15117-1-AP

antibody from Proteintech Group

Targeting: LMOD1 1D, 64kD, D1

Provider product page for 15117-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [20]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 15117-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15117-1-AP, RRID:AB_2136682
Product name: LMOD1 antibody
Antibody type: Polyclonal
Description: KD/KO validated LMOD1 antibody (Cat. #15117-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

LMOD1 protein structure - 15117-1-AP shown in red.

Submitted references Integrative multiomics analysis of neointima proliferation in human saphenous vein: implications for bypass graft disease.

Kim D, Goo B, Shi H, Coffey P, Veerapaneni P, Chouhaita R, Cyriac N, Aboud G, Cave S, Greenway J, Mundkur R, Ahmadieh S, Harb R, Ogbi M, Fulton DJ, Huo Y, Zhang W, Long X, Guha A, Kim HW, Shi Y, Rice RD, Gallo DR, Patel V, Lee R, Weintraub NL
bioRxiv : the preprint server for biology 2023 Nov 17;

The Long Noncoding RNA Cardiac Mesoderm Enhancer-Associated Noncoding RNA (Carmn) Is a Critical Regulator of Gastrointestinal Smooth Muscle Contractile Function and Motility.

He X, Dong K, Shen J, Hu G, Mintz JD, Atawia RT, Zhao J, Chen X, Caldwell RW, Xiang M, Stepp DW, Fulton DJ, Zhou J
Gastroenterology 2023 Jul;165(1):71-87

Heterozygous Actg2(R257C) mice mimic the phenotype of megacystis microcolon intestinal hypoperistalsis syndrome.

Cai H, Xiao Y, Chen S, Lu Y, Du J, You Y, Zhu J, Zhou J, Cai W, Wang Y
Neurogastroenterology and motility 2023 Jan;35(1):e14472

Deletion of Smooth Muscle O-GlcNAc Transferase Prevents Development of Atherosclerosis in Western Diet-Fed Hyperglycemic ApoE(-/-) Mice In Vivo.

Khanal S, Bhavnani N, Mathias A, Lallo J, Gupta S, Ohanyan V, Ferrell JM, Raman P
International journal of molecular sciences 2023 Apr 26;24(9)

Sex-specific differences in atherosclerosis, thrombospondin-1, and smooth muscle cell differentiation in metabolic syndrome versus non-metabolic syndrome mice.

Gupta S, Khanal S, Bhavnani N, Mathias A, Lallo J, Kiriakou A, Ferrell J, Raman P
Frontiers in cardiovascular medicine 2022;9:1020006

Loss-of-function variants within LMOD1 actin-binding site 2 cause pediatric intestinal pseudo-obstruction by impairing protein stability and actin nucleation.

Liu K, Lu L, Chen S, Gu B, Cai H, Wang Y, Cai W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Mar;36(3):e22194

Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk.

Turner AW, Hu SS, Mosquera JV, Ma WF, Hodonsky CJ, Wong D, Auguste G, Song Y, Sol-Church K, Farber E, Kundu S, Kundaje A, Lopez NG, Ma L, Ghosh SKB, Onengut-Gumuscu S, Ashley EA, Quertermous T, Finn AV, Leeper NJ, Kovacic JC, Björkegren JLM, Zang C, Miller CL
Nature genetics 2022 Jun;54(6):804-816

Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm.

Zhang C, Mohan A, Shi H, Yan C
Journal of the American Heart Association 2022 Jan 18;11(2):e023053

Mediterranean G6PD variant rats are protected from Angiotensin II-induced hypertension and kidney damage, but not from inflammation and arterial stiffness.

Matsumura S, D'Addiaro C, Slivano OJ, De Miguel C, Stier C, Gupte R, Miano JM, Gupte SA
Vascular pharmacology 2022 Aug;145:107002

Depiction of Aging-Based Molecular Phenotypes With Diverse Clinical Prognosis and Immunological Features in Gastric Cancer.

He F, Ding H, Zhou Y, Wang Y, Xie J, Yang S, Zhu Y
Frontiers in medicine 2021;8:792740

Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression.

Gao P, Lyu Q, Ghanam AR, Lazzarotto CR, Newby GA, Zhang W, Choi M, Slivano OJ, Holden K, Walker JA 2nd, Kadina AP, Munroe RJ, Abratte CM, Schimenti JC, Liu DR, Tsai SQ, Long X, Miano JM
Genome biology 2021 Mar 16;22(1):83

Putative Autoantigen Leiomodin-1 Is Expressed in the Human Brain and in the Membrane Fraction of Newly Formed Neurons.

Nauen DW, Haffner MC, Kim J, Zheng Q, Yin H, DeMarzo AM, Mahairaki V, Colantuoni C, Pickering JG, Johnson TP
Pathogens (Basel, Switzerland) 2020 Dec 10;9(12)

Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation.

Wu W, Zhang W, Choi M, Zhao J, Gao P, Xue M, Singer HA, Jourd'heuil D, Long X
Redox biology 2019 Apr;22:101137

Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus.

Nanda V, Wang T, Pjanic M, Liu B, Nguyen T, Matic LP, Hedin U, Koplev S, Ma L, Franzén O, Ruusalepp A, Schadt EE, Björkegren JLM, Montgomery SB, Snyder MP, Quertermous T, Leeper NJ, Miller CL
PLoS genetics 2018 Nov;14(11):e1007755

Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice.

Halim D, Wilson MP, Oliver D, Brosens E, Verheij JB, Han Y, Nanda V, Lyu Q, Doukas M, Stoop H, Brouwer RW, van IJcken WF, Slivano OJ, Burns AJ, Christie CK, de Mesy Bentley KL, Brooks AS, Tibboel D, Xu S, Jin ZG, Djuwantono T, Yan W, Alves MM, Hofstra RM, Miano JM
Proceedings of the National Academy of Sciences of the United States of America 2017 Mar 28;114(13):E2739-E2747

Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus.

Johnson TP, Tyagi R, Lee PR, Lee MH, Johnson KR, Kowalak J, Elkahloun A, Medynets M, Hategan A, Kubofcik J, Sejvar J, Ratto J, Bunga S, Makumbi I, Aceng JR, Nutman TB, Dowell SF, Nath A
Science translational medicine 2017 Feb 15;9(377)

CRISPR-Cas9 genome editing of a single regulatory element nearly abolishes target gene expression in mice--brief report.

Han Y, Slivano OJ, Christie CK, Cheng AW, Miano JM
Arteriosclerosis, thrombosis, and vascular biology 2015 Feb;35(2):312-5

Gene Expression by Mouse Inner Ear Hair Cells during Development.

Scheffer DI, Shen J, Corey DP, Chen ZY
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Apr 22;35(16):6366-80

Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA.

Bell RD, Long X, Lin M, Bergmann JH, Nanda V, Cowan SL, Zhou Q, Han Y, Spector DL, Zheng D, Miano JM
Arteriosclerosis, thrombosis, and vascular biology 2014 Jun;34(6):1249-59

Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells.

Nanda V, Miano JM
The Journal of biological chemistry 2012 Jan 20;287(4):2459-67

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 15117-1-AP(LMOD1 antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of A375 cells, using LMOD1 antibody 15117-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line