Journal of ethnopharmacology 2023 Apr 24;306:116050
Journal of ethnopharmacology 2023 Apr 24;306:116050
The dynamic nature of the coronavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia.
Manna VJ, Choi H, Rotoli SM, Caradonna SJ
BBA advances 2022;2:100044
BBA advances 2022;2:100044
Propionate alleviates myocardial ischemia-reperfusion injury aggravated by Angiotensin II dependent on caveolin-1/ACE2 axis through GPR41.
Deng F, Zhang LQ, Wu H, Chen Y, Yu WQ, Han RH, Han Y, Zhang XQ, Sun QS, Lin ZB, Wang Y, Liu YP, Chen JY, Liu KX, Hu JJ
International journal of biological sciences 2022;18(2):858-872
International journal of biological sciences 2022;18(2):858-872
Single-cell sequencing of brain tissues reveal the central nervous system's susceptibility to SARS-CoV-2 and the drug.
Lu Z, Wang Z, Song Z, Chen C, Ma H, Gong P, Xu Y
Frontiers in pharmacology 2022;13:971017
Frontiers in pharmacology 2022;13:971017
Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid Rafts.
Teixeira L, Temerozo JR, Pereira-Dutra FS, Ferreira AC, Mattos M, Gonçalves BS, Sacramento CQ, Palhinha L, Cunha-Fernandes T, Dias SSG, Soares VC, Barreto EA, Cesar-Silva D, Fintelman-Rodrigues N, Pão CRR, de Freitas CS, Reis PA, Hottz ED, Bozza FA, Bou-Habib DC, Saraiva EM, de Almeida CJG, Viola JPB, Souza TML, Bozza PT
Frontiers in immunology 2022;13:820131
Frontiers in immunology 2022;13:820131
Fusion assays for screening of fusion inhibitors targeting SARS-CoV-2 entry and syncytia formation.
Chan SW
Frontiers in pharmacology 2022;13:1007527
Frontiers in pharmacology 2022;13:1007527
Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.
Jin S, He X, Ma L, Zhuang Z, Wang Y, Lin M, Cai S, Wei L, Wang Z, Zhao Z, Wu Y, Sun L, Li C, Xie W, Zhao Y, Songyang Z, Peng K, Zhao J, Cui J
Nature communications 2022 Sep 3;13(1):5204
Nature communications 2022 Sep 3;13(1):5204
Effects of growth hormone/estrogen/androgen on COVID-19-type proinflammatory responses in normal human lung epithelial BEAS-2B cells.
Zhu Z, Zhao Z, Chen X, Chu Z, He Y, Tan Y, Zhou J, Tang C
BMC molecular and cell biology 2022 Sep 29;23(1):42
BMC molecular and cell biology 2022 Sep 29;23(1):42
Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the host cells and spike-mediated cell fusion.
Ho HPT, Vo DNK, Lin TY, Hung JN, Chiu YH, Tsai MH
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113766
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113766
The Expression Levels of SARS-CoV-2 Infection-Mediating Molecules Promoted by Interferon-γ and Tumor Necrosis Factor-α Are Downregulated by Hydrogen Sulfide.
Zhao X, Cao Y, Zhao E, Li T, Cong T, Gao Y, Zhang J
International journal of molecular sciences 2022 Nov 7;23(21)
International journal of molecular sciences 2022 Nov 7;23(21)
Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection.
Yi R, Hashimoto R, Sakamoto A, Matsumura Y, Nagao M, Takahashi K, Takayama K
iScience 2022 Nov 18;25(11):105427
iScience 2022 Nov 18;25(11):105427
The effects of angiotensin I-converting enzyme inhibitory peptide VGINYW and the hydrolysate of α-lactalbumin on blood pressure, oxidative stress and gut microbiota of spontaneously hypertensive rats.
Xie D, Shen Y, Su E, Du L, Xie J, Wei D
Food & function 2022 Mar 7;13(5):2743-2755
Food & function 2022 Mar 7;13(5):2743-2755
The "LLQY" Motif on SARS-CoV-2 Spike Protein Affects S Incorporation into Virus Particles.
Du S, Xu W, Wang Y, Li L, Hao P, Tian M, Wang M, Li T, Wu S, Liu Q, Bai J, Qu X, Jin N, Zhou B, Liao M, Li C
Journal of virology 2022 Mar 23;96(6):e0189721
Journal of virology 2022 Mar 23;96(6):e0189721
The accessible promoter-mediated supplementary effect of host factors provides new insight into the tropism of SARS-CoV-2.
Du G, Xu X, Wang J, Wang X, Ding Y, Li F, Sun Y, Tao H, Luo Y, Li H, Bo X, Chen H
Molecular therapy. Nucleic acids 2022 Jun 14;28:249-258
Molecular therapy. Nucleic acids 2022 Jun 14;28:249-258
Nanoantidote for repression of acidosis pH promoting COVID-19 infection.
Liu Q, Ruan H, Sheng Z, Sun X, Li S, Cui W, Li C
View (Beijing, China) 2022 Jul;3(4):20220004
View (Beijing, China) 2022 Jul;3(4):20220004
SARS-CoV-2 recombinant proteins-induced degeneration of taste buds in rat circumvallate papillae.
Yamamoto T, Koyama Y, Imai Y, Sawada E, Kishimoto N, Seo K
Journal of dental sciences 2022 Jul;17(3):1450-1453
Journal of dental sciences 2022 Jul;17(3):1450-1453
Caveolin-1 Alleviates Acetaminophen-Induced Hepatotoxicity in Alcoholic Fatty Liver Disease by Regulating the Ang II/EGFR/ERK Axis.
Xin J, You T, Jiang X, Fu D, Wang J, Jiang W, Feng X, Wen J, Huang Y, Hu C
International journal of molecular sciences 2022 Jul 8;23(14)
International journal of molecular sciences 2022 Jul 8;23(14)
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2.
Gu Y, Cao J, Zhang X, Gao H, Wang Y, Wang J, He J, Jiang X, Zhang J, Shen G, Yang J, Zheng X, Hu G, Zhu Y, Du S, Zhu Y, Zhang R, Xu J, Lan F, Qu D, Xu G, Zhao Y, Gao D, Xie Y, Luo M, Lu Z
Cell research 2022 Jan;32(1):24-37
Cell research 2022 Jan;32(1):24-37
SARS-CoV-2 spike engagement of ACE2 primes S2' site cleavage and fusion initiation.
Yu S, Zheng X, Zhou B, Li J, Chen M, Deng R, Wong G, Lavillette D, Meng G
Proceedings of the National Academy of Sciences of the United States of America 2022 Jan 4;119(1)
Proceedings of the National Academy of Sciences of the United States of America 2022 Jan 4;119(1)
Single Treatment of Vitamin D3 Ameliorates LPS-Induced Acute Lung Injury through Changing Lung Rodentibacter abundance.
Jin A, Zhao Y, Yuan Y, Ma S, Chen J, Yang X, Lu S, Sun Q
Molecular nutrition & food research 2022 Feb;66(3):e2100952
Molecular nutrition & food research 2022 Feb;66(3):e2100952
Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.
Chen Y, Qu L, Li Y, Chen C, He W, Shen L, Zhang R
Inflammation 2022 Feb;45(1):253-266
Inflammation 2022 Feb;45(1):253-266
Establishment of a pseudovirus neutralization assay based on SARS-CoV-2 S protein incorporated into lentiviral particles.
Wang S, Liu L, Wang C, Wang Z, Duan X, Chen G, Zhou H, Shao H
Biosafety and health 2022 Feb;4(1):38-44
Biosafety and health 2022 Feb;4(1):38-44
Broad antiviral and anti-inflammatory efficacy of nafamostat against SARS-CoV-2 and seasonal coronaviruses in primary human bronchiolar epithelia.
Niemeyer BF, Miller CM, Ledesma-Feliciano C, Morrison JH, Jimenez-Valdes R, Clifton C, Poeschla EM, Benam KH
Nano select : open access 2022 Feb;3(2):437-449
Nano select : open access 2022 Feb;3(2):437-449
Carbohydrate Ligands for COVID-19 Spike Proteins.
Lee YK, Chang WC, Prakash E, Peng YJ, Tu ZJ, Lin CH, Hsu PH, Chang CF
Viruses 2022 Feb 6;14(2)
Viruses 2022 Feb 6;14(2)
Pandemic Influenza Infection Promotes Streptococcus pneumoniae Infiltration, Necrotic Damage, and Proteomic Remodeling in the Heart.
Platt MP, Lin YH, Wiscovitch-Russo R, Yu Y, Gonzalez-Juarbe N
mBio 2022 Feb 22;13(1):e0325721
mBio 2022 Feb 22;13(1):e0325721
Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids.
Rahmani W, Chung H, Sinha S, Bui-Marinos MP, Arora R, Jaffer A, Corcoran JA, Biernaskie J, Chun J
iScience 2022 Feb 18;25(2):103818
iScience 2022 Feb 18;25(2):103818
ACE2 Affects the Expression and Function of IFITM3 During SARS-CoV-2 Pseudovirus Infection in Vero E6 Cells.
Long S, Li S, Zhang X, Peng Q, Chen S, Wang J
Viral immunology 2022 Dec;35(10):653-662
Viral immunology 2022 Dec;35(10):653-662
Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response.
Ash MK, Bhimalli PP, Cho BK, Mattamana BB, Gambut S, Tarhoni I, Fhied CL, Reyes AF, Welninski SJ, Arivalagan J, Negrão F, Goel R, Beck TL, Hope TJ, Sha BE, Goo YA, Al-Harthi L, Mamede JI, Borgia JA, Kelleher NL, Schneider JR
Cell reports 2022 Dec 13;41(11):111799
Cell reports 2022 Dec 13;41(11):111799
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.
Rebendenne A, Roy P, Bonaventure B, Chaves Valadão AL, Desmarets L, Arnaud-Arnould M, Rouillé Y, Tauziet M, Giovannini D, Touhami J, Lee Y, DeWeirdt P, Hegde M, Urbach S, Koulali KE, de Gracia FG, McKellar J, Dubuisson J, Wencker M, Belouzard S, Moncorgé O, Doench JG, Goujon C
Nature genetics 2022 Aug;54(8):1090-1102
Nature genetics 2022 Aug;54(8):1090-1102
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures.
Guo W, Porter LM, Crozier TW, Coates M, Jha A, McKie M, Nathan JA, Lehner PJ, Greenwood EJ, McCaughan F
Life science alliance 2022 Apr;5(4)
Life science alliance 2022 Apr;5(4)
SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response.
Liu X, Wei L, Xu F, Zhao F, Huang Y, Fan Z, Mei S, Hu Y, Zhai L, Guo J, Zheng A, Cen S, Liang C, Guo F
Science signaling 2022 Apr 12;15(729):eabg8744
Science signaling 2022 Apr 12;15(729):eabg8744
COVID-19-Related Chronic Bilateral Dacryoadenitis: A Clinicopathological Study.
Kase S, Ishida S
JAMA ophthalmology 2022 Apr 1;140(4):312-318
JAMA ophthalmology 2022 Apr 1;140(4):312-318
Predicting the efficacy of COVID-19 convalescent plasma donor units with the Lumit Dx anti-receptor binding domain assay.
Janaka SK, Clark NM, Evans DT, Mou H, Farzan M, Connor JP
PloS one 2021;16(7):e0253551
PloS one 2021;16(7):e0253551
Dl-3-n-Butylphthalide Ameliorates Diabetic Nephropathy by Ameliorating Excessive Fibrosis and Podocyte Apoptosis.
Xu J, Tang Z, He Y, Cai S, Wang B, Zhang S, Wu M, Qian K, Zhang K, Chai B, Chen G, Xu K, Ji H, Xiao J, Wu Y
Frontiers in pharmacology 2021;12:628950
Frontiers in pharmacology 2021;12:628950
A SCID mouse-human lung xenograft model of SARS-CoV-2 infection.
Fu W, Wang W, Yuan L, Lin Y, Huang X, Chen R, Cai M, Liu C, Chen L, Zhou M, Wu K, Zhao H, Pan D, Ma J, Hong J, Zhai B, Zhang Y, Kong Z, Wang Y, Chen Y, Yuan Q, Zhu H, Cheng T, Guan Y, Xia N
Theranostics 2021;11(13):6607-6615
Theranostics 2021;11(13):6607-6615
Effects of endurance training on the expression of host proteins involved in SARS-CoV-2 cell entry in C57BL/6J mouse.
Tamura Y, Jee E, Kouzaki K, Kotani T, Nakazato K
Physiological reports 2021 Sep;9(17):e15014
Physiological reports 2021 Sep;9(17):e15014
COVID-19: a fatal case of acute liver failure associated with SARS-CoV-2 infection in pre-existing liver cirrhosis.
Ihlow J, Seelhoff A, Corman VM, Gruber AD, Dökel S, Meinhardt J, Radbruch H, Späth-Schwalbe E, Elezkurtaj S, Horst D, Herbst H
BMC infectious diseases 2021 Sep 3;21(1):901
BMC infectious diseases 2021 Sep 3;21(1):901
Activation of angiotensin-converting enzyme 2/angiotensin (1-7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling.
Dang R, Yang M, Cui C, Wang C, Zhang W, Geng C, Han W, Jiang P
Aging cell 2021 Oct;20(10):e13480
Aging cell 2021 Oct;20(10):e13480
Jian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects.
Liu X, Deng R, Wei X, Wang Y, Weng J, Lao Y, Lu J, Xiong G, Li S
Bioscience reports 2021 Oct 29;41(10)
Bioscience reports 2021 Oct 29;41(10)
Co-expression of the SARS-CoV-2 entry molecules ACE2 and TMPRSS2 in human ovaries: Identification of cell types and trends with age.
Wu M, Ma L, Xue L, Zhu Q, Zhou S, Dai J, Yan W, Zhang J, Wang S
Genomics 2021 Nov;113(6):3449-3460
Genomics 2021 Nov;113(6):3449-3460
Kite-Shaped Molecules Block SARS-CoV-2 Cell Entry at a Post-Attachment Step.
Chan SW, Shafi T, Ford RC
Viruses 2021 Nov 19;13(11)
Viruses 2021 Nov 19;13(11)
Brief communication: Immunohistochemical detection of ACE2 in human salivary gland.
Usami Y, Hirose K, Okumura M, Toyosawa S, Sakai T
Oral science international 2021 May;18(2):101-104
Oral science international 2021 May;18(2):101-104
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.
Rebendenne A, Roy P, Bonaventure B, Chaves VAL, Desmarets L, Rouillé Y, Tauziet M, Arnaud-Arnould M, Giovannini D, Lee Y, DeWeirdt P, Hegde M, Garcia de GF, McKellar J, Wencker M, Dubuisson J, Belouzard S, Moncorgé O, Doench JG, Goujon C
Research square 2021 May 27;
Research square 2021 May 27;
Activation of STING Signaling Pathway Effectively Blocks Human Coronavirus Infection.
Liu W, Reyes HM, Yang JF, Li Y, Stewart KM, Basil MC, Lin SM, Katzen J, Morrisey EE, Weiss SR, You J
Journal of virology 2021 May 24;95(12)
Journal of virology 2021 May 24;95(12)
Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2.
Gu C, Wu Y, Guo H, Zhu Y, Xu W, Wang Y, Zhou Y, Sun Z, Cai X, Li Y, Liu J, Huang Z, Yuan Z, Zhang R, Deng Q, Qu D, Xie Y
Science bulletin 2021 May 15;66(9):925-936
Science bulletin 2021 May 15;66(9):925-936
Protective effect of recombinant Lactobacillus plantarum against H(2)O(2)-induced oxidative stress in HUVEC cells.
Wang G, Hao M, Liu Q, Jiang Y, Huang H, Yang G, Wang C
Journal of Zhejiang University. Science. B 2021 May 15;22(5):348-365
Journal of Zhejiang University. Science. B 2021 May 15;22(5):348-365
SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin system.
Verma S, Joshi CS, Silverstein RB, He M, Carter EB, Mysorekar IU
Med (New York, N.Y.) 2021 May 14;2(5):575-590.e5
Med (New York, N.Y.) 2021 May 14;2(5):575-590.e5
The potential effects of clinical antidiabetic agents on SARS-CoV-2.
Qu H, Zheng Y, Wang Y, Li H, Liu X, Xiong X, Zhang L, Gu J, Yang G, Zhu Z, Zheng H, Ouyang Q
Journal of diabetes 2021 Mar;13(3):243-252
Journal of diabetes 2021 Mar;13(3):243-252
ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes.
Sherman EJ, Emmer BT
bioRxiv : the preprint server for biology 2021 Mar 26;
bioRxiv : the preprint server for biology 2021 Mar 26;
Landscape of SARS-CoV-2 spike protein-interacting cells in human tissues.
Zheng B, Yuan M, Ma Q, Wang S, Tan Y, Xu Y, Ye J, Gao Y, Sun X, Yang Z, Xu P, Kong L, Wu X, Xu Q
International immunopharmacology 2021 Jun;95:107567
International immunopharmacology 2021 Jun;95:107567
Parental PM(2) (.5) exposure changes Th17/Treg cells in offspring, is associated with the elevation of blood pressure.
Pan K, Jiang S, Du X, Zeng X, Zhang J, Song L, Lei L, Zhou J, Kan H, Sun Q, Xie Y, Dong C, Zhao J
Environmental toxicology 2021 Jun;36(6):1152-1161
Environmental toxicology 2021 Jun;36(6):1152-1161
JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells.
Lee HK, Jung O, Hennighausen L
Communications biology 2021 Jun 2;4(1):654
Communications biology 2021 Jun 2;4(1):654
Male bias in ACE2 basic science research: missed opportunity for discovery in the time of COVID-19.
Miličić Stanić B, Maddox S, de Souza AMA, Wu X, Mehranfard D, Ji H, Speth RC, Sandberg K
American journal of physiology. Regulatory, integrative and comparative physiology 2021 Jun 1;320(6):R925-R937
American journal of physiology. Regulatory, integrative and comparative physiology 2021 Jun 1;320(6):R925-R937
Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells.
Schweitzer KS, Crue T, Nall JM, Foster D, Sajuthi S, Correll KA, Nakamura M, Everman JL, Downey GP, Seibold MA, Bridges JP, Serban KA, Chu HW, Petrache I
The European respiratory journal 2021 Jul;58(1)
The European respiratory journal 2021 Jul;58(1)
Kidney injury molecule-1 is a potential receptor for SARS-CoV-2.
Yang C, Zhang Y, Zeng X, Chen H, Chen Y, Yang D, Shen Z, Wang X, Liu X, Xiong M, Chen H, Huang K
Journal of molecular cell biology 2021 Jul 6;13(3):185-196
Journal of molecular cell biology 2021 Jul 6;13(3):185-196
High Expression of ACE2 on Keratinocytes Reveals Skin as a Potential Target for SARS-CoV-2.
Xue X, Mi Z, Wang Z, Pang Z, Liu H, Zhang F
The Journal of investigative dermatology 2021 Jan;141(1):206-209.e1
The Journal of investigative dermatology 2021 Jan;141(1):206-209.e1
Biomimetic Human Disease Model of SARS-CoV-2-Induced Lung Injury and Immune Responses on Organ Chip System.
Zhang M, Wang P, Luo R, Wang Y, Li Z, Guo Y, Yao Y, Li M, Tao T, Chen W, Han J, Liu H, Cui K, Zhang X, Zheng Y, Qin J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Feb;8(3):2002928
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Feb;8(3):2002928
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.
Meinhardt J, Radke J, Dittmayer C, Franz J, Thomas C, Mothes R, Laue M, Schneider J, Brünink S, Greuel S, Lehmann M, Hassan O, Aschman T, Schumann E, Chua RL, Conrad C, Eils R, Stenzel W, Windgassen M, Rößler L, Goebel HH, Gelderblom HR, Martin H, Nitsche A, Schulz-Schaeffer WJ, Hakroush S, Winkler MS, Tampe B, Scheibe F, Körtvélyessy P, Reinhold D, Siegmund B, Kühl AA, Elezkurtaj S, Horst D, Oesterhelweg L, Tsokos M, Ingold-Heppner B, Stadelmann C, Drosten C, Corman VM, Radbruch H, Heppner FL
Nature neuroscience 2021 Feb;24(2):168-175
Nature neuroscience 2021 Feb;24(2):168-175
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide.
Li F, Han M, Dai P, Xu W, He J, Tao X, Wu Y, Tong X, Xia X, Guo W, Zhou Y, Li Y, Zhu Y, Zhang X, Liu Z, Aji R, Cai X, Li Y, Qu D, Chen Y, Jiang S, Wang Q, Ji H, Xie Y, Sun Y, Lu L, Gao D
Nature communications 2021 Feb 8;12(1):866
Nature communications 2021 Feb 8;12(1):866
ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes.
Sherman EJ, Emmer BT
Scientific reports 2021 Aug 5;11(1):15900
Scientific reports 2021 Aug 5;11(1):15900
Endomembrane targeting of human OAS1 p46 augments antiviral activity.
Soveg FW, Schwerk J, Gokhale NS, Cerosaletti K, Smith JR, Pairo-Castineira E, Kell AM, Forero A, Zaver SA, Esser-Nobis K, Roby JA, Hsiang TY, Ozarkar S, Clingan JM, McAnarney ET, Stone AE, Malhotra U, Speake C, Perez J, Balu C, Allenspach EJ, Hyde JL, Menachery VD, Sarkar SN, Woodward JJ, Stetson DB, Baillie JK, Buckner JH, Gale M Jr, Savan R
eLife 2021 Aug 3;10
eLife 2021 Aug 3;10
Oral Mucosa Could Be an Infectious Target of SARS-CoV-2.
Okui T, Matsuda Y, Karino M, Hideshima K, Kanno T
Healthcare (Basel, Switzerland) 2021 Aug 19;9(8)
Healthcare (Basel, Switzerland) 2021 Aug 19;9(8)
Age and gender differences in ACE2 and TMPRSS2 expressions in oral epithelial cells.
Peng J, Sun J, Zhao J, Deng X, Guo F, Chen L
Journal of translational medicine 2021 Aug 19;19(1):358
Journal of translational medicine 2021 Aug 19;19(1):358
A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants.
Du Y, Shi R, Zhang Y, Duan X, Li L, Zhang J, Wang F, Zhang R, Shen H, Wang Y, Wu Z, Peng Q, Pan T, Sun W, Huang W, Feng Y, Feng H, Xiao J, Tan W, Wang Y, Wang C, Yan J
Nature communications 2021 Aug 17;12(1):5000
Nature communications 2021 Aug 17;12(1):5000
2019-nCoV may create complications in colon cancer patients with ACE2 expression.
Chen Y, Gong W, Wei H, Dai W, Xu S
International journal of clinical and experimental pathology 2020;13(9):2305-2311
International journal of clinical and experimental pathology 2020;13(9):2305-2311
Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model.
Gu T, Zhao S, Jin G, Song M, Zhi Y, Zhao R, Ma F, Zheng Y, Wang K, Liu H, Xin M, Han W, Li X, Dong CD, Liu K, Dong Z
Frontiers in immunology 2020;11:621441
Frontiers in immunology 2020;11:621441
Clinicopathological Features and Outcomes of Acute Kidney Injury in Critically Ill COVID-19 with Prolonged Disease Course: A Retrospective Cohort.
Xia P, Wen Y, Duan Y, Su H, Cao W, Xiao M, Ma J, Zhou Y, Chen G, Jiang W, Wu H, Hu Y, Xu S, Cai H, Liu Z, Zhou X, Du B, Wang J, Li T, Yan X, Chen L, Liang Z, Zhang S, Zhang C, Qin Y, Wang G, Li X
Journal of the American Society of Nephrology : JASN 2020 Sep;31(9):2205-2221
Journal of the American Society of Nephrology : JASN 2020 Sep;31(9):2205-2221
Activation of the SARS-CoV-2 Receptor Ace2 through JAK/STAT-Dependent Enhancers during Pregnancy.
Hennighausen L, Lee HK
Cell reports 2020 Sep 29;32(13):108199
Cell reports 2020 Sep 29;32(13):108199
SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients.
Pérez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Ramadoss GN, Silva AC, Flanigan WR, Li H, Nakamura K, Whitman JD, Ott M, Conklin BR, McDevitt TC
bioRxiv : the preprint server for biology 2020 Sep 12;
bioRxiv : the preprint server for biology 2020 Sep 12;
Concomitant calciphylaxis and COVID-19 associated thrombotic retiform purpura.
Rotman JA, Dean KE, Magro C, Nuovo G, Bartolotta RJ
Skeletal radiology 2020 Nov;49(11):1879-1884
Skeletal radiology 2020 Nov;49(11):1879-1884
MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes.
Lu D, Chatterjee S, Xiao K, Riedel I, Wang Y, Foo R, Bär C, Thum T
Journal of molecular and cellular cardiology 2020 Nov;148:46-49
Journal of molecular and cellular cardiology 2020 Nov;148:46-49
Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.
Ghazizadeh Z, Majd H, Richter M, Samuel R, Zekavat SM, Asgharian H, Farahvashi S, Kalantari A, Ramirez J, Zhao H, Natarajan P, Goodarzi H, Fattahi F
bioRxiv : the preprint server for biology 2020 May 15;
bioRxiv : the preprint server for biology 2020 May 15;
Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.
Bilinska K, Jakubowska P, Von Bartheld CS, Butowt R
ACS chemical neuroscience 2020 Jun 3;11(11):1555-1562
ACS chemical neuroscience 2020 Jun 3;11(11):1555-1562
Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients.
Wang C, Xie J, Zhao L, Fei X, Zhang H, Tan Y, Nie X, Zhou L, Liu Z, Ren Y, Yuan L, Zhang Y, Zhang J, Liang L, Chen X, Liu X, Wang P, Han X, Weng X, Chen Y, Yu T, Zhang X, Cai J, Chen R, Shi ZL, Bian XW
EBioMedicine 2020 Jul;57:102833
EBioMedicine 2020 Jul;57:102833
HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry.
Wei C, Wan L, Yan Q, Wang X, Zhang J, Yang X, Zhang Y, Fan C, Li D, Deng Y, Sun J, Gong J, Yang X, Wang Y, Wang X, Li J, Yang H, Li H, Zhang Z, Wang R, Du P, Zong Y, Yin F, Zhang W, Wang N, Peng Y, Lin H, Feng J, Qin C, Chen W, Gao Q, Zhang R, Cao Y, Zhong H
Nature metabolism 2020 Dec;2(12):1391-1400
Nature metabolism 2020 Dec;2(12):1391-1400
Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles.
Gamage AM, Tan KS, Chan WOY, Liu J, Tan CW, Ong YK, Thong M, Andiappan AK, Anderson DE, Wang Y, Wang LF
PLoS pathogens 2020 Dec;16(12):e1009130
PLoS pathogens 2020 Dec;16(12):e1009130
Docked severe acute respiratory syndrome coronavirus 2 proteins within the cutaneous and subcutaneous microvasculature and their role in the pathogenesis of severe coronavirus disease 2019.
Magro CM, Mulvey JJ, Laurence J, Seshan S, Crowson AN, Dannenberg AJ, Salvatore S, Harp J, Nuovo GJ
Human pathology 2020 Dec;106:106-116
Human pathology 2020 Dec;106:106-116
A cross-talk between epithelium and endothelium mediates human alveolar-capillary injury during SARS-CoV-2 infection.
Wang P, Luo R, Zhang M, Wang Y, Song T, Tao T, Li Z, Jin L, Zheng H, Chen W, Zhao M, Zheng Y, Qin J
Cell death & disease 2020 Dec 8;11(12):1042
Cell death & disease 2020 Dec 8;11(12):1042
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells.
Wang K, Chen W, Zhang Z, Deng Y, Lian JQ, Du P, Wei D, Zhang Y, Sun XX, Gong L, Yang X, He L, Zhang L, Yang Z, Geng JJ, Chen R, Zhang H, Wang B, Zhu YM, Nan G, Jiang JL, Li L, Wu J, Lin P, Huang W, Xie L, Zheng ZH, Zhang K, Miao JL, Cui HY, Huang M, Zhang J, Fu L, Yang XM, Zhao Z, Sun S, Gu H, Wang Z, Wang CF, Lu Y, Liu YY, Wang QY, Bian H, Zhu P, Chen ZN
Signal transduction and targeted therapy 2020 Dec 4;5(1):283
Signal transduction and targeted therapy 2020 Dec 4;5(1):283
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.
Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W, Andino R, Zhao H, Natarajan P, Erle DJ, Ott M, Goodarzi H, Fattahi F
Cell stem cell 2020 Dec 3;27(6):876-889.e12
Cell stem cell 2020 Dec 3;27(6):876-889.e12
Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system.
Cui C, Xu P, Li G, Qiao Y, Han W, Geng C, Liao D, Yang M, Chen D, Jiang P
Redox biology 2019 Sep;26:101295
Redox biology 2019 Sep;26:101295
Highly Porous Microcarriers for Minimally Invasive In Situ Skeletal Muscle Cell Delivery.
Kankala RK, Zhao J, Liu CG, Song XJ, Yang DY, Zhu K, Wang SB, Zhang YS, Chen AZ
Small (Weinheim an der Bergstrasse, Germany) 2019 Jun;15(25):e1901397
Small (Weinheim an der Bergstrasse, Germany) 2019 Jun;15(25):e1901397
Anti-hypersensitive effect of angiotensin (1-7) on streptozotocin-induced diabetic neuropathic pain in mice.
Ogata Y, Nemoto W, Yamagata R, Nakagawasai O, Shimoyama S, Furukawa T, Ueno S, Tan-No K
European journal of pain (London, England) 2019 Apr;23(4):739-749
European journal of pain (London, England) 2019 Apr;23(4):739-749
A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway.
Li W, Wang R, Ma JY, Wang M, Cui J, Wu WB, Liu RM, Zhang CX, Li W, Wang SM
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1152-1167
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1152-1167
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ACE2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ACE2. This antibody recognizes human, mouse, rat antigen. The ACE2 antibody has been validated for the following applications: ELISA, WB analysis.
