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- References [248]
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- Product number
- MA1-21907 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- MUC5AC Monoclonal Antibody (45M1)
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Recommended positive controls: Suitable tissue control sections for Immunohistochemistry:Stomach. Amount of BSA in this product is equal to or less than 0.01%.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 45M1
- Vial size
- 500 µL
- Storage
- 4°C
Submitted references Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides.
ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer.
Hedgehog signaling in the airway epithelium of patients with chronic obstructive pulmonary disease.
Inflammation-induced upregulation of P2X(4) expression augments mucin secretion in airway epithelia.
Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke.
Cigarette smoke differentially affects IL-13-induced gene expression in human airway epithelial cells.
Mometasone Furoate Suppresses PMA-Induced MUC-5AC and MUC-2 Production in Human Airway Epithelial Cells.
Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway.
IFN-γ Blocks Development of an Asthma Phenotype in Rhinovirus-Infected Baby Mice by Inhibiting Type 2 Innate Lymphoid Cells.
Generation of airway epithelial cells with native characteristics from mouse induced pluripotent stem cells.
Production of 3-D Airway Organoids From Primary Human Airway Basal Cells and Their Use in High-Throughput Screening.
Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms.
Suppressive effects of coixol, glyceryl trilinoleate and natural products derived from Coix Lachryma-Jobi var. ma-yuen on gene expression, production and secretion of airway MUC5AC mucin.
GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells.
Construction of an in vitro primary lung co-culture platform derived from New Zealand white rabbits.
The effect of Nrf2 knockout on ocular surface protection from acute tobacco smoke exposure: evidence from Nrf2 knockout mice.
The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma.
Identification of PAM4 (clivatuzumab)-reactive epitope on MUC5AC: a promising biomarker and therapeutic target for pancreatic cancer.
Macrolides attenuate phorbol ester-induced tumor necrosis factor-α and mucin production from human airway epithelial cells.
Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation.
Club cell 10-kDa protein attenuates airway mucus hypersecretion and inflammation.
Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells.
Supplementation with γ-tocopherol attenuates endotoxin-induced airway neutrophil and mucous cell responses in rats.
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma.
Effects of the root of Platycodon grandiflorum on airway mucin hypersecretion in vivo and platycodin D(3) and deapi-platycodin on production and secretion of airway mucin in vitro.
Mucosal reactive oxygen species are required for antiviral response: role of Duox in influenza a virus infection.
Inhibition of TNF-α-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-κB signaling in airway epithelial cells.
Effects of ophiopogonin D and spicatoside A derived from Liriope Tuber on secretion and production of mucin from airway epithelial cells.
Gastric signet ring cell carcinoma presenting as diffuse, infiltrating myositis--a case report and review of the literature.
Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas.
Cigarette smoke alters non-neuronal cholinergic system components inducing MUC5AC production in the H292 cell line.
The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium.
HIV gp120 induces mucus formation in human bronchial epithelial cells through CXCR4/α7-nicotinic acetylcholine receptors.
Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma.
Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis.
Effect of Prunetin on TNF-α-Induced MUC5AC Mucin Gene Expression, Production, Degradation of IκB and Translocation of NF-κB p65 in Human Airway Epithelial Cells.
TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells.
Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice.
Vesicular nucleotide transporter regulates the nucleotide content in airway epithelial mucin granules.
Early Gastric Cancer-Like Advanced Gastric Cancer versus Advanced Gastric Cancer-Like Early Gastric Cancer.
Blocking of thromboxane A₂ receptor attenuates airway mucus hyperproduction induced by cigarette smoke.
Regulator of G-protein signaling 2 inhibits acid-induced mucin5AC hypersecretion in human airway epithelial cells.
TGF-β₂ decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells.
Rhythmic pressure waves induce mucin5AC expression via an EGFR-mediated signaling pathway in human airway epithelial cells.
Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs.
Mucin deficiency causes functional and structural changes of the ocular surface.
Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation.
Triiodothyronine represses MUC5AC expression by antagonizing Sp1 binding to its promoter in human bronchial epithelial HBE16 cells.
Silibinin regulates gene expression, production and secretion of mucin from cultured airway epithelial cells.
Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo.
Atherogenic and pulmonary responses of ApoE- and LDL receptor-deficient mice to sidestream cigarette smoke.
Effect of Chrysin on Gene Expression and Production of MUC5AC Mucin from Cultured Airway Epithelial Cells.
Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.
Change of mucosal color in early gastric cancer.
Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells.
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
Biopsy harvesting site and distance from the explant affect conjunctival epithelial phenotype ex vivo.
Quercetin attenuates airway inflammation and mucus production induced by cigarette smoke in rats.
Regional conjunctivectomy with postoperative mitomycin C to treat chronic hyperemic conjunctiva.
Expression of MUC5AC and Trefoil Peptide 1 (TFF1) in the Subtypes of Intestinal Metaplasia.
Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.
Increased human Ca²⁺-activated Cl⁻ channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients.
Asian sand dust enhances allergen-induced th2 allergic inflammatory changes and mucin production in BALB/c mouse lungs.
Divergent effects of urban particulate air pollution on allergic airway responses in experimental asthma: a comparison of field exposure studies.
Dual oxidase 2 is essential for the toll-like receptor 5-mediated inflammatory response in airway mucosa.
Chronic mechanical stress induces mucin 5AC expression in human bronchial epithelial cells through ERK dependent pathways.
Expression analysis of the regenerating gene (Reg) family members Reg-IIIβ and Reg-IIIγ in the mouse during development.
β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium.
Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin.
Regulation of particulate matter-induced mucin secretion by transient receptor potential vanilloid 1 receptors.
Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin.
Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia.
Development of primary human nasal epithelial cell cultures for the study of cystic fibrosis pathophysiology.
Cigarette smoke induces growth differentiation factor 15 production in human lung epithelial cells: implication in mucin over-expression.
Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways.
Effects of an oral MMP-9 and -12 inhibitor, AZD1236, on biomarkers in moderate/severe COPD: a randomised controlled trial.
The inhibition of aldose reductase on mucus production induced by interleukin-13 in the human bronchial epithelial cells.
Flagellin/TLR5 responses induce mucus hypersecretion by activating EGFR via an epithelial cell signaling cascades.
Effects of furosemide on allergic asthmatic responses in mice.
Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice.
IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides.
RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism.
Mucin from rheumatoid arthritis synovial fluid enhances interleukin-6 production by human peripheral blood mononuclear cells.
Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice.
Notch-dependent differentiation of adult airway basal stem cells.
Inhibition of airway MUC5AC mucin production and gene expression induced by epidermal growth factor or phorbol ester by glycyrrhizin and carbenoxolone.
Regulation of cigarette smoke-induced mucin expression by neuregulin1β/ErbB3 signalling in human airway epithelial cells.
Induction of mucin and MUC5AC expression by the protease activity of Aspergillus fumigatus in airway epithelial cells.
Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways.
IL-13-induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cells.
Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells.
Combined tubular adenocarcinoma and hepatoid adenocarcinoma arising in Barrett esophagus.
Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro.
MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac.
Critical role of cytosolic phospholipase A2{alpha} in bronchial mucus hypersecretion in CFTR-deficient mice.
Primary signet-ring cell carcinoma of the cervix: case report and review of the literature.
Acute pulmonary response of mice to multi-wall carbon nanotubes.
Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway.
Simvastatin attenuates acrolein-induced mucin production in rats: involvement of the Ras/extracellular signal-regulated kinase pathway.
Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotides.
Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.
Sphingosine kinase 1 regulates mucin production via ERK phosphorylation.
Prognostic significance of MUC1, MUC2 and MUC5AC expressions in gastric carcinoma.
Prognostic significance of MUC1, MUC2 and MUC5AC expressions in gastric carcinoma.
Nicotine suppresses inflammatory factors in HBE16 airway epithelial cells after exposure to cigarette smoke extract and lipopolysaccharide.
Establishment and characterization of a murine xenograft model of appendiceal mucinous adenocarcinoma.
Exploring the peritoneal surface malignancy phenotype--a pilot immunohistochemical study of human pseudomyxoma peritonei and derived animal models.
MUC5AC expression in human middle ear epithelium of patients with otitis media.
Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allosteric alpha7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditions.
Cigarette smoke total particulate matter increases mucous secreting cell numbers in vitro: a potential model of goblet cell hyperplasia.
Multipotential ability of primitive germ cells from neonatal pig testis cultured in vitro.
Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.
Effects of cigarette smoking on mucin production in human middle ear epithelial cells.
Chronic intermittent mechanical stress increases MUC5AC protein expression.
Structure of the oesophagus and morphometric, histochemical-immunohistochemical profiles of the oesophageal gland during the post-hatching period of Japanese quails (Coturnix coturnix japonica).
Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells.
Mitochondrial dysfunction increases allergic airway inflammation.
Rhinovirus-induced major airway mucin production involves a novel TLR3-EGFR-dependent pathway.
A critical role of SHP-1 in regulation of type 2 inflammation in the lung.
Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats.
A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice.
Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological phenomenon using genome wide expression data.
Different effects of telithromycin on MUC5AC production induced by human neutrophil peptide-1 or lipopolysaccharide in NCI-H292 cells compared with azithromycin and clarithromycin.
Nitric oxide gas phase release in human small airway epithelial cells.
Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease.
Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury.
CREB mediates prostaglandin F2alpha-induced MUC5AC overexpression.
Suppression of prostaglandin E2-induced MUC5AC overproduction by RGS4 in the airway.
Unclassified mucin phenotype of gastric adenocarcinoma exhibits the highest invasiveness.
EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors.
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
Protease-activated receptor-2 (PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro.
CD34+ testicular stromal cells support long-term expansion of embryonic and adult stem and progenitor cells.
Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans.
MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway.
Oligopotent stem cells are distributed throughout the mammalian ocular surface.
Role of epidermal growth factor receptor in maintaining airway goblet cell hyperplasia in rats sensitized to allergen.
Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease.
Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease.
IL-13 induces a bronchial epithelial phenotype that is profibrotic.
Expression of mucin 3 and mucin 5AC in arthritic synovial tissue.
Synergistic induction of MUC5AC mucin by nontypeable Haemophilus influenzae and Streptococcus pneumoniae.
IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
Reactive oxygen species regulate Pseudomonas aeruginosa lipopolysaccharide-induced MUC5AC mucin expression via PKC-NADPH oxidase-ROS-TGF-alpha signaling pathways in human airway epithelial cells.
Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.
Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.
Munc18/SNARE proteins' regulation of exocytosis in guinea pig duodenal Brunner's gland acini.
Munc18/SNARE proteins' regulation of exocytosis in guinea pig duodenal Brunner's gland acini.
Histamine induces MUC5AC expression via a hCLCA1 pathway.
Differentiation of tracheal basal cells to ciliated cells and tissue reconstruction on the synthesized basement membrane substratum in vitro.
IL-13 regulates cilia loss and foxj1 expression in human airway epithelium.
Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice.
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
Regulation of mucin gene expression by CREB via a nonclassical retinoic acid signaling pathway.
Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.
Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.
Human bronchial epithelial cell transcriptome: gene expression changes following acute exposure to whole cigarette smoke in vitro.
A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice.
Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction.
Nitric oxide induces MUC5AC mucin in respiratory epithelial cells through PKC and ERK dependent pathways.
Complement C3a regulates Muc5ac expression by airway Clara cells independently of Th2 responses.
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm.
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation.
Coagulation factor Xa modulates airway remodeling in a murine model of asthma.
A morphometric study of mucins and small airway plugging in cystic fibrosis.
A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae.
A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae.
Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori.
CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure.
Maintenance of airway epithelium in acutely rejected orthotopic vascularized mouse lung transplants.
Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas.
Effects of sulfur dioxide on the expressions of MUC5AC and ICAM-1 in airway of asthmatic rats.
Persistent effects induced by IL-13 in the lung.
Effect of fibroblasts on tracheal epithelial regeneration in vitro.
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers.
Characterizing mucous cell remodeling in cystic fibrosis: relationship to neutrophils.
Cigarette smoke extract modulates respiratory defence mechanisms through effects on T-cells and airway epithelial cells.
Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members.
The inhibitory effects of rebamipide on cigarette smoke-induced airway mucin production.
An enzyme-linked immunosorbent assay (ELISA) for the determination of mucin levels in bronchoalveolar lavage fluid.
Rhamnolipids are virulence factors that promote early infiltration of primary human airway epithelia by Pseudomonas aeruginosa.
Peroxisome proliferator-activated receptor-gamma inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells.
ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo.
Culture of murine nasal epithelia: model for cystic fibrosis.
Effects of Helicobacter pylori infection on mucin expression in gastric carcinoma and pericancerous tissues.
Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals.
Differential Muc2 and Muc5ac secretion by stimulated guinea pig tracheal epithelial cells in vitro.
MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an epidermal growth factor receptor pathway in the human gallbladder.
Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells.
A three-dimensional model of differentiation of immortalized human bronchial epithelial cells.
Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C{delta}-mediated mechanism.
Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C{delta}-mediated mechanism.
Gefitinib inhibits MUC5AC synthesis in mucin-secreting non-small cell lung cancer cells.
Effect of suplatast tosilate on goblet cell metaplasia in patients with asthma.
Tissue microarray analysis of multiple gene expression in intestinal metaplasia, dysplasia and carcinoma of the stomach.
Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm.
Promoter analysis and aberrant expression of the MUC5B gene in diffuse panbronchiolitis.
Differences in biological features of gastric dysplasia, indefinite dysplasia, reactive hyperplasia and discriminant analysis of these lesions.
Differences in biological features of gastric dysplasia, indefinite dysplasia, reactive hyperplasia and discriminant analysis of these lesions.
Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells.
Mucin biosynthesis: upregulation of core 2 beta 1,6 N-acetylglucosaminyltransferase by retinoic acid and Th2 cytokines in a human airway epithelial cell line.
Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells.
E-cadherin promotes EGFR-mediated cell differentiation and MUC5AC mucin expression in cultured human airway epithelial cells.
Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells.
pH-dependent intraluminal organization of mucin granules in live human mucous/goblet cells.
Relationship between MUC5AC and altered expression of MLH1 protein in mucinous and non-mucinous colorectal carcinomas.
Azithromycin inhibits MUC5AC production induced by the Pseudomonas aeruginosa autoinducer N-(3-Oxododecanoyl) homoserine lactone in NCI-H292 Cells.
Intranasal steroids decrease eosinophils but not mucin expression in nasal polyps.
Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma.
Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma.
Differentiated cultures of primary hamster tracheal airway epithelial cells.
PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms.
A mouse model for the study of recurrent corneal epithelial erosions: alpha9beta1 integrin implicated in progression of the disease.
A mouse model for the study of recurrent corneal epithelial erosions: alpha9beta1 integrin implicated in progression of the disease.
Differentiation-dependent responsiveness of bronchial epithelial cells to IL-4/13 stimulation.
Correlation between MUC5AC expression and the prognosis of patients with adenocarcinoma of the uterine cervix.
Correlation between MUC5AC expression and the prognosis of patients with adenocarcinoma of the uterine cervix.
Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia.
Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling.
Reduced airway inflammation and remodeling in parallel with mucin 5AC protein expression decreased by s-carboxymethylcysteine, a mucoregulant, in the airways of rats exposed to sulfur dioxide.
Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression.
Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression.
IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation.
Alterations of MUC1 and MUC3 expression in gastric carcinoma: relevance to patient clinicopathological features.
Alterations of MUC1 and MUC3 expression in gastric carcinoma: relevance to patient clinicopathological features.
Profiling, comparison and validation of gene expression in gastric carcinoma and normal stomach.
Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats.
Role of MUC1 and MUC5AC expressions as prognostic indicators in gastric carcinomas.
Ozone exposure enhances endotoxin-induced mucous cell metaplasia in rat pulmonary airways.
Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway.
Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation.
Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways.
Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist.
Viral induction of a chronic asthma phenotype and genetic segregation from the acute response.
Effect of gefarnate on the ocular surface in squirrel monkeys.
Effect of gefarnate on the ocular surface in squirrel monkeys.
Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway.
Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation.
Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation.
Ethanol vapour-fixation of rat lung for immunocytochemistry investigations.
Ethanol vapour-fixation of rat lung for immunocytochemistry investigations.
Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils.
Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils.
Selective secretion and replenishment of discrete mucin glycoforms from intestinal goblet cells.
Selective secretion and replenishment of discrete mucin glycoforms from intestinal goblet cells.
Lai Y, Fois G, Flores JR, Tuvim MJ, Zhou Q, Yang K, Leitz J, Peters J, Zhang Y, Pfuetzner RA, Esquivies L, Jones P, Frick M, Dickey BF, Brunger AT
Nature 2022 Mar;603(7903):949-956
Nature 2022 Mar;603(7903):949-956
ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer.
Napoli M, Wu SJ, Gore BL, Abbas HA, Lee K, Checker R, Dhar S, Rajapakshe K, Tan AC, Lee MG, Coarfa C, Flores ER
Nature communications 2022 Feb 1;13(1):614
Nature communications 2022 Feb 1;13(1):614
Hedgehog signaling in the airway epithelium of patients with chronic obstructive pulmonary disease.
Tam A, Hughes M, McNagny KM, Obeidat M, Hackett TL, Leung JM, Shaipanich T, Dorscheid DR, Singhera GK, Yang CWT, Paré PD, Hogg JC, Nickle D, Sin DD
Scientific reports 2019 Mar 4;9(1):3353
Scientific reports 2019 Mar 4;9(1):3353
Inflammation-induced upregulation of P2X(4) expression augments mucin secretion in airway epithelia.
Winkelmann VE, Thompson KE, Neuland K, Jaramillo AM, Fois G, Schmidt H, Wittekindt OH, Han W, Tuvim MJ, Dickey BF, Dietl P, Frick M
American journal of physiology. Lung cellular and molecular physiology 2019 Jan 1;316(1):L58-L70
American journal of physiology. Lung cellular and molecular physiology 2019 Jan 1;316(1):L58-L70
Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke.
Glass K, Thibault D, Guo F, Mitchel JA, Pham B, Qiu W, Li Y, Jiang Z, Castaldi PJ, Silverman EK, Raby B, Park JA, Yuan GC, Zhou X
Scientific reports 2018 Aug 24;8(1):12750
Scientific reports 2018 Aug 24;8(1):12750
Cigarette smoke differentially affects IL-13-induced gene expression in human airway epithelial cells.
Mertens TCJ, van der Does AM, Kistemaker LE, Ninaber DK, Taube C, Hiemstra PS
Physiological reports 2017 Jul;5(13)
Physiological reports 2017 Jul;5(13)
Mometasone Furoate Suppresses PMA-Induced MUC-5AC and MUC-2 Production in Human Airway Epithelial Cells.
Poachanukoon O, Koontongkaew S, Monthanapisut P, Pattanacharoenchai N
Tuberculosis and respiratory diseases 2017 Jan;80(1):60-68
Tuberculosis and respiratory diseases 2017 Jan;80(1):60-68
Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway.
Weeden CE, Chen Y, Ma SB, Hu Y, Ramm G, Sutherland KD, Smyth GK, Asselin-Labat ML
PLoS biology 2017 Jan;15(1):e2000731
PLoS biology 2017 Jan;15(1):e2000731
IFN-γ Blocks Development of an Asthma Phenotype in Rhinovirus-Infected Baby Mice by Inhibiting Type 2 Innate Lymphoid Cells.
Han M, Hong JY, Jaipalli S, Rajput C, Lei J, Hinde JL, Chen Q, Hershenson NM, Bentley JK, Hershenson MB
American journal of respiratory cell and molecular biology 2017 Feb;56(2):242-251
American journal of respiratory cell and molecular biology 2017 Feb;56(2):242-251
Generation of airway epithelial cells with native characteristics from mouse induced pluripotent stem cells.
Yoshie S, Imaizumi M, Nakamura R, Otsuki K, Ikeda M, Nomoto Y, Wada I, Omori K
Cell and tissue research 2016 May;364(2):319-30
Cell and tissue research 2016 May;364(2):319-30
Production of 3-D Airway Organoids From Primary Human Airway Basal Cells and Their Use in High-Throughput Screening.
Hild M, Jaffe AB
Current protocols in stem cell biology 2016 May 12;37:IE.9.1-IE.9.15
Current protocols in stem cell biology 2016 May 12;37:IE.9.1-IE.9.15
Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms.
Kim YB, Lee SY, Kim JH, Sung IK, Park HS, Shim CS, Han HS
Gut and liver 2016 Mar;10(2):220-7
Gut and liver 2016 Mar;10(2):220-7
Suppressive effects of coixol, glyceryl trilinoleate and natural products derived from Coix Lachryma-Jobi var. ma-yuen on gene expression, production and secretion of airway MUC5AC mucin.
Lee HJ, Ryu J, Park SH, Seo EK, Han AR, Lee SK, Kim YS, Hong JH, Seok JH, Lee CJ
Archives of pharmacal research 2015;38(5):620-7
Archives of pharmacal research 2015;38(5):620-7
GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells.
Gao X, Bali AS, Randell SH, Hogan BL
The Journal of cell biology 2015 Nov 9;211(3):669-82
The Journal of cell biology 2015 Nov 9;211(3):669-82
Construction of an in vitro primary lung co-culture platform derived from New Zealand white rabbits.
Powell JD, Hess BM, Hutchison JR, Straub TM
In vitro cellular & developmental biology. Animal 2015 May;51(5):433-40
In vitro cellular & developmental biology. Animal 2015 May;51(5):433-40
The effect of Nrf2 knockout on ocular surface protection from acute tobacco smoke exposure: evidence from Nrf2 knockout mice.
Kojima T, Dogru M, Higuchi A, Nagata T, Ibrahim OM, Inaba T, Tsubota K
The American journal of pathology 2015 Mar;185(3):776-85
The American journal of pathology 2015 Mar;185(3):776-85
The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma.
Krah NM, De La O JP, Swift GH, Hoang CQ, Willet SG, Chen Pan F, Cash GM, Bronner MP, Wright CV, MacDonald RJ, Murtaugh LC
eLife 2015 Jul 7;4
eLife 2015 Jul 7;4
Identification of PAM4 (clivatuzumab)-reactive epitope on MUC5AC: a promising biomarker and therapeutic target for pancreatic cancer.
Liu D, Chang CH, Gold DV, Goldenberg DM
Oncotarget 2015 Feb 28;6(6):4274-85
Oncotarget 2015 Feb 28;6(6):4274-85
Macrolides attenuate phorbol ester-induced tumor necrosis factor-α and mucin production from human airway epithelial cells.
Poachanukoon O, Koontongkaew S, Monthanapisut P, Pattanacharoenchai N
Pharmacology 2014;93(1-2):92-9
Pharmacology 2014;93(1-2):92-9
Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation.
Persson BD, Jaffe AB, Fearns R, Danahay H
PloS one 2014;9(7):e102368
PloS one 2014;9(7):e102368
Club cell 10-kDa protein attenuates airway mucus hypersecretion and inflammation.
Tokita E, Tanabe T, Asano K, Suzaki H, Rubin BK
The European respiratory journal 2014 Oct;44(4):1002-10
The European respiratory journal 2014 Oct;44(4):1002-10
Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells.
Sikder MA, Lee HJ, Ryu J, Park SH, Kim JO, Hong JH, Seok JH, Lee CJ
Tuberculosis and respiratory diseases 2014 Mar;76(3):120-6
Tuberculosis and respiratory diseases 2014 Mar;76(3):120-6
Supplementation with γ-tocopherol attenuates endotoxin-induced airway neutrophil and mucous cell responses in rats.
Wagner JG, Birmingham NP, Jackson-Humbles D, Jiang Q, Harkema JR, Peden DB
Free radical biology & medicine 2014 Mar;68:101-9
Free radical biology & medicine 2014 Mar;68:101-9
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma.
von Figura G, Fukuda A, Roy N, Liku ME, Morris Iv JP, Kim GE, Russ HA, Firpo MA, Mulvihill SJ, Dawson DW, Ferrer J, Mueller WF, Busch A, Hertel KJ, Hebrok M
Nature cell biology 2014 Mar;16(3):255-67
Nature cell biology 2014 Mar;16(3):255-67
Effects of the root of Platycodon grandiflorum on airway mucin hypersecretion in vivo and platycodin D(3) and deapi-platycodin on production and secretion of airway mucin in vitro.
Ryu J, Lee HJ, Park SH, Kim J, Lee D, Lee SK, Kim YS, Hong JH, Seok JH, Lee CJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2014 Mar 15;21(4):529-33
Phytomedicine : international journal of phytotherapy and phytopharmacology 2014 Mar 15;21(4):529-33
Mucosal reactive oxygen species are required for antiviral response: role of Duox in influenza a virus infection.
Strengert M, Jennings R, Davanture S, Hayes P, Gabriel G, Knaus UG
Antioxidants & redox signaling 2014 Jun 10;20(17):2695-709
Antioxidants & redox signaling 2014 Jun 10;20(17):2695-709
Inhibition of TNF-α-induced MUC5AC mucin gene expression and production by wogonin through the inactivation of NF-κB signaling in airway epithelial cells.
Sikder MA, Lee HJ, Mia MZ, Park SH, Ryu J, Kim JH, Min SY, Hong JH, Seok JH, Lee CJ
Phytotherapy research : PTR 2014 Jan;28(1):62-8
Phytotherapy research : PTR 2014 Jan;28(1):62-8
Effects of ophiopogonin D and spicatoside A derived from Liriope Tuber on secretion and production of mucin from airway epithelial cells.
Park SH, Lee HJ, Ryu J, Son KH, Kwon SY, Lee SK, Kim YS, Hong JH, Seok JH, Lee CJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2014 Jan 15;21(2):172-6
Phytomedicine : international journal of phytotherapy and phytopharmacology 2014 Jan 15;21(2):172-6
Gastric signet ring cell carcinoma presenting as diffuse, infiltrating myositis--a case report and review of the literature.
Futtrup TB, Hasselby JP, Baeksgaard L
Journal of gastrointestinal cancer 2014 Dec;45 Suppl 1:62-5
Journal of gastrointestinal cancer 2014 Dec;45 Suppl 1:62-5
Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas.
Van de Laar E, Clifford M, Hasenoeder S, Kim BR, Wang D, Lee S, Paterson J, Vu NM, Waddell TK, Keshavjee S, Tsao MS, Ailles L, Moghal N
Respiratory research 2014 Dec 31;15(1):160
Respiratory research 2014 Dec 31;15(1):160
Cigarette smoke alters non-neuronal cholinergic system components inducing MUC5AC production in the H292 cell line.
Montalbano AM, Albano GD, Anzalone G, Bonanno A, Riccobono L, Di Sano C, Gagliardo R, Siena L, Pieper MP, Gjomarkaj M, Profita M
European journal of pharmacology 2014 Aug 5;736:35-43
European journal of pharmacology 2014 Aug 5;736:35-43
The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium.
Seibold MA, Smith RW, Urbanek C, Groshong SD, Cosgrove GP, Brown KK, Schwarz MI, Schwartz DA, Reynolds SD
PloS one 2013;8(3):e58658
PloS one 2013;8(3):e58658
HIV gp120 induces mucus formation in human bronchial epithelial cells through CXCR4/α7-nicotinic acetylcholine receptors.
Gundavarapu S, Mishra NC, Singh SP, Langley RJ, Saeed AI, Feghali-Bostwick CA, McIntosh JM, Hutt J, Hegde R, Buch S, Sopori ML
PloS one 2013;8(10):e77160
PloS one 2013;8(10):e77160
Differential effects of rapamycin and dexamethasone in mouse models of established allergic asthma.
Mushaben EM, Brandt EB, Hershey GK, Le Cras TD
PloS one 2013;8(1):e54426
PloS one 2013;8(1):e54426
Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis.
Warneke VS, Behrens HM, Haag J, Krüger S, Simon E, Mathiak M, Ebert MP, Röcken C
British journal of cancer 2013 Oct 15;109(8):2217-27
British journal of cancer 2013 Oct 15;109(8):2217-27
Effect of Prunetin on TNF-α-Induced MUC5AC Mucin Gene Expression, Production, Degradation of IκB and Translocation of NF-κB p65 in Human Airway Epithelial Cells.
Ryu J, Lee HJ, Park SH, Sikder MA, Kim JO, Hong JH, Seok JH, Lee CJ
Tuberculosis and respiratory diseases 2013 Nov;75(5):205-9
Tuberculosis and respiratory diseases 2013 Nov;75(5):205-9
TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells.
Mitrovic S, Nogueira C, Cantero-Recasens G, Kiefer K, Fernández-Fernández JM, Popoff JF, Casano L, Bard FA, Gomez R, Valverde MA, Malhotra V
eLife 2013 May 28;2:e00658
eLife 2013 May 28;2:e00658
Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice.
Park JA, Sharif AS, Shiomi T, Kobzik L, Kasahara DI, Tschumperlin DJ, Voynow J, Drazen JM
American journal of physiology. Lung cellular and molecular physiology 2013 May 15;304(10):L701-7
American journal of physiology. Lung cellular and molecular physiology 2013 May 15;304(10):L701-7
Vesicular nucleotide transporter regulates the nucleotide content in airway epithelial mucin granules.
Sesma JI, Kreda SM, Okada SF, van Heusden C, Moussa L, Jones LC, O'Neal WK, Togawa N, Hiasa M, Moriyama Y, Lazarowski ER
American journal of physiology. Cell physiology 2013 May 15;304(10):C976-84
American journal of physiology. Cell physiology 2013 May 15;304(10):C976-84
Early Gastric Cancer-Like Advanced Gastric Cancer versus Advanced Gastric Cancer-Like Early Gastric Cancer.
Park HS, Lee SY, Hong SN, Kim JH, Sung IK, Park HS, Shim CS, Jin CJ
Clinical endoscopy 2013 Mar;46(2):155-60
Clinical endoscopy 2013 Mar;46(2):155-60
Blocking of thromboxane A₂ receptor attenuates airway mucus hyperproduction induced by cigarette smoke.
An J, Li JQ, Wang T, Li XO, Guo LL, Wan C, Liao ZL, Dong JJ, Xu D, Wen FQ
European journal of pharmacology 2013 Mar 5;703(1-3):11-7
European journal of pharmacology 2013 Mar 5;703(1-3):11-7
Regulator of G-protein signaling 2 inhibits acid-induced mucin5AC hypersecretion in human airway epithelial cells.
Liu C, Li Q, Zhou X, Kolosov VP, Perelman JM
Respiratory physiology & neurobiology 2013 Jan 15;185(2):265-71
Respiratory physiology & neurobiology 2013 Jan 15;185(2):265-71
TGF-β₂ decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells.
Harrop CA, Gore RB, Evans CM, Thornton DJ, Herrick SE
Experimental lung research 2013 Feb;39(1):39-47
Experimental lung research 2013 Feb;39(1):39-47
Rhythmic pressure waves induce mucin5AC expression via an EGFR-mediated signaling pathway in human airway epithelial cells.
Liu C, Li Q, Zhou X, Kolosov VP, Perelman JM
DNA and cell biology 2013 Aug;32(8):423-9
DNA and cell biology 2013 Aug;32(8):423-9
Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs.
Bartlett JA, Albertolle ME, Wohlford-Lenane C, Pezzulo AA, Zabner J, Niles RK, Fisher SJ, McCray PB Jr, Williams KE
American journal of physiology. Lung cellular and molecular physiology 2013 Aug 1;305(3):L256-66
American journal of physiology. Lung cellular and molecular physiology 2013 Aug 1;305(3):L256-66
Mucin deficiency causes functional and structural changes of the ocular surface.
Floyd AM, Zhou X, Evans C, Rompala OJ, Zhu L, Wang M, Chen Y
PloS one 2012;7(12):e50704
PloS one 2012;7(12):e50704
Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation.
Jang S, Park JW, Cha HR, Jung SY, Lee JE, Jung SS, Kim JO, Kim SY, Lee CS, Park HS
International journal of nanomedicine 2012;7:1329-43
International journal of nanomedicine 2012;7:1329-43
Triiodothyronine represses MUC5AC expression by antagonizing Sp1 binding to its promoter in human bronchial epithelial HBE16 cells.
Wang X, Li Q, Zhou X, Kolosov VP, Perelman JM
Journal of biomedicine & biotechnology 2012;2012:648170
Journal of biomedicine & biotechnology 2012;2012:648170
Silibinin regulates gene expression, production and secretion of mucin from cultured airway epithelial cells.
Kim KD, Lee HJ, Lim SP, Sikder A, Lee SY, Lee CJ
Phytotherapy research : PTR 2012 Sep;26(9):1301-7
Phytotherapy research : PTR 2012 Sep;26(9):1301-7
Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo.
Gundavarapu S, Wilder JA, Mishra NC, Rir-Sima-Ah J, Langley RJ, Singh SP, Saeed AI, Jaramillo RJ, Gott KM, Peña-Philippides JC, Harrod KS, McIntosh JM, Buch S, Sopori ML
The Journal of allergy and clinical immunology 2012 Sep;130(3):770-780.e11
The Journal of allergy and clinical immunology 2012 Sep;130(3):770-780.e11
Atherogenic and pulmonary responses of ApoE- and LDL receptor-deficient mice to sidestream cigarette smoke.
Han SG, Howatt DA, Daugherty A, Gairola CG
Toxicology 2012 Sep 28;299(2-3):133-8
Toxicology 2012 Sep 28;299(2-3):133-8
Effect of Chrysin on Gene Expression and Production of MUC5AC Mucin from Cultured Airway Epithelial Cells.
Shin HD, Lee HJ, Sikder MA, Park SH, Ryu J, Hong JH, Kim JO, Seok JH, Lee CJ
Tuberculosis and respiratory diseases 2012 Oct;73(4):204-9
Tuberculosis and respiratory diseases 2012 Oct;73(4):204-9
Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.
Kang H, An HJ, Song JY, Kim TH, Heo JH, Ahn DH, Kim G
Histopathology 2012 Oct;61(4):576-86
Histopathology 2012 Oct;61(4):576-86
Change of mucosal color in early gastric cancer.
Lee HH, Lee SY, Yoon HY, Hong SN, Kim JH, Sung IK, Park HS, Shim CS, Han HS
Journal of digestive diseases 2012 Oct;13(10):510-6
Journal of digestive diseases 2012 Oct;13(10):510-6
Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells.
Seagrave J, Albrecht HH, Hill DB, Rogers DF, Solomon G
Respiratory research 2012 Oct 31;13(1):98
Respiratory research 2012 Oct 31;13(1):98
Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR
Proceedings of the National Academy of Sciences of the United States of America 2012 Oct 2;109(40):16354-9
Proceedings of the National Academy of Sciences of the United States of America 2012 Oct 2;109(40):16354-9
Biopsy harvesting site and distance from the explant affect conjunctival epithelial phenotype ex vivo.
Fostad IG, Eidet JR, Shatos MA, Utheim TP, Utheim OA, Raeder S, Dartt DA
Experimental eye research 2012 Nov;104:15-25
Experimental eye research 2012 Nov;104:15-25
Quercetin attenuates airway inflammation and mucus production induced by cigarette smoke in rats.
Yang T, Luo F, Shen Y, An J, Li X, Liu X, Ying B, Liao Z, Dong J, Guo L, Wang T, Xu D, Chen L, Wen F
International immunopharmacology 2012 May;13(1):73-81
International immunopharmacology 2012 May;13(1):73-81
Regional conjunctivectomy with postoperative mitomycin C to treat chronic hyperemic conjunctiva.
Kim BH
Cornea 2012 Mar;31(3):236-44
Cornea 2012 Mar;31(3):236-44
Expression of MUC5AC and Trefoil Peptide 1 (TFF1) in the Subtypes of Intestinal Metaplasia.
Song JY, Kim BW, Lee AW, Lee KY, Chung IS, Lee BI, Choi H, Ji JS, Chae HS, Choi KY
Clinical endoscopy 2012 Jun;45(2):151-4
Clinical endoscopy 2012 Jun;45(2):151-4
Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.
Vincent DF, Gout J, Chuvin N, Arfi V, Pommier RM, Bertolino P, Jonckheere N, Ripoche D, Kaniewski B, Martel S, Langlois JB, Goddard-Léon S, Colombe A, Janier M, Van Seuningen I, Losson R, Valcourt U, Treilleux I, Dubus P, Bardeesy N, Bartholin L
The American journal of pathology 2012 Jun;180(6):2214-21
The American journal of pathology 2012 Jun;180(6):2214-21
Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.
Lee J, Komatsu K, Lee BC, Lim JH, Jono H, Xu H, Kai H, Zhang ZJ, Yan C, Li JD
The Journal of biological chemistry 2012 Jun 29;287(27):22799-811
The Journal of biological chemistry 2012 Jun 29;287(27):22799-811
Increased human Ca²⁺-activated Cl⁻ channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients.
Iwashita H, Fujimoto K, Morita S, Nakanishi A, Kubo K
Respiratory research 2012 Jun 25;13(1):55
Respiratory research 2012 Jun 25;13(1):55
Asian sand dust enhances allergen-induced th2 allergic inflammatory changes and mucin production in BALB/c mouse lungs.
Kang IG, Jung JH, Kim ST
Allergy, asthma & immunology research 2012 Jul;4(4):206-13
Allergy, asthma & immunology research 2012 Jul;4(4):206-13
Divergent effects of urban particulate air pollution on allergic airway responses in experimental asthma: a comparison of field exposure studies.
Wagner JG, Morishita M, Keeler GJ, Harkema JR
Environmental health : a global access science source 2012 Jul 6;11:45
Environmental health : a global access science source 2012 Jul 6;11:45
Dual oxidase 2 is essential for the toll-like receptor 5-mediated inflammatory response in airway mucosa.
Joo JH, Ryu JH, Kim CH, Kim HJ, Suh MS, Kim JO, Chung SY, Lee SN, Kim HM, Bae YS, Yoon JH
Antioxidants & redox signaling 2012 Jan 1;16(1):57-70
Antioxidants & redox signaling 2012 Jan 1;16(1):57-70
Chronic mechanical stress induces mucin 5AC expression in human bronchial epithelial cells through ERK dependent pathways.
Li N, Li Q, Zhou XD, Kolosov VP, Perelman JM
Molecular biology reports 2012 Feb;39(2):1019-28
Molecular biology reports 2012 Feb;39(2):1019-28
Expression analysis of the regenerating gene (Reg) family members Reg-IIIβ and Reg-IIIγ in the mouse during development.
Matsumoto S, Konishi H, Maeda R, Kiryu-Seo S, Kiyama H
The Journal of comparative neurology 2012 Feb 15;520(3):479-94
The Journal of comparative neurology 2012 Feb 15;520(3):479-94
β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium.
Hashimoto S, Chen H, Que J, Brockway BL, Drake JA, Snyder JC, Randell SH, Stripp BR
Journal of cell science 2012 Feb 15;125(Pt 4):932-42
Journal of cell science 2012 Feb 15;125(Pt 4):932-42
Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin.
Val S, Belade E, George I, Boczkowski J, Baeza-Squiban A
Archives of toxicology 2012 Dec;86(12):1851-9
Archives of toxicology 2012 Dec;86(12):1851-9
Regulation of particulate matter-induced mucin secretion by transient receptor potential vanilloid 1 receptors.
Yu H, Li Q, Kolosov VP, Perelman JM, Zhou X
Inflammation 2012 Dec;35(6):1851-9
Inflammation 2012 Dec;35(6):1851-9
Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin.
Kim JO, Sikder MA, Lee HJ, Rahman M, Kim JH, Chang GT, Lee CJ
Phytotherapy research : PTR 2012 Dec;26(12):1784-8
Phytotherapy research : PTR 2012 Dec;26(12):1784-8
Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia.
Syu LJ, El-Zaatari M, Eaton KA, Liu Z, Tetarbe M, Keeley TM, Pero J, Ferris J, Wilbert D, Kaatz A, Zheng X, Qiao X, Grachtchouk M, Gumucio DL, Merchant JL, Samuelson LC, Dlugosz AA
The American journal of pathology 2012 Dec;181(6):2114-25
The American journal of pathology 2012 Dec;181(6):2114-25
Development of primary human nasal epithelial cell cultures for the study of cystic fibrosis pathophysiology.
de Courcey F, Zholos AV, Atherton-Watson H, Williams MT, Canning P, Danahay HL, Elborn JS, Ennis M
American journal of physiology. Cell physiology 2012 Dec 1;303(11):C1173-9
American journal of physiology. Cell physiology 2012 Dec 1;303(11):C1173-9
Cigarette smoke induces growth differentiation factor 15 production in human lung epithelial cells: implication in mucin over-expression.
Wu Q, Jiang D, Chu HW
Innate immunity 2012 Aug;18(4):617-26
Innate immunity 2012 Aug;18(4):617-26
Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways.
Yu H, Li Q, Kolosov VP, Perelman JM, Zhou X
Journal of applied toxicology : JAT 2012 Apr;32(4):282-92
Journal of applied toxicology : JAT 2012 Apr;32(4):282-92
Effects of an oral MMP-9 and -12 inhibitor, AZD1236, on biomarkers in moderate/severe COPD: a randomised controlled trial.
Dahl R, Titlestad I, Lindqvist A, Wielders P, Wray H, Wang M, Samuelsson V, Mo J, Holt A
Pulmonary pharmacology & therapeutics 2012 Apr;25(2):169-77
Pulmonary pharmacology & therapeutics 2012 Apr;25(2):169-77
The inhibition of aldose reductase on mucus production induced by interleukin-13 in the human bronchial epithelial cells.
Jiang D, Li Q, Kolosov VP, Zhou X
International immunopharmacology 2012 Apr;12(4):588-93
International immunopharmacology 2012 Apr;12(4):588-93
Flagellin/TLR5 responses induce mucus hypersecretion by activating EGFR via an epithelial cell signaling cascades.
Yu H, Zhou X, Wen S, Xiao Q
Experimental cell research 2012 Apr 1;318(6):723-31
Experimental cell research 2012 Apr 1;318(6):723-31
Effects of furosemide on allergic asthmatic responses in mice.
Wang S, Xiang YY, Ellis R, Wattie J, Feng M, Inman MD, Lu WY
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2011 Oct;41(10):1456-67
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2011 Oct;41(10):1456-67
Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice.
Yageta Y, Ishii Y, Morishima Y, Masuko H, Ano S, Yamadori T, Itoh K, Takeuchi K, Yamamoto M, Hizawa N
Journal of virology 2011 May;85(10):4679-90
Journal of virology 2011 May;85(10):4679-90
IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides.
Zuyderduyn S, Ninaber DK, Schrumpf JA, van Sterkenburg MA, Verhoosel RM, Prins FA, van Wetering S, Rabe KF, Hiemstra PS
Respiratory research 2011 May 2;12(1):59
Respiratory research 2011 May 2;12(1):59
RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism.
Ma B, Dela Cruz CS, Hartl D, Kang MJ, Takyar S, Homer RJ, Lee CG, Elias JA
American journal of respiratory and critical care medicine 2011 May 15;183(10):1322-35
American journal of respiratory and critical care medicine 2011 May 15;183(10):1322-35
Mucin from rheumatoid arthritis synovial fluid enhances interleukin-6 production by human peripheral blood mononuclear cells.
Hamaguchi M, Kawahito Y, Ishino H, Takeuchi N, Tokunaga D, Hojo T, Yamamoto A, Kadoya M, Seno T, Kohno M, Nakada H
Human immunology 2011 Mar;72(3):241-8
Human immunology 2011 Mar;72(3):241-8
Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice.
Shen Y, Wang Y, Chen Z, Wang D, Wang X, Jin M, Bai C
Journal of cellular and molecular medicine 2011 Jun;15(6):1355-63
Journal of cellular and molecular medicine 2011 Jun;15(6):1355-63
Notch-dependent differentiation of adult airway basal stem cells.
Rock JR, Gao X, Xue Y, Randell SH, Kong YY, Hogan BL
Cell stem cell 2011 Jun 3;8(6):639-48
Cell stem cell 2011 Jun 3;8(6):639-48
Inhibition of airway MUC5AC mucin production and gene expression induced by epidermal growth factor or phorbol ester by glycyrrhizin and carbenoxolone.
Lee HJ, Lee SY, Bae HS, Kim JH, Chang GT, Seok JH, Lee CJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2011 Jun 15;18(8-9):743-7
Phytomedicine : international journal of phytotherapy and phytopharmacology 2011 Jun 15;18(8-9):743-7
Regulation of cigarette smoke-induced mucin expression by neuregulin1β/ErbB3 signalling in human airway epithelial cells.
Yu H, Li Q, Kolosov VP, Perelman JM, Zhou X
Basic & clinical pharmacology & toxicology 2011 Jul;109(1):63-72
Basic & clinical pharmacology & toxicology 2011 Jul;109(1):63-72
Induction of mucin and MUC5AC expression by the protease activity of Aspergillus fumigatus in airway epithelial cells.
Oguma T, Asano K, Tomomatsu K, Kodama M, Fukunaga K, Shiomi T, Ohmori N, Ueda S, Takihara T, Shiraishi Y, Sayama K, Kagawa S, Natori Y, Lilly CM, Satoh K, Makimura K, Ishizaka A
Journal of immunology (Baltimore, Md. : 1950) 2011 Jul 15;187(2):999-1005
Journal of immunology (Baltimore, Md. : 1950) 2011 Jul 15;187(2):999-1005
Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways.
Cortijo J, Mata M, Milara J, Donet E, Gavaldà A, Miralpeix M, Morcillo EJ
The European respiratory journal 2011 Feb;37(2):244-54
The European respiratory journal 2011 Feb;37(2):244-54
IL-13-induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cells.
Kanoh S, Tanabe T, Rubin BK
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2011 Dec;41(12):1747-56
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2011 Dec;41(12):1747-56
Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells.
Seagrave J, Albrecht H, Park YS, Rubin B, Solomon G, Kim KC
Experimental lung research 2011 Dec;37(10):606-14
Experimental lung research 2011 Dec;37(10):606-14
Combined tubular adenocarcinoma and hepatoid adenocarcinoma arising in Barrett esophagus.
Kuroda N, Onishi K, Lee GH
Annals of diagnostic pathology 2011 Dec;15(6):450-3
Annals of diagnostic pathology 2011 Dec;15(6):450-3
Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro.
Nishimoto Y, Hisatsune A, Katsuki H, Miyata T, Yokomizo K, Isohama Y
Journal of pharmacological sciences 2010;113(1):76-83
Journal of pharmacological sciences 2010;113(1):76-83
MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac.
Foster WM, Adler KB, Crews AL, Potts EN, Fischer BM, Voynow JA
American journal of physiology. Lung cellular and molecular physiology 2010 Sep;299(3):L345-52
American journal of physiology. Lung cellular and molecular physiology 2010 Sep;299(3):L345-52
Critical role of cytosolic phospholipase A2{alpha} in bronchial mucus hypersecretion in CFTR-deficient mice.
Dif F, Wu YZ, Burgel PR, Ollero M, Leduc D, Aarbiou J, Borot F, Garcia-Verdugo I, Martin C, Chignard M, Israel-Biet D, Kita Y, Scholte BJ, Touqui L
The European respiratory journal 2010 Nov;36(5):1120-30
The European respiratory journal 2010 Nov;36(5):1120-30
Primary signet-ring cell carcinoma of the cervix: case report and review of the literature.
Balci S, Saglam A, Usubutun A
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2010 Mar;29(2):181-4
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2010 Mar;29(2):181-4
Acute pulmonary response of mice to multi-wall carbon nanotubes.
Han SG, Andrews R, Gairola CG
Inhalation toxicology 2010 Mar;22(4):340-7
Inhalation toxicology 2010 Mar;22(4):340-7
Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway.
Woo HJ, Yoo WJ, Bae CH, Song SY, Kim YW, Park SY, Kim YD
Experimental lung research 2010 Jun;36(5):262-9
Experimental lung research 2010 Jun;36(5):262-9
Simvastatin attenuates acrolein-induced mucin production in rats: involvement of the Ras/extracellular signal-regulated kinase pathway.
Chen YJ, Chen P, Wang HX, Wang T, Chen L, Wang X, Sun BB, Liu DS, Xu D, An J, Wen FQ
International immunopharmacology 2010 Jun;10(6):685-93
International immunopharmacology 2010 Jun;10(6):685-93
Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotides.
Kreda SM, Seminario-Vidal L, van Heusden CA, O'Neal W, Jones L, Boucher RC, Lazarowski ER
The Journal of physiology 2010 Jun 15;588(Pt 12):2255-67
The Journal of physiology 2010 Jun 15;588(Pt 12):2255-67
Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.
Hata S, Abe M, Suzuki H, Kitamura F, Toyama-Sorimachi N, Abe K, Sakimura K, Sorimachi H
PLoS genetics 2010 Jul 29;6(7):e1001040
PLoS genetics 2010 Jul 29;6(7):e1001040
Sphingosine kinase 1 regulates mucin production via ERK phosphorylation.
Kono Y, Nishiuma T, Okada T, Kobayashi K, Funada Y, Kotani Y, Jahangeer S, Nakamura S, Nishimura Y
Pulmonary pharmacology & therapeutics 2010 Feb;23(1):36-42
Pulmonary pharmacology & therapeutics 2010 Feb;23(1):36-42
Prognostic significance of MUC1, MUC2 and MUC5AC expressions in gastric carcinoma.
İlhan Ö, Han Ü, Önal B, Çelık SY
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2010 Dec;21(4):345-52
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2010 Dec;21(4):345-52
Prognostic significance of MUC1, MUC2 and MUC5AC expressions in gastric carcinoma.
İlhan Ö, Han Ü, Önal B, Çelık SY
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2010 Dec;21(4):345-52
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2010 Dec;21(4):345-52
Nicotine suppresses inflammatory factors in HBE16 airway epithelial cells after exposure to cigarette smoke extract and lipopolysaccharide.
Li Q, Zhou X, Kolosov VP, Perelman JM
Translational research : the journal of laboratory and clinical medicine 2010 Dec;156(6):326-34
Translational research : the journal of laboratory and clinical medicine 2010 Dec;156(6):326-34
Establishment and characterization of a murine xenograft model of appendiceal mucinous adenocarcinoma.
Mavanur AA, Parimi V, O'Malley M, Nikiforova M, Bartlett DL, Davison JM
International journal of experimental pathology 2010 Aug;91(4):357-67
International journal of experimental pathology 2010 Aug;91(4):357-67
Exploring the peritoneal surface malignancy phenotype--a pilot immunohistochemical study of human pseudomyxoma peritonei and derived animal models.
Flatmark K, Davidson B, Kristian A, Stavnes HT, Førsund M, Reed W
Human pathology 2010 Aug;41(8):1109-19
Human pathology 2010 Aug;41(8):1109-19
MUC5AC expression in human middle ear epithelium of patients with otitis media.
Kerschner JE, Tripathi S, Khampang P, Papsin BC
Archives of otolaryngology--head & neck surgery 2010 Aug;136(8):819-24
Archives of otolaryngology--head & neck surgery 2010 Aug;136(8):819-24
Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allosteric alpha7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditions.
Narumoto O, Horiguchi K, Horiguchi S, Moriwaki Y, Takano-Ohmuro H, Shoji S, Misawa H, Yamashita N, Nagase T, Kawashima K, Yamashita N
Biochemical and biophysical research communications 2010 Aug 6;398(4):713-8
Biochemical and biophysical research communications 2010 Aug 6;398(4):713-8
Cigarette smoke total particulate matter increases mucous secreting cell numbers in vitro: a potential model of goblet cell hyperplasia.
Haswell LE, Hewitt K, Thorne D, Richter A, Gaça MD
Toxicology in vitro : an international journal published in association with BIBRA 2010 Apr;24(3):981-7
Toxicology in vitro : an international journal published in association with BIBRA 2010 Apr;24(3):981-7
Multipotential ability of primitive germ cells from neonatal pig testis cultured in vitro.
Goel S, Fujihara M, Tsuchiya K, Takagi Y, Minami N, Yamada M, Imai H
Reproduction, fertility, and development 2009;21(5):696-708
Reproduction, fertility, and development 2009;21(5):696-708
Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.
Tachdjian R, Mathias C, Al Khatib S, Bryce PJ, Kim HS, Blaeser F, O'Connor BD, Rzymkiewicz D, Chen A, Holtzman MJ, Hershey GK, Garn H, Harb H, Renz H, Oettgen HC, Chatila TA
The Journal of experimental medicine 2009 Sep 28;206(10):2191-204
The Journal of experimental medicine 2009 Sep 28;206(10):2191-204
Effects of cigarette smoking on mucin production in human middle ear epithelial cells.
Cho JG, Woo JS, Lee HM, Jung HH, Hwang SJ, Chae S
International journal of pediatric otorhinolaryngology 2009 Oct;73(10):1447-51
International journal of pediatric otorhinolaryngology 2009 Oct;73(10):1447-51
Chronic intermittent mechanical stress increases MUC5AC protein expression.
Park JA, Tschumperlin DJ
American journal of respiratory cell and molecular biology 2009 Oct;41(4):459-66
American journal of respiratory cell and molecular biology 2009 Oct;41(4):459-66
Structure of the oesophagus and morphometric, histochemical-immunohistochemical profiles of the oesophageal gland during the post-hatching period of Japanese quails (Coturnix coturnix japonica).
Sağsöz H, Liman N
Anatomia, histologia, embryologia 2009 Oct;38(5):330-40
Anatomia, histologia, embryologia 2009 Oct;38(5):330-40
Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells.
Heo HJ, Lee SY, Lee MN, Lee HJ, Seok JH, Lee CJ
Phytotherapy research : PTR 2009 Oct;23(10):1458-61
Phytotherapy research : PTR 2009 Oct;23(10):1458-61
Mitochondrial dysfunction increases allergic airway inflammation.
Aguilera-Aguirre L, Bacsi A, Saavedra-Molina A, Kurosky A, Sur S, Boldogh I
Journal of immunology (Baltimore, Md. : 1950) 2009 Oct 15;183(8):5379-87
Journal of immunology (Baltimore, Md. : 1950) 2009 Oct 15;183(8):5379-87
Rhinovirus-induced major airway mucin production involves a novel TLR3-EGFR-dependent pathway.
Zhu L, Lee PK, Lee WM, Zhao Y, Yu D, Chen Y
American journal of respiratory cell and molecular biology 2009 May;40(5):610-9
American journal of respiratory cell and molecular biology 2009 May;40(5):610-9
A critical role of SHP-1 in regulation of type 2 inflammation in the lung.
Oh SY, Zheng T, Kim YK, Cohn L, Homer RJ, McKenzie AN, Zhu Z
American journal of respiratory cell and molecular biology 2009 May;40(5):568-74
American journal of respiratory cell and molecular biology 2009 May;40(5):568-74
Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats.
Wang T, Liu Y, Chen L, Wang X, Hu XR, Feng YL, Liu DS, Xu D, Duan YP, Lin J, Ou XM, Wen FQ
The European respiratory journal 2009 May;33(5):1122-32
The European respiratory journal 2009 May;33(5):1122-32
A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice.
Shinagawa K, Ploplis VA, Castellino FJ
American journal of physiology. Lung cellular and molecular physiology 2009 May;296(5):L763-70
American journal of physiology. Lung cellular and molecular physiology 2009 May;296(5):L763-70
Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological phenomenon using genome wide expression data.
Tong L, Chew J, Yang H, Ang LP, Tan DT, Beuerman RW
BMC medical genomics 2009 Mar 10;2:14
BMC medical genomics 2009 Mar 10;2:14
Different effects of telithromycin on MUC5AC production induced by human neutrophil peptide-1 or lipopolysaccharide in NCI-H292 cells compared with azithromycin and clarithromycin.
Ishimoto H, Mukae H, Sakamoto N, Amenomori M, Kitazaki T, Imamura Y, Fujita H, Ishii H, Nakayama S, Yanagihara K, Kohno S
The Journal of antimicrobial chemotherapy 2009 Jan;63(1):109-14
The Journal of antimicrobial chemotherapy 2009 Jan;63(1):109-14
Nitric oxide gas phase release in human small airway epithelial cells.
Jiang J, Malavia N, Suresh V, George SC
Respiratory research 2009 Jan 19;10(1):3
Respiratory research 2009 Jan 19;10(1):3
Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease.
Cho HY, Imani F, Miller-DeGraff L, Walters D, Melendi GA, Yamamoto M, Polack FP, Kleeberger SR
American journal of respiratory and critical care medicine 2009 Jan 15;179(2):138-50
American journal of respiratory and critical care medicine 2009 Jan 15;179(2):138-50
Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury.
Cortijo J, Iranzo A, Milara X, Mata M, Cerdá-Nicolás M, Ruiz-Saurí A, Tenor H, Hatzelmann A, Morcillo EJ
British journal of pharmacology 2009 Feb;156(3):534-44
British journal of pharmacology 2009 Feb;156(3):534-44
CREB mediates prostaglandin F2alpha-induced MUC5AC overexpression.
Chung WC, Ryu SH, Sun H, Zeldin DC, Koo JS
Journal of immunology (Baltimore, Md. : 1950) 2009 Feb 15;182(4):2349-56
Journal of immunology (Baltimore, Md. : 1950) 2009 Feb 15;182(4):2349-56
Suppression of prostaglandin E2-induced MUC5AC overproduction by RGS4 in the airway.
Song KS, Choi YH, Kim JM, Lee H, Lee TJ, Yoon JH
American journal of physiology. Lung cellular and molecular physiology 2009 Apr;296(4):L684-92
American journal of physiology. Lung cellular and molecular physiology 2009 Apr;296(4):L684-92
Unclassified mucin phenotype of gastric adenocarcinoma exhibits the highest invasiveness.
Han HS, Lee SY, Lee KY, Hong SN, Kim JH, Sung IK, Park HS, Jin CJ, Min YI
Journal of gastroenterology and hepatology 2009 Apr;24(4):658-66
Journal of gastroenterology and hepatology 2009 Apr;24(4):658-66
EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors.
Sartori G, Cavazza A, Sgambato A, Marchioni A, Barbieri F, Longo L, Bavieri M, Murer B, Meschiari E, Tamberi S, Cadioli A, Luppi F, Migaldi M, Rossi G
American journal of clinical pathology 2009 Apr;131(4):478-89
American journal of clinical pathology 2009 Apr;131(4):478-89
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
Luxen S, Noack D, Frausto M, Davanture S, Torbett BE, Knaus UG
Journal of cell science 2009 Apr 15;122(Pt 8):1238-47
Journal of cell science 2009 Apr 15;122(Pt 8):1238-47
Protease-activated receptor-2 (PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro.
Lin KW, Park J, Crews AL, Li Y, Adler KB
The international journal of biochemistry & cell biology 2008;40(6-7):1379-88
The international journal of biochemistry & cell biology 2008;40(6-7):1379-88
CD34+ testicular stromal cells support long-term expansion of embryonic and adult stem and progenitor cells.
Kim J, Seandel M, Falciatori I, Wen D, Rafii S
Stem cells (Dayton, Ohio) 2008 Oct;26(10):2516-22
Stem cells (Dayton, Ohio) 2008 Oct;26(10):2516-22
Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans.
Almolki A, Guenegou A, Golda S, Boyer L, Benallaoua M, Amara N, Bachoual R, Martin C, Rannou F, Lanone S, Dulak J, Burgel PR, El-Benna J, Leynaert B, Aubier M, Boczkowski J
The American journal of pathology 2008 Oct;173(4):981-92
The American journal of pathology 2008 Oct;173(4):981-92
MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway.
Ha UH, Lim JH, Kim HJ, Wu W, Jin S, Xu H, Li JD
The Journal of biological chemistry 2008 Nov 7;283(45):30624-31
The Journal of biological chemistry 2008 Nov 7;283(45):30624-31
Oligopotent stem cells are distributed throughout the mammalian ocular surface.
Majo F, Rochat A, Nicolas M, Jaoudé GA, Barrandon Y
Nature 2008 Nov 13;456(7219):250-4
Nature 2008 Nov 13;456(7219):250-4
Role of epidermal growth factor receptor in maintaining airway goblet cell hyperplasia in rats sensitized to allergen.
Takeyama K, Tamaoki J, Kondo M, Isono K, Nagai A
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008 May;38(5):857-65
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008 May;38(5):857-65
Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease.
Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, Yamaya M, Nakayama K, Kubo H, Watanabe M, Sagara H, Sugiyama K, Tanaka H, Toda S, Hayashi H, Inoue H, Hoshino T, Shiraki A, Inoue M, Suzuki K, Aizawa H, Okinami S, Nagai H, Hasegawa M, Fukuda T, Green ED, Izuhara K
Journal of immunology (Baltimore, Md. : 1950) 2008 May 1;180(9):6262-9
Journal of immunology (Baltimore, Md. : 1950) 2008 May 1;180(9):6262-9
Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease.
Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, Yamaya M, Nakayama K, Kubo H, Watanabe M, Sagara H, Sugiyama K, Tanaka H, Toda S, Hayashi H, Inoue H, Hoshino T, Shiraki A, Inoue M, Suzuki K, Aizawa H, Okinami S, Nagai H, Hasegawa M, Fukuda T, Green ED, Izuhara K
Journal of immunology (Baltimore, Md. : 1950) 2008 May 1;180(9):6262-9
Journal of immunology (Baltimore, Md. : 1950) 2008 May 1;180(9):6262-9
IL-13 induces a bronchial epithelial phenotype that is profibrotic.
Malavia NK, Mih JD, Raub CB, Dinh BT, George SC
Respiratory research 2008 Mar 18;9(1):27
Respiratory research 2008 Mar 18;9(1):27
Expression of mucin 3 and mucin 5AC in arthritic synovial tissue.
Volin MV, Shahrara S, Haines GK 3rd, Woods JM, Koch AE
Arthritis and rheumatism 2008 Jan;58(1):46-52
Arthritis and rheumatism 2008 Jan;58(1):46-52
Synergistic induction of MUC5AC mucin by nontypeable Haemophilus influenzae and Streptococcus pneumoniae.
Shen H, Yoshida H, Yan F, Li W, Xu F, Huang H, Jono H, Li JD
Biochemical and biophysical research communications 2008 Jan 25;365(4):795-800
Biochemical and biophysical research communications 2008 Jan 25;365(4):795-800
IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA
Journal of immunology (Baltimore, Md. : 1950) 2008 Jan 1;180(1):522-9
Journal of immunology (Baltimore, Md. : 1950) 2008 Jan 1;180(1):522-9
IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA
Journal of immunology (Baltimore, Md. : 1950) 2008 Jan 1;180(1):522-9
Journal of immunology (Baltimore, Md. : 1950) 2008 Jan 1;180(1):522-9
Reactive oxygen species regulate Pseudomonas aeruginosa lipopolysaccharide-induced MUC5AC mucin expression via PKC-NADPH oxidase-ROS-TGF-alpha signaling pathways in human airway epithelial cells.
Yan F, Li W, Jono H, Li Q, Zhang S, Li JD, Shen H
Biochemical and biophysical research communications 2008 Feb 8;366(2):513-9
Biochemical and biophysical research communications 2008 Feb 8;366(2):513-9
Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.
Lee CG, Hartl D, Matsuura H, Dunlop FM, Scotney PD, Fabri LJ, Nash AD, Chen NY, Tang CY, Chen Q, Homer RJ, Baca M, Elias JA
American journal of respiratory cell and molecular biology 2008 Dec;39(6):739-46
American journal of respiratory cell and molecular biology 2008 Dec;39(6):739-46
Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production.
Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD
American journal of respiratory cell and molecular biology 2008 Apr;38(4):446-54
American journal of respiratory cell and molecular biology 2008 Apr;38(4):446-54
Munc18/SNARE proteins' regulation of exocytosis in guinea pig duodenal Brunner's gland acini.
Cosen-Binker LI, Morris GP, Vanner S, Gaisano HY
World journal of gastroenterology 2008 Apr 21;14(15):2314-22
World journal of gastroenterology 2008 Apr 21;14(15):2314-22
Munc18/SNARE proteins' regulation of exocytosis in guinea pig duodenal Brunner's gland acini.
Cosen-Binker LI, Morris GP, Vanner S, Gaisano HY
World journal of gastroenterology 2008 Apr 21;14(15):2314-22
World journal of gastroenterology 2008 Apr 21;14(15):2314-22
Histamine induces MUC5AC expression via a hCLCA1 pathway.
Kim YM, Won TB, Kim SW, Min YG, Lee CH, Rhee CS
Pharmacology 2007;80(4):219-26
Pharmacology 2007;80(4):219-26
Differentiation of tracheal basal cells to ciliated cells and tissue reconstruction on the synthesized basement membrane substratum in vitro.
Hosokawa T, Betsuyaku T, Nishimura M, Furuyama A, Katagiri K, Mochitate K
Connective tissue research 2007;48(1):9-18
Connective tissue research 2007;48(1):9-18
IL-13 regulates cilia loss and foxj1 expression in human airway epithelium.
Gomperts BN, Kim LJ, Flaherty SA, Hackett BP
American journal of respiratory cell and molecular biology 2007 Sep;37(3):339-46
American journal of respiratory cell and molecular biology 2007 Sep;37(3):339-46
Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice.
Mohsenin A, Mi T, Xia Y, Kellems RE, Chen JF, Blackburn MR
American journal of physiology. Lung cellular and molecular physiology 2007 Sep;293(3):L753-61
American journal of physiology. Lung cellular and molecular physiology 2007 Sep;293(3):L753-61
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, Rafii S
Nature 2007 Sep 20;449(7160):346-50
Nature 2007 Sep 20;449(7160):346-50
Regulation of mucin gene expression by CREB via a nonclassical retinoic acid signaling pathway.
Kim SW, Hong JS, Ryu SH, Chung WC, Yoon JH, Koo JS
Molecular and cellular biology 2007 Oct;27(19):6933-47
Molecular and cellular biology 2007 Oct;27(19):6933-47
Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.
Chapoval SP, Al-Garawi A, Lora JM, Strickland I, Ma B, Lee PJ, Homer RJ, Ghosh S, Coyle AJ, Elias JA
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov 15;179(10):7030-41
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov 15;179(10):7030-41
Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.
Chapoval SP, Al-Garawi A, Lora JM, Strickland I, Ma B, Lee PJ, Homer RJ, Ghosh S, Coyle AJ, Elias JA
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov 15;179(10):7030-41
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov 15;179(10):7030-41
Human bronchial epithelial cell transcriptome: gene expression changes following acute exposure to whole cigarette smoke in vitro.
Maunders H, Patwardhan S, Phillips J, Clack A, Richter A
American journal of physiology. Lung cellular and molecular physiology 2007 May;292(5):L1248-56
American journal of physiology. Lung cellular and molecular physiology 2007 May;292(5):L1248-56
A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice.
Wu Q, Martin RJ, Rino JG, Jeyaseelan S, Breed R, Chu HW
American journal of physiology. Lung cellular and molecular physiology 2007 May;292(5):L1064-72
American journal of physiology. Lung cellular and molecular physiology 2007 May;292(5):L1064-72
Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction.
Hallstrand TS, Debley JS, Farin FM, Henderson WR Jr
The Journal of allergy and clinical immunology 2007 May;119(5):1092-8
The Journal of allergy and clinical immunology 2007 May;119(5):1092-8
Nitric oxide induces MUC5AC mucin in respiratory epithelial cells through PKC and ERK dependent pathways.
Song JS, Kang CM, Yoo MB, Kim SJ, Yoon HK, Kim YK, Kim KH, Moon HS, Park SH
Respiratory research 2007 Mar 29;8(1):28
Respiratory research 2007 Mar 29;8(1):28
Complement C3a regulates Muc5ac expression by airway Clara cells independently of Th2 responses.
Dillard P, Wetsel RA, Drouin SM
American journal of respiratory and critical care medicine 2007 Jun 15;175(12):1250-8
American journal of respiratory and critical care medicine 2007 Jun 15;175(12):1250-8
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm.
Que J, Okubo T, Goldenring JR, Nam KT, Kurotani R, Morrisey EE, Taranova O, Pevny LH, Hogan BL
Development (Cambridge, England) 2007 Jul;134(13):2521-31
Development (Cambridge, England) 2007 Jul;134(13):2521-31
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma.
Xiang YY, Wang S, Liu M, Hirota JA, Li J, Ju W, Fan Y, Kelly MM, Ye B, Orser B, O'Byrne PM, Inman MD, Yang X, Lu WY
Nature medicine 2007 Jul;13(7):862-7
Nature medicine 2007 Jul;13(7):862-7
Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation.
Skowron-zwarg M, Boland S, Caruso N, Coraux C, Marano F, Tournier F
Experimental cell research 2007 Jul 15;313(12):2695-702
Experimental cell research 2007 Jul 15;313(12):2695-702
Coagulation factor Xa modulates airway remodeling in a murine model of asthma.
Shinagawa K, Martin JA, Ploplis VA, Castellino FJ
American journal of respiratory and critical care medicine 2007 Jan 15;175(2):136-43
American journal of respiratory and critical care medicine 2007 Jan 15;175(2):136-43
A morphometric study of mucins and small airway plugging in cystic fibrosis.
Burgel PR, Montani D, Danel C, Dusser DJ, Nadel JA
Thorax 2007 Feb;62(2):153-61
Thorax 2007 Feb;62(2):153-61
A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae.
Ha U, Lim JH, Jono H, Koga T, Srivastava A, Malley R, Pagès G, Pouysségur J, Li JD
Journal of immunology (Baltimore, Md. : 1950) 2007 Feb 1;178(3):1736-47
Journal of immunology (Baltimore, Md. : 1950) 2007 Feb 1;178(3):1736-47
A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae.
Ha U, Lim JH, Jono H, Koga T, Srivastava A, Malley R, Pagès G, Pouysségur J, Li JD
Journal of immunology (Baltimore, Md. : 1950) 2007 Feb 1;178(3):1736-47
Journal of immunology (Baltimore, Md. : 1950) 2007 Feb 1;178(3):1736-47
Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori.
Yoshizawa N, Takenaka Y, Yamaguchi H, Tetsuya T, Tanaka H, Tatematsu M, Nomura S, Goldenring JR, Kaminishi M
Laboratory investigation; a journal of technical methods and pathology 2007 Dec;87(12):1265-76
Laboratory investigation; a journal of technical methods and pathology 2007 Dec;87(12):1265-76
CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure.
Borchers MT, Wesselkamper SC, Harris NL, Deshmukh H, Beckman E, Vitucci M, Tichelaar JW, Leikauf GD
Experimental and molecular pathology 2007 Dec;83(3):301-10
Experimental and molecular pathology 2007 Dec;83(3):301-10
Maintenance of airway epithelium in acutely rejected orthotopic vascularized mouse lung transplants.
Okazaki M, Gelman AE, Tietjens JR, Ibricevic A, Kornfeld CG, Huang HJ, Richardson SB, Lai J, Garbow JR, Patterson GA, Krupnick AS, Brody SL, Kreisel D
American journal of respiratory cell and molecular biology 2007 Dec;37(6):625-30
American journal of respiratory cell and molecular biology 2007 Dec;37(6):625-30
Diagnostic value of mucins (MUC1, MUC2 and MUC5AC) expression profile in endoscopic ultrasound-guided fine-needle aspiration specimens of the pancreas.
Wang Y, Gao J, Li Z, Jin Z, Gong Y, Man X
International journal of cancer 2007 Dec 15;121(12):2716-22
International journal of cancer 2007 Dec 15;121(12):2716-22
Effects of sulfur dioxide on the expressions of MUC5AC and ICAM-1 in airway of asthmatic rats.
Li R, Meng Z, Xie J
Regulatory toxicology and pharmacology : RTP 2007 Aug;48(3):284-91
Regulatory toxicology and pharmacology : RTP 2007 Aug;48(3):284-91
Persistent effects induced by IL-13 in the lung.
Fulkerson PC, Fischetti CA, Hassman LM, Nikolaidis NM, Rothenberg ME
American journal of respiratory cell and molecular biology 2006 Sep;35(3):337-46
American journal of respiratory cell and molecular biology 2006 Sep;35(3):337-46
Effect of fibroblasts on tracheal epithelial regeneration in vitro.
Kobayashi K, Nomoto Y, Suzuki T, Tada Y, Miyake M, Hazama A, Kanemaru S, Nakamura T, Omori K
Tissue engineering 2006 Sep;12(9):2619-28
Tissue engineering 2006 Sep;12(9):2619-28
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers.
Carolan BJ, Heguy A, Harvey BG, Leopold PL, Ferris B, Crystal RG
Cancer research 2006 Nov 15;66(22):10729-40
Cancer research 2006 Nov 15;66(22):10729-40
Characterizing mucous cell remodeling in cystic fibrosis: relationship to neutrophils.
Hays SR, Fahy JV
American journal of respiratory and critical care medicine 2006 Nov 1;174(9):1018-24
American journal of respiratory and critical care medicine 2006 Nov 1;174(9):1018-24
Cigarette smoke extract modulates respiratory defence mechanisms through effects on T-cells and airway epithelial cells.
Glader P, Möller S, Lilja J, Wieslander E, Löfdahl CG, von Wachenfeldt K
Respiratory medicine 2006 May;100(5):818-27
Respiratory medicine 2006 May;100(5):818-27
Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members.
Patel AC, Morton JD, Kim EY, Alevy Y, Swanson S, Tucker J, Huang G, Agapov E, Phillips TE, Fuentes ME, Iglesias A, Aud D, Allard JD, Dabbagh K, Peltz G, Holtzman MJ
Physiological genomics 2006 May 16;25(3):502-13
Physiological genomics 2006 May 16;25(3):502-13
The inhibitory effects of rebamipide on cigarette smoke-induced airway mucin production.
Lee SY, Kang EJ, Hur GY, Jung KH, Jung HC, Lee SY, Kim JH, Shin C, In KH, Kang KH, Yoo SH, Shim JJ
Respiratory medicine 2006 Mar;100(3):503-11
Respiratory medicine 2006 Mar;100(3):503-11
An enzyme-linked immunosorbent assay (ELISA) for the determination of mucin levels in bronchoalveolar lavage fluid.
Phillips JE, Case NR, Celly C, Chapman RW, Hey JA, Minnicozzi M
Journal of pharmacological and toxicological methods 2006 Mar-Apr;53(2):160-7
Journal of pharmacological and toxicological methods 2006 Mar-Apr;53(2):160-7
Rhamnolipids are virulence factors that promote early infiltration of primary human airway epithelia by Pseudomonas aeruginosa.
Zulianello L, Canard C, Köhler T, Caille D, Lacroix JS, Meda P
Infection and immunity 2006 Jun;74(6):3134-47
Infection and immunity 2006 Jun;74(6):3134-47
Peroxisome proliferator-activated receptor-gamma inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells.
Lee SY, Kang EJ, Hur GY, Jung KH, Jung HC, Lee SY, Kim JH, Shin C, In KH, Kang KH, Yoo SH, Shim JJ
American journal of physiology. Lung cellular and molecular physiology 2006 Jul;291(1):L84-90
American journal of physiology. Lung cellular and molecular physiology 2006 Jul;291(1):L84-90
ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo.
Lee PJ, Zhang X, Shan P, Ma B, Lee CG, Homer RJ, Zhu Z, Rincon M, Mossman BT, Elias JA
The Journal of clinical investigation 2006 Jan;116(1):163-73
The Journal of clinical investigation 2006 Jan;116(1):163-73
Culture of murine nasal epithelia: model for cystic fibrosis.
Grubb BR, Rogers TD, Diggs PC, Boucher RC, Ostrowski LE
American journal of physiology. Lung cellular and molecular physiology 2006 Feb;290(2):L270-7
American journal of physiology. Lung cellular and molecular physiology 2006 Feb;290(2):L270-7
Effects of Helicobacter pylori infection on mucin expression in gastric carcinoma and pericancerous tissues.
Wang RQ, Fang DC
Journal of gastroenterology and hepatology 2006 Feb;21(2):425-31
Journal of gastroenterology and hepatology 2006 Feb;21(2):425-31
Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals.
Tyner JW, Kim EY, Ide K, Pelletier MR, Roswit WT, Morton JD, Battaile JT, Patel AC, Patterson GA, Castro M, Spoor MS, You Y, Brody SL, Holtzman MJ
The Journal of clinical investigation 2006 Feb;116(2):309-21
The Journal of clinical investigation 2006 Feb;116(2):309-21
Differential Muc2 and Muc5ac secretion by stimulated guinea pig tracheal epithelial cells in vitro.
Chorley BN, Crews AL, Li Y, Adler KB, Minnicozzi M, Martin LD
Respiratory research 2006 Feb 25;7:35
Respiratory research 2006 Feb 25;7:35
MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an epidermal growth factor receptor pathway in the human gallbladder.
Finzi L, Barbu V, Burgel PR, Mergey M, Kirkwood KS, Wick EC, Scoazec JY, Peschaud F, Paye F, Nadel JA, Housset C
The American journal of pathology 2006 Dec;169(6):2031-41
The American journal of pathology 2006 Dec;169(6):2031-41
Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells.
Ibricevic A, Pekosz A, Walter MJ, Newby C, Battaile JT, Brown EG, Holtzman MJ, Brody SL
Journal of virology 2006 Aug;80(15):7469-80
Journal of virology 2006 Aug;80(15):7469-80
A three-dimensional model of differentiation of immortalized human bronchial epithelial cells.
Vaughan MB, Ramirez RD, Wright WE, Minna JD, Shay JW
Differentiation; research in biological diversity 2006 Apr;74(4):141-8
Differentiation; research in biological diversity 2006 Apr;74(4):141-8
Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C{delta}-mediated mechanism.
Park JA, He F, Martin LD, Li Y, Chorley BN, Adler KB
The American journal of pathology 2005 Sep;167(3):651-61
The American journal of pathology 2005 Sep;167(3):651-61
Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C{delta}-mediated mechanism.
Park JA, He F, Martin LD, Li Y, Chorley BN, Adler KB
The American journal of pathology 2005 Sep;167(3):651-61
The American journal of pathology 2005 Sep;167(3):651-61
Gefitinib inhibits MUC5AC synthesis in mucin-secreting non-small cell lung cancer cells.
Kitazaki T, Soda H, Doi S, Nakano H, Nakamura Y, Kohno S
Lung cancer (Amsterdam, Netherlands) 2005 Oct;50(1):19-24
Lung cancer (Amsterdam, Netherlands) 2005 Oct;50(1):19-24
Effect of suplatast tosilate on goblet cell metaplasia in patients with asthma.
Hoshino M, Fujita Y, Saji J, Inoue T, Nakagawa T, Miyazawa T
Allergy 2005 Nov;60(11):1394-400
Allergy 2005 Nov;60(11):1394-400
Tissue microarray analysis of multiple gene expression in intestinal metaplasia, dysplasia and carcinoma of the stomach.
Sun Y, Li JY, He JS, Zhou LX, Chen K
Histopathology 2005 May;46(5):505-14
Histopathology 2005 May;46(5):505-14
Markers of adenocarcinoma characteristic of the site of origin: development of a diagnostic algorithm.
Dennis JL, Hvidsten TR, Wit EC, Komorowski J, Bell AK, Downie I, Mooney J, Verbeke C, Bellamy C, Keith WN, Oien KA
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 May 15;11(10):3766-72
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 May 15;11(10):3766-72
Promoter analysis and aberrant expression of the MUC5B gene in diffuse panbronchiolitis.
Kamio K, Matsushita I, Hijikata M, Kobashi Y, Tanaka G, Nakata K, Ishida T, Tokunaga K, Taguchi Y, Homma S, Nakata K, Azuma A, Kudoh S, Keicho N
American journal of respiratory and critical care medicine 2005 May 1;171(9):949-57
American journal of respiratory and critical care medicine 2005 May 1;171(9):949-57
Differences in biological features of gastric dysplasia, indefinite dysplasia, reactive hyperplasia and discriminant analysis of these lesions.
Dong B, Xie YQ, Chen K, Wang T, Tang W, You WC, Li JY
World journal of gastroenterology 2005 Jun 21;11(23):3595-600
World journal of gastroenterology 2005 Jun 21;11(23):3595-600
Differences in biological features of gastric dysplasia, indefinite dysplasia, reactive hyperplasia and discriminant analysis of these lesions.
Dong B, Xie YQ, Chen K, Wang T, Tang W, You WC, Li JY
World journal of gastroenterology 2005 Jun 21;11(23):3595-600
World journal of gastroenterology 2005 Jun 21;11(23):3595-600
Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells.
Lu W, Lillehoj EP, Kim KC
American journal of physiology. Lung cellular and molecular physiology 2005 Jan;288(1):L52-60
American journal of physiology. Lung cellular and molecular physiology 2005 Jan;288(1):L52-60
Mucin biosynthesis: upregulation of core 2 beta 1,6 N-acetylglucosaminyltransferase by retinoic acid and Th2 cytokines in a human airway epithelial cell line.
Beum PV, Basma H, Bastola DR, Cheng PW
American journal of physiology. Lung cellular and molecular physiology 2005 Jan;288(1):L116-24
American journal of physiology. Lung cellular and molecular physiology 2005 Jan;288(1):L116-24
Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells.
Mata M, Sarriá B, Buenestado A, Cortijo J, Cerdá M, Morcillo EJ
Thorax 2005 Feb;60(2):144-52
Thorax 2005 Feb;60(2):144-52
E-cadherin promotes EGFR-mediated cell differentiation and MUC5AC mucin expression in cultured human airway epithelial cells.
Kim S, Schein AJ, Nadel JA
American journal of physiology. Lung cellular and molecular physiology 2005 Dec;289(6):L1049-60
American journal of physiology. Lung cellular and molecular physiology 2005 Dec;289(6):L1049-60
Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells.
Chokki M, Eguchi H, Hamamura I, Mitsuhashi H, Kamimura T
The FEBS journal 2005 Dec;272(24):6387-99
The FEBS journal 2005 Dec;272(24):6387-99
pH-dependent intraluminal organization of mucin granules in live human mucous/goblet cells.
Perez-Vilar J, Olsen JC, Chua M, Boucher RC
The Journal of biological chemistry 2005 Apr 29;280(17):16868-81
The Journal of biological chemistry 2005 Apr 29;280(17):16868-81
Relationship between MUC5AC and altered expression of MLH1 protein in mucinous and non-mucinous colorectal carcinomas.
Losi L, Scarselli A, Benatti P, Ponz de Leon M, Roncucci L, Pedroni M, Borghi F, Lamberti I, Rossi G, Marino M, Ponti G, Zangardi G, Menigatti M, Di Gregorio C
Pathology, research and practice 2004;200(5):371-7
Pathology, research and practice 2004;200(5):371-7
Azithromycin inhibits MUC5AC production induced by the Pseudomonas aeruginosa autoinducer N-(3-Oxododecanoyl) homoserine lactone in NCI-H292 Cells.
Imamura Y, Yanagihara K, Mizuta Y, Seki M, Ohno H, Higashiyama Y, Miyazaki Y, Tsukamoto K, Hirakata Y, Tomono K, Kadota J, Kohno S
Antimicrobial agents and chemotherapy 2004 Sep;48(9):3457-61
Antimicrobial agents and chemotherapy 2004 Sep;48(9):3457-61
Intranasal steroids decrease eosinophils but not mucin expression in nasal polyps.
Burgel PR, Cardell LO, Ueki IF, Nadel JA
The European respiratory journal 2004 Oct;24(4):594-600
The European respiratory journal 2004 Oct;24(4):594-600
Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma.
Chu HW, Balzar S, Seedorf GJ, Westcott JY, Trudeau JB, Silkoff P, Wenzel SE
The American journal of pathology 2004 Oct;165(4):1097-106
The American journal of pathology 2004 Oct;165(4):1097-106
Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma.
Chu HW, Balzar S, Seedorf GJ, Westcott JY, Trudeau JB, Silkoff P, Wenzel SE
The American journal of pathology 2004 Oct;165(4):1097-106
The American journal of pathology 2004 Oct;165(4):1097-106
Differentiated cultures of primary hamster tracheal airway epithelial cells.
Rowe RK, Brody SL, Pekosz A
In vitro cellular & developmental biology. Animal 2004 Nov-Dec;40(10):303-11
In vitro cellular & developmental biology. Animal 2004 Nov-Dec;40(10):303-11
PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms.
Hewson CA, Edbrooke MR, Johnston SL
Journal of molecular biology 2004 Nov 26;344(3):683-95
Journal of molecular biology 2004 Nov 26;344(3):683-95
A mouse model for the study of recurrent corneal epithelial erosions: alpha9beta1 integrin implicated in progression of the disease.
Pal-Ghosh S, Pajoohesh-Ganji A, Brown M, Stepp MA
Investigative ophthalmology & visual science 2004 Jun;45(6):1775-88
Investigative ophthalmology & visual science 2004 Jun;45(6):1775-88
A mouse model for the study of recurrent corneal epithelial erosions: alpha9beta1 integrin implicated in progression of the disease.
Pal-Ghosh S, Pajoohesh-Ganji A, Brown M, Stepp MA
Investigative ophthalmology & visual science 2004 Jun;45(6):1775-88
Investigative ophthalmology & visual science 2004 Jun;45(6):1775-88
Differentiation-dependent responsiveness of bronchial epithelial cells to IL-4/13 stimulation.
Kikuchi T, Shively JD, Foley JS, Drazen JM, Tschumperlin DJ
American journal of physiology. Lung cellular and molecular physiology 2004 Jul;287(1):L119-26
American journal of physiology. Lung cellular and molecular physiology 2004 Jul;287(1):L119-26
Correlation between MUC5AC expression and the prognosis of patients with adenocarcinoma of the uterine cervix.
Mitsuhashi A, Yamazawa K, Nagai Y, Tanaka N, Matsui H, Sekiya S
Annals of surgical oncology 2004 Jan;11(1):40-4
Annals of surgical oncology 2004 Jan;11(1):40-4
Correlation between MUC5AC expression and the prognosis of patients with adenocarcinoma of the uterine cervix.
Mitsuhashi A, Yamazawa K, Nagai Y, Tanaka N, Matsui H, Sekiya S
Annals of surgical oncology 2004 Jan;11(1):40-4
Annals of surgical oncology 2004 Jan;11(1):40-4
Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia.
Gray T, Coakley R, Hirsh A, Thornton D, Kirkham S, Koo JS, Burch L, Boucher R, Nettesheim P
American journal of physiology. Lung cellular and molecular physiology 2004 Feb;286(2):L320-30
American journal of physiology. Lung cellular and molecular physiology 2004 Feb;286(2):L320-30
Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling.
Gray T, Nettesheim P, Loftin C, Koo JS, Bonner J, Peddada S, Langenbach R
Molecular pharmacology 2004 Aug;66(2):337-46
Molecular pharmacology 2004 Aug;66(2):337-46
Reduced airway inflammation and remodeling in parallel with mucin 5AC protein expression decreased by s-carboxymethylcysteine, a mucoregulant, in the airways of rats exposed to sulfur dioxide.
Sueyoshi S, Miyata Y, Masumoto Y, Ishibashi Y, Matsuzawa S, Harano N, Tsuru K, Imai S
International archives of allergy and immunology 2004 Aug;134(4):273-80
International archives of allergy and immunology 2004 Aug;134(4):273-80
Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression.
Rossi G, Murer B, Cavazza A, Losi L, Natali P, Marchioni A, Migaldi M, Capitanio G, Brambilla E
The American journal of surgical pathology 2004 Apr;28(4):442-52
The American journal of surgical pathology 2004 Apr;28(4):442-52
Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression.
Rossi G, Murer B, Cavazza A, Losi L, Natali P, Marchioni A, Migaldi M, Capitanio G, Brambilla E
The American journal of surgical pathology 2004 Apr;28(4):442-52
The American journal of surgical pathology 2004 Apr;28(4):442-52
IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation.
Atherton HC, Jones G, Danahay H
American journal of physiology. Lung cellular and molecular physiology 2003 Sep;285(3):L730-9
American journal of physiology. Lung cellular and molecular physiology 2003 Sep;285(3):L730-9
Alterations of MUC1 and MUC3 expression in gastric carcinoma: relevance to patient clinicopathological features.
Wang RQ, Fang DC
Journal of clinical pathology 2003 May;56(5):378-84
Journal of clinical pathology 2003 May;56(5):378-84
Alterations of MUC1 and MUC3 expression in gastric carcinoma: relevance to patient clinicopathological features.
Wang RQ, Fang DC
Journal of clinical pathology 2003 May;56(5):378-84
Journal of clinical pathology 2003 May;56(5):378-84
Profiling, comparison and validation of gene expression in gastric carcinoma and normal stomach.
Oien KA, Vass JK, Downie I, Fullarton G, Keith WN
Oncogene 2003 Jul 3;22(27):4287-300
Oncogene 2003 Jul 3;22(27):4287-300
Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats.
Mata M, Ruíz A, Cerdá M, Martinez-Losa M, Cortijo J, Santangelo F, Serrano-Mollar A, Llombart-Bosch A, Morcillo EJ
The European respiratory journal 2003 Dec;22(6):900-5
The European respiratory journal 2003 Dec;22(6):900-5
Role of MUC1 and MUC5AC expressions as prognostic indicators in gastric carcinomas.
Wang JY, Chang CT, Hsieh JS, Lee LW, Huang TJ, Chai CY, Lin SR
Journal of surgical oncology 2003 Aug;83(4):253-60
Journal of surgical oncology 2003 Aug;83(4):253-60
Ozone exposure enhances endotoxin-induced mucous cell metaplasia in rat pulmonary airways.
Wagner JG, Van Dyken SJ, Wierenga JR, Hotchkiss JA, Harkema JR
Toxicological sciences : an official journal of the Society of Toxicology 2003 Aug;74(2):437-46
Toxicological sciences : an official journal of the Society of Toxicology 2003 Aug;74(2):437-46
Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway.
Blackburn MR, Lee CG, Young HW, Zhu Z, Chunn JL, Kang MJ, Banerjee SK, Elias JA
The Journal of clinical investigation 2003 Aug;112(3):332-44
The Journal of clinical investigation 2003 Aug;112(3):332-44
Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation.
Kohri K, Ueki IF, Nadel JA
American journal of physiology. Lung cellular and molecular physiology 2002 Sep;283(3):L531-40
American journal of physiology. Lung cellular and molecular physiology 2002 Sep;283(3):L531-40
Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways.
Lee CG, Homer RJ, Cohn L, Link H, Jung S, Craft JE, Graham BS, Johnson TR, Elias JA
The Journal of biological chemistry 2002 Sep 20;277(38):35466-74
The Journal of biological chemistry 2002 Sep 20;277(38):35466-74
Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist.
Koo JS, Kim YD, Jetten AM, Belloni P, Nettesheim P
Experimental lung research 2002 Jun;28(4):315-32
Experimental lung research 2002 Jun;28(4):315-32
Viral induction of a chronic asthma phenotype and genetic segregation from the acute response.
Walter MJ, Morton JD, Kajiwara N, Agapov E, Holtzman MJ
The Journal of clinical investigation 2002 Jul;110(2):165-75
The Journal of clinical investigation 2002 Jul;110(2):165-75
Effect of gefarnate on the ocular surface in squirrel monkeys.
Toshida H, Nakata K, Hamano T, Nakamura M, Nguyen D, Beuerman RW
Cornea 2002 Apr;21(3):292-9
Cornea 2002 Apr;21(3):292-9
Effect of gefarnate on the ocular surface in squirrel monkeys.
Toshida H, Nakata K, Hamano T, Nakamura M, Nguyen D, Beuerman RW
Cornea 2002 Apr;21(3):292-9
Cornea 2002 Apr;21(3):292-9
Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway.
Hoshino M, Morita S, Iwashita H, Sagiya Y, Nagi T, Nakanishi A, Ashida Y, Nishimura O, Fujisawa Y, Fujino M
American journal of respiratory and critical care medicine 2002 Apr 15;165(8):1132-6
American journal of respiratory and critical care medicine 2002 Apr 15;165(8):1132-6
Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation.
Burgel PR, Lazarus SC, Tam DC, Ueki IF, Atabai K, Birch M, Nadel JA
Journal of immunology (Baltimore, Md. : 1950) 2001 Nov 15;167(10):5948-54
Journal of immunology (Baltimore, Md. : 1950) 2001 Nov 15;167(10):5948-54
Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation.
Burgel PR, Lazarus SC, Tam DC, Ueki IF, Atabai K, Birch M, Nadel JA
Journal of immunology (Baltimore, Md. : 1950) 2001 Nov 15;167(10):5948-54
Journal of immunology (Baltimore, Md. : 1950) 2001 Nov 15;167(10):5948-54
Ethanol vapour-fixation of rat lung for immunocytochemistry investigations.
Wilson HH, Chauhan J, Kerry PJ, Evans JG
Journal of immunological methods 2001 Jan 1;247(1-2):187-90
Journal of immunological methods 2001 Jan 1;247(1-2):187-90
Ethanol vapour-fixation of rat lung for immunocytochemistry investigations.
Wilson HH, Chauhan J, Kerry PJ, Evans JG
Journal of immunological methods 2001 Jan 1;247(1-2):187-90
Journal of immunological methods 2001 Jan 1;247(1-2):187-90
Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils.
Takeyama K, Dabbagh K, Jeong Shim J, Dao-Pick T, Ueki IF, Nadel JA
Journal of immunology (Baltimore, Md. : 1950) 2000 Feb 1;164(3):1546-52
Journal of immunology (Baltimore, Md. : 1950) 2000 Feb 1;164(3):1546-52
Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils.
Takeyama K, Dabbagh K, Jeong Shim J, Dao-Pick T, Ueki IF, Nadel JA
Journal of immunology (Baltimore, Md. : 1950) 2000 Feb 1;164(3):1546-52
Journal of immunology (Baltimore, Md. : 1950) 2000 Feb 1;164(3):1546-52
Selective secretion and replenishment of discrete mucin glycoforms from intestinal goblet cells.
Stanley CM, Phillips TE
The American journal of physiology 1999 Jul;277(1):G191-200
The American journal of physiology 1999 Jul;277(1):G191-200
Selective secretion and replenishment of discrete mucin glycoforms from intestinal goblet cells.
Stanley CM, Phillips TE
The American journal of physiology 1999 Jul;277(1 Pt 1):G191-200
The American journal of physiology 1999 Jul;277(1 Pt 1):G191-200
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- Immunohistochemical (Paraffin) analysis of human stomach tissue using (Product # MA1-21907) MUC5AC Monoclonal Antibody (45M1).
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- Extended Data Fig. 8 Related to Figure 4 . SP9 penetrates epithelial cells when conjugated to CPPs and inhibit mucin secretion from airway epithelium cells. a , Representative confocal images (z-sections) of fixed HAE cells treated with SP9-Cy3 or SP9-Cy3 conjugated to CPPs or biotin. Biotin-SP9-Cy3 was bound to streptavidin-conjugated C2 or CRM197. The experiment was repeated twice with ALI cultures from different donors with similar results. Scale bar, 10 um. b , The diagram illustrates the analysis of intracellular localization of MUC5AC, Cy3, and DAPI in airway secretory cells. Fluorescence intensities of DAPI, AlexaFluor 488 (MUC5AC) and Cy3 were analysed within individual MUC5AC + cells at each z-section, normalized and fluorescence intensity traces calculated along the basolateral to apical cell axis. c , Representative western blot immunofluorescence images for MUC5AC on apical surface of untreated HAE cells (control 1 and 2) or HAE cells treated with 100 muM SP9-Cy3, PEN-SP9-Cy3, TAT-SP9-Cy3, PEN-P9-Cy3, or TAT-P9-Cy3 for 24 h before stimulation. Wash represents MUC5AC accumulated during culture and before start of experiment. Baseline represents unstimulated MUC5AC secretion during a 15 min period after removal of accumulated MUC5AC and experimental represents MUC5AC secreted within 15 min of stimulation with (ATP) or without (no ATP) 100 uM ATP. Lysate represents MUC5AC within HAE cells at the end of the experiment. Cells were treated with IL-13 to induce mucous me
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- Fig. 4 SP9 inhibits mucin secretion from airway epithelial cells. a , The design of synthesized SP9 with biotin or CPPs conjugated to the N terminus and Cy3 to the C terminus, respectively. Biotin-SP9-Cy3 was bound to streptavidin-conjugated C2 or CRM197. b , Diagram of the analysis of cumulated Cy3 intensities within individual HAE cells. c , Confocal collapse (projected) images of fixed HAE cells that were treated with SP9-Cy3 or SP9-Cy3 conjugated to bacterial toxins (C2, CRM197) or CPPs. Scale bar, 10 um. The experiment was independently repeated twice with air-liquid interface (ALI) cultures from different donors with similar results. d , Quantitative analysis of intracellular Cy3 fluorescence for each peptide in MUC5AC + HAE cells. Box plots and data points are shown for n cells (indicated below each box plot). Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by post hoc Dunnett's test; *** P < 0.0001. e , Schematic of the peptide application and sample collection from HAE cells maintained under ALI conditions. f , Representative western blot immunofluorescence images for MUC5AC on an apical surface of untreated HAE cells (control), HAE cells treated with 10 muM of SP9-Cy3, or 10 muM of either SP9-Cy3 or P9-Cy3 conjugated to CPPs for 30 min before stimulation. Basl., MUC5AC secretion during a 30 min period before stimulation (baseline). Exp., MUC5AC secreted within a 30 min experimental period with (IL-13 + ATP) or without (IL-13) s
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- Figure 6 Ptch1 +/- mice were partially protected from HDM-induced mucous expression compared to HDM-exposed Wt mice. ( A ) Periodic acid Schiff (PAS)-, B) MUC5AC- and ( C ) Ki67-stained sections of paraffin-embedded mouse lung tissues from Wt and Ptch1 +/- mice after PBS or HDM exposures were shown. ( D ) Airway-specific PAS staining was normalized to length of basement membrane (BM). ( E ) Ki67+ epithelial cells and ( G ) airway epithelial thickness were normalized to length of BM. Scale bar = 50 um. Values were expressed as mean +- SEM. One-way analysis of variance with Bonferroni's multiple comparisons test was used in panels D-F. ( G - H ) Representative images and quantification of epithelial-specific Ptch1 protein expression in all visible distal airways in a representative Wt PBS- and Ptch1 +/- PBS-treated mouse.
