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- Antigen structure
- References [16]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15912-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15912-1-AP, RRID:AB_2211462
- Product name
- UBE1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated UBE1 antibody (Cat. #15912-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Macrophage-specific UBA1 knockout attenuates sepsis-induced liver dysfunction by regulating inflammatory responses via the BMAL1/CLOCK-REV-ERBα axis.
Biomarkers for early detection and monitoring of abnormal brain development in mild fetal growth restriction.
The UBA1-STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade.
Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth.
Thermostability-assisted limited proteolysis-coupled mass spectrometry for capturing drug target proteins and sites.
DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation.
HIV-1 promotes ubiquitination of the amyloidogenic C-terminal fragment of APP to support viral replication.
Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia.
β-arrestin1 is an E3 ubiquitin ligase adaptor for substrate linear polyubiquitination.
Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival.
The E3 ubiquitin ligase RBCK1 promotes the invasion and metastasis of hepatocellular carcinoma by destroying the PPARγ/PGC1α complex.
Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology.
Ubiquitin-Like Modifier Activating Enzyme 1 as a Novel Diagnostic and Prognostic Indicator That Correlates With Ferroptosis and the Malignant Phenotypes of Liver Cancer Cells.
Graphene Oxide Causes Disordered Zonation Due to Differential Intralobular Localization in the Liver.
CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p16(INK4a).
iTRAQ-based quantitative proteomic analysis for identification of oligodendroglioma biomarkers related with loss of heterozygosity on chromosomal arm 1p.
Jin LY, Cui C, Lv SY, Li HH
International immunopharmacology 2026 Jan 1;168(Pt 1):115799
International immunopharmacology 2026 Jan 1;168(Pt 1):115799
Biomarkers for early detection and monitoring of abnormal brain development in mild fetal growth restriction.
Onoda A, Kitase Y, Coq JO, Ueda K, Shimizu S, Tsuji M, Hayakawa M, Sato Y
iScience 2025 Sep 19;28(9):113237
iScience 2025 Sep 19;28(9):113237
The UBA1-STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade.
Bao Y, Cruz G, Zhang Y, Qiao Y, Mannan R, Hu J, Yang F, Gondal M, Shahine M, Kang S, Mahapatra S, Chu A, Choi JE, Yu J, Lin H, Miner SJ, Robinson DR, Wu YM, Zheng Y, Cao X, Su F, Wang R, Hosseini N, Cieslik M, Kryczek I, Vaishampayan U, Zou W, Chinnaiyan AM
Cancer discovery 2025 Feb 7;15(2):363-381
Cancer discovery 2025 Feb 7;15(2):363-381
Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth.
Rao K, Zhang X, Luo Y, Xia Q, Jin Y, He J
Cell reports 2025 Apr 22;44(4):115441
Cell reports 2025 Apr 22;44(4):115441
Thermostability-assisted limited proteolysis-coupled mass spectrometry for capturing drug target proteins and sites.
Yang L, Guo CW, Luo QM, Guo ZF, Chen L, Ishihama Y, Li P, Yang H, Gao W
Analytica chimica acta 2024 Jul 11;1312:342755
Analytica chimica acta 2024 Jul 11;1312:342755
DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation.
Xu X, Chang CW, Li M, Omabe K, Le N, Chen YH, Liang F, Liu Y
Nature communications 2023 Mar 4;14(1):1233
Nature communications 2023 Mar 4;14(1):1233
HIV-1 promotes ubiquitination of the amyloidogenic C-terminal fragment of APP to support viral replication.
Gu F, Boisjoli M, Naghavi MH
Nature communications 2023 Jul 15;14(1):4227
Nature communications 2023 Jul 15;14(1):4227
Chronic Microcystin-LR-Induced α-Synuclein Promotes Neuroinflammation Through Activation of the NLRP3 Inflammasome in Microglia.
Yan M, Jin H, Pan C, Han X
Molecular neurobiology 2023 Feb;60(2):884-900
Molecular neurobiology 2023 Feb;60(2):884-900
β-arrestin1 is an E3 ubiquitin ligase adaptor for substrate linear polyubiquitination.
McElrath CJ, Benzow S, Zhuo Y, Marchese A
The Journal of biological chemistry 2023 Dec;299(12):105474
The Journal of biological chemistry 2023 Dec;299(12):105474
Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival.
Danan CH, Naughton KE, Hayer KE, Vellappan S, McMillan EA, Zhou Y, Matsuda R, Nettleford SK, Katada K, Parham LR, Ma X, Chowdhury A, Wilkins BJ, Shah P, Weitzman MD, Hamilton KE
bioRxiv : the preprint server for biology 2023 Apr 21;
bioRxiv : the preprint server for biology 2023 Apr 21;
The E3 ubiquitin ligase RBCK1 promotes the invasion and metastasis of hepatocellular carcinoma by destroying the PPARγ/PGC1α complex.
Xu Z, Shao J, Zheng C, Cai J, Li B, Peng X, Chen L, Liu T
American journal of cancer research 2022;12(3):1372-1392
American journal of cancer research 2022;12(3):1372-1392
Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology.
Zhang Y, Chen X, Wang Q, Du C, Lu W, Yuan H, Zhang Z, Li D, Ling X, Ren X, Zhao Y, Su Q, Xing Z, Qin Y, Yang X, Shen Y, Wu H, Qi Y
Journal of molecular medicine (Berlin, Germany) 2021 Dec;99(12):1797-1813
Journal of molecular medicine (Berlin, Germany) 2021 Dec;99(12):1797-1813
Ubiquitin-Like Modifier Activating Enzyme 1 as a Novel Diagnostic and Prognostic Indicator That Correlates With Ferroptosis and the Malignant Phenotypes of Liver Cancer Cells.
Shan Y, Yang G, Huang H, Zhou Y, Hu X, Lu Q, Guo P, Hou J, Cao L, Tian F, Pan Q
Frontiers in oncology 2020;10:592413
Frontiers in oncology 2020;10:592413
Graphene Oxide Causes Disordered Zonation Due to Differential Intralobular Localization in the Liver.
Wu Y, Feng W, Liu R, Xia T, Liu S
ACS nano 2020 Jan 28;14(1):877-890
ACS nano 2020 Jan 28;14(1):877-890
CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p16(INK4a).
Du W, Liu Z, Zhu W, Li T, Zhu Z, Wei L, Song J, Pei D
Cancer biology & medicine 2019 Aug;16(3):514-529
Cancer biology & medicine 2019 Aug;16(3):514-529
iTRAQ-based quantitative proteomic analysis for identification of oligodendroglioma biomarkers related with loss of heterozygosity on chromosomal arm 1p.
Yang LS, Xu XE, Liu XP, Jin H, Chen ZQ, Liu XH, Wang Y, Huang FP, Shi Q
Journal of proteomics 2012 Dec 21;77:480-91
Journal of proteomics 2012 Dec 21;77:480-91
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HL-60 cells were subjected to SDS PAGE followed by western blot with 15912-1-AP(UBE1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 15912-1-AP(UBE1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UBE1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UBE1. This antibody recognizes human,mouse,rat antigen. The UBE1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
