Antibody data
- Antibody Data
- Antigen structure
- References [81]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
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- Product number
- 20384-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20384-1-AP, RRID:AB_10697662
- Product name
- NPHS2 antibody
- Antibody type
- Polyclonal
- Description
- NPHS2 antibody (Cat. #20384-1-AP) is a rabbit polyclonal antibody that shows reactivity with mouse, rat and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CYBB-Mediated Ferroptosis Drives Podocyte Injury in Lupus Nephritis and Represents a Therapeutic Target.
CYR61 promotes obesity-induced kidney injury by activating endoplasmic reticulum stress.
Autoantibodies against nephrin and podocin are associated with disease severity and steroid dependence in adult-onset nephrotic syndrome.
Allium macrostemon Bge. delays chronic renal failure by modulating IL-17 signaling pathway and affecting tryptophan/glycerophospholipid metabolism.
Zinc deficiency exacerbates and supplementation attenuates early-stage obesity-related podocyte injury via Nrf2/HO-1-mediated pyroptosis.
Integrated network pharmacology and bioinformatics analysis reveals MME as key target of Notoginsenoside R1 in diabetic nephropathy.
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PKCδ/SHP-1-dependent ER stress and relieving podocyte damage and inflammation.
An AI-Guided Structure-Based Strategy for the Discovery and Biological Validation of Natural Products Targeting the Vitamin D Receptor From YSQYP in Diabetic Kidney Disease.
Sulforaphane alleviates membranous nephropathy by inhibiting oxidative stress-associated podocyte pyroptosis.
Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin β3 in the Glomerulus.
Luteolin prevents axitinib-induced kidney damage in mice.
Sanqi qushi formula ameliorates podocyte injury in membranous nephropathy by inhibiting endoplasmic reticulum stress-induced ferroptosis.
Jianpi Qushi Heluo formula ameliorates podocytes injury related with ROS-mediated NLRP3 inflammasome activation in membranous nephropathy by promoting PINK1-dependent mitophagy.
Cdk5 Contributes to Diabetic Islet β Cell and Kidney Injury by Impairing Autophagy.
Liraglutide Mitigates Renal Injury in Diabetic Kidney Disease by Suppressing Podocyte Cholesterol Accumulation Through mTOR/VMP1-Regulated Autophagy.
FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice.
Melanocortin 5 receptor signaling protects against podocyte injury in proteinuric glomerulopathies.
Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Through the Promotion of Type 2 Macrophage Polarization.
IPSC-induced podocytes from a BORS patient with EYA1 gene mutation showed glucocorticoid-resistant and cytoskeletal rearrangement.
The compound XueShuanTong promotes podocyte mitochondrial autophagy via the AMPK/mTOR pathway to alleviate diabetic nephropathy injury.
Windows of susceptibility to neonatal acute kidney injury and nephron loss in a rabbit model.
Network pharmacology, molecular docking, and experimental verification to reveal the mechanism of colquhounia root tablet in the treatment of diabetic nephropathy.
METTL10 attenuates adriamycin-induced podocyte injury by targeting cell dedifferentiation.
Fbxo11 maintains mitochondrial function and prevents podocyte injury in adriamycin-induced nephropathy by mediating the ubiquitin degradation of Fosl2.
Targeting to Intensify M2 Macrophage Polarization Ameliorate Podocyte Lipid Accumulation and Damage by Tea Polyphenols via Activating SIRT1 in the Aged Model Rats With DKD.
Renal Implications of Kappa Opioid Receptor Signaling in Sprague-Dawley Rats.
Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.
Tanshinone IIA Promoted Autophagy and Inhibited Inflammation to Alleviate Podocyte Injury in Diabetic Nephropathy.
Effectiveness of a novel rat model of off-target PLA2R1 knockout to renal impairment.
Rutaecarpine protects podocytes in diabetic kidney disease by targeting VEGFR2/NLRP3-mediated pyroptosis.
Effects of xenogeneic transplantation of umbilical cord-derived mesenchymal stem cells combined with irbesartan on renal podocyte damage in diabetic rats.
Placenta-derived mesenchymal stem cells protect against diabetic kidney disease by upregulating autophagy-mediated SIRT1/FOXO1 pathway.
The inhibition of rutin on Src kinase blocks high glucose-induced EGFR/ERK transactivation in diabetic nephropathy by integrative approach of network pharmacology and experimental verification.
Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy.
Identification and Validation of the miR/RAS/RUNX2 Autophagy Regulatory Network in AngII-Induced Hypertensive Nephropathy in MPC5 Cells Treated with Hydrogen Sulfide Donors.
A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome.
Unraveling the interplay of ferroptosis and immune dysregulation in diabetic kidney disease: a comprehensive molecular analysis.
The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.
Mapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot process.
Minnelide combined with anti-ANGPTL3-FLD monoclonal antibody completely protects mice with adriamycin nephropathy by promoting autophagy and inhibiting apoptosis.
Irisin ameliorates diabetic kidney disease by restoring autophagy in podocytes.
Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease.
Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice.
mTOR/ULK1 signaling axis mediated ultrashort wave regulation of autophagy to alleviate diabetic kidney disease.
Deciphering the pharmacological mechanisms of Rostellularia procumbens (L) Nees. Extract alleviates adriamycin-induced nephropathy in vivo and in vitro.
Podocyte-specific deletion of ubiquitin carboxyl-terminal hydrolase L1 causes podocyte injury by inducing endoplasmic reticulum stress.
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Minnelide combined with Angptl3 knockout completely protects mice with adriamycin nephropathy via suppression of TGF-β1-Smad2 and p53 pathways.
Placental Mesenchymal Stem Cells Alleviate Podocyte Injury in Diabetic Kidney Disease by Modulating Mitophagy via the SIRT1-PGC-1alpha-TFAM Pathway.
Qian Yang Yu Yin granule improves hypertensive renal damage: A potential role for TRPC6-CaMKKβ-AMPK-mTOR-mediated autophagy.
Minnelide Markedly Reduces Proteinuria in Mice with Adriamycin Nephropathy by Protecting Against Podocyte Injury.
Qizhi Jiangtang capsule activates podocyte autophagy in diabetic kidney disease by inhibiting phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathways.
Adeno-associated virus gene therapy prevents progression of kidney disease in genetic models of nephrotic syndrome.
Peroxisome Proliferator-Activated Receptor Gene Knockout Promotes Podocyte Injury in Diabetic Mice.
Canagliflozin reverses Th1/Th2 imbalance and promotes podocyte autophagy in rats with membranous nephropathy.
Yi-Shen-Hua-Shi Granule Alleviates Adriamycin-Induced Glomerular Fibrosis by Suppressing the BMP2/Smad Signaling Pathway.
Effects of Shenkang Pills on Early-Stage Diabetic Nephropathy in db/db Mice via Inhibiting AURKB/RacGAP1/RhoA Signaling Pathway.
ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model.
Podocyte-specific Crb2 knockout mice develop focal segmental glomerulosclerosis.
Experimental study on renoprotective effect of intermedin on diabetic nephropathy.
Carnosine alleviates podocyte injury in diabetic nephropathy by targeting caspase-1-mediated pyroptosis.
A Technique for Studying Glomerular Filtration Integrity in the Zebrafish Pronephros.
Adriamycin does not damage podocytes of zebrafish larvae.
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
An integrated transcriptomics and network pharmacology approach to exploring the mechanism of adriamycin-induced kidney injury.
Prolonged podocyte depletion in larval zebrafish resembles mammalian focal and segmental glomerulosclerosis.
Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1.
Exploration the active compounds of Astragali Radix in treatment of adriamycin nephropathy by network pharmacology combined with transcriptomic approach.
Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells.
MiR-320a induces diabetic nephropathy via inhibiting MafB.
Inhibiting 4E-BP1 re-activation represses podocyte cell cycle re-entry and apoptosis induced by adriamycin.
Critical roles of PI3K/Akt/NF‑κB survival axis in angiotensin II‑induced podocyte injury.
Fractalkine is Involved in Lipopolysaccharide-Induced Podocyte Injury through the Wnt/β-Catenin Pathway in an Acute Kidney Injury Mouse Model.
Expression and distribution of PIEZO1 in the mouse urinary tract.
Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage.
Nestin Improves Preeclampsia-Like Symptoms by Inhibiting Activity of Cyclin-Dependent Kinase 5.
Quercetin ameliorates podocyte injury via inhibition of oxidative stress and the TGF-β1/Smad pathway in DN rats.
Response of Renal Podocytes to Excessive Hydrostatic Pressure: a Pathophysiologic Cascade in a Malignant Hypertension Model.
Acute podocyte injury is not a stimulus for podocytes to migrate along the glomerular basement membrane in zebrafish larvae.
Glomeruli or interstitium targeted by inter-renal injections supplemented by electroporation: Still a useful tool in renal research.
Effects of asiaticoside on levels of podocyte cytoskeletal proteins and renal slit diaphragm proteins in adriamycin-induced rat nephropathy.
Wang B, Jiang H, Wu D, Liu M, Chen H, Zhao S, Yan Y, Li S, Fang X, Wu R
Journal of inflammation research 2026;19:575320
Journal of inflammation research 2026;19:575320
CYR61 promotes obesity-induced kidney injury by activating endoplasmic reticulum stress.
Li B, Lv H, Gong K, Gao Y, Zhen J, Hu Z
Molecular immunology 2026 May;193:91-102
Molecular immunology 2026 May;193:91-102
Autoantibodies against nephrin and podocin are associated with disease severity and steroid dependence in adult-onset nephrotic syndrome.
Hayashi N, Akai R, Kagaya Y, Fujimoto K, Iwawaki T, Yokoyama H, Furuichi K
Scientific reports 2026 Mar 16;16(1)
Scientific reports 2026 Mar 16;16(1)
Allium macrostemon Bge. delays chronic renal failure by modulating IL-17 signaling pathway and affecting tryptophan/glycerophospholipid metabolism.
Zhao Y, Ge JX, Zhang N, Lei ZX, Sun SY, Luo ZW, Yang YF, Wu HZ
Journal of ethnopharmacology 2026 Mar 1;358:120946
Journal of ethnopharmacology 2026 Mar 1;358:120946
Zinc deficiency exacerbates and supplementation attenuates early-stage obesity-related podocyte injury via Nrf2/HO-1-mediated pyroptosis.
Guan Y, Li Y, Bai X, Luo P, Luo M
International immunopharmacology 2026 Jul 1;180:116703
International immunopharmacology 2026 Jul 1;180:116703
Integrated network pharmacology and bioinformatics analysis reveals MME as key target of Notoginsenoside R1 in diabetic nephropathy.
Gan X, Liang M, Shadekejiang H, Hong H, Lu J, Li X, Zhang X, Lu C
BMC complementary medicine and therapies 2026 Feb 1;26(1)
BMC complementary medicine and therapies 2026 Feb 1;26(1)
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PKCδ/SHP-1-dependent ER stress and relieving podocyte damage and inflammation.
Li Z, Tan D, Lin J, Zhang T, Liu B, Zhao B, Liang D, Li L, Wei X, Lv Z, Wang R, Hu M
Journal of advanced research 2026 Apr;82:845-862
Journal of advanced research 2026 Apr;82:845-862
An AI-Guided Structure-Based Strategy for the Discovery and Biological Validation of Natural Products Targeting the Vitamin D Receptor From YSQYP in Diabetic Kidney Disease.
Liu X, Shi J, An J, He Q, Jiao Y, Yang Y, Shi H, Zeng H, Wang S, Zhuo L, Li W
Chemical biology & drug design 2026 Apr;107(4):e70289
Chemical biology & drug design 2026 Apr;107(4):e70289
Sulforaphane alleviates membranous nephropathy by inhibiting oxidative stress-associated podocyte pyroptosis.
Lv D, Chu L, Du Y, Li C, Bao N, Su Y, Wang G, Zheng Y, Yu Y
Iranian journal of basic medical sciences 2025;28(2):237-244
Iranian journal of basic medical sciences 2025;28(2):237-244
Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin β3 in the Glomerulus.
Liu S, Meng M, Huang C, He L, Wang P, Tang Z, Ran X, Gao H, Guo Y, He Y, Chen J, Hu H, He S, Zhao Y, Hou Z, Li L, Li W, Wang W, Wang X
Journal of diabetes research 2025;2025:6683126
Journal of diabetes research 2025;2025:6683126
Luteolin prevents axitinib-induced kidney damage in mice.
Niu N, Li X, Tang D, Jin TQ, Ji SW, Yu CL, Li Y
Chemico-biological interactions 2025 Sep 5;418:111628
Chemico-biological interactions 2025 Sep 5;418:111628
Sanqi qushi formula ameliorates podocyte injury in membranous nephropathy by inhibiting endoplasmic reticulum stress-induced ferroptosis.
Sun Y, Cen Z, Li Y, Li H, Wu Q, Lin Z, Yang J, Liu B, Wu Y, Bao K, Zhao T
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120453
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120453
Jianpi Qushi Heluo formula ameliorates podocytes injury related with ROS-mediated NLRP3 inflammasome activation in membranous nephropathy by promoting PINK1-dependent mitophagy.
Yan L, Zeng Q, Wang W, Liang Y, Lang R, Zhan J, Yang J, Yu R, Wang X
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120291
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120291
Cdk5 Contributes to Diabetic Islet β Cell and Kidney Injury by Impairing Autophagy.
Tao Y, Wang L, Liu Y, Wei Y, Wang R, Sha S, Zheng S, Hou S, Liu S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71134
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 31;39(20):e71134
Liraglutide Mitigates Renal Injury in Diabetic Kidney Disease by Suppressing Podocyte Cholesterol Accumulation Through mTOR/VMP1-Regulated Autophagy.
Zou Q, Li L, Ye H, Chen Q, Li B, Wei L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71229
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71229
FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice.
Zhou J, Wang S, Lou J, Pan B, Zhao M, Li Q, Zhou J, Du Y, Ding S, Yu M, Zhou J, Chen X, Jin L, Wang X, Hu Y, Wang Z, Li X, Zheng C, Sun J, Huang Z
Nature communications 2025 Nov 25;16(1):10430
Nature communications 2025 Nov 25;16(1):10430
Melanocortin 5 receptor signaling protects against podocyte injury in proteinuric glomerulopathies.
Chen B, Chen M, Chang M, Ge Y, Gunning W, Assaly R, Dworkin LD, Qiao YJ, Gong R
Kidney international 2025 May;107(5):835-851
Kidney international 2025 May;107(5):835-851
Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Through the Promotion of Type 2 Macrophage Polarization.
Zhu X, Wang Y, Sun Z, Cheng W, Chen K, Gao X, Meng J, Li S, Zheng W, Wang Y, Yin X, Zhou X
Stem cells and development 2025 Jun;34(11-12):258-270
Stem cells and development 2025 Jun;34(11-12):258-270
IPSC-induced podocytes from a BORS patient with EYA1 gene mutation showed glucocorticoid-resistant and cytoskeletal rearrangement.
Li G, Lu D, Xu L, Zhou S, Zhang J, Wu L, Shi L, Wang L, Lin X, Ma Z, Liu M, Gao X
Cellular and molecular life sciences : CMLS 2025 Jun 16;82(1):240
Cellular and molecular life sciences : CMLS 2025 Jun 16;82(1):240
The compound XueShuanTong promotes podocyte mitochondrial autophagy via the AMPK/mTOR pathway to alleviate diabetic nephropathy injury.
Zhang C, Ren W, Lu X, Feng L, Li J, Zhu B
Mitochondrion 2025 Jul;83:102024
Mitochondrion 2025 Jul;83:102024
Windows of susceptibility to neonatal acute kidney injury and nephron loss in a rabbit model.
Indugula S, Yarlagadda S, Drumgool L, Lindquist D, Fugate E, Walters S, Rudman-Melnick V, Charlton JR, VandenHeuvel K, Dudley J, Schuh MP
Scientific reports 2025 Jul 1;15(1):21160
Scientific reports 2025 Jul 1;15(1):21160
Network pharmacology, molecular docking, and experimental verification to reveal the mechanism of colquhounia root tablet in the treatment of diabetic nephropathy.
Chen D, Wang S, Sun Z, Zhang X, Chong N, Shu J, Wang Q, Xu Y
Biochemical and biophysical research communications 2025 Jan;745:151086
Biochemical and biophysical research communications 2025 Jan;745:151086
METTL10 attenuates adriamycin-induced podocyte injury by targeting cell dedifferentiation.
Bao J, Li Z, Yao H, Wu B, Gu L, Pan Y, Wang L
Scientific reports 2025 Jan 7;15(1):1218
Scientific reports 2025 Jan 7;15(1):1218
Fbxo11 maintains mitochondrial function and prevents podocyte injury in adriamycin-induced nephropathy by mediating the ubiquitin degradation of Fosl2.
Jin Y, Wang H, Xin Y, Zhang Y
Experimental cell research 2025 Jan 1;444(1):114345
Experimental cell research 2025 Jan 1;444(1):114345
Targeting to Intensify M2 Macrophage Polarization Ameliorate Podocyte Lipid Accumulation and Damage by Tea Polyphenols via Activating SIRT1 in the Aged Model Rats With DKD.
Chen S, Wang X, Li C, Cheng L, Lv C, Xue L, Zhang C, Li X, Li M, Guo Q, Zhao Y, Zhao H
Food science & nutrition 2025 Aug;13(8):e70736
Food science & nutrition 2025 Aug;13(8):e70736
Renal Implications of Kappa Opioid Receptor Signaling in Sprague-Dawley Rats.
Didik S, Golosova D, Zietara A, Bohovyk R, Ahrari A, Levchenko V, Kravtsova O, Taneja K, Khedr S, Semenikhina M, Palygin O, Staruschenko A
Function (Oxford, England) 2025 Aug 1;6(4)
Function (Oxford, England) 2025 Aug 1;6(4)
Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.
Zhang P, Liu Z, Ma G, Wang J, Shao J, Ma C, Wang L, Ma C
Archives of physiology and biochemistry 2025 Apr;131(2):285-292
Archives of physiology and biochemistry 2025 Apr;131(2):285-292
Tanshinone IIA Promoted Autophagy and Inhibited Inflammation to Alleviate Podocyte Injury in Diabetic Nephropathy.
Li Y, Wu T, Li H, Liu M, Xu H
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:2709-2724
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:2709-2724
Effectiveness of a novel rat model of off-target PLA2R1 knockout to renal impairment.
Huang B, Zhang Z, Sui W, Zhao L, Li Y, Feng L, Yang D, Zhou Y
Genomics 2024 Mar;116(2):110796
Genomics 2024 Mar;116(2):110796
Rutaecarpine protects podocytes in diabetic kidney disease by targeting VEGFR2/NLRP3-mediated pyroptosis.
Hu X, Wang J, Jiang L, Liu X, Ge Q, Wang Q, Qi X, Wu Y
International immunopharmacology 2024 Mar 30;130:111790
International immunopharmacology 2024 Mar 30;130:111790
Effects of xenogeneic transplantation of umbilical cord-derived mesenchymal stem cells combined with irbesartan on renal podocyte damage in diabetic rats.
Meng J, Gao X, Liu X, Zheng W, Wang Y, Wang Y, Sun Z, Yin X, Zhou X
Stem cell research & therapy 2024 Jul 30;15(1):239
Stem cell research & therapy 2024 Jul 30;15(1):239
Placenta-derived mesenchymal stem cells protect against diabetic kidney disease by upregulating autophagy-mediated SIRT1/FOXO1 pathway.
Liu H, Wang J, Yue G, Xu J
Renal failure 2024 Dec;46(1):2303396
Renal failure 2024 Dec;46(1):2303396
The inhibition of rutin on Src kinase blocks high glucose-induced EGFR/ERK transactivation in diabetic nephropathy by integrative approach of network pharmacology and experimental verification.
Wu L, Li L, Wang X, Wu H, Li M, Wang Y, Sheng P, An X, Yan M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156220
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156220
Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy.
Hu Z, Zhou Y, Gao C, Liu J, Pan C, Guo J
Diabetology & metabolic syndrome 2024 Dec 18;16(1):296
Diabetology & metabolic syndrome 2024 Dec 18;16(1):296
Identification and Validation of the miR/RAS/RUNX2 Autophagy Regulatory Network in AngII-Induced Hypertensive Nephropathy in MPC5 Cells Treated with Hydrogen Sulfide Donors.
Ye Q, Ren M, Fan D, Mao Y, Zhu YZ
Antioxidants (Basel, Switzerland) 2024 Aug 7;13(8)
Antioxidants (Basel, Switzerland) 2024 Aug 7;13(8)
A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome.
Kuzmuk V, Pranke I, Rollason R, Butler M, Ding WY, Beesley M, Waters AM, Coward RJ, Sessions R, Tuffin J, Foster RR, Mollet G, Antignac C, Edelman A, Welsh GI, Saleem MA
Kidney international 2024 Apr;105(4):744-758
Kidney international 2024 Apr;105(4):744-758
Unraveling the interplay of ferroptosis and immune dysregulation in diabetic kidney disease: a comprehensive molecular analysis.
Jiao Y, Liu X, Shi J, An J, Yu T, Zou G, Li W, Zhuo L
Diabetology & metabolic syndrome 2024 Apr 20;16(1):86
Diabetology & metabolic syndrome 2024 Apr 20;16(1):86
The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.
Ma Y, Chen Y, Xu H, Du N
Frontiers in immunology 2023;14:1228399
Frontiers in immunology 2023;14:1228399
Mapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot process.
Gerlach GF, Imseis ZH, Cooper SL, Santos AN, O'Brien LL
Frontiers in cell and developmental biology 2023;11:1195037
Frontiers in cell and developmental biology 2023;11:1195037
Minnelide combined with anti-ANGPTL3-FLD monoclonal antibody completely protects mice with adriamycin nephropathy by promoting autophagy and inhibiting apoptosis.
Ji B, Liu J, Yin Y, Xu H, Shen Q, Yu J
Cell death & disease 2023 Sep 9;14(9):601
Cell death & disease 2023 Sep 9;14(9):601
Irisin ameliorates diabetic kidney disease by restoring autophagy in podocytes.
Lai W, Luo D, Li Y, Li Y, Wang Q, Hu Z, Ye Z, Peng H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23175
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23175
Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease.
Jiang W, Gan C, Zhou X, Yang Q, Chen D, Xiao H, Dai L, Chen Y, Wang M, Yang H, Li Q
Cardiovascular diabetology 2023 Oct 27;22(1):293
Cardiovascular diabetology 2023 Oct 27;22(1):293
Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice.
Li X, Liu Z, He Z, Wang X, Li R, Wang J, Ma G, Zhang P, Ma C
BMC endocrine disorders 2023 Oct 23;23(1):230
BMC endocrine disorders 2023 Oct 23;23(1):230
mTOR/ULK1 signaling axis mediated ultrashort wave regulation of autophagy to alleviate diabetic kidney disease.
Yan Y, Yu S, Fan Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Nov;32(11):1265-1277
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Nov;32(11):1265-1277
Deciphering the pharmacological mechanisms of Rostellularia procumbens (L) Nees. Extract alleviates adriamycin-induced nephropathy in vivo and in vitro.
Ai Z, Wang M, Zhou Y, Yuan D, Jian Q, Wu S, Liu B, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154736
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154736
Podocyte-specific deletion of ubiquitin carboxyl-terminal hydrolase L1 causes podocyte injury by inducing endoplasmic reticulum stress.
Hu Y, Qi C, Shi J, Tan W, Adiljan Abdurusul, Zhao Z, Xu Y, Wu H, Zhang Z
Cellular and molecular life sciences : CMLS 2023 Mar 23;80(4):106
Cellular and molecular life sciences : CMLS 2023 Mar 23;80(4):106
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Song D, Zhang A, Hu X, Zeng M, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Minnelide combined with Angptl3 knockout completely protects mice with adriamycin nephropathy via suppression of TGF-β1-Smad2 and p53 pathways.
Ji B, Liu J, Ma Y, Yin Y, Xu H, Shen Q, Yu J
International immunopharmacology 2023 Feb;115:109656
International immunopharmacology 2023 Feb;115:109656
Placental Mesenchymal Stem Cells Alleviate Podocyte Injury in Diabetic Kidney Disease by Modulating Mitophagy via the SIRT1-PGC-1alpha-TFAM Pathway.
Han X, Wang J, Li R, Huang M, Yue G, Guan L, Deng Y, Cai W, Xu J
International journal of molecular sciences 2023 Feb 28;24(5)
International journal of molecular sciences 2023 Feb 28;24(5)
Qian Yang Yu Yin granule improves hypertensive renal damage: A potential role for TRPC6-CaMKKβ-AMPK-mTOR-mediated autophagy.
Ma S, Xu J, Zheng Y, Li Y, Wang Y, Li H, Fang Z, Li J
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115878
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115878
Minnelide Markedly Reduces Proteinuria in Mice with Adriamycin Nephropathy by Protecting Against Podocyte Injury.
Ji B, Liu J, Ma Y, Yin Y, Xu H, Shen Q, Yu J
Applied biochemistry and biotechnology 2023 Dec;195(12):7379-7396
Applied biochemistry and biotechnology 2023 Dec;195(12):7379-7396
Qizhi Jiangtang capsule activates podocyte autophagy in diabetic kidney disease by inhibiting phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathways.
Zhaoan G, Lina S, Yingying L, Ruifeng LI, Chong L, Ke D, Jing S, Jun S
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Aug;43(4):667-675
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Aug;43(4):667-675
Adeno-associated virus gene therapy prevents progression of kidney disease in genetic models of nephrotic syndrome.
Ding WY, Kuzmuk V, Hunter S, Lay A, Hayes B, Beesley M, Rollason R, Hurcombe JA, Barrington F, Masson C, Cathery W, May C, Tuffin J, Roberts T, Mollet G, Chu CJ, McIntosh J, Coward RJ, Antignac C, Nathwani A, Welsh GI, Saleem MA
Science translational medicine 2023 Aug 9;15(708):eabc8226
Science translational medicine 2023 Aug 9;15(708):eabc8226
Peroxisome Proliferator-Activated Receptor Gene Knockout Promotes Podocyte Injury in Diabetic Mice.
Yan R, Zhang Y, Yang Y, Liu L, Liu L, Guo Z, Yu H, Wang Y, Guo B
BioMed research international 2022;2022:9018379
BioMed research international 2022;2022:9018379
Canagliflozin reverses Th1/Th2 imbalance and promotes podocyte autophagy in rats with membranous nephropathy.
Lv X, Wang J, Zhang L, Shao X, Lin Y, Liu H, Ma G, Li J, Zhou S, Yu P
Frontiers in immunology 2022;13:993869
Frontiers in immunology 2022;13:993869
Yi-Shen-Hua-Shi Granule Alleviates Adriamycin-Induced Glomerular Fibrosis by Suppressing the BMP2/Smad Signaling Pathway.
Tan Z, Si Y, Yu Y, Ding J, Huang L, Xu Y, Zhang H, Lu Y, Wang C, Yu B, Yuan L
Frontiers in pharmacology 2022;13:917428
Frontiers in pharmacology 2022;13:917428
Effects of Shenkang Pills on Early-Stage Diabetic Nephropathy in db/db Mice via Inhibiting AURKB/RacGAP1/RhoA Signaling Pathway.
Wang F, Fan J, Pei T, He Z, Zhang J, Ju L, Han Z, Wang M, Xiao W
Frontiers in pharmacology 2022;13:781806
Frontiers in pharmacology 2022;13:781806
ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model.
Gao Y, Ma Y, Xie D, Jiang H
International immunopharmacology 2022 Jun;107:108711
International immunopharmacology 2022 Jun;107:108711
Podocyte-specific Crb2 knockout mice develop focal segmental glomerulosclerosis.
Tanoue A, Katayama K, Ito Y, Joh K, Toda M, Yasuma T, D'Alessandro-Gabazza CN, Kawachi H, Yan K, Ito M, Gabazza EC, Tryggvason K, Dohi K
Scientific reports 2021 Oct 15;11(1):20556
Scientific reports 2021 Oct 15;11(1):20556
Experimental study on renoprotective effect of intermedin on diabetic nephropathy.
Wang Y, Tian J, Mi Y, Ren X, Lian S, Kang J, Wang J, Zang H, Wu Z, Yang J, Qiao X, Zhou X, Wang G, Zhou Y, Li R
Molecular and cellular endocrinology 2021 May 15;528:111224
Molecular and cellular endocrinology 2021 May 15;528:111224
Carnosine alleviates podocyte injury in diabetic nephropathy by targeting caspase-1-mediated pyroptosis.
Zhu W, Li YY, Zeng HX, Liu XQ, Sun YT, Jiang L, Xia LL, Wu YG
International immunopharmacology 2021 Dec;101(Pt B):108236
International immunopharmacology 2021 Dec;101(Pt B):108236
A Technique for Studying Glomerular Filtration Integrity in the Zebrafish Pronephros.
Kolatsi-Joannou M, Osborn D
Methods in molecular biology (Clifton, N.J.) 2020;2067:25-39
Methods in molecular biology (Clifton, N.J.) 2020;2067:25-39
Adriamycin does not damage podocytes of zebrafish larvae.
Schindler M, Blumenthal A, Moeller MJ, Endlich K, Endlich N
PloS one 2020;15(11):e0242436
PloS one 2020;15(11):e0242436
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
Yang F, Qu Q, Zhao C, Liu X, Yang P, Li Z, Han L, Shi X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
An integrated transcriptomics and network pharmacology approach to exploring the mechanism of adriamycin-induced kidney injury.
He S, Li A, Zhang W, Zhang L, Liu Y, Li K, Qin X
Chemico-biological interactions 2020 Jul 1;325:109096
Chemico-biological interactions 2020 Jul 1;325:109096
Prolonged podocyte depletion in larval zebrafish resembles mammalian focal and segmental glomerulosclerosis.
Hansen KUI, Siegerist F, Daniel S, Schindler M, Iervolino A, Blumenthal A, Daniel C, Amann K, Zhou W, Endlich K, Endlich N
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Dec;34(12):15961-15974
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Dec;34(12):15961-15974
Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1.
Fang Y, Li F, Qi C, Mao X, Xu Y, Zhao Z, Wu H, Zhang Z
Biochemical and biophysical research communications 2020 Aug 13;529(1):112-118
Biochemical and biophysical research communications 2020 Aug 13;529(1):112-118
Exploration the active compounds of Astragali Radix in treatment of adriamycin nephropathy by network pharmacology combined with transcriptomic approach.
Li AP, He SS, Zhang WN, Zhang LC, Liu YT, Li K, Qin XM
Journal of ethnopharmacology 2020 Aug 10;258:112537
Journal of ethnopharmacology 2020 Aug 10;258:112537
Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells.
Nguyen L, Spitzhorn LS, Adjaye J
Stem cells international 2019;2019:3298432
Stem cells international 2019;2019:3298432
MiR-320a induces diabetic nephropathy via inhibiting MafB.
He M, Wang J, Yin Z, Zhao Y, Hou H, Fan J, Li H, Wen Z, Tang J, Wang Y, Wang DW, Chen C
Aging 2019 May 17;11(10):3055-3079
Aging 2019 May 17;11(10):3055-3079
Inhibiting 4E-BP1 re-activation represses podocyte cell cycle re-entry and apoptosis induced by adriamycin.
Li F, Mao X, Zhuang Q, Zhao Z, Zhang Z, Wu H
Cell death & disease 2019 Mar 11;10(3):241
Cell death & disease 2019 Mar 11;10(3):241
Critical roles of PI3K/Akt/NF‑κB survival axis in angiotensin II‑induced podocyte injury.
Wang J, Fu D, Senouthai S, You Y
Molecular medicine reports 2019 Dec;20(6):5134-5144
Molecular medicine reports 2019 Dec;20(6):5134-5144
Fractalkine is Involved in Lipopolysaccharide-Induced Podocyte Injury through the Wnt/β-Catenin Pathway in an Acute Kidney Injury Mouse Model.
Senouthai S, Wang J, Fu D, You Y
Inflammation 2019 Aug;42(4):1287-1300
Inflammation 2019 Aug;42(4):1287-1300
Expression and distribution of PIEZO1 in the mouse urinary tract.
Dalghi MG, Clayton DR, Ruiz WG, Al-Bataineh MM, Satlin LM, Kleyman TR, Ricke WA, Carattino MD, Apodaca G
American journal of physiology. Renal physiology 2019 Aug 1;317(2):F303-F321
American journal of physiology. Renal physiology 2019 Aug 1;317(2):F303-F321
Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage.
Zuo Z, Shen JX, Pan Y, Pu J, Li YG, Shao XH, Wang WP
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(1):244-261
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(1):244-261
Nestin Improves Preeclampsia-Like Symptoms by Inhibiting Activity of Cyclin-Dependent Kinase 5.
Yang X, Ding Y, Yang M, Yu L, Hu Y, Deng Y
Kidney & blood pressure research 2018;43(2):616-627
Kidney & blood pressure research 2018;43(2):616-627
Quercetin ameliorates podocyte injury via inhibition of oxidative stress and the TGF-β1/Smad pathway in DN rats.
Gao F, He X, Liang S, Liu S, Liu H, He Q, Chen L, Jiang H, Zhang Y
RSC advances 2018 Oct 15;8(62):35413-35421
RSC advances 2018 Oct 15;8(62):35413-35421
Response of Renal Podocytes to Excessive Hydrostatic Pressure: a Pathophysiologic Cascade in a Malignant Hypertension Model.
Abu Hamad R, Berman S, Hachmo Y, Stark M, Hasan F, Doenyas-Barak K, Efrati S
Kidney & blood pressure research 2017;42(6):1104-1118
Kidney & blood pressure research 2017;42(6):1104-1118
Acute podocyte injury is not a stimulus for podocytes to migrate along the glomerular basement membrane in zebrafish larvae.
Siegerist F, Blumenthal A, Zhou W, Endlich K, Endlich N
Scientific reports 2017 Mar 2;7:43655
Scientific reports 2017 Mar 2;7:43655
Glomeruli or interstitium targeted by inter-renal injections supplemented by electroporation: Still a useful tool in renal research.
Mao X, Li F, Yang N, Qi C, Zhang SQ, Zhang Z, Wu H
The journal of gene medicine 2016 Nov;18(11-12):343-352
The journal of gene medicine 2016 Nov;18(11-12):343-352
Effects of asiaticoside on levels of podocyte cytoskeletal proteins and renal slit diaphragm proteins in adriamycin-induced rat nephropathy.
Wang Z, Liu J, Sun W
Life sciences 2013 Sep 3;93(8):352-8
Life sciences 2013 Sep 3;93(8):352-8
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- Main image

- Experimental details
- mouse colon tissue were subjected to SDS PAGE followed by western blot with 20384-1-AP(NPHS2 antibody) at dilution of 1:400
- Sample type
- tissue