15792-1-AP

antibody from Proteintech Group

Targeting: S100A8 60B8AG, CAGA, CFAG, CGLA, MRP8, P8

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

15792-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#15792-1-AP, RRID:AB_10666315

Product name

S100A8 antibody

Antibody type

Polyclonal

Description

KD/KO validated S100A8 antibody (Cat. #15792-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IHC, WB, ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

QDPR deficiency drives immune suppression in pancreatic cancer.

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Cell metabolism 2024 May 7;36(5):984-999.e8

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Scleroglucan protects the intestine from irradiation-induced injury by targeting the IL-17 signaling pathway.

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Nebulized platelet-derived extracellular vesicles attenuate chronic cigarette smoke-induced murine emphysema.

Xuan W, Wang S, Alarcon-Calderon A, Bagwell MS, Para R, Wang F, Zhang C, Tian X, Stalboerger P, Peterson T, Sabbah MS, Du Z, Sarrafian T, Mahlberg R, Hillestad ML, Rizzo SA, Paradise CR, Behfar A, Vassallo R
Translational research : the journal of laboratory and clinical medicine 2024 Jul;269:76-93

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A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection.

Jiang H, Zhao Y, Su M, Sun L, Chen M, Zhang Z, Ilyas I, Wang Z, Little PJ, Wang L, Weng J, Ge J, Xu S
Pharmacological research 2024 Jan;199:107029

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Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors.

Wang Y, Sun Y, Deng S, Liu J, Yu J, Chi H, Han X, Zhang Y, Shi J, Wang Y, Quan Y, Li H, Xu J
Cell reports. Medicine 2024 Jan 16;5(1):101374

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Single-cell RNA profiling reveals classification and characteristics of mononuclear phagocytes in colorectal cancer.

Ji T, Fu H, Wang L, Chen J, Tian S, Wang G, Wang L, Wang Z
PLoS genetics 2024 Feb;20(2):e1011176

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Hyperactivation of β-catenin signal in hepatocellular carcinoma recruits myeloid-derived suppressor cells through PF4-CXCR3 axis.

Wang K, Wu J, Yang Z, Zheng B, Shen S, Wang RR, Zhang Y, Wang HY, Chen L, Qiu X
Cancer letters 2024 Apr 1;586:216690

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Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas.

Gao Y, Long Q, Yang H, Hu Y, Xu Y, Tang C, Gu C, Yong S
Experimental and therapeutic medicine 2023 Nov;26(5):533

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Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging.

Feng X, Wang L, Zhou R, Zhou R, Chen L, Peng H, Huang Y, Guo Q, Luo X, Zhou H
Nature communications 2023 Jun 2;14(1):3208

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Fra-1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury.

Chen Y, Dong Y, Zhang ZL, Han J, Chen FS, Tong XY, Ma H
Brain pathology (Zurich, Switzerland) 2023 Jan;33(1):e13113

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S100A8/A9 as a risk factor for breast cancer negatively regulated by DACH1.

Zhang X, Niu M, Li T, Wu Y, Gao J, Yi M, Wu K
Biomarker research 2023 Dec 13;11(1):106

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Targeting of SLC25A22 boosts the immunotherapeutic response in KRAS-mutant colorectal cancer.

Zhou Q, Peng Y, Ji F, Chen H, Kang W, Chan LS, Gou H, Lin Y, Huang P, Chen D, Wei Q, Su H, Liang C, Zhang X, Yu J, Wong CC
Nature communications 2023 Aug 4;14(1):4677

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Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis.

Zhang S, Fang W, Zhou S, Zhu D, Chen R, Gao X, Li Z, Fu Y, Zhang Y, Yang F, Zhao J, Wu H, Wang P, Shen Y, Shen S, Xu G, Wang L, Yan C, Zou X, Chen D, Lv Y
Nature communications 2023 Aug 23;14(1):5123

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Effects of ambient PM(2.5) on development of psoriasiform inflammation through KRT17-dependent activation of AKT/mTOR/HIF-1α pathway.

Wang X, Niu L, Kang A, Pang Y, Zhang Y, Wang W, Zhang Y, Huang X, Liu Q, Geng Z, He L, Niu Y, Zhang R
Ecotoxicology and environmental safety 2022 Sep 15;243:114008

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S100A8 regulates autophagy-dependent ferroptosis in microglia after experimental subarachnoid hemorrhage.

Tao Q, Qiu X, Li C, Zhou J, Gu L, Zhang L, Pang J, Zhang L, Yin S, Jiang Y, Peng J
Experimental neurology 2022 Nov;357:114171

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Inflammatory markers S100A8/A9 and metabolic alteration for evaluating signs of early phase toxicity of anticancer agent treatment.

Morikawa-Ichinose T, Fujimura Y, Kumazoe M, Onda H, Miura D, Tachibana H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Nov;169:113421

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S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy.

Li J, Shu X, Xu J, Su SM, Chan UI, Mo L, Liu J, Zhang X, Adhav R, Chen Q, Wang Y, An T, Zhang X, Lyu X, Li X, Lei JH, Miao K, Sun H, Xing F, Zhang A, Deng C, Xu X
Nature communications 2022 Mar 18;13(1):1481

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Comprehensive Profiling of Early Neoplastic Gastric Microenvironment Modifications and Biodynamics in Impaired BMP-Signaling FoxL1(+)-Telocytes.

Alfonso AB, Pomerleau V, Nicolás VR, Raisch J, Jurkovic CM, Boisvert FM, Perreault N
Biomedicines 2022 Dec 22;11(1)

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The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing.

Wang C, Yu Q, Song T, Wang Z, Song L, Yang Y, Shao J, Li J, Ni Y, Chao N, Zhang L, Li W
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Hexokinase 1 cellular localization regulates the metabolic fate of glucose.

De Jesus A, Keyhani-Nejad F, Pusec CM, Goodman L, Geier JA, Stoolman JS, Stanczyk PJ, Nguyen T, Xu K, Suresh KV, Chen Y, Rodriguez AE, Shapiro JS, Chang HC, Chen C, Shah KP, Ben-Sahra I, Layden BT, Chandel NS, Weinberg SE, Ardehali H
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BRG1 Stimulates Endothelial Derived Alarmin MRP8 to Promote Macrophage Infiltration in an Animal Model of Cardiac Hypertrophy.

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Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation.

Yu Z, Zhao S, Ren L, Wang L, Chen Z, Hoffman RM, Zhou J
Oncotarget 2017 Sep 8;8(38):63461-63483

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HRD1 sensitizes breast cancer cells to Tamoxifen by promoting S100A8 degradation.

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Protein profiling the differences between diabetic and normal mouse cumulus cells.

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Molecular reproduction and development 2014 Dec;81(12):1080-5

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

K-562 cells were subjected to SDS PAGE followed by western blot with 15792-1-AP(S100A8 antibody) at dilution of 1:1000

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human stomach cancer using 15792-1-AP(S100A8 antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The S100A8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human S100A8. This antibody recognizes human, mouse antigen. The S100A8 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

15792-1-AP.pdf

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