CACNA1E

Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

Description

Calcium voltage-gated channel subunit alpha1 E

Tissue specificity

Tissue enriched (brain)

Subcell location

Plasma membrane, Actin filaments, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Voltage-gated ion channels

Chromosome

1 (181317690 - 181808084)

Ensembl ID

ENSG00000198216  (ver. 103.38)

Orthologs

Mouse Cacna1e: ENSMUSG00000004110

UniProt

Q15878

neXtProt

NX_Q15878

Human splice variants
Mouse splice variants

Protein structure