HPA000288

antibody from Atlas Antibodies

Targeting: ACE2

Provider product page for HPA000288

Western blot

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [38]
Comments [0]
Validations
Immunohistochemistry [1]

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Product number: HPA000288 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA000288, RRID:AB_1078160
Product name: Anti-ACE2
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human ACE2, Gene description: angiotensin I converting enzyme 2, Validated applications: IHC, WB, Uniprot ID: Q9BYF1, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.1 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

ACE2 protein structure - HPA000288 shown in red.

Submitted references Neuronal progenitors of the dentate gyrus express the SARS-CoV-2 cell receptor during migration in the developing human hippocampus

Hernandez-Lopez J, Hernandez-Medina C, Medina-Corvalan C, Rodenas M, Francisca A, Perez-Garcia C, Echevarria D, Carratala F, Geijo-Barrientos E, Martinez S
Cellular and Molecular Life Sciences 2023;80(6)

Myocardial Angiotensin-Converting Enzyme 2 Protein Expression in Ischemic Heart Failure

Siratavičiūtė V, Pangonytė D, Utkienė L, Jusienė L, Marcinkevičienė J, Stanionienė Z, Radikė R
International Journal of Molecular Sciences 2023;24(24):17145

Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface

Frieman M, Chatterjee M, Huang L, Mykytyn A, Wang C, Lamers M, Westendorp B, Wubbolts R, van Putten J, Bosch B, Haagmans B, Strijbis K
PLOS Pathogens 2023;19(8):e1011571

SARS-CoV-2 replicates and displays oncolytic properties in clear cell and papillary renal cell carcinoma.

Choong OK, Jakobsson R, Bergdahl AG, Brunet S, Kärmander A, Waldenström J, Arvidsson Y, Altiparmak G, Nilsson JA, Karlsson J, Nyström K, Johansson ME
PloS one 2023;18(1):e0279578

Regulation of angiotensin-converting enzyme 2 isoforms by type 2 inflammation and viral infection in human airway epithelium

Stocker N, Radzikowska U, Wawrzyniak P, Tan G, Huang M, Ding M, Akdis C, Sokolowska M
Mucosal Immunology 2023;16(1):5-16

Higher angiotensin-converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer’s disease

Reveret L, Leclerc M, Emond V, Tremblay C, Loiselle A, Bourassa P, Bennett D, Hébert S, Calon F
Acta Neuropathologica Communications 2023;11(1)

Louise R, Manon L, Vincent E, Andréanne L, Philippe B, Cyntia T, Bennett D, Sébastien H, Frédéric C
2023

Spike protein of SARS-CoV-2 suppresses gonadotrophin secretion from bovine anterior pituitaries

ABDILLAH D, KEREILWE O, FERDOUSY R, SAITO R, KADOKAWA H
Journal of Reproduction and Development 2022;68(2):152-159

Fulminant Myocarditis 24 Days after Coronavirus Disease Messenger Ribonucleic Acid Vaccination

Kawano H, Motokawa T, Kurohama H, Okano S, Akashi R, Yonekura T, Ikeda S, Izumikawa K, Maemura K
Internal Medicine 2022;61(15):2319-2325

Angiotensin-converting enzyme 2 in peripheral lung club cells modulates the susceptibility to SARS-CoV-2 in chronic obstructive pulmonary disease

Peng Y, Wang Z, Chen S, Xu A, Fang Z, Sun J, Zhou Z, Hou X, Cen L, Ma J, Zhao J, Guan W, Wang D, Zhong N
American Journal of Physiology-Lung Cellular and Molecular Physiology 2022;322(5):L712-L721

ACE2 Protein Expression During Childhood, Adolescence, and Early Adulthood

Schurink B, Roos E, Vos W, Breur M, van der Valk P, Bugiani M
Pediatric and Developmental Pathology 2022;25(4):404-408

Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium

Pinto A, Rai R, Brown J, Griffin P, Edgar J, Shah A, Singanayagam A, Hogg C, Barclay W, Futter C, Burgoyne T
Nature Communications 2022;13(1)

Comprehensive Analysis of Disease Pathology in Immunocompetent and Immunocompromised Hosts following Pulmonary SARS-CoV-2 Infection

Ramasamy S, Kolloli A, Kumar R, Husain S, Soteropoulos P, Chang T, Subbian S
Biomedicines 2022;10(6):1343

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

Ullah I, Prévost J, Ladinsky M, Stone H, Lu M, Anand S, Beaudoin-Bussières G, Symmes K, Benlarbi M, Ding S, Gasser R, Fink C, Chen Y, Tauzin A, Goyette G, Bourassa C, Medjahed H, Mack M, Chung K, Wilen C, Dekaban G, Dikeakos J, Bruce E, Kaufmann D, Stamatatos L, McGuire A, Richard J, Pazgier M, Bjorkman P, Mothes W, Finzi A, Kumar P, Uchil P
Immunity 2021;54(9):2143-2158.e15

Acute Respiratory Distress in Aged, SARS-CoV-2–Infected African Green Monkeys but Not Rhesus Macaques

Blair R, Vaccari M, Doyle-Meyers L, Roy C, Russell-Lodrigue K, Fahlberg M, Monjure C, Beddingfield B, Plante K, Plante J, Weaver S, Qin X, Midkiff C, Lehmicke G, Golden N, Threeton B, Penney T, Allers C, Barnes M, Pattison M, Datta P, Maness N, Birnbaum A, Fischer T, Bohm R, Rappaport J
The American Journal of Pathology 2021;191(2):274-282

Secukinumab lowers expression of ACE2 in affected skin of patients with psoriasis

Krueger J, Murrell D, Garcet S, Navrazhina K, Lee P, Muscianisi E, Blauvelt A
Journal of Allergy and Clinical Immunology 2021;147(3):1107-1109.e2

Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection

Heuberger J, Trimpert J, Vladimirova D, Goosmann C, Lin M, Schmuck R, Mollenkopf H, Brinkmann V, Tacke F, Osterrieder N, Sigal M
EMBO Molecular Medicine 2021;13(4)

Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection

Ottaiano A, Scala S, D’Alterio C, Trotta A, Bello A, Rea G, Picone C, Santorsola M, Petrillo A, Nasti G
Therapeutic Advances in Medical Oncology 2021;13

Ovulatory upregulation of angiotensin-converting enzyme 2, a receptor for SARS-CoV-2, in dominant follicles of the human ovary

Choi Y, Jeon H, Brännström M, Akin J, Curry T, Jo M
Fertility and Sterility 2021;116(6):1631-1640

Elevation in viral entry genes and innate immunity compromise underlying increased infectivity and severity of COVID-19 in cancer patients

Kwan J, Lin L, Bell R, Bruce J, Richardson C, Pugh T, Liu F
Scientific Reports 2021;11(1)

Effects of Angiotensin II Type 1A Receptor on ACE2, Neprilysin and KIM-1 in Two Kidney One Clip (2K1C) Model of Renovascular Hypertension

Alawi L, Dhakal S, Emberesh S, Sawant H, Hosawi A, Thanekar U, Grobe N, Elased K
Frontiers in Pharmacology 2021;11

Nasal delivery of single-domain antibody improves symptoms of SARS-CoV-2 infection in an animal model.

Haga K, Takai-Todaka R, Matsumura Y, Song C, Takano T, Tojo T, Nagami A, Ishida Y, Masaki H, Tsuchiya M, Ebisudani T, Sugimoto S, Sato T, Yasuda H, Fukunaga K, Sawada A, Nemoto N, Murata K, Morimoto T, Katayama K
PLoS pathogens 2021 Oct;17(10):e1009542

An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells.

Lamers MM, van der Vaart J, Knoops K, Riesebosch S, Breugem TI, Mykytyn AZ, Beumer J, Schipper D, Bezstarosti K, Koopman CD, Groen N, Ravelli RBG, Duimel HQ, Demmers JAA, Verjans GMGM, Koopmans MPG, Muraro MJ, Peters PJ, Clevers H, Haagmans BL
The EMBO journal 2021 Mar 1;40(5):e105912

ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities

Zamorano Cuervo N, Grandvaux N
eLife 2020;9

A profiling analysis on the receptor ACE2 expression reveals the potential risk of different type of cancers vulnerable to SARS-CoV-2 infection

Dai Y, Hu F, Li H, Huang H, Wang D, Liang Y
Annals of Translational Medicine 2020;8(7):481-481

Effect of hyperglycemia and rosiglitazone on renal and urinary neprilysin indb/dbdiabetic mice

Alawi L, Emberesh S, Owuor B, Chodavarapu H, Fadnavis R, El‐Amouri S, Elased K
Physiological Reports 2020;8(3)

A bioinformatics analysis on the potential role of ACE2 in cardiac impairment of patients with coronavirus disease 2019

Wang W, Lv S, Gan W, Zeng Z, Yang M
Annals of Translational Medicine 2020;8(21):1403-1403

Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19

Fu J, Zhou B, Zhang L, Balaji K, Wei C, Liu X, Chen H, Peng J, Fu J
Molecular Biology Reports 2020;47(6):4383-4392

Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19

Kusmartseva I, Wu W, Syed F, Van Der Heide V, Jorgensen M, Joseph P, Tang X, Candelario-Jalil E, Yang C, Nick H, Harbert J, Posgai A, Paulsen J, Lloyd R, Cechin S, Pugliese A, Campbell-Thompson M, Vander Heide R, Evans-Molina C, Homann D, Atkinson M
Cell Metabolism 2020;32(6):1041-1051.e6

Bioinformatic Analysis of Correlation between Immune Infiltration and COVID-19 in Cancer Patients

Huang X, He C, Hua X, Kan A, Sun S, Wang J, Li S
International Journal of Biological Sciences 2020;16(13):2464-2476

Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2

Bader M, Barker H, Parkkila S
PLOS ONE 2020;15(10):e0240647

ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs

Lee I, Nakayama T, Wu C, Goltsev Y, Jiang S, Gall P, Liao C, Shih L, Schürch C, McIlwain D, Chu P, Borchard N, Zarabanda D, Dholakia S, Yang A, Kim D, Chen H, Kanie T, Lin C, Tsai M, Phillips K, Kim R, Overdevest J, Tyler M, Yan C, Lin C, Lin Y, Bau D, Tsay G, Patel Z, Tsou Y, Tzankov A, Matter M, Tai C, Yeh T, Hwang P, Nolan G, Nayak J, Jackson P
Nature Communications 2020;11(1)

The protein expression profile of ACE2 in human tissues.

Hikmet F, Méar L, Edvinsson Å, Micke P, Uhlén M, Lindskog C
Molecular systems biology 2020 Jul;16(7):e9610

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells.

Coate KC, Cha J, Shrestha S, Wang W, Gonçalves LM, Almaça J, Kapp ME, Fasolino M, Morgan A, Dai C, Saunders DC, Bottino R, Aramandla R, Jenkins R, Stein R, Kaestner KH, Vahedi G, HPAP Consortium, Brissova M, Powers AC
Cell metabolism 2020 Dec 1;32(6):1028-1040.e4

Duijf P
2020

Lee I, Nakayama T, Wu C, Goltsev Y, Jiang S, Gall P, Liao C, Shih L, Schürch C, McIlwain D, Chu P, Borchard N, Zarabanda D, Dholakia S, Yang A, Kim D, Kanie T, Lin C, Tsai M, Phillips K, Kim R, Overdevest J, Tyler M, Yan C, Lin C, Lin Y, Bau D, Tsay G, Patel Z, Tsou Y, Tai C, Yeh T, Hwang P, Nolan G, Nayak J, Jackson P
2020

Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model

Kato B, Nicholson G, Neiman M, Rantalainen M, Holmes C, Barrett A, Uhlén M, Nilsson P, Spector T, Schwenk J
Proteome Science 2011;9(1):73

Gene Expression Profiling of Metaplastic Lineages Identifies CDH17 as a Prognostic Marker in Early Stage Gastric Cancer

Lee H, Nam K, Park H, Kim M, LaFleur B, Aburatani H, Yang H, Kim W, Goldenring J
Gastroenterology 2010;139(1):213-225.e3

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human small intestine and tonsil tissues using HPA000288 antibody. Corresponding ACE2 RNA-seq data are presented for the same tissues.
Sample type: Human
Protocol: Protocol
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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