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- References [13]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 12995-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12995-1-AP, RRID:AB_2149206
- Product name
- NEU4 antibody
- Antibody type
- Polyclonal
- Description
- NEU4 antibody (Cat. #12995-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The landscape of gene mutations in a cohort of 3353 Han Chinese children with nonsyndromic hearing loss.
The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms.
Sialidase NEU3 silencing inhibits angiogenesis of EA.hy926 cells by regulating Wnt/β-catenin signaling pathway.
Targeting Neuraminidase 4 Attenuates Kidney Fibrosis in Mice.
NEU4-mediated desialylation enhances the activation of the oncogenic receptors for the dissemination of ovarian carcinoma.
Neuraminidase inhibition promotes the collective migration of neurons and recovery of brain function.
A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes.
A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer.
Macrophages discriminate glycosylation patterns of apoptotic cell-derived microparticles.
Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo.
Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for neurotrophin activation of Trk receptors and cellular signaling.
Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.
Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase.
Xiao Y, Chen L, Han Y, Luo J, Wang M, Ai Y, Liu W, Xiong W, Jin Y, Kong S, Xu K, Fan Z, Xu L, Wang H
EBioMedicine 2026 Apr;126:106211
EBioMedicine 2026 Apr;126:106211
The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms.
Ansari MN, Jha SK, Khan A, Rajput K, Pandey N, Jain D, Tripathi R, Medatwal N, Sharma P, Datta S, Kar A, Pani T, Ali SA, Cholke K, Rana K, Snijesh VP, Mukherjee G, Deo SVS, Basak S, Mishra A, Prabhu JS, Mukhopadhyay A, Bajaj A, Dasgupta U
PLoS biology 2025 Sep;23(9):e3003362
PLoS biology 2025 Sep;23(9):e3003362
Sialidase NEU3 silencing inhibits angiogenesis of EA.hy926 cells by regulating Wnt/β-catenin signaling pathway.
Wu Y, Yuan X, Zhang Y, Ma F, Zhao W, Sun X, Ma X, Chen Y
Biochemical and biophysical research communications 2025 Jan;742:151098
Biochemical and biophysical research communications 2025 Jan;742:151098
Targeting Neuraminidase 4 Attenuates Kidney Fibrosis in Mice.
Xiao PT, Hao JH, Kuang YJ, Dai CX, Rong XL, Jiang LL, Xie ZS, Zhang L, Chen QQ, Liu EH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(39):e2406936
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(39):e2406936
NEU4-mediated desialylation enhances the activation of the oncogenic receptors for the dissemination of ovarian carcinoma.
Shi J, Zhou R, Wang S, Liu Y, Tian B, Liu Y, Chen Y, Hu T, Mu Y, Wang S, Shao X, Yan J, Qu P, Wei D, Yang S, Shi Y, Li J, Wang L
Oncogene 2024 Nov;43(49):3556-3569
Oncogene 2024 Nov;43(49):3556-3569
Neuraminidase inhibition promotes the collective migration of neurons and recovery of brain function.
Matsumoto M, Matsushita K, Hane M, Wen C, Kurematsu C, Ota H, Bang Nguyen H, Quynh Thai T, Herranz-Pérez V, Sawada M, Fujimoto K, García-Verdugo JM, Kimura KD, Seki T, Sato C, Ohno N, Sawamoto K
EMBO molecular medicine 2024 Jun;16(6):1228-1253
EMBO molecular medicine 2024 Jun;16(6):1228-1253
A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes.
Alghamdi F, Guo M, Abdulkhalek S, Crawford N, Amith SR, Szewczuk MR
Cellular signalling 2014 Jun;26(6):1355-68
Cellular signalling 2014 Jun;26(6):1355-68
A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer.
Gilmour AM, Abdulkhalek S, Cheng TS, Alghamdi F, Jayanth P, O'Shea LK, Geen O, Arvizu LA, Szewczuk MR
Cellular signalling 2013 Dec;25(12):2587-603
Cellular signalling 2013 Dec;25(12):2587-603
Macrophages discriminate glycosylation patterns of apoptotic cell-derived microparticles.
Bilyy RO, Shkandina T, Tomin A, Muñoz LE, Franz S, Antonyuk V, Kit YY, Zirngibl M, Fürnrohr BG, Janko C, Lauber K, Schiller M, Schett G, Stoika RS, Herrmann M
The Journal of biological chemistry 2012 Jan 2;287(1):496-503
The Journal of biological chemistry 2012 Jan 2;287(1):496-503
Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo.
Finlay TM, Abdulkhalek S, Gilmour A, Guzzo C, Jayanth P, Amith SR, Gee K, Beyaert R, Szewczuk MR
Glycoconjugate journal 2010 Aug;27(6):583-600
Glycoconjugate journal 2010 Aug;27(6):583-600
Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for neurotrophin activation of Trk receptors and cellular signaling.
Jayanth P, Amith SR, Gee K, Szewczuk MR
Cellular signalling 2010 Aug;22(8):1193-205
Cellular signalling 2010 Aug;22(8):1193-205
Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.
Finlay TM, Jayanth P, Amith SR, Gilmour A, Guzzo C, Gee K, Beyaert R, Szewczuk MR
Glycoconjugate journal 2010 Apr;27(3):329-48
Glycoconjugate journal 2010 Apr;27(3):329-48
Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase.
Amith SR, Jayanth P, Franchuk S, Siddiqui S, Seyrantepe V, Gee K, Basta S, Beyaert R, Pshezhetsky AV, Szewczuk MR
Glycoconjugate journal 2009 Dec;26(9):1197-212
Glycoconjugate journal 2009 Dec;26(9):1197-212
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- L02 cells were subjected to SDS PAGE followed by western blot with 12995-1-AP(NEU4 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 12995-1-AP(NEU4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NEU4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NEU4. This antibody recognizes human antigen. The NEU4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
