Antibody data
- Antibody Data
- Antigen structure
- References [1]
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- Product number
- MA1-35682 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- MRP4 Monoclonal Antibody (M4I-80)
- Antibody type
- Monoclonal
- Antigen
- Other
- Reactivity
- Human, Mouse
- Host
- Rat
- Isotype
- IgG
- Antibody clone number
- M4I-80
- Vial size
- 1 mL
- Concentration
- 200 µg/mL
- Storage
- 4° C
Submitted references Downregulation of Renal MRPs Transporters in Acute Lymphoblastic Leukemia Mediated by the IL-6/STAT3/PXR Signaling Pathway.
Zhou Y, Nie AQ, Chen S, Wang MM, Yin R, Tang BH, Wu YE, Yang F, Du B, Shi HY, Yang XM, Hao GX, Guo XL, Han QJ, Zheng Y, Zhao W
Journal of inflammation research 2021;14:2239-2252
Journal of inflammation research 2021;14:2239-2252
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 2 Expression of MRPs transporters in HK-2. ( A ) HK-2 cells were exposed to 10 ng/mL IL-6 with STAT3 and PXR siRNA for subsequent Western blotting. ( B - D ) Protein expression of targeted transporters was quantified and is viewed in the bar graphs. * p < 0.05, ** p < 0.01, versus control group. ( E ) The fold change with respect to mRNA expression of STAT3, PXR, MRP2 , and MRP4 in HK-2 cells treated with IL-6 (10 ng/mL) compared to HK-2 cells. ** p < 0.01, versus control group.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 4 Expression of targeted renal proteins and mRNA in NOD/SCID mice treated with Tocilizumab. ( A ) Expression of target proteins in NOD/SCID mice detected using Western blotting. ( B ) Expression of targeted proteins was quantified and can be seen in the bar graphs. *p < 0.05, ** p < 0.01, versus the control group; # p < 0.05, ## p < 0.01, the ALL-TCZ group versus the ALL group. ( C ) The fold change with respect to mRNA expression of Stat3, Pxr, Mrp2 , and Mrp4 in NOD/SCID mice. * p < 0.05, ** p < 0.01, versus the control group.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 5 Expression of targeted renal proteins and mRNA in NOD/SCID mice treated with S3I-201. ( A ) Expression of target proteins in NOD/SCID mice kidney detected using Western blotting. ( B ) Expression of targeted proteins was quantified and can be seen in the bar graphs. *p < 0.05, ** p < 0.01, versus the control group; # p < 0.05, ## p < 0.01, the ALL-S3I-201 group versus the control group. ( C ) The fold change with respect to mRNA expression of Stat3, Pxr, Mrp2 , and Mrp4 in NOD/SCID mice. * p < 0.05, ** p < 0.01, versus the control group.