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- Antibody Data
- Antigen structure
- References [6]
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- Product number
- MAB1427-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human ADAM10 Ectodomain Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human ADAM10 in direct ELISAs and Western blots. In Western blots, shows less than 5% cross-reactivity with recombinant human (rh) ADAM8, 9, 15, 17/TACE, and recombinant mouse ADAM10.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
O14672- Isotype
- IgG
- Antibody clone number
- 163003
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Non-cell-autonomous function of DR6 in Schwann cell proliferation.
Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells.
A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).
Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.
Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans.
Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes.
Colombo A, Hsia HE, Wang M, Kuhn PH, Brill MS, Canevazzi P, Feederle R, Taveggia C, Misgeld T, Lichtenthaler SF
The EMBO journal 2018 Apr 3;37(7)
The EMBO journal 2018 Apr 3;37(7)
Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells.
Zingoni A, Cecere F, Vulpis E, Fionda C, Molfetta R, Soriani A, Petrucci MT, Ricciardi MR, Fuerst D, Amendola MG, Mytilineos J, Cerboni C, Paolini R, Cippitelli M, Santoni A
Journal of immunology (Baltimore, Md. : 1950) 2015 Jul 15;195(2):736-48
Journal of immunology (Baltimore, Md. : 1950) 2015 Jul 15;195(2):736-48
A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).
Breshears LM, Schlievert PM, Peterson ML
The Journal of biological chemistry 2012 Sep 21;287(39):32578-87
The Journal of biological chemistry 2012 Sep 21;287(39):32578-87
Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.
Koenen RR, Pruessmeyer J, Soehnlein O, Fraemohs L, Zernecke A, Schwarz N, Reiss K, Sarabi A, Lindbom L, Hackeng TM, Weber C, Ludwig A
Blood 2009 May 7;113(19):4799-809
Blood 2009 May 7;113(19):4799-809
Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans.
Janes PW, Saha N, Barton WA, Kolev MV, Wimmer-Kleikamp SH, Nievergall E, Blobel CP, Himanen JP, Lackmann M, Nikolov DB
Cell 2005 Oct 21;123(2):291-304
Cell 2005 Oct 21;123(2):291-304
Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes.
Johansson MW, Lye MH, Barthel SR, Duffy AK, Annis DS, Mosher DF
American journal of respiratory cell and molecular biology 2004 Oct;31(4):413-22
American journal of respiratory cell and molecular biology 2004 Oct;31(4):413-22
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