12036-1-AP

antibody from Proteintech Group

Targeting: CHI3L1 GP39, YK-40, YKL40

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

12036-1-AP

Provider

Proteintech Group

Product name

CHI3L1/YKL40 antibody

Antibody type

Polyclonal

Description

CHI3L1/YKL40 antibody (Cat. #12036-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Molecular Mechanisms of Rotator Cuff Degeneration Identified by Spatial Transcriptomics and Multiplex Immunofluorescence.

Yao S, Yang R, Ling S, Li G, Wang H, Li R, Xu Y, Zhang Y, Zhuang C, Wang L
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2026 Mar;44(3):e70163

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Clinical and molecular features of primary gliosarcoma with digital spatial whole-transcriptome analysis of glial and mesenchymal components.

Wood MD, Zangirolani G, Lee J, Hakar MH, Neff T, Zhang KY, Corless CL
Brain pathology (Zurich, Switzerland) 2026 Mar 18;:e70091

---

Elevated CHI3L1 as a Potential Biomarker of Cognitive Dysfunction in Anti-NMDAR Encephalitis: Evidence From Clinical Results and Mice Model.

Li Y, Ding R, Yang J, Yang X, Han Z, Li X, Liu J, Jiang Y, Cheng L, Ma J, Luo H, Jiang L
CNS neuroscience & therapeutics 2026 Jan;32(1):e70739

---

CHI3L1: a key driver in gastritis-to-cancer transformation.

Li T, Jiang H, Gong Y, Liao M, Jia Y, Chen J, Dai M, Yan Y, Lu X, Chen R, Li Y, Chen Y, Lin J, Li Y, Ding X
Journal of translational medicine 2025 Mar 19;23(1):349

---

STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma.

Yu W, Gui S, Peng L, Luo H, Xie J, Xiao J, Yilamu Y, Sun Y, Cai S, Cheng Z, Tao Z
Developmental cell 2025 Jun 23;60(12):1751-1767.e9

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Secretome enriched with small extracellular vesicles derived from human gingiva-derived mesenchymal stem cells enhances rat tongue muscle regeneration.

Zhang Q, He P, Shi S, Xu Q, Granquist EJ, Winkelstein BA, Shanti RM, Le AD
Journal of nanobiotechnology 2025 Jun 10;23(1):434

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A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's disease.

Gong Z, Guo D, Lin Y, Liu Z, Lv M, Liu X, Yao Y, Wang S, Wang Y, Wang Z
Heliyon 2025 Feb 15;11(3):e42051

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In Vivo Differentiation of hESC-Derived Neural Crest Cells into Trabecular Meshwork Cells.

Su Y, Duan H, Zhu H, Dong C, Zou D, Bu Q, Zhu W, Zhou Q, Li Z, Pan X
Tissue engineering. Part A 2025 Dec;31(23-24):1309-1318

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Nociceptive Nerve-Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b(+) CD146(+) Fibroblast Differentiation.

Ye Z, Zhao A, Li X, Hao Y, Huang D, Chen J, Li T, Dai Y, Sun W, Ma L, Zhang S, Xin L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e07128

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Using Multi-Omics Analysis to Explore Diagnostic Tool and Optimize Drug Therapy Selection for Patients with Glioma Based on Cross-Talk Gene Signature.

Yang Y, Hu C, Lei S, Bao X, Zeng Z, Cao W
Oncology research 2024;32(12):1921-1934

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Identification of candidate genes and chemicals associated with osteonecrosis of femoral head by multiomics studies and chemical-gene interaction analysis.

Lu X, Wang X, Wang P, Zhu Y, Liu J, Liu G, Liu R
Frontiers in endocrinology 2024;15:1419742

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SIRT6 modulates lesion microenvironment in LPC induced demyelination by targeting astrocytic CHI3L1.

Du J, Yin Y, Wu D, Diao C, Zhao T, Peng F, Li N, Wang D, Shi J, Wang L, Kong L, Zhou W, Hao A
Journal of neuroinflammation 2024 Sep 28;21(1):243

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Comprehensive machine learning-based integration develops a novel prognostic model for glioblastoma.

Jiang Q, Yang X, Deng T, Yan J, Guo F, Mo L, An S, Huang Q
Molecular therapy. Oncology 2024 Sep 19;32(3):200838

---

Peptidoglycan-Chi3l1 interaction shapes gut microbiota in intestinal mucus layer.

Chen Y, Yang R, Qi B, Shan Z
eLife 2024 Oct 7;13

---

Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution.

Hong NE, Chaplin A, Di L, Ravodina A, Bevan GH, Gao H, Asase C, Gangwar RS, Cameron MJ, Mignery M, Cherepanova O, Finn AV, Nayak L, Pieper AA, Maiseyeu A
Cell reports 2024 Nov 26;43(11):114911

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miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization.

Zhou Y, Yuan Y, Yao X, Wang L, Yao L, Tang D, Chen F, Li J
Biology direct 2024 Nov 18;19(1):117

---

CHI3L1 as a Prognostic Biomarker and Therapeutic Target in Glioma.

Zhou J, Zhao D, Tan H, Lan J, Bao Y
International journal of molecular sciences 2024 Jun 28;25(13)

---

Neuron-like lineage differentiation induced by exogenous Neurexin-1 as a potential therapeutic strategy for glioma.

Liao C, Chen Y, Peng D, Li S, Liu L, Li Q, Huang R, Huang L, Jiang T, Hu H, Li Y
Cancer letters 2024 Dec 8;611:217387

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Single-cell profile reveals the landscape of cardiac immunity and identifies a cardio-protective Ym-1(hi) neutrophil in myocardial ischemia-reperfusion injury.

Dong Y, Kang Z, Zhang Z, Zhang Y, Zhou H, Liu Y, Shuai X, Li J, Yin L, Wang X, Ma Y, Fan H, Jiang F, Lin Z, Ding C, Yun Jin K, Sarapultsev A, Li F, Zhang G, Xie T, Yin C, Cheng X, Luo S, Liu Y, Hu D
Science bulletin 2024 Apr 15;69(7):949-967

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Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury states.

Yao J, Dai S, Zhu R, Tan J, Zhao Q, Yin Y, Sun J, Du X, Ge L, Xu J, Hou C, Li N, Li J, Ji W, Zhu C, Zhang R, Li T
eLife 2024 Apr 12;12

---

ALKBH5-PYCR2 Positive Feedback Loop Promotes Proneural-Mesenchymal Transition Via Proline Synthesis In GBM.

Li L, Yang M, Pu X, Tang Y, Fei F, Li Z, Hou H, Chen Q, Wang Q, Wu Y, Zhang Y, Ren C, Gong A
Journal of Cancer 2023;14(9):1579-1591

---

Mining host candidate regulators of schistosomiasis-induced liver fibrosis in response to artesunate therapy through transcriptomics approach.

Yuan Y, Lv X, Wu Y, Weng Y, Dai F, Ding H, Chen R, Zheng B, Zhao W, Tong Q, Ding J, Lou D, Lai Y, Chu X, Zhao L, Lu S, Kong Q
PLoS neglected tropical diseases 2023 Sep;17(9):e0011626

---

CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation.

Jiang W, Zhu F, Xu H, Xu L, Li H, Yang X, Khan Afridi S, Lai S, Qiu X, Liu C, Li H, Long Y, Wang Y, Connolly K, Elias JA, Lee CG, Cui Y, Huang YA, Qiu W, Tang C
Science advances 2023 Sep 29;9(39):eadg8148

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Epithelial Membrane Protein-3 and Chitinase-3-like Protein-1 as New Prognostic Predictors of Glioma, a Two-Gene Study.

Shen K, Zhu J, Zhou S, Jin X, Zhai W, Sun L, Wu J, Yu Z
Current oncology (Toronto, Ont.) 2023 Sep 23;30(10):8686-8702

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CHI3L1 promotes myocardial fibrosis via regulating lncRNA TUG1/miR-495-3p/ETS1 axis.

Sun Y, Shan X, Guo J, Liu X, Ma D
Apoptosis : an international journal on programmed cell death 2023 Oct;28(9-10):1436-1451

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Dauricine regulates prostate cancer progression by inhibiting PI3K/AKT-dependent M2 polarization of macrophages.

Li M, Che N, Liu X, Xuan Y, Jin Y
Biochemical pharmacology 2023 Nov;217:115838

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Molecules of senescent glial cells differentiate Alzheimer's disease from ageing.

Dai L, Gao F, Wang Q, Lv X, Cheng Z, Wu Y, Chai X, Zetterberg H, Blennow K, Levey AI, Shi J, Shen Y, CANDI Consortium
Journal of neurology, neurosurgery, and psychiatry 2023 Jul;94(7):550-559

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The immune landscape of human thymic epithelial tumors.

Xin Z, Lin M, Hao Z, Chen D, Chen Y, Chen X, Xu X, Li J, Wu D, Chai Y, Wu P
Nature communications 2022 Sep 17;13(1):5463

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Chitooligosaccharides Improve the Efficacy of Checkpoint Inhibitors in a Mouse Model of Lung Cancer.

Johansen AZ, Carretta M, Thorseth ML, Khan S, Fjæstad KY, Brøchner CB, Linder H, Ankjærgaard C, Donia M, Chen I, Nielsen DL, Behrens CP, Madsen DH
Pharmaceutics 2022 May 12;14(5)

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Differential expression of Chitinase 3-Like 1 protein in appendicitis and appendix carcinomas.

Zhang Y, Li Y, Li F, Li L, Wang C, Wang H, Chen Y, Zhang C, Zhang Y, Wang W
Journal of clinical laboratory analysis 2022 Dec;36(12):e24790

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Hyaluronic acids mediate the infiltration, migration, and M2 polarization of macrophages: evaluating metabolic molecular phenotypes in gliomas.

Zhang H, Zhang N, Dai Z, Wang Z, Zhang X, Liang X, Zhang L, Feng S, Wu W, Ye W, Zhang J, Luo P, Liu Z, Cheng Q, Liu Z
Molecular oncology 2022 Dec;16(22):3927-3948

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Effects of chitinase-3-like protein 1 on brain death-induced hepatocyte apoptosis via PAR2-JNK-caspase-3.

Li ZX, Yang DJ, Huo ZK, Wen PH, Hu BW, Wang ZH, Guo WZ, Zhang SJ
Biochemical and biophysical research communications 2021 May 7;552:150-156

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Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment.

Shan Z, Li L, Atkins CL, Wang M, Wen Y, Jeong J, Moreno NF, Feng D, Gui X, Zhang N, Lee CG, Elias JA, Lee WM, Gao B, Lam FW, An Z, Ju C
eLife 2021 Jun 10;10

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MIN score predicts primary response to infliximab/adalimumab and vedolizumab therapy in patients with inflammatory bowel diseases.

Shi Y, He W, Zhong M, Yu M
Genomics 2021 Jul;113(4):1988-1998

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LINC00963 Promotes Ovarian Cancer Proliferation, Migration and EMT via the miR-378g /CHI3L1 Axis.

Liu W, Yang YJ, An Q
Cancer management and research 2020;12:463-473

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BYSL Promotes Glioblastoma Cell Migration, Invasion, and Mesenchymal Transition Through the GSK-3β/β-Catenin Signaling Pathway.

Sha Z, Zhou J, Wu Y, Zhang T, Li C, Meng Q, Musunuru PP, You F, Wu Y, Yu R, Gao S
Frontiers in oncology 2020;10:565225

---

Icariin induces apoptosis by suppressing autophagy in tamoxifen-resistant breast cancer cell line MCF-7/TAM.

Cheng X, Tan S, Duan F, Yuan Q, Li Q, Deng G
Breast cancer (Tokyo, Japan) 2019 Nov;26(6):766-775

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SSEA-4 and YKL-40 positive progenitor subtypes in the subventricular zone of developing human neocortex.

Brøchner CB, Møllgård K
Glia 2016 Jan;64(1):90-104

---

Outer brain barriers in rat and human development.

Brøchner CB, Holst CB, Møllgård K
Frontiers in neuroscience 2015;9:75

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The CHI3L1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CHI3L1. This antibody recognizes human,mouse,rat antigen. The CHI3L1 antibody has been validated for the following applications: ELISA, IHC analysis.

Appendix

12036-1-AP.pdf

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