25900-1-AP

antibody from Proteintech Group

Targeting: ADAM10 CD156C, HsT18717, kuz, MADM

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

25900-1-AP

Provider

Proteintech Group

Product name

ADAM10 antibody

Antibody type

Polyclonal

Description

ADAM10 antibody (Cat. #25900-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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Zhao L, Jia C, Zhao Y, Li H, Li X, Yang D, Chen T, Yang Z, Zhou S, Wang C, Jin M
Advanced healthcare materials 2026 Mar 28;:e05184

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Neuronal DJ-1 regulates microglial activation in Parkinson's disease.

Zhao A, Ding Y, Zhong M, Niu M, Wang L, Jiao Y, Liu J, Li Y
Neural regeneration research 2026 Jul 1;21(7):3130-3138

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Chronic inflammation promotes gastric cancer progression via ADAM10-mediated cleavage of CX3CL1.

Song Z, Liu Y, Wang Z, Zhao S, Zhang J, Wei Y, Zhao Z, Jiang T, Zhang G
Scientific reports 2026 Feb 15;16(1)

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Luteolin as a novel therapeutic for diabetic kidney disease: Targeting the ADAM10-TREM2 pathway.

Deng L, Wang Y, Shi C, Wu J, Yao J, Shen W, Zhang Z, Liu R, Wang X, Zhu H, Zhang L, Cai G, Zhou J, Hong Q, Chen X
Journal of advanced research 2026 Apr 24;

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ADAM10 is a key player in the diagnosis, prognosis and metastasis of non-small cell lung cancer (NSCLC).

Zhang W, Yang L, Li M, Zhang L, Cheng J, El-Far AH, Xu Y, Fu J
Journal of Cancer 2025;16(5):1736-1746

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Increase of brain Aβ peptides and secretase activity during normal aging in rodent and human.

Godoy-Lugo JA, Thorwald MA, Head E, Gomm AL, Zhang C, Tanzi RE, Finch CE
GeroScience 2025 Oct 14;

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Social memory maintenance relies on social interaction-induced proteolytic products of neuroligin 1.

Liu A, Li X, Zhuang M, Ren Q, Zhang J, Lv D, Wu M, Bian X, Zhu C, Yang X, Li M, Wang Y, Jia Z, Xie W
Signal transduction and targeted therapy 2025 Nov 24;10(1):387

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CPNE7 Regulates Amyloidogenesis Through CAP1-Dependent ADAM10 Translation.

Yang J, Pu YL, Pan QL, Wang L, Li CL, Xie XY, Chen X, Li XY, Bai DQ, Zhu BL, Chen GJ
Journal of neurochemistry 2025 Mar;169(3):e70026

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ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells.

Huang Y, Zhang Y, Yang N, Qian Z, Fang Z, Zeng L, Huang Y, Li H, Luo M, Yan J, Ruan L, Zhang C, Zhang L
GeroScience 2025 Jun;47(3):5089-5110

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miR-26a-5p/ADAM17-Mediated Proteolysis of TREM2 Regulates Neuroinflammation in Hypertensive Mice Following Lead Exposure.

Wang Y, Wang Z, Hao H, Zhao Y, Wang J, Wang W
Toxics 2025 Jan 5;13(1)

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Microglia-derived Galectin-9 drives amyloid-β pathology in Alzheimer's disease.

Zhang G, Peng Q, Guo X, Pan L, Xiong M, Zhang X, Dai L, Zhang Z, Xiao T, He J, Liu M, Ke W, Zhang Z
Aging cell 2025 Feb;24(2):e14396

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A disintegrin and metalloproteinase domain 10 expression inhibition by the small molecules adenosine, cordycepin and N6, N6-dimethyladenosine and immune regulation in malignant cancers.

Zhang W, Fu J, Du J, Liu X, Cheng J, Wei C, Xu Y, Fu J
Frontiers in immunology 2024;15:1434027

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Social isolation impairs cognition via Aβ-mediated synaptic dysfunction.

Huang F, Liu X, Guo Q, Mahaman YAR, Zhang B, Wang JZ, Luo H, Liu R, Wang X
Translational psychiatry 2024 Sep 18;14(1):380

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Myeloid ectopic viral integration site 2 accelerates the progression of Alzheimer's disease.

Cui Y, Zhang X, Liu J, Hou Y, Song Q, Cao M, Zhang J, Wang X, Liu C, Wang P, Wang Y
Aging cell 2024 Oct;23(10):e14260

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α5-nAChR/ADAM10 signaling mediates nicotine-related cutaneous melanoma progression via STAT3 activation.

Li X, Meng X, Fan H, Wang Y, Jia Y, Jiao J, Ma X
Archives of dermatological research 2024 May 25;316(6):269

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ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection.

Bazzone LE, Zhu J, King M, Liu G, Guo Z, MacKay CR, Kyawe PP, Qaisar N, Rojas-Quintero J, Owen CA, Brass AL, McDougall W, Baer CE, Cashman T, Trivedi CM, Gack MU, Finberg RW, Kurt-Jones EA
Nature communications 2024 May 16;15(1):4153

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Novel Social Stimulation Ameliorates Memory Deficit in Alzheimer's Disease Model through Activating α-Secretase.

Ren Q, Wang S, Li J, Cao K, Zhuang M, Wu M, Geng J, Jia Z, Xie W, Liu A
The Journal of neuroscience : the official journal of the Society for Neuroscience 2024 Mar 20;44(12)

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Linarin Ameliorates Restenosis After Vascular Injury in Type 2 Diabetes Mellitus via Regulating ADAM10-Mediated Notch Signaling Pathway.

Jiang A, Liu L, Wang J, Liu Y, Deng S, Jiang T
Cardiovascular toxicology 2024 Jun;24(6):587-597

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Nicotinic acetylcholine receptor activation induces BACE1 transcription via the phosphorylation and stabilization of nuclear SP1.

Nakano M, Tsuchida T, Mitsuishi Y, Nishimura M
Neuroscience research 2024 Jun;203:28-41

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Short-term regulation of TSFM level does not alter amyloidogenesis and mitochondrial function in type-specific cells.

Li XY, Zhou GF, Xie XY, Pu YL, -Chen X, Li CL, Yang J, Wang L, Chen GJ
Molecular biology reports 2024 Apr 5;51(1):484

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Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43.

Tanaka Y, Ito SI, Honma Y, Hasegawa M, Kametani F, Suzuki G, Kozuma L, Takeya K, Eto M
The Journal of biological chemistry 2023 Nov;299(11):105272

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Amyloid futures in the expanding pathology of brain aging and dementia.

Thorwald MA, Silva J, Head E, Finch CE
Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Jun;19(6):2605-2617

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Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome.

Shu X, Wei C, Tu WY, Zhong K, Qi S, Wang A, Bai L, Zhang SX, Luo B, Xu ZZ, Zhang K, Shen C
Cell reports 2023 Feb 28;42(2):112133

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Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.

Huo Y, Yang J, Zheng J, Xu D, Yang M, Tao L, Yao H, Fu X, Yang J, Liu D, Hua R, Zhang J, Sun Y, Hu L, Liu W
Cell proliferation 2022 May;55(5):e13237

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IDO1 can impair NK cells function against non-small cell lung cancer by downregulation of NKG2D Ligand via ADAM10.

Fang X, Guo L, Xing Z, Shi L, Liang H, Li A, Kuang C, Tao B, Yang Q
Pharmacological research 2022 Mar;177:106132

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NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.

Dang NN, Li XB, Zhang M, Han C, Fan XY, Huang SH
Frontiers in cell and developmental biology 2021;9:662763

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Periodontitis Deteriorates Cognitive Function and Impairs Neurons and Glia in a Mouse Model of Alzheimer's Disease.

Qian X, Zhang S, Duan L, Yang F, Zhang K, Yan F, Ge S
Journal of Alzheimer's disease : JAD 2021;79(4):1785-1800

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ADAM10 and ADAM17 are degraded by lysosomal pathway via asparagine endopeptidase.

Zhang X, Tang L, Zhang Z
Biochemical and biophysical research communications 2021 Jan 22;537:15-21

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Bottom up proteomics identifies neuronal differentiation pathway networks activated by cathepsin inhibition treatment in neuroblastoma cells that are enhanced by concurrent 13-cis retinoic acid treatment.

Halakos EG, Connell AJ, Glazewski L, Wei S, Mason RW
Journal of proteomics 2021 Feb 10;232:104068

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Epigenetic Regulation of a Disintegrin and Metalloproteinase (ADAM) Transcription in Colorectal Cancer Cells: Involvement of β-Catenin, BRG1, and KDM4.

Sun L, Chen B, Wu J, Jiang C, Fan Z, Feng Y, Xu Y
Frontiers in cell and developmental biology 2020;8:581692

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Effect of Lentivirus-Mediated miR-499a-3p on Human Umbilical Vein Endothelial Cells.

Zheng H, Li J, Chen Y, Gong D, Wen J, Mai L, Zeng Z
BioMed research international 2020;2020:9372961

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MiR-891a-5p as a prognostic marker and therapeutic target for hormone receptor-positive breast cancer.

Zhang Z, Xu L, He L, Wang J, Shi X, Li Z, Shi S, Hou K, Teng Y, Qu X
Journal of Cancer 2020;11(13):3771-3782

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Spinosin Inhibits Aβ(1-42) Production and Aggregation via Activating Nrf2/HO-1 Pathway.

Zhang X, Wang J, Gong G, Ma R, Xu F, Yan T, Wu B, Jia Y
Biomolecules & therapeutics 2020 May 1;28(3):259-266

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The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43.

Hicks DA, Jones AC, Pickering-Brown SM, Hooper NM
Bioscience reports 2020 Apr 30;40(4)

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Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress.

Li F, Zhang Y, Lu X, Shi J, Gong Q
Life sciences 2019 Oct 1;234:116739

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Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting.

Zhang Y, Xie JZ, Xu XY, Hu J, Xu T, Jin S, Yang SJ, Wang JZ
Neuroscience bulletin 2019 Aug;35(4):724-734

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Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122.

Chai FN, Ma WY, Zhang J, Xu HS, Li YF, Zhou QD, Li XG, Ye XL
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1002-1011

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Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy.

Wu B, Cui J, Yang XM, Liu ZY, Song F, Li L, Jiang JL, Chen ZN
Cell death & disease 2017 Jul 13;8(7):e2925