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- Antibody Data
- Antigen structure
- References [13]
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- Validations
- Western blot [1]
- Immunoprecipitation [2]
- Immunohistochemistry [2]
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- Product number
- 13895-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13895-1-AP, RRID:AB_2089330
- Product name
- D2HGDH antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated D2HGDH antibody (Cat. #13895-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase.
Oncometabolite d-2HG alters T cell metabolism to impair CD8(+) T cell function.
MYC, mitochondrial metabolism and O-GlcNAcylation converge to modulate the activity and subcellular localization of DNA and RNA demethylases.
D-2-hydroxyglutarate dehydrogenase in breast carcinoma as a potent prognostic marker associated with proliferation.
Urinary 2-Hydroxyglutarate Enantiomers Are Markedly Elevated in a Murine Model of Type 2 Diabetic Kidney Disease.
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.
Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations.
D-2-hydroxyglutaric aciduria Type I: Functional analysis of D2HGDH missense variants.
D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2.
Hypoxia Induces Production of L-2-Hydroxyglutarate.
Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.
D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth.
Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma.
Liu Y, Wang M, Guo Y, Wang L, Guo W
Cell reports 2023 Feb 28;42(2):112067
Cell reports 2023 Feb 28;42(2):112067
Oncometabolite d-2HG alters T cell metabolism to impair CD8(+) T cell function.
Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, Zaganjor E, McBrayer SK, Sorger PK, Sharpe AH, Wucherpfennig KW, Santagata S, Agar NYR, Suvà ML, Haigis MC
Science (New York, N.Y.) 2022 Sep 30;377(6614):1519-1529
Science (New York, N.Y.) 2022 Sep 30;377(6614):1519-1529
MYC, mitochondrial metabolism and O-GlcNAcylation converge to modulate the activity and subcellular localization of DNA and RNA demethylases.
Lin AP, Qiu Z, Ethiraj P, Sasi B, Jaafar C, Rakheja D, Aguiar RCT
Leukemia 2022 Apr;36(4):1150-1159
Leukemia 2022 Apr;36(4):1150-1159
D-2-hydroxyglutarate dehydrogenase in breast carcinoma as a potent prognostic marker associated with proliferation.
Hayashi C, Takagi K, Sato A, Yamaguchi M, Minemura H, Miki Y, Harada-Shoji N, Miyashita M, Sasano H, Suzuki T
Histology and histopathology 2021 Oct;36(10):1053-1062
Histology and histopathology 2021 Oct;36(10):1053-1062
Urinary 2-Hydroxyglutarate Enantiomers Are Markedly Elevated in a Murine Model of Type 2 Diabetic Kidney Disease.
Baek J, Pennathur S
Metabolites 2021 Jul 21;11(8)
Metabolites 2021 Jul 21;11(8)
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.
Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Madesh M, Shiio Y, Dahia PLM, Aguiar RCT
Cell chemical biology 2020 May 21;27(5):538-550.e7
Cell chemical biology 2020 May 21;27(5):538-550.e7
Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations.
Berger RS, Ellmann L, Reinders J, Kreutz M, Stempfl T, Oefner PJ, Dettmer K
Scientific reports 2019 May 15;9(1):7436
Scientific reports 2019 May 15;9(1):7436
D-2-hydroxyglutaric aciduria Type I: Functional analysis of D2HGDH missense variants.
Pop A, Struys EA, Jansen EEW, Fernandez MR, Kanhai WA, van Dooren SJM, Ozturk S, van Oostendorp J, Lennertz P, Kranendijk M, van der Knaap MS, Gibson KM, van Schaftingen E, Salomons GS
Human mutation 2019 Jul;40(7):975-982
Human mutation 2019 Jul;40(7):975-982
D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2.
Lin AP, Abbas S, Kim SW, Ortega M, Bouamar H, Escobedo Y, Varadarajan P, Qin Y, Sudderth J, Schulz E, Deutsch A, Mohan S, Ulz P, Neumeister P, Rakheja D, Gao X, Hinck A, Weintraub ST, DeBerardinis RJ, Sill H, Dahia PL, Aguiar RC
Nature communications 2015 Jul 16;6:7768
Nature communications 2015 Jul 16;6:7768
Hypoxia Induces Production of L-2-Hydroxyglutarate.
Intlekofer AM, Dematteo RG, Venneti S, Finley LW, Lu C, Judkins AR, Rustenburg AS, Grinaway PB, Chodera JD, Cross JR, Thompson CB
Cell metabolism 2015 Aug 4;22(2):304-11
Cell metabolism 2015 Aug 4;22(2):304-11
Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.
Oldham WM, Clish CB, Yang Y, Loscalzo J
Cell metabolism 2015 Aug 4;22(2):291-303
Cell metabolism 2015 Aug 4;22(2):291-303
D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth.
Ma S, Jiang B, Deng W, Gu ZK, Wu FZ, Li T, Xia Y, Yang H, Ye D, Xiong Y, Guan KL
Oncotarget 2015 Apr 20;6(11):8606-20
Oncotarget 2015 Apr 20;6(11):8606-20
Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma.
Krell D, Assoku M, Galloway M, Mulholland P, Tomlinson I, Bardella C
PloS one 2011;6(5):e19868
PloS one 2011;6(5):e19868
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human liver tissue were subjected to SDS PAGE followed by western blot with 13895-1-AP(D2HGDH antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP result of anti-D2HGDH (13895-1-AP for IP and Detection) with mouse liver tissue lysate.
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-D2HGDH (IP:13895-1-AP, 3ug; Detection:13895-1-AP 1:500) with mouse liver tissue lysate 5000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 13895-1-AP(D2HGDH antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The D2HGDH antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human D2HGDH. This antibody recognizes human,mouse,rat antigen. The D2HGDH antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
