66699-1-Ig

antibody from Proteintech Group

Targeting: ACE2

Provider product page for 66699-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [45]
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Product number: 66699-1-Ig - Provider product page
Provider: Proteintech Group
Product name: ACE2 antibody
Antibody type: Monoclonal
Description: ACE2 antibody (Cat. #66699-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2F12A4
Vial size: 20ul, 150ul

ACE2 protein structure - 66699-1-Ig shown in red.

Submitted references A pH-driven receptor switch from ACE2 to NPC1 enables endosomal entry of SARS-CoV-2.

Zheng YH, Liu Z, Pang Y, Khan I, Ou L, Hu Y, Li S, Richner J, Zhou T
Research square 2026 Mar 4;

ACE2 mitigates Streptococcus uberis-induced ferroptosis in goat mammary epithelial cells by inhibiting ROS-chaperone-mediated autophagic degradation of GPX4.

Wu G, Ma C, Xu J, Chen X, Chen X, Wang G, Zhang Y
Microbial pathogenesis 2026 Jan;210:108141

Renin-angiotensin imbalance promotes excessive fibrin deposition through M2 macrophage-derived tissue factor expression in eosinophilic chronic rhinosinusitis.

Takabayashi T, Yoshida K, Kato Y, Sakashita M, Fujieda S
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026 Apr 28;75(1)

Key β1-4 galactosylated glycan receptors of SARS-CoV-2 and its inhibitor from the galactosylated glycoproteins of bovine milk.

Yu H, Chen W, Shu J, Wu X, Quan J, Cheng H, Bao X, Wu D, Wang X, Li Z
Journal of advanced research 2025 Oct;76:159-172

Exploring Spike-Dependent and ACE2-Independent Viral Entry into Salivary Epithelial Cells in the Absence of ACE2.

Barrows C, Young S, Farach-Carson M
bioRxiv : the preprint server for biology 2025 May 22;

Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET.

Akıl C, Xu J, Shen J, Zhang P
Nature communications 2025 Jun 3;16(1):5150

Unveiling the Complete Spectrum of SARS-CoV-2 Fusion Stages by In Situ Cryo-ET.

Akıl C, Xu J, Shen J, Zhang P
bioRxiv : the preprint server for biology 2025 Feb 27;

ACE2 Alleviates Microglia Neuroinflammation by RANK-RANKL-OPG Axis in Parkinson's Disease.

Xu Y, An Z, Hou K, Zhou M, Liu Y, Wang J, Hashimoto M, Wei J
Inflammation 2025 Dec;48(6):4364-4378

High-Fidelity and Cost-Effective Engineering of SARS-CoV-2.

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Viruses 2025 Dec 11;17(12)

Rapid and accurate detection of infectious SARS-CoV-2 by viral receptor capture combined with loop-mediated isothermal amplification.

Yang Z, Zhou X, Sun X, Cao L, Xu T, Li K, Liu H, Ji Y, Liu L, Ivanov KI, Yang Z, Guo D, Li CM
Virologica Sinica 2025 Aug;40(4):613-623

Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2.

Xu L, Yu D, Xu M, Liu Y, Yang LX, Zou QC, Feng XL, Li MH, Sheng N, Yao YG
EBioMedicine 2024 Sep;107:105281

Discovery of a novel inhibitor of macropinocytosis with antiviral activity.

Porebski B, Christ W, Corman A, Haraldsson M, Barz M, Lidemalm L, Häggblad M, Ilmain J, Wright SC, Murga M, Schlegel J, Jarvius M, Lapins M, Sezgin E, Bhabha G, Lauschke VM, Carreras-Puigvert J, Lafarga M, Klingström J, Hühn D, Fernandez-Capetillo O
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Sep 4;32(9):3012-3024

Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection.

Zhang T, Li Y, Pan L, Sha J, Bailey M, Faure-Kumar E, Williams CK, Wohlschlegel J, Magaki S, Niu C, Lee Y, Su YC, Li X, Vinters HV, Geschwind DH
Nature aging 2024 Nov;4(11):1598-1618

Fucoidan from Ascophyllum nodosum and Undaria pinnatifida attenuate SARS-CoV-2 infection in vitro and in vivo by suppressing ACE2 and alleviating inflammation.

Shi FS, Xie YH, Yang YL, Xu LD, Li JJ, Wang X, Zhu LY, Wang WW, Shen PL, Huang YW, Li XQ
Carbohydrate polymers 2024 May 15;332:121884

Detection of SARS-CoV-2 virus in middle ear effusions and its association with otitis media with effusion.

Fu X, Wang Z, Chen B, Sun H, Lyu J, Shao J, Lu X, Xu J, Yang J, Chi F, Huang Y, Ren D
Journal of medical virology 2024 Mar;96(3):e29545

The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane.

La Rosa P, Tiberi J, Palermo E, Stefanelli R, Tiano SML, Canterini S, Cortese M, Hiscott J, Fiorenza MT
Cell & bioscience 2024 Dec 20;14(1):148

Catecholamine induces endothelial dysfunction via Angiotensin II and intermediate conductance calcium activated potassium channel.

Fan X, Yang G, Yang Z, Uhlig S, Sattler K, Bieback K, Hamdani N, El-Battrawy I, Duerschmied D, Zhou X, Akin I
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116928

A rapid procedure to generate stably transfected HEK293 suspension cells for recombinant protein manufacturing: Yield improvements, bioreactor production and downstream processing.

Dash S, Farnós O, Yang Z, Sudalaiyadum Perumal A, Chaves Fulber JP, Venereo-Sánchez A, Leclerc D, Kamen AA
Protein expression and purification 2023 Oct;210:106295

SIM imaging resolves endocytosis of SARS-CoV-2 spike RBD in living cells.

Miao L, Yan C, Chen Y, Zhou W, Zhou X, Qiao Q, Xu Z
Cell chemical biology 2023 Mar 16;30(3):248-260.e4

Determination of soluble angiotensin-converting enzyme 2 in saliva samples and its association with nicotine.

Bru S, González-Marrón A, Lidón-Moyano C, Carballar R, Martínez-Láinez JM, Pérez-Martín H, Fu M, Pérez-Ortuño R, Ballbè M, Pascual JA, Fernández E, Clotet J, Martínez-Sánchez JM
Environmental research 2023 Jan 1;216(Pt 1):114443

Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release.

Stewart H, Palmulli R, Johansen KH, McGovern N, Shehata OM, Carnell GW, Jackson HK, Lee JS, Brown JC, Burgoyne T, Heeney JL, Okkenhaug K, Firth AE, Peden AA, Edgar JR
EMBO reports 2023 Dec 6;24(12):e57224

SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication.

Montezano AC, Camargo LL, Mary S, Neves KB, Rios FJ, Stein R, Lopes RA, Beattie W, Thomson J, Herder V, Szemiel AM, McFarlane S, Palmarini M, Touyz RM
Scientific reports 2023 Aug 28;13(1):14086

Dihydroceramide Δ4-Desaturase 1 Is Not Involved in SARS-CoV-2 Infection.

Hayashi Y, Matsuda K, Tanigawa K, Tanikawa T, Maeda K, Tsuchiya K
Biological & pharmaceutical bulletin 2022;45(10):1559-1563

The dynamic nature of the coronavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia.

Manna VJ, Choi H, Rotoli SM, Caradonna SJ
BBA advances 2022;2:100044

Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections.

Wang Y, Liu S, Li L, Li L, Zhou X, Wan M, Lou P, Zhao M, Lv K, Yuan Y, Chen Y, Lu Y, Cheng J, Liu J
Journal of controlled release : official journal of the Controlled Release Society 2022 Sep;349:118-132

Co-Expression and Localization of Angiotensin-Converting Enzyme-2 (ACE2) and the Transmembrane Serine Protease 2 (TMPRSS2) in Paranasal Ciliated Epithelium of Patients with Chronic Rhinosinusitis.

Kawasumi T, Takeno S, Ishino T, Ueda T, Hamamoto T, Takemoto K, Horibe Y, Takashi O
American journal of rhinology & allergy 2022 May;36(3):313-322

ACE2 Affects the Expression and Function of IFITM3 During SARS-CoV-2 Pseudovirus Infection in Vero E6 Cells.

Long S, Li S, Zhang X, Peng Q, Chen S, Wang J
Viral immunology 2022 Dec;35(10):653-662

Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic.

Stewart H, Palmulli R, Johansen KH, McGovern N, Shehata OM, Carnell GW, Jackson HK, Lee JS, Brown JC, Burgoyne T, Heeney JL, Okkenhaug K, Firth AE, Peden AA, Edgar JR
bioRxiv : the preprint server for biology 2022 Dec 22;

Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2.

Tanikawa T, Kiba Y, Yu J, Hsu K, Chen S, Ishii A, Yokogawa T, Suzuki R, Inoue Y, Kitamura M
Molecules (Basel, Switzerland) 2022 Aug 24;27(17)

SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination.

Zhang Z, Zheng Y, Niu Z, Zhang B, Wang C, Yao X, Peng H, Franca DN, Wang Y, Zhu Y, Su Y, Tang M, Jiang X, Ren H, He M, Wang Y, Gao L, Zhao P, Shi H, Chen Z, Wang X, Piacentini M, Bian X, Melino G, Liu L, Huang H, Sun Q
Cell death and differentiation 2021 Sep;28(9):2765-2777

Differential expression of angiotensin-converting enzyme-2 in human paranasal sinus mucosa in patients with chronic rhinosinusitis.

Kawasumi T, Takeno S, Nishimura M, Ishino T, Ueda T, Hamamoto T, Takemoto K, Horibe Y
The Journal of laryngology and otology 2021 Sep;135(9):773-778

Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection.

Ren H, Ma C, Peng H, Zhang B, Zhou L, Su Y, Gao X, Huang H
Biology direct 2021 Oct 21;16(1):20

[Congxin Lunzhi Fang improves aortic atherosclerosis and regulates ACE2 expression in ApoE(-/-) mice].

Gu Y, Jiang J, Zhang Y, Chen Y, Chen Y, Jiang W, Huang Z, Zhou F
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2021 Nov 20;41(11):1623-1630

SARS-CoV-2 infection of the oral cavity and saliva.

Huang N, Pérez P, Kato T, Mikami Y, Okuda K, Gilmore RC, Conde CD, Gasmi B, Stein S, Beach M, Pelayo E, Maldonado JO, Lafont BA, Jang SI, Nasir N, Padilla RJ, Murrah VA, Maile R, Lovell W, Wallet SM, Bowman NM, Meinig SL, Wolfgang MC, Choudhury SN, Novotny M, Aevermann BD, Scheuermann RH, Cannon G, Anderson CW, Lee RE, Marchesan JT, Bush M, Freire M, Kimple AJ, Herr DL, Rabin J, Grazioli A, Das S, French BN, Pranzatelli T, Chiorini JA, Kleiner DE, Pittaluga S, Hewitt SM, Burbelo PD, Chertow D, NIH COVID-19 Autopsy Consortium, HCA Oral and Craniofacial Biological Network, Frank K, Lee J, Boucher RC, Teichmann SA, Warner BM, Byrd KM
Nature medicine 2021 May;27(5):892-903

Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways.

Sarute N, Cheng H, Yan Z, Salas-Briceno K, Richner J, Rong L, Ross SR
PLoS pathogens 2021 Jun;17(6):e1009662

Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells with potential to inhibit SARS-CoV-2 infection and COVID-19 disease progression.

Sheehan SA, Hamilton KL, Retzbach EP, Balachandran P, Krishnan H, Leone P, Lopez-Gonzalez M, Suryavanshi S, Kumar P, Russo R, Goldberg GS
Experimental cell research 2021 Jun 1;403(1):112594

SARS-CoV-2 receptor ACE2 is expressed in human conjunctival tissue, especially in diseased conjunctival tissue.

Li S, Li D, Fang J, Liu Q, Cao W, Sun X, Xu G
The ocular surface 2021 Jan;19:249-251

Quantifying Absolute Neutralization Titers against SARS-CoV-2 by a Standardized Virus Neutralization Assay Allows for Cross-Cohort Comparisons of COVID-19 Sera.

Oguntuyo KY, Stevens CS, Hung CT, Ikegame S, Acklin JA, Kowdle SS, Carmichael JC, Chiu HP, Azarm KD, Haas GD, Amanat F, Klingler J, Baine I, Arinsburg S, Bandres JC, Siddiquey MNA, Schilke RM, Woolard MD, Zhang H, COVIDAR Argentina Consortium, Duty AJ, Kraus TA, Moran TM, Tortorella D, Lim JK, Gamarnik AV, Hioe CE, Zolla-Pazner S, Ivanov SS, Kamil JP, Krammer F, Lee B
mBio 2021 Feb 16;12(1)

Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro.

Huang HC, Lai YJ, Liao CC, Yang WF, Huang KB, Lee IJ, Chou WC, Wang SH, Wang LH, Hsu JM, Sun CP, Kuo CT, Wang J, Hsiao TC, Yang PJ, Lee TA, Huang W, Li FA, Shen CY, Lin YL, Tao MH, Li CW
EBioMedicine 2021 Dec;74:103712

N-(4-Hydroxyphenyl) Retinamide Suppresses SARS-CoV-2 Spike Protein-Mediated Cell-Cell Fusion by a Dihydroceramide Δ4-Desaturase 1-Independent Mechanism.

Hayashi Y, Tsuchiya K, Yamamoto M, Nemoto-Sasaki Y, Tanigawa K, Hama K, Ueda Y, Tanikawa T, Gohda J, Maeda K, Inoue JI, Yamashita A
Journal of virology 2021 Aug 10;95(17):e0080721

Integrated Single-Cell Atlases Reveal an Oral SARS-CoV-2 Infection and Transmission Axis.

Huang N, Perez P, Kato T, Mikami Y, Okuda K, Gilmore RC, Domínguez Conde C, Gasmi B, Stein S, Beach M, Pelayo E, Maldonado J, LaFont B, Padilla R, Murrah V, Maile R, Lovell W, Wallet S, Bowman NM, Meinig SL, Wolfgang MC, Choudhury SN, Novotny M, Aevermann BD, Scheuermann R, Cannon G, Anderson C, Marchesan J, Bush M, Freire M, Kimple A, Herr DL, Rabin J, Grazioli A, French BN, Pranzatelli T, Chiorini JA, Kleiner DE, Pittaluga S, Hewitt S, Burbelo PD, Chertow D, Frank K, Lee J, Boucher RC, Teichmann SA, Warner BM, Byrd KM
medRxiv : the preprint server for health sciences 2020 Oct 27;

Evidence that Maackia amurensis seed lectin (MASL) exerts pleiotropic actions on oral squamous cells to inhibit SARS-CoV-2 infection and COVID-19 disease progression.

Sheehan SA, Hamilton KL, Retzbach EP, Balachandran P, Krishnan H, Leone P, Goldberg GS
Research square 2020 Oct 23;

Neuropilin-1 is a host factor for SARS-CoV-2 infection.

Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Antón-Plágaro C, Shoemark DK, Simón-Gracia L, Bauer M, Hollandi R, Greber UF, Horvath P, Sessions RB, Helenius A, Hiscox JA, Teesalu T, Matthews DA, Davidson AD, Collins BM, Cullen PJ, Yamauchi Y
Science (New York, N.Y.) 2020 Nov 13;370(6518):861-865

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.

Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W, Andino R, Zhao H, Natarajan P, Erle DJ, Ott M, Goodarzi H, Fattahi F
Cell stem cell 2020 Dec 3;27(6):876-889.e12

Quantifying absolute neutralization titers against SARS-CoV-2 by a standardized virus neutralization assay allows for cross-cohort comparisons of COVID-19 sera.

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