Explore
Validate
Learn
Western blot
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- AB936 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal ADAM10 Antibody
- Antibody type
- Polyclonal
- Description
- Protein A or G purified. Detects human ADAM10 in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse ADAM10, approximately 5% cross-reactivity with recombinant human (rh) TACE, and less than 1% cross-reactivity with rhADAM8, rhADAM9, rhADAM15, and rhBACE is observed.
- Reactivity
- Human
- Host
- Goat
- Isotype
- IgG
- Vial size
- 1 mg
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients.
Induction of neuronal death by microglial AGE-albumin: implications for Alzheimer's disease.
Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma.
Álvarez-Fernández SM, Barbariga M, Cannizzaro L, Cannistraci CV, Hurley L, Zanardi A, Conti A, Sanvito F, Innocenzi A, Pecorelli N, Braga M, Alessio M
Oncotarget 2016 Nov 29;7(48):80059-80076
Oncotarget 2016 Nov 29;7(48):80059-80076
Induction of neuronal death by microglial AGE-albumin: implications for Alzheimer's disease.
Byun K, Bayarsaikhan E, Kim D, Kim CY, Mook-Jung I, Paek SH, Kim SU, Yamamoto T, Won MH, Song BJ, Park YM, Lee B
PloS one 2012;7(5):e37917
PloS one 2012;7(5):e37917
Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma.
Kohga K, Takehara T, Tatsumi T, Miyagi T, Ishida H, Ohkawa K, Kanto T, Hiramatsu N, Hayashi N
Cancer research 2009 Oct 15;69(20):8050-7
Cancer research 2009 Oct 15;69(20):8050-7
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- ADAM10 in Human Prostate Cancer Tissue. ADAM10 was detected in immersion fixed paraffin-embedded sections of human prostate cancer tissue using 5 µg/mL Goat Anti-Human ADAM10 Ectodomain Polyclonal Antibody (Catalog # AB936) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
