11067-2-AP

antibody from Proteintech Group

Targeting: PROX1

Provider product page for 11067-2-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [47]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 11067-2-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11067-2-AP, RRID:AB_2268804
Product name: PROX1 antibody
Antibody type: Polyclonal
Description: KD/KO validated PROX1 antibody (Cat. #11067-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PROX1 protein structure - 11067-2-AP shown in red.

Submitted references Neutrophil extracellular trap-mediated impairment of meningeal lymphatic drainage exacerbates secondary hydrocephalus after intraventricular hemorrhage.

Zhang Q, Chen Y, Li Y, Feng Z, Liang L, Hao X, Kang W, Zhang Z, Zhang X, Hu R, Feng H, Chen Z
Theranostics 2024;14(5):1909-1938

Knockdown of PROX1 promotes milk fatty acid synthesis by targeting PPARGC1A in dairy goat mammary gland.

He Q, Yao W, Luo J, Wu J, Zhang F, Li C, Gao L, Zhang Y
International journal of biological macromolecules 2024 May;266(Pt 2):131043

Spatiotemporal characteristics of tissue derived small extracellular vesicles is associated with tumor relapse and anti-PD-1 response.

Fu QY, Xiong XP, Xia HF, Liu XC, Yu ZL, Liu KW, Zeng J, Sun YF, Jia J, Chen G
Cancer letters 2024 Jun 1;591:216897

ChIP-GPT: a managed large language model for robust data extraction from biomedical database records.

Cinquin O
Briefings in bioinformatics 2024 Jan 22;25(2)

Berberine promotes lacteal junction zippering and ameliorates diet-induced obesity through the RhoA/ROCK signaling pathway.

Wang H, Chen S, Tang Y, Nie K, Gao Y, Wang Z, Su H, Wu F, Gong J, Fang K, Dong H, Hu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155268

Triptolide inhibits the progression of Glioblastoma U251 cells via targeting PROX1.

Yuan C, Liao Y, Liao S, Huang M, Li D, Wu W, Quan Y, Li L, Yu X, Si W
Frontiers in oncology 2023;13:1077640

Single-nucleus RNA sequencing reveals heterogenous microenvironments and specific drug response between cervical squamous cell carcinoma and adenocarcinoma.

Lin S, Sun Y, Cao C, Zhu Z, Xu Y, Liu B, Hu B, Peng T, Zhi W, Xu M, Ding W, Ren F, Ma D, Li G, Wu P
EBioMedicine 2023 Nov;97:104846

PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway.

Ohata H, Shiokawa D, Sakai H, Kanda Y, Okimoto Y, Kaneko S, Hamamoto R, Nakagama H, Okamoto K
Cell reports 2023 Jun 27;42(6):112519

KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposi's sarcoma studies.

Tuohinto K, DiMaio TA, Kiss EA, Laakkonen P, Saharinen P, Karnezis T, Lagunoff M, Ojala PM
PLoS pathogens 2023 Jan;19(1):e1010753

Extracellular HSP90 promotes differentiation of lens epithelial cells to fiber cells by activating LRP1-YAP-PROX1 axis.

Li J, Yu J, Huang W, Sang F, Li J, Ren Y, Huang H, Wang M, Li K, Zhang J, Li H, Cui X, Zhang J, Hu M, Yuan F, Guo W, Zhang F, Mu H, Hu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22783

Isolation and short-term culturing of primary lymphatic endothelial cells from collecting lymphatics: A techniques study.

Jablon KL, Akerstrom VL, Li M, Braun SE, Norton CE, Castorena-Gonzalez JA
Microcirculation (New York, N.Y. : 1994) 2023 Apr;30(2-3):e12778

Mechanisms of Neuropathic Pain and Pain-Relieving Effects of Exercise Therapy in a Rat Neuropathic Pain Model.

Sumizono M, Yoshizato Y, Yamamoto R, Imai T, Tani A, Nakanishi K, Nakakogawa T, Matsuoka T, Matsuzaki R, Tanaka T, Sakakima H
Journal of pain research 2022;15:1925-1938

Pharmacological inhibition of FOXO1 promotes lymphatic valve growth in a congenital lymphedema mouse model.

Ogunsina O, Banerjee R, Knauer LA, Yang Y
Frontiers in cell and developmental biology 2022;10:1024628

Loss of BAF (mSWI/SNF) chromatin-remodeling ATPase Brg1 causes multiple malformations of cortical development in mice.

Jin Y, Gao X, Lu M, Chen G, Yang X, Ren N, Song Y, Hou C, Li J, Liu Q, Gao J
Human molecular genetics 2022 Oct 10;31(20):3504-3520

AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis.

Wang Y, Luo M, Wang F, Tong Y, Li L, Shu Y, Qiao K, Zhang L, Yan G, Liu J, Ji H, Xie Y, Zhang Y, Gao WQ, Liu Y
Nature communications 2022 Nov 24;13(1):7215

Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis.

Meçe O, Houbaert D, Sassano ML, Durré T, Maes H, Schaaf M, More S, Ganne M, García-Caballero M, Borri M, Verhoeven J, Agrawal M, Jacobs K, Bergers G, Blacher S, Ghesquière B, Dewerchin M, Swinnen JV, Vinckier S, Soengas MS, Carmeliet P, Noël A, Agostinis P
Nature communications 2022 May 19;13(1):2760

Disrupted in Schizophrenia 1 Regulates Ectopic Neurogenesis in the Mouse Hilus After Pilocarpine-induced Status Epilepticus.

Chen L, Zhu L, Xu J, Xu P, Han Y, Chang L, Wu Q
Neuroscience 2022 Jul 1;494:69-81

Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in weaning piglets.

Chen X, Chen L, Qin Y, Mao Z, Jia G, Zhao H, Liu G, Huang Z
Animal biotechnology 2022 Dec;33(7):1389-1397

In Vitro Induction of Human Dental Pulp Stem Cells to Lymphatic Endothelial Cells.

Qi S, Ye L, Hu L, Pan J
Cellular reprogramming 2022 Aug;24(4):186-194

Ubiquitin C-terminal hydrolase L1 promotes lymph node metastasis in small cell neuroendocrine carcinomas of the cervix.

Zhang Y, Ding J, Zhang X, Hua K
The Journal of international medical research 2022 Apr;50(4):3000605221087620

Tumor microenvironment remodeling modulates macrophage phenotype in breast cancer lymphangiogenesis.

Du Y, Cao M, Liu Y, He Y, Yang C, Zhang G, Fan Y, Gao F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Apr;36(4):e22248

Defect of LSS Disrupts Lens Development in Cataractogenesis.

Zhao M, Mei T, Shang B, Zou B, Lian Q, Xu W, Wu K, Lai Y, Liu C, Wei L, Zhu J, Zhang K, Liu Y, Zhao L
Frontiers in cell and developmental biology 2021;9:788422

Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells.

Cheng L, Xie M, Qiao W, Song Y, Zhang Y, Geng Y, Xu W, Wang L, Wang Z, Huang K, Dong N, Sun Y
Communications biology 2021 Sep 6;4(1):1039

ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer.

Pozo K, Kollipara RK, Kelenis DP, Rodarte KE, Ullrich MS, Zhang X, Minna JD, Johnson JE
iScience 2021 Sep 24;24(9):102953

Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells.

Li J, Li E, Czepielewski RS, Chi J, Guo X, Han YH, Wang D, Wang L, Hu B, Dawes B, Jacobs C, Tenen D, Lin SJ, Lee B, Morris D, Tobias A, Randolph GJ, Cohen P, Tsai L, Rosen ED
Cell metabolism 2021 Jul 6;33(7):1449-1465.e6

MiR-155-5p suppresses SOX1 to promote proliferation of cholangiocarcinoma via RAF/MEK/ERK pathway.

Wang D, Xiong F, Wu G, Liu W, Wang B, Chen Y
Cancer cell international 2021 Dec 7;21(1):656

Heteronemin Suppresses Lymphangiogenesis through ARF-1 and MMP-9/VE-Cadherin/Vimentin.

Chen HL, Su YC, Chen HC, Su JH, Wu CY, Wang SW, Lin IP, Chen CY, Lee CH
Biomedicines 2021 Aug 29;9(9)

Dentate Gyrus Proliferative Responses After Traumatic Brain Injury and Binge Alcohol in Adult Rats.

Ton ST, Adamczyk NS, Gerling JP, Vaagenes IC, Wu JY, Hsu K, O'Brien TE, Tsai SY, Kartje GL
Neuroscience insights 2020;15:2633105520968904

Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts.

Ma R, Martínez-Ramírez AS, Borders TL, Gao F, Sosa-Pineda B
eLife 2020 Mar 10;9

The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development.

Aryal S, Viet J, Weatherbee BAT, Siddam AD, Hernandez FG, Gautier-Courteille C, Paillard L, Lachke SA
Human genetics 2020 Dec;139(12):1541-1554

Oncogenic Herpesvirus Engages Endothelial Transcription Factors SOX18 and PROX1 to Increase Viral Genome Copies and Virus Production.

Gramolelli S, Elbasani E, Tuohinto K, Nurminen V, Günther T, Kallinen RE, Kaijalainen SP, Diaz R, Grundhoff A, Haglund C, Ziegelbauer JM, Pellinen T, Bower M, Francois M, Ojala PM
Cancer research 2020 Aug 1;80(15):3116-3129

Native Coronary Collateral Microcirculation Reserve in Rat Hearts.

Liu X, Dong H, Huang B, Miao H, Xu Z, Yuan Y, Qiu F, Chen J, Zhang H, Liu Z, Quan X, Zhu L, Zhang Z
Journal of the American Heart Association 2019 Mar 5;8(5):e011220

Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium.

Stone OA, Stainier DYR
Developmental cell 2019 Jul 22;50(2):247-255.e3

Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth.

Urner S, Planas-Paz L, Hilger LS, Henning C, Branopolski A, Kelly-Goss M, Stanczuk L, Pitter B, Montanez E, Peirce SM, Mäkinen T, Lammert E
The EMBO journal 2019 Jan 15;38(2)

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid.

Ahn JH, Cho H, Kim JH, Kim SH, Ham JS, Park I, Suh SH, Hong SP, Song JH, Hong YK, Jeong Y, Park SH, Koh GY
Nature 2019 Aug;572(7767):62-66

Cyp1b1 expression impacts the angiogenic and inflammatory properties of liver sinusoidal endothelial cells.

Falero-Perez J, Song YS, Zhao Y, Teixeira L, Sorenson CM, Sheibani N
PloS one 2018;13(10):e0206756

Transplantation of artificial human lymphatic vascular tissues fabricated using a cell-accumulation technique and their engraftment in mouse tissue with vascular remodelling.

Asano Y, Shimoda H, Matsusaki M, Akashi M
Journal of tissue engineering and regenerative medicine 2018 Mar;12(3):e1501-e1510

Suppression of PROX1-mediated TERT expression in hepatitis B viral hepatocellular carcinoma.

Kim YJ, Yoo JE, Jeon Y, Chong JU, Choi GH, Song DG, Jung SH, Oh BK, Park YN
International journal of cancer 2018 Dec 15;143(12):3155-3168

Diet-induced obesity accelerates blood lactate accumulation of rats in response to incremental exercise to maximum.

Chen CJ, Liao YH, Lin SY, Yu JX, Li ZJ, Lin YC, Chang GJ, Lin CH, Wong AM
American journal of physiology. Regulatory, integrative and comparative physiology 2017 Nov 1;313(5):R601-R607

Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells.

Ren JG, Xia HF, Yang JG, Zhu JY, Zhang W, Chen G, Zhao JH, Sun YF, Zhao YF
Human pathology 2017 Jul;65:231-238

Liver-specific Prox1 inactivation causes hepatic injury and glucose intolerance in mice.

Goto T, Elbahrawy A, Furuyama K, Horiguchi M, Hosokawa S, Aoyama Y, Tsuboi K, Sakikubo M, Hirata K, Masui T, Kubo H, Sakai Y, Uemoto S, Kawaguchi Y
FEBS letters 2017 Feb;591(4):624-635

The role of fatty acid β-oxidation in lymphangiogenesis.

Wong BW, Wang X, Zecchin A, Thienpont B, Cornelissen I, Kalucka J, García-Caballero M, Missiaen R, Huang H, Brüning U, Blacher S, Vinckier S, Goveia J, Knobloch M, Zhao H, Dierkes C, Shi C, Hägerling R, Moral-Dardé V, Wyns S, Lippens M, Jessberger S, Fendt SM, Luttun A, Noel A, Kiefer F, Ghesquière B, Moons L, Schoonjans L, Dewerchin M, Eelen G, Lambrechts D, Carmeliet P
Nature 2017 Feb 2;542(7639):49-54

Liu Y, Zhang Y, Wang S, Dong QZ, Shen Z, Wang W, Tao S, Gu C, Liu J, Xie Y, Qin LX
Hepatology (Baltimore, Md.) 2017 Dec;66(6):1894-1909

Mesenchymal status of lymphatic endothelial cell: enlightening treatment of lymphatic malformation.

Cai X, Zhang W, Chen G, Li RF, Sun YF, Zhao YF
International journal of clinical and experimental medicine 2015;8(8):12239-51

Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP.

Cho E, Kim DH, Hur YN, Whitcomb DJ, Regan P, Hong JH, Kim H, Ho Suh Y, Cho K, Park M
Scientific reports 2015 Jul 29;5:12624

The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors.

Srinivasan RS, Escobedo N, Yang Y, Interiano A, Dillard ME, Finkelstein D, Mukatira S, Gil HJ, Nurmi H, Alitalo K, Oliver G
Genes & development 2014 Oct 1;28(19):2175-87

PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1α expression and protein stability.

Liu Y, Zhang JB, Qin Y, Wang W, Wei L, Teng Y, Guo L, Zhang B, Lin Z, Liu J, Ren ZG, Ye QH, Xie Y
Hepatology (Baltimore, Md.) 2013 Aug;58(2):692-705

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human liver tissue were subjected to SDS PAGE followed by western blot with 11067-2-AP(PROX1 antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using PROX1 antibody 11067-2-AP at 1:100 dilution and FITC-labeled donkey anti-rabbit IgG(green). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lymphoma using 11067-2-AP(PROX1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue