CABT-B9178

antibody from Creative Diagnostics

Targeting: PPP2R5A B56A, B56alpha, PR61A

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9178

Provider

Creative Diagnostics

Product name

Mouse anti-Human PP2A-B56-alpha monoclonal antibody, clone 34/C67Ï«

Antibody type

Monoclonal

Description

Reversible phosphorylation by protein kinases and phosphatases regulates key signaling pathways in eukaryotic cells. Type 2A protein phosphatases (PP2A) are composed of two regulatory and one catalytic subunit. The active PP2A is a heterotrimer, composed of A, B, and C subunits, each encoded by different genes. B56 is a new gene family that encodes Ï«, ÉÇ, and ÎÛ proteins for the B subunit. The three B56 isoforms are approximately 70% homologous to each other and more divergent within the first 251amino acids. While the Ï« subunit is widely expressed, the ÎÛ isoform is most abundant in heart and muscle, and the ÉÇ subunit is found predominantly in brain tissue. Availability of different B subunits appears to be a key determinant in the protein substrate specificity for PP2A and could influence the subcellular distribution of the holoenzyme.

Reactivity

Human, Mouse, Rat, Canine, Chicken/Avian

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

34/C67Ï«

Vial size

50 _g

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.