MAB946-100

antibody from R&D Systems

Targeting: ADAM10 CD156C, HsT18717, kuz, MADM

Western blot (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

MAB946-100

Provider

R&D Systems

Product name

Mouse ADAM10 Ectodomain Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from hybridoma culture supernatant. Detects mouse ADAM10 in direct ELISAs and Western blots. In direct ELISAs, approximately 25% cross-reactivity with recombinant human (rh) rhADAM10 is observed and no cross-reactivity with rhADAM8, recombinant mouse (rm) ADAM9, rmADAM15, rhBACE, or rhTACE is observed.

Reactivity

Mouse

Host

Rat

Conjugate

Unconjugated

Antigen sequence

O35598


Isotype

IgG

Antibody clone number

139712

Vial size

100 ug

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.

Seipold L, Damme M, Prox J, Rabe B, Kasparek P, Sedlacek R, Altmeppen H, Willem M, Boland B, Glatzel M, Saftig P
Biochimica et biophysica acta. Molecular cell research 2017 Jan;1864(1):217-230

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Pyroptosis of resident macrophages differentially orchestrates inflammatory responses to Staphylococcus aureus in resistant and susceptible mice.

Accarias S, Lugo-Villarino G, Foucras G, Neyrolles O, Boullier S, Tabouret G
European journal of immunology 2015 Mar;45(3):794-806

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The sheddase ADAM10 is a potent modulator of prion disease.

Altmeppen HC, Prox J, Krasemann S, Puig B, Kruszewski K, Dohler F, Bernreuther C, Hoxha A, Linsenmeier L, Sikorska B, Liberski PP, Bartsch U, Saftig P, Glatzel M
eLife 2015 Feb 5;4

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Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation.

Ridder K, Keller S, Dams M, Rupp AK, Schlaudraff J, Del Turco D, Starmann J, Macas J, Karpova D, Devraj K, Depboylu C, Landfried B, Arnold B, Plate KH, Höglinger G, Sültmann H, Altevogt P, Momma S
PLoS biology 2014 Jun;12(6):e1001874

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Adrenergic regulation of IgE involves modulation of CD23 and ADAM10 expression on exosomes.

Padro CJ, Shawler TM, Gormley MG, Sanders VM
Journal of immunology (Baltimore, Md. : 1950) 2013 Dec 1;191(11):5383-97

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Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures.

Glomski K, Monette S, Manova K, De Strooper B, Saftig P, Blobel CP
Blood 2011 Jul 28;118(4):1163-74

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A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16.

Gough PJ, Garton KJ, Wille PT, Rychlewski M, Dempsey PJ, Raines EW
Journal of immunology (Baltimore, Md. : 1950) 2004 Mar 15;172(6):3678-85