12-6319-42

antibody from Invitrogen Antibodies
Targeting: ADAM10 CD156C, HsT18717, kuz, MADM
Provider product page for 12-6319-42

Antibody data

Product number
12-6319-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
Anti-CD156c (ADAM10) Monoclonal Antibody (OV1F12), PE, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This OV1F12 (1F12HE) monoclonal antibody reacts with human CD156c, which is also known as a disintegrin and metalloproteinase domain-containing protein (ADAM) 10. This type I transmembrane glycoprotein is expressed ubiquitously on hematopoietic and non-hematopoietic cell types. Studies demonstrate that CD156c expression is regulated by PAX2 in cancer cells. CD156c plays a critical role in hematopoiesis, including lymphocyte development, and autoimmunity by regulating the shedding and secretion of various receptors and chemokines, including Notch, CD23, CXCL16, and the IL-6R. Finally, deregulated CD156c expression has been associated with T-cell acute lymphoblastic lymphoma (T-ALL) and Alzheimer's disease. Applications Reported: This OV1F12 antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This OV1F12 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 µm post-manufacturing filtered.
Reactivity
Human
Host
Mouse
Conjugate
Yellow dye
Isotype
IgG
Antibody clone number
OV1F12
Vial size
100 Tests
Concentration
5 µl/Test
Storage
4° C, store in dark, DO NOT FREEZE!
ADAM10 protein structure - 12-6319-42 shown in red.