Antibody data
- Antibody Data
- Antigen structure
- References [51]
- Comments [0]
- Validations
- Western blot [2]
- Immunocytochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- AF2727 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Prox1 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human Prox1 in direct ELISAs and Western blots.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q92786
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation.
PDK1 Deficit Impairs the Development of the Dentate Gyrus in Mice.
Gq-Coupled Muscarinic Receptor Enhancement of KCNQ2/3 Channels and Activation of TRPC Channels in Multimodal Control of Excitability in Dentate Gyrus Granule Cells.
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.
Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.
Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling.
Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype.
Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells.
Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction.
Neurogliaform cortical interneurons derive from cells in the preoptic area.
PROX1 is a transcriptional regulator of MMP14.
Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease.
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program.
High PROX1 expression in gastric cancer predicts better survival.
Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4.
BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain.
Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration.
Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma.
Peg3/PW1 Is a Marker of a Subset of Vessel Associated Endothelial Progenitors.
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1.
Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity.
Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development.
Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat.
Transcriptomic and anatomic parcellation of 5-HT(3A)R expressing cortical interneuron subtypes revealed by single-cell RNA sequencing.
The role of prospero homeobox 1 (PROX1) expression in follicular thyroid carcinoma cells.
VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations.
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.
Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice.
Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea.
Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic.
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves.
CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity.
Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation.
Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.
A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research.
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.
Bone marrow-derived cells are implicated as a source of lymphatic endothelial progenitors in human breast cancer.
The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel.
Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
Murine Notch1 is required for lymphatic vascular morphogenesis during development.
Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions.
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy.
The germinal matrices in the developing dentate gyrus are composed of neuronal progenitors at distinct differentiation stages.
Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence.
Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis.
Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.
Expression and prognostic value of transcription factor PROX1 in colorectal cancer.
CKIα ablation highlights a critical role for p53 in invasiveness control.
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.
Norman TA Jr, Gower AC, Chen F, Fine A
PloS one 2019;14(5):e0216795
PloS one 2019;14(5):e0216795
PDK1 Deficit Impairs the Development of the Dentate Gyrus in Mice.
Xu M, Han X, Liu R, Li Y, Qi C, Yang Z, Zhao C, Gao J
Cerebral cortex (New York, N.Y. : 1991) 2019 Mar 1;29(3):1185-1198
Cerebral cortex (New York, N.Y. : 1991) 2019 Mar 1;29(3):1185-1198
Gq-Coupled Muscarinic Receptor Enhancement of KCNQ2/3 Channels and Activation of TRPC Channels in Multimodal Control of Excitability in Dentate Gyrus Granule Cells.
Carver CM, Shapiro MS
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Feb 27;39(9):1566-1587
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Feb 27;39(9):1566-1587
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.
Pluvinage JV, Haney MS, Smith BAH, Sun J, Iram T, Bonanno L, Li L, Lee DP, Morgens DW, Yang AC, Shuken SR, Gate D, Scott M, Khatri P, Luo J, Bertozzi CR, Bassik MC, Wyss-Coray T
Nature 2019 Apr;568(7751):187-192
Nature 2019 Apr;568(7751):187-192
Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.
Genga RMJ, Kernfeld EM, Parsi KM, Parsons TJ, Ziller MJ, Maehr R
Cell reports 2019 Apr 16;27(3):708-718.e10
Cell reports 2019 Apr 16;27(3):708-718.e10
Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling.
Cha B, Geng X, Mahamud MR, Zhang JY, Chen L, Kim W, Jho EH, Kim Y, Choi D, Dixon JB, Chen H, Hong YK, Olson L, Kim TH, Merrill BJ, Davis MJ, Srinivasan RS
Cell reports 2018 Oct 16;25(3):571-584.e5
Cell reports 2018 Oct 16;25(3):571-584.e5
Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype.
Goudarzi KM, Espinoza JA, Guo M, Bartek J, Nistér M, Lindström MS, Hägerstrand D
Cancer research 2018 Oct 15;78(20):5901-5916
Cancer research 2018 Oct 15;78(20):5901-5916
Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells.
Högström J, Heino S, Kallio P, Lähde M, Leppänen VM, Balboa D, Wiener Z, Alitalo K
Cancer research 2018 Oct 15;78(20):5820-5832
Cancer research 2018 Oct 15;78(20):5820-5832
Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction.
Vuorio T, Ylä-Herttuala E, Laakkonen JP, Laidinen S, Liimatainen T, Ylä-Herttuala S
Scientific reports 2018 Nov 12;8(1):16709
Scientific reports 2018 Nov 12;8(1):16709
Neurogliaform cortical interneurons derive from cells in the preoptic area.
Niquille M, Limoni G, Markopoulos F, Cadilhac C, Prados J, Holtmaat A, Dayer A
eLife 2018 Mar 20;7
eLife 2018 Mar 20;7
PROX1 is a transcriptional regulator of MMP14.
Gramolelli S, Cheng J, Martinez-Corral I, Vähä-Koskela M, Elbasani E, Kaivanto E, Rantanen V, Tuohinto K, Hautaniemi S, Bower M, Haglund C, Alitalo K, Mäkinen T, Petrova TV, Lehti K, Ojala PM
Scientific reports 2018 Jun 22;8(1):9531
Scientific reports 2018 Jun 22;8(1):9531
Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease.
Rhee S, Chung JI, King DA, D'amato G, Paik DT, Duan A, Chang A, Nagelberg D, Sharma B, Jeong Y, Diehn M, Wu JC, Morrison AJ, Red-Horse K
Nature communications 2018 Jan 25;9(1):368
Nature communications 2018 Jan 25;9(1):368
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program.
Frye M, Taddei A, Dierkes C, Martinez-Corral I, Fielden M, Ortsäter H, Kazenwadel J, Calado DP, Ostergaard P, Salminen M, He L, Harvey NL, Kiefer F, Mäkinen T
Nature communications 2018 Apr 17;9(1):1511
Nature communications 2018 Apr 17;9(1):1511
High PROX1 expression in gastric cancer predicts better survival.
Laitinen A, Böckelman C, Hagström J, Kokkola A, Kallio P, Haglund C
PloS one 2017;12(8):e0183868
PloS one 2017;12(8):e0183868
Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4.
Volk-Draper LD, Hall KL, Wilber AC, Ran S
PloS one 2017;12(6):e0179257
PloS one 2017;12(6):e0179257
BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain.
Teoh JJ, Iwano T, Kunii M, Atik N, Avriyanti E, Yoshimura SI, Moriwaki K, Harada A
PloS one 2017;12(4):e0175888
PloS one 2017;12(4):e0175888
Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration.
Lin YC, Ohbayashi N, Hongu T, Katagiri N, Funakoshi Y, Lee H, Kanaho Y
Scientific reports 2017 Sep 12;7(1):11431
Scientific reports 2017 Sep 12;7(1):11431
Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma.
Kim J, Park DY, Bae H, Park DY, Kim D, Lee CK, Song S, Chung TY, Lim DH, Kubota Y, Hong YK, He Y, Augustin HG, Oliver G, Koh GY
The Journal of clinical investigation 2017 Oct 2;127(10):3877-3896
The Journal of clinical investigation 2017 Oct 2;127(10):3877-3896
Peg3/PW1 Is a Marker of a Subset of Vessel Associated Endothelial Progenitors.
Malinverno M, Corada M, Ferrarini L, Formicola L, Marazzi G, Sassoon D, Dejana E
Stem cells (Dayton, Ohio) 2017 May;35(5):1328-1340
Stem cells (Dayton, Ohio) 2017 May;35(5):1328-1340
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1.
Jha SK, Rauniyar K, Karpanen T, Leppänen VM, Brouillard P, Vikkula M, Alitalo K, Jeltsch M
Scientific reports 2017 Jul 7;7(1):4916
Scientific reports 2017 Jul 7;7(1):4916
Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity.
Yan KS, Gevaert O, Zheng GXY, Anchang B, Probert CS, Larkin KA, Davies PS, Cheng ZF, Kaddis JS, Han A, Roelf K, Calderon RI, Cynn E, Hu X, Mandleywala K, Wilhelmy J, Grimes SM, Corney DC, Boutet SC, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Wang F, von Furstenberg RJ, Smith NR, Chandrakesan P, May R, Chrissy MAS, Jain R, Cartwright CA, Niland JC, Hong YK, Carrington J, Breault DT, Epstein J, Houchen CW, Lynch JP, Martin MG, Plevritis SK, Curtis C, Ji HP, Li L, Henning SJ, Wong MH, Kuo CJ
Cell stem cell 2017 Jul 6;21(1):78-90.e6
Cell stem cell 2017 Jul 6;21(1):78-90.e6
Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development.
Mimura-Yamamoto Y, Shinohara H, Kashiwagi T, Sato T, Shioda S, Seki T
Scientific reports 2017 Jul 17;7(1):5647
Scientific reports 2017 Jul 17;7(1):5647
Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat.
Jung E, Gardner D, Choi D, Park E, Jin Seong Y, Yang S, Castorena-Gonzalez J, Louveau A, Zhou Z, Lee GK, Perrault DP, Lee S, Johnson M, Daghlian G, Lee M, Jin Hong Y, Kato Y, Kipnis J, Davis MJ, Wong AK, Hong YK
Scientific reports 2017 Jul 17;7(1):5577
Scientific reports 2017 Jul 17;7(1):5577
Transcriptomic and anatomic parcellation of 5-HT(3A)R expressing cortical interneuron subtypes revealed by single-cell RNA sequencing.
Frazer S, Prados J, Niquille M, Cadilhac C, Markopoulos F, Gomez L, Tomasello U, Telley L, Holtmaat A, Jabaudon D, Dayer A
Nature communications 2017 Jan 30;8:14219
Nature communications 2017 Jan 30;8:14219
The role of prospero homeobox 1 (PROX1) expression in follicular thyroid carcinoma cells.
Rudzinska M, Ledwon JK, Gawel D, Sikorska J, Czarnocka B
Oncotarget 2017 Dec 26;8(69):114136-114155
Oncotarget 2017 Dec 26;8(69):114136-114155
VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations.
Hägerling R, Drees D, Scherzinger A, Dierkes C, Martin-Almedina S, Butz S, Gordon K, Schäfers M, Hinrichs K, Ostergaard P, Vestweber D, Goerge T, Mansour S, Jiang X, Mortimer PS, Kiefer F
JCI insight 2017 Aug 17;2(16)
JCI insight 2017 Aug 17;2(16)
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.
Castellano JM, Mosher KI, Abbey RJ, McBride AA, James ML, Berdnik D, Shen JC, Zou B, Xie XS, Tingle M, Hinkson IV, Angst MS, Wyss-Coray T
Nature 2017 Apr 27;544(7651):488-492
Nature 2017 Apr 27;544(7651):488-492
Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice.
Matsushita J, Inagaki S, Nishie T, Sakasai T, Tanaka J, Watanabe C, Mizutani KI, Miwa Y, Matsumoto K, Takara K, Naito H, Kidoya H, Takakura N, Nagai T, Takahashi S, Ema M
Scientific reports 2017 Apr 20;7:46597
Scientific reports 2017 Apr 20;7:46597
Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea.
Geng R, Noda T, Mulvaney JF, Lin VY, Edge AS, Dabdoub A
PloS one 2016;11(2):e0148339
PloS one 2016;11(2):e0148339
Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic.
Iftakhar-E-Khuda I, Fair-Mäkelä R, Kukkonen-Macchi A, Elima K, Karikoski M, Rantakari P, Miyasaka M, Salmi M, Jalkanen S
Proceedings of the National Academy of Sciences of the United States of America 2016 Sep 20;113(38):10643-8
Proceedings of the National Academy of Sciences of the United States of America 2016 Sep 20;113(38):10643-8
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
Lund AW, Wagner M, Fankhauser M, Steinskog ES, Broggi MA, Spranger S, Gajewski TF, Alitalo K, Eikesdal HP, Wiig H, Swartz MA
The Journal of clinical investigation 2016 Sep 1;126(9):3389-402
The Journal of clinical investigation 2016 Sep 1;126(9):3389-402
Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves.
Cha B, Geng X, Mahamud MR, Fu J, Mukherjee A, Kim Y, Jho EH, Kim TH, Kahn ML, Xia L, Dixon JB, Chen H, Srinivasan RS
Genes & development 2016 Jun 15;30(12):1454-69
Genes & development 2016 Jun 15;30(12):1454-69
CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity.
Crosswhite PL, Podsiadlowska JJ, Curtis CD, Gao S, Xia L, Srinivasan RS, Griffin CT
The Journal of clinical investigation 2016 Jun 1;126(6):2254-66
The Journal of clinical investigation 2016 Jun 1;126(6):2254-66
Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation.
Fatima A, Wang Y, Uchida Y, Norden P, Liu T, Culver A, Dietz WH, Culver F, Millay M, Mukouyama YS, Kume T
The Journal of clinical investigation 2016 Jul 1;126(7):2437-51
The Journal of clinical investigation 2016 Jul 1;126(7):2437-51
Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.
Geng X, Cha B, Mahamud MR, Lim KC, Silasi-Mansat R, Uddin MKM, Miura N, Xia L, Simon AM, Engel JD, Chen H, Lupu F, Srinivasan RS
Developmental biology 2016 Jan 1;409(1):218-233
Developmental biology 2016 Jan 1;409(1):218-233
A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research.
Bianchi R, Teijeira A, Proulx ST, Christiansen AJ, Seidel CD, Rülicke T, Mäkinen T, Hägerling R, Halin C, Detmar M
PloS one 2015;10(4):e0122976
PloS one 2015;10(4):e0122976
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.
Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K
The Journal of experimental medicine 2015 Jun 29;212(7):991-9
The Journal of experimental medicine 2015 Jun 29;212(7):991-9
Bone marrow-derived cells are implicated as a source of lymphatic endothelial progenitors in human breast cancer.
Van't Hull EF, Bron S, Henry L, Ifticene-Treboux A, Turrini R, Coukos G, Delaloye JF, Doucey MA
Oncoimmunology 2014;3:e29080
Oncoimmunology 2014;3:e29080
The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel.
Aspelund A, Tammela T, Antila S, Nurmi H, Leppänen VM, Zarkada G, Stanczuk L, Francois M, Mäkinen T, Saharinen P, Immonen I, Alitalo K
The Journal of clinical investigation 2014 Sep;124(9):3975-86
The Journal of clinical investigation 2014 Sep;124(9):3975-86
Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
Park DY, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong KY, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong YK, Koh GY
The Journal of clinical investigation 2014 Sep;124(9):3960-74
The Journal of clinical investigation 2014 Sep;124(9):3960-74
Murine Notch1 is required for lymphatic vascular morphogenesis during development.
Fatima A, Culver A, Culver F, Liu T, Dietz WH, Thomson BR, Hadjantonakis AK, Quaggin SE, Kume T
Developmental dynamics : an official publication of the American Association of Anatomists 2014 Jul;243(7):957-64
Developmental dynamics : an official publication of the American Association of Anatomists 2014 Jul;243(7):957-64
Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions.
Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen EA, Orsenigo F, Lohela M, D'Amico G, Holopainen T, Leow CC, Dejana E, Petrova TV, Augustin HG, Alitalo K
Genes & development 2014 Jul 15;28(14):1592-603
Genes & development 2014 Jul 15;28(14):1592-603
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy.
Hägerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams RH, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F
The EMBO journal 2013 Mar 6;32(5):629-44
The EMBO journal 2013 Mar 6;32(5):629-44
The germinal matrices in the developing dentate gyrus are composed of neuronal progenitors at distinct differentiation stages.
Sugiyama T, Osumi N, Katsuyama Y
Developmental dynamics : an official publication of the American Association of Anatomists 2013 Dec;242(12):1442-53
Developmental dynamics : an official publication of the American Association of Anatomists 2013 Dec;242(12):1442-53
Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence.
Brzezinski JA 4th, Uoon Park K, Reh TA
Developmental biology 2013 Dec 15;384(2):194-204
Developmental biology 2013 Dec 15;384(2):194-204
Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis.
Meinecke AK, Nagy N, Lago GD, Kirmse S, Klose R, Schrödter K, Zimmermann A, Helfrich I, Rundqvist H, Theegarten D, Anhenn O, Orian-Rousseau V, Johnson RS, Alitalo K, Fischer JW, Fandrey J, Stockmann C
Blood 2012 Jun 14;119(24):5931-42
Blood 2012 Jun 14;119(24):5931-42
Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.
Debrincat MA, Josefsson EC, James C, Henley KJ, Ellis S, Lebois M, Betterman KL, Lane RM, Rogers KL, White MJ, Roberts AW, Harvey NL, Metcalf D, Kile BT
Blood 2012 Jun 14;119(24):5850-8
Blood 2012 Jun 14;119(24):5850-8
Expression and prognostic value of transcription factor PROX1 in colorectal cancer.
Skog M, Bono P, Lundin M, Lundin J, Louhimo J, Linder N, Petrova TV, Andersson LC, Joensuu H, Alitalo K, Haglund CH
British journal of cancer 2011 Oct 25;105(9):1346-51
British journal of cancer 2011 Oct 25;105(9):1346-51
CKIα ablation highlights a critical role for p53 in invasiveness control.
Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, Snir-Alkalay I, Burstain I, Haffner-Krausz R, Jung S, Wiener Z, Alitalo K, Oren M, Pikarsky E, Ben-Neriah Y
Nature 2011 Feb 17;470(7334):409-13
Nature 2011 Feb 17;470(7334):409-13
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Ylä-Herttuala S, Wedge SR, Jürgensmeier JM, Alitalo K
Cancer research 2008 Jun 15;68(12):4754-62
Cancer research 2008 Jun 15;68(12):4754-62
Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.
Philipp M, Fralish GB, Meloni AR, Chen W, MacInnes AW, Barak LS, Caron MG
Molecular biology of the cell 2008 Dec;19(12):5478-89
Molecular biology of the cell 2008 Dec;19(12):5478-89
No comments: Submit comment
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Human Prox1 by Western Blot. Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human Prox1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2727) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for Prox1 at approximately 83 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Human Prox1 by Simple WesternTM. Simple Western lane view shows lysates of HepG2 human hepatocellular carcinoma cell line, loaded at 0.2 mg/mL. A specific band was detected for Prox1 at approximately 114 kDa (as indicated) using 10 µg/mL of Goat Anti-Human Prox1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2727) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Prox1 in HepG2 Human Hepatocellular Carcinoma Cell Line. Prox1 was detected in immersion fixed HepG2 human hepatocellular carcinoma cell line using Goat Anti-Human Prox1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2727) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (left panel, red; Catalog # NL001) and counterstained with DAPI (right panel, blue). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.