Antibody data
- Antibody Data
- Antigen structure
- References [67]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 15792-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15792-1-AP, RRID:AB_10666315
- Product name
- S100A8 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated S100A8 antibody (Cat. #15792-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A Needlelike Nano-hydroxyapatite-Based Hydrogel Accelerates Critical Bone Defect Regeneration via Osteo-/Angiogenesis and Osteoimmune Regulation.
Thromboxane receptor activation in dendritic cells mitigates sepsis by suppressing S100a8/a9-mediated neutrophil recruitment.
Hyperactivation of sympathetic nerves fuels basophil infiltration in atopic dermatitis.
Daucosterol ameliorates acute inflammation and fibrosis following myocardial infarction via regulation of the ZBTB16 protein.
Cancer biomarkers discovered using pan-cancer plasma proteomic profiling.
S100A8 dysregulation as a neuroimmune nexus: Bridging childhood inflammatory infections to adult schizophrenia-like behaviors via the ELNI model.
Fuyuan Huoxue decoction ameliorates CFA-induced pain by modulating chemokine and IL-17 signaling pathways.
Identification of monomethylsulochrin as a novel agent to ameliorate DSS-induced ulcerative colitis through dual modulation of the IL-17/TNF pathway and gut microbiota.
Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation.
Catalpol Alleviates HFpEF via Inhibition of the S100A8-RAGE-NOX4 Inflammatory Axis in Murine Hearts.
Single-cell RNA sequencing reveals that myeloid S100A8/A9 is a novel regulator of the transition from adaptive hypertrophy to heart failure after pressure overload.
Immune microenvironment and fibroblast subpopulation in diabetic wound healing.
RIPK3 promotes skin inflammation by enhancing IL-36α signaling and necroptosis in keratinocytes.
Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco flavored e-cigarette exposed mouse lungs.
S100A8 induces cyclophosphamide-induced alopecia via NCF2/NOX2-mediated ferroptosis.
Impact of obesity on proteomic profiles of follicular fluid-derived small extracellular vesicles: A comparison between PCOS and non-PCOS women.
Up-regulated vitronectin in Kawasaki disease shock syndrome serves as a potential biomarker.
Distinct composition of different types of Abeta plaques in the pathogenesis of Alzheimer's disease and the role of neutrophil-derived myeloperoxidase.
Generalized Pustular Psoriasis as a Systemic Inflammatory Disease: Experience With 38 Japanese Cases Over 15 Years at a Single Institution.
Geniposide via enema alleviates colitis by modulating intestinal flora and bile acid metabolites, inhibiting S100A8/S100A9/NF-κB, and promoting TGR5 inhibition of NLRP3 inflammasome.
S100A8 regulates postoperative responses following tooth extraction in rats.
A Differential Proteomic Analysis on Patient Sera with Neuromyelitis Spectrum Disorders (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) Suggested Shared and Distinct Disease Mechanisms.
Effect of acupuncture on brain microenvironment in rats with post-stroke limb spasticity based on single-cell transcriptome sequencing technology.
Human peripheral osteoclast-precursor-development patterns reveal the significance of RPS17-dependent ribosome synthesis to Ankylosing Spondylitis lesions.
Formononetin From Sophora flavescens Aiton Alleviates Atopic Dermatitis by Suppressing Neutrophil Extracellular Traps.
Card9 deficiency exacerbates vulvovaginal candidiasis by impairing the IL-17 production and vaginal epithelial barrier.
Study on the involvement of microglial S100A8 in neuroinflammation and microglia activation during migraine attacks.
Spatial resolved transcriptomics reveals distinct cross-talk between cancer cells and tumor-associated macrophages in intrahepatic cholangiocarcinoma.
Neutrophil extracellular traps and neutrophil extracellular traps-related genes are involved in new-onset atrial fibrillation in LPS-induced sepsis.
Characterization of PANoptosis-related genes with immunoregulatory features in osteoarthritis.
QDPR deficiency drives immune suppression in pancreatic cancer.
Scleroglucan protects the intestine from irradiation-induced injury by targeting the IL-17 signaling pathway.
Increase in GPIHBP1 expression in advanced stage colorectal cancer indicates poor immune surveillance.
Alarmin S100A8 imparts chemoresistance of esophageal cancer by reprogramming cancer-associated fibroblasts.
Nebulized platelet-derived extracellular vesicles attenuate chronic cigarette smoke-induced murine emphysema.
A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection.
Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors.
Single-cell RNA profiling reveals classification and characteristics of mononuclear phagocytes in colorectal cancer.
EVA1B facilitates esophageal squamous carcinoma progression and recruitment of immunosuppressive myeloid-derived suppressor cells in the tumor microenvironment.
Bongkrekic acid alleviates airway inflammation via breaking the mPTP/mtDAMPs/RAGE feedback loop in a steroid-insensitive asthma model.
Immunocompatible elastomer with increased resistance to the foreign body response.
Hyperactivation of β-catenin signal in hepatocellular carcinoma recruits myeloid-derived suppressor cells through PF4-CXCR3 axis.
Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas.
Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging.
Fra-1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury.
S100A8/A9 as a risk factor for breast cancer negatively regulated by DACH1.
Targeting of SLC25A22 boosts the immunotherapeutic response in KRAS-mutant colorectal cancer.
Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis.
Effects of ambient PM(2.5) on development of psoriasiform inflammation through KRT17-dependent activation of AKT/mTOR/HIF-1α pathway.
S100A8 regulates autophagy-dependent ferroptosis in microglia after experimental subarachnoid hemorrhage.
Inflammatory markers S100A8/A9 and metabolic alteration for evaluating signs of early phase toxicity of anticancer agent treatment.
S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy.
Comprehensive Profiling of Early Neoplastic Gastric Microenvironment Modifications and Biodynamics in Impaired BMP-Signaling FoxL1(+)-Telocytes.
The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing.
Hexokinase 1 cellular localization regulates the metabolic fate of glucose.
Triptolide analog LLDT-8 ameliorates psoriasis-like dermatitis in BALB/c mice via suppressing the IL-36α signaling pathway.
Bulk and single-cell transcriptome profiling reveal the metabolic heterogeneity in human breast cancers.
Keratin 1 attenuates hypoxic pulmonary artery hypertension by suppressing pulmonary artery media smooth muscle expansion.
BRG1 Stimulates Endothelial Derived Alarmin MRP8 to Promote Macrophage Infiltration in an Animal Model of Cardiac Hypertrophy.
Human Isogenic Cell Line Models for Neutrophils and Myeloid-Derived Suppressor Cells.
Curcumin increases the sensitivity of K562/DOX cells to doxorubicin by targeting S100 calcium-binding protein A8 and P-glycoprotein.
Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation.
Global Proteome and Phosphoproteome Characterization of Sepsis-induced Kidney Injury.
KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.
Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation.
HRD1 sensitizes breast cancer cells to Tamoxifen by promoting S100A8 degradation.
Protein profiling the differences between diabetic and normal mouse cumulus cells.
Xu D, Lian L, Luo Z, Dong Y, He C, Chu M, Lu L, Ma W, Gan K
Biomaterials research 2026;30:0344
Biomaterials research 2026;30:0344
Thromboxane receptor activation in dendritic cells mitigates sepsis by suppressing S100a8/a9-mediated neutrophil recruitment.
Du R, Pan T, Wang Y, Fan Y, Liu Q, Tao X, Guo S, Tian D, Foo RS, Xie K, Zhou J, Shen Y, Yu Y
Signal transduction and targeted therapy 2026 Mar 3;11(1)
Signal transduction and targeted therapy 2026 Mar 3;11(1)
Hyperactivation of sympathetic nerves fuels basophil infiltration in atopic dermatitis.
Xie X, Jiang W, Lun L, Huang X, Xu R, Li X, Zhan J, Xie Y, Shen M, Li X, Yan X, Tang X, Tang R, Gao Y, Zhai W, Su H, Luo X, Han J, Klose CSN, Li F, Wang F
Immunity 2026 Mar 10;59(3):598-617.e11
Immunity 2026 Mar 10;59(3):598-617.e11
Daucosterol ameliorates acute inflammation and fibrosis following myocardial infarction via regulation of the ZBTB16 protein.
Sheng S, Wu P, Wu C, Su H, Guo Z, Wang R, Li J, Duan Y, Zhang S, Ma L
British journal of pharmacology 2026 Jan;183(2):313-332
British journal of pharmacology 2026 Jan;183(2):313-332
Cancer biomarkers discovered using pan-cancer plasma proteomic profiling.
Bai L, Lyu J, Feng J, Qiao X, Qu Y, Yang G, Zhu Y, Liao L, Gao H, Zang A, Xu Z, Ji T, Ran P, Ding W, Zhang H, Zhu L, Wang Y, Wang L, Wang X, Li Y, Li J, Yin X, Zhao G, Liu D, Gao X, Tian S, Tan S, Pu Y, Li L, Song Z, Song J, Guo W, Liao Y, Ye D, Yang W, Jia Y, Ding C
Nature biomedical engineering 2026 Jan;10(1):16-38
Nature biomedical engineering 2026 Jan;10(1):16-38
S100A8 dysregulation as a neuroimmune nexus: Bridging childhood inflammatory infections to adult schizophrenia-like behaviors via the ELNI model.
Tengfei C, Shiyu W, Longyu S, Lei C, Ni F, Yaoyu W, Jianing Z, Qing L, Kang L, Jie L, Yahaya BHB, Lin J, Li W
Schizophrenia research 2026 Feb;288:47-56
Schizophrenia research 2026 Feb;288:47-56
Fuyuan Huoxue decoction ameliorates CFA-induced pain by modulating chemokine and IL-17 signaling pathways.
Bai Y, Cheng S, Gao H, Yang Y, He H, Tian Z, Ji Y, Wang H, Tan Z, Zhou Y
Journal of ethnopharmacology 2026 Feb 28;357:120857
Journal of ethnopharmacology 2026 Feb 28;357:120857
Identification of monomethylsulochrin as a novel agent to ameliorate DSS-induced ulcerative colitis through dual modulation of the IL-17/TNF pathway and gut microbiota.
Xing S, Cheng X, Hou S, Qin L, Wang J, Ding Y, Shen Z, Dai Z, Huang X, Liu Y, Zhu D
International immunopharmacology 2026 Apr 15;175:116451
International immunopharmacology 2026 Apr 15;175:116451
Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation.
Huo S, Wang M, Du M, Ren B, Yang T, Peng L, Jiang Y, Peng D, Men L, Shi W, Guo J, Zhang C, Lv J, Li S, Lin L
International journal of biological sciences 2025;21(7):3061-3080
International journal of biological sciences 2025;21(7):3061-3080
Catalpol Alleviates HFpEF via Inhibition of the S100A8-RAGE-NOX4 Inflammatory Axis in Murine Hearts.
Cao Y, Li S, Zhang Y, He M, Shen Y
Journal of inflammation research 2025;18:17143-17161
Journal of inflammation research 2025;18:17143-17161
Single-cell RNA sequencing reveals that myeloid S100A8/A9 is a novel regulator of the transition from adaptive hypertrophy to heart failure after pressure overload.
Yu WJ, Jiang WX, Liu SJ, Li HH, Lin QY
Theranostics 2025;15(16):8587-8608
Theranostics 2025;15(16):8587-8608
Immune microenvironment and fibroblast subpopulation in diabetic wound healing.
Gan J, Chen Y, Tang L, Dong H, Gao X, Huang Y, Pan Y, Hong J, Bai Z, Chen X, Lin Z, Zhu H
iScience 2025 Sep 19;28(9):113440
iScience 2025 Sep 19;28(9):113440
RIPK3 promotes skin inflammation by enhancing IL-36α signaling and necroptosis in keratinocytes.
Li QQ, Yang T, Ren JJ, Hui ZZ, Lei SY, Feng CL, Yang XQ, Tang W
Cell death & disease 2025 Oct 24;16(1):759
Cell death & disease 2025 Oct 24;16(1):759
Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco flavored e-cigarette exposed mouse lungs.
Kaur G, Lamb T, Tjitropranoto A, Irfan R
bioRxiv : the preprint server for biology 2025 Nov 17;
bioRxiv : the preprint server for biology 2025 Nov 17;
S100A8 induces cyclophosphamide-induced alopecia via NCF2/NOX2-mediated ferroptosis.
Xu W, Li Y, Wan S, Zhang B, Wei D, Zhang H, Jin X, Xie B, Guan C, Song X
Free radical biology & medicine 2025 Mar 16;230:112-126
Free radical biology & medicine 2025 Mar 16;230:112-126
Impact of obesity on proteomic profiles of follicular fluid-derived small extracellular vesicles: A comparison between PCOS and non-PCOS women.
Chang Q, Wang S, Mai Q, Zhou C
Journal of ovarian research 2025 Jun 4;18(1):121
Journal of ovarian research 2025 Jun 4;18(1):121
Up-regulated vitronectin in Kawasaki disease shock syndrome serves as a potential biomarker.
Wei Z, Bai B, Zheng Y, Wang H, Zhang M, Zhang Q, Li X
Translational pediatrics 2025 Jun 27;14(6):1230-1244
Translational pediatrics 2025 Jun 27;14(6):1230-1244
Distinct composition of different types of Abeta plaques in the pathogenesis of Alzheimer's disease and the role of neutrophil-derived myeloperoxidase.
Sun J, Shao X, Wang X, Yin XS, Qiu W, Qian X, Liu F, Chen Y, Ma C
Molecular brain 2025 Jun 22;18(1):53
Molecular brain 2025 Jun 22;18(1):53
Generalized Pustular Psoriasis as a Systemic Inflammatory Disease: Experience With 38 Japanese Cases Over 15 Years at a Single Institution.
Kikuchi N, Kusano M, Yamamoto T
Cureus 2025 Jul;17(7):e88108
Cureus 2025 Jul;17(7):e88108
Geniposide via enema alleviates colitis by modulating intestinal flora and bile acid metabolites, inhibiting S100A8/S100A9/NF-κB, and promoting TGR5 inhibition of NLRP3 inflammasome.
Zheng BX, Yi Y, Wang XW, Li CY, Zhao Y, Tian JZ, Wang LM, Han JY, Pan C, Liu SY, Liu CY, Qin SS, Tang X, Liu MT, Liang AH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156791
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156791
S100A8 regulates postoperative responses following tooth extraction in rats.
Zhao X, Liu J, Jin C, Pan K, Du Y, Zuo Z, Yu X
Odontology 2025 Jul;113(3):1128-1136
Odontology 2025 Jul;113(3):1128-1136
A Differential Proteomic Analysis on Patient Sera with Neuromyelitis Spectrum Disorders (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) Suggested Shared and Distinct Disease Mechanisms.
Hu X, Sun X, Yang T, Sun X, Wen M, Chen C, Qiu W, Jin Y
Journal of proteome research 2025 Jul 4;24(7):3697-3714
Journal of proteome research 2025 Jul 4;24(7):3697-3714
Effect of acupuncture on brain microenvironment in rats with post-stroke limb spasticity based on single-cell transcriptome sequencing technology.
Qiongshuai Z, Yi LI, Fang C, Mujun Z, Le W, Ruyao L, Juanjuan F
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Dec;45(6):1273-1282
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Dec;45(6):1273-1282
Human peripheral osteoclast-precursor-development patterns reveal the significance of RPS17-dependent ribosome synthesis to Ankylosing Spondylitis lesions.
Ke D, Dai H, Han J, Su Y, Zhu H, Zhang R, Gao T, Yang L, Yu Y, Bai X, Zhang C, Xu J
Bone research 2025 Dec 4;13(1):100
Bone research 2025 Dec 4;13(1):100
Formononetin From Sophora flavescens Aiton Alleviates Atopic Dermatitis by Suppressing Neutrophil Extracellular Traps.
Cheng L, Du Z, Yan X, Che M, Zhi G, Ma X, Geng F, Li B
Phytotherapy research : PTR 2025 Aug;39(8):3784-3799
Phytotherapy research : PTR 2025 Aug;39(8):3784-3799
Card9 deficiency exacerbates vulvovaginal candidiasis by impairing the IL-17 production and vaginal epithelial barrier.
Liu W, Song Y, Wang R, Wan Z, Li R, Wang X
Medical mycology 2025 Apr 2;63(4)
Medical mycology 2025 Apr 2;63(4)
Study on the involvement of microglial S100A8 in neuroinflammation and microglia activation during migraine attacks.
An N, Zhang Y, Xie J, Li J, Lin J, Li Q, Wang Y, Liu Y, Yang Y
Molecular and cellular neurosciences 2024 Sep;130:103957
Molecular and cellular neurosciences 2024 Sep;130:103957
Spatial resolved transcriptomics reveals distinct cross-talk between cancer cells and tumor-associated macrophages in intrahepatic cholangiocarcinoma.
Dong ZR, Zhang MY, Qu LX, Zou J, Yang YH, Ma YL, Yang CC, Cao XL, Wang LY, Zhang XL, Li T
Biomarker research 2024 Sep 11;12(1):100
Biomarker research 2024 Sep 11;12(1):100
Neutrophil extracellular traps and neutrophil extracellular traps-related genes are involved in new-onset atrial fibrillation in LPS-induced sepsis.
Xiang J, Cao J, Wang X, Shao S, Huang J, Zhang L, Tang B
International immunopharmacology 2024 Sep 10;138:112550
International immunopharmacology 2024 Sep 10;138:112550
Characterization of PANoptosis-related genes with immunoregulatory features in osteoarthritis.
Lan Z, Yang Y, Sun R, Lin X, Yan J, Chen X, Tian K, Wu G, Saad M, Wu Z, Xue D, Jin Q
International immunopharmacology 2024 Oct 25;140:112889
International immunopharmacology 2024 Oct 25;140:112889
QDPR deficiency drives immune suppression in pancreatic cancer.
Liu J, He X, Deng S, Zhao S, Zhang S, Chen Z, Xue C, Zeng L, Zhao H, Zhou Y, Bai R, Xu Z, Liu S, Zhou Q, Li M, Zhang J, Huang X, Chen R, Wang L, Lin D, Zheng J
Cell metabolism 2024 May 7;36(5):984-999.e8
Cell metabolism 2024 May 7;36(5):984-999.e8
Scleroglucan protects the intestine from irradiation-induced injury by targeting the IL-17 signaling pathway.
Huang D, Wang Y, Zhai X, Shen Q, Zhang L, Fang D, Fang L, Zhang J, Ma Y, Chu C, Liu G, Cheng Y, Liu C, Du J, Cai J
International immunopharmacology 2024 Mar 10;129:111614
International immunopharmacology 2024 Mar 10;129:111614
Increase in GPIHBP1 expression in advanced stage colorectal cancer indicates poor immune surveillance.
Gao M, Liao L, Lin Z, Hu X, Jia L, Gong W, Jia X
Translational cancer research 2024 Jun 30;13(6):2691-2703
Translational cancer research 2024 Jun 30;13(6):2691-2703
Alarmin S100A8 imparts chemoresistance of esophageal cancer by reprogramming cancer-associated fibroblasts.
Chen X, Cheng G, Zhu L, Liu T, Yang X, Liu R, Ou Z, Zhang S, Tan W, Lin D, Wu C
Cell reports. Medicine 2024 Jun 18;5(6):101576
Cell reports. Medicine 2024 Jun 18;5(6):101576
Nebulized platelet-derived extracellular vesicles attenuate chronic cigarette smoke-induced murine emphysema.
Xuan W, Wang S, Alarcon-Calderon A, Bagwell MS, Para R, Wang F, Zhang C, Tian X, Stalboerger P, Peterson T, Sabbah MS, Du Z, Sarrafian T, Mahlberg R, Hillestad ML, Rizzo SA, Paradise CR, Behfar A, Vassallo R
Translational research : the journal of laboratory and clinical medicine 2024 Jul;269:76-93
Translational research : the journal of laboratory and clinical medicine 2024 Jul;269:76-93
A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection.
Jiang H, Zhao Y, Su M, Sun L, Chen M, Zhang Z, Ilyas I, Wang Z, Little PJ, Wang L, Weng J, Ge J, Xu S
Pharmacological research 2024 Jan;199:107029
Pharmacological research 2024 Jan;199:107029
Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors.
Wang Y, Sun Y, Deng S, Liu J, Yu J, Chi H, Han X, Zhang Y, Shi J, Wang Y, Quan Y, Li H, Xu J
Cell reports. Medicine 2024 Jan 16;5(1):101374
Cell reports. Medicine 2024 Jan 16;5(1):101374
Single-cell RNA profiling reveals classification and characteristics of mononuclear phagocytes in colorectal cancer.
Ji T, Fu H, Wang L, Chen J, Tian S, Wang G, Wang L, Wang Z
PLoS genetics 2024 Feb;20(2):e1011176
PLoS genetics 2024 Feb;20(2):e1011176
EVA1B facilitates esophageal squamous carcinoma progression and recruitment of immunosuppressive myeloid-derived suppressor cells in the tumor microenvironment.
Xia T, Zhang Y, Peng H, Jia X, Yang D, Wei L, Li T, Yao W
Pharmacological research 2024 Dec;210:107521
Pharmacological research 2024 Dec;210:107521
Bongkrekic acid alleviates airway inflammation via breaking the mPTP/mtDAMPs/RAGE feedback loop in a steroid-insensitive asthma model.
Chen Y, Huang J, Li Y, Chen Y, Gong Z, Xu M, Ma Y, Hu D, Peng X, Xu G, Cai S, Liu L, Zhao W, Zhao H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117111
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117111
Immunocompatible elastomer with increased resistance to the foreign body response.
Zhou X, Lu Z, Cao W, Zhu Z, Chen Y, Ni Y, Liu Z, Jia F, Ye Y, Han H, Yao K, Liu W, Wang Y, Ji J, Zhang P
Nature communications 2024 Aug 30;15(1):7526
Nature communications 2024 Aug 30;15(1):7526
Hyperactivation of β-catenin signal in hepatocellular carcinoma recruits myeloid-derived suppressor cells through PF4-CXCR3 axis.
Wang K, Wu J, Yang Z, Zheng B, Shen S, Wang RR, Zhang Y, Wang HY, Chen L, Qiu X
Cancer letters 2024 Apr 1;586:216690
Cancer letters 2024 Apr 1;586:216690
Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas.
Gao Y, Long Q, Yang H, Hu Y, Xu Y, Tang C, Gu C, Yong S
Experimental and therapeutic medicine 2023 Nov;26(5):533
Experimental and therapeutic medicine 2023 Nov;26(5):533
Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging.
Feng X, Wang L, Zhou R, Zhou R, Chen L, Peng H, Huang Y, Guo Q, Luo X, Zhou H
Nature communications 2023 Jun 2;14(1):3208
Nature communications 2023 Jun 2;14(1):3208
Fra-1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury.
Chen Y, Dong Y, Zhang ZL, Han J, Chen FS, Tong XY, Ma H
Brain pathology (Zurich, Switzerland) 2023 Jan;33(1):e13113
Brain pathology (Zurich, Switzerland) 2023 Jan;33(1):e13113
S100A8/A9 as a risk factor for breast cancer negatively regulated by DACH1.
Zhang X, Niu M, Li T, Wu Y, Gao J, Yi M, Wu K
Biomarker research 2023 Dec 13;11(1):106
Biomarker research 2023 Dec 13;11(1):106
Targeting of SLC25A22 boosts the immunotherapeutic response in KRAS-mutant colorectal cancer.
Zhou Q, Peng Y, Ji F, Chen H, Kang W, Chan LS, Gou H, Lin Y, Huang P, Chen D, Wei Q, Su H, Liang C, Zhang X, Yu J, Wong CC
Nature communications 2023 Aug 4;14(1):4677
Nature communications 2023 Aug 4;14(1):4677
Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis.
Zhang S, Fang W, Zhou S, Zhu D, Chen R, Gao X, Li Z, Fu Y, Zhang Y, Yang F, Zhao J, Wu H, Wang P, Shen Y, Shen S, Xu G, Wang L, Yan C, Zou X, Chen D, Lv Y
Nature communications 2023 Aug 23;14(1):5123
Nature communications 2023 Aug 23;14(1):5123
Effects of ambient PM(2.5) on development of psoriasiform inflammation through KRT17-dependent activation of AKT/mTOR/HIF-1α pathway.
Wang X, Niu L, Kang A, Pang Y, Zhang Y, Wang W, Zhang Y, Huang X, Liu Q, Geng Z, He L, Niu Y, Zhang R
Ecotoxicology and environmental safety 2022 Sep 15;243:114008
Ecotoxicology and environmental safety 2022 Sep 15;243:114008
S100A8 regulates autophagy-dependent ferroptosis in microglia after experimental subarachnoid hemorrhage.
Tao Q, Qiu X, Li C, Zhou J, Gu L, Zhang L, Pang J, Zhang L, Yin S, Jiang Y, Peng J
Experimental neurology 2022 Nov;357:114171
Experimental neurology 2022 Nov;357:114171
Inflammatory markers S100A8/A9 and metabolic alteration for evaluating signs of early phase toxicity of anticancer agent treatment.
Morikawa-Ichinose T, Fujimura Y, Kumazoe M, Onda H, Miura D, Tachibana H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Nov;169:113421
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Nov;169:113421
S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy.
Li J, Shu X, Xu J, Su SM, Chan UI, Mo L, Liu J, Zhang X, Adhav R, Chen Q, Wang Y, An T, Zhang X, Lyu X, Li X, Lei JH, Miao K, Sun H, Xing F, Zhang A, Deng C, Xu X
Nature communications 2022 Mar 18;13(1):1481
Nature communications 2022 Mar 18;13(1):1481
Comprehensive Profiling of Early Neoplastic Gastric Microenvironment Modifications and Biodynamics in Impaired BMP-Signaling FoxL1(+)-Telocytes.
Alfonso AB, Pomerleau V, Nicolás VR, Raisch J, Jurkovic CM, Boisvert FM, Perreault N
Biomedicines 2022 Dec 22;11(1)
Biomedicines 2022 Dec 22;11(1)
The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing.
Wang C, Yu Q, Song T, Wang Z, Song L, Yang Y, Shao J, Li J, Ni Y, Chao N, Zhang L, Li W
Signal transduction and targeted therapy 2022 Aug 26;7(1):289
Signal transduction and targeted therapy 2022 Aug 26;7(1):289
Hexokinase 1 cellular localization regulates the metabolic fate of glucose.
De Jesus A, Keyhani-Nejad F, Pusec CM, Goodman L, Geier JA, Stoolman JS, Stanczyk PJ, Nguyen T, Xu K, Suresh KV, Chen Y, Rodriguez AE, Shapiro JS, Chang HC, Chen C, Shah KP, Ben-Sahra I, Layden BT, Chandel NS, Weinberg SE, Ardehali H
Molecular cell 2022 Apr 7;82(7):1261-1277.e9
Molecular cell 2022 Apr 7;82(7):1261-1277.e9
Triptolide analog LLDT-8 ameliorates psoriasis-like dermatitis in BALB/c mice via suppressing the IL-36α signaling pathway.
Qi Q, Li Q, Zhu H, Lu H, Yang X, Wu Y, Feng C, Fan C, Li H, Wu B, Gao Y, Zhang Z, Zhou H, Zuo J, Tang W
Pharmacological research 2021 Jul;169:105678
Pharmacological research 2021 Jul;169:105678
Bulk and single-cell transcriptome profiling reveal the metabolic heterogeneity in human breast cancers.
Yu TJ, Ma D, Liu YY, Xiao Y, Gong Y, Jiang YZ, Shao ZM, Hu X, Di GH
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jul 7;29(7):2350-2365
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jul 7;29(7):2350-2365
Keratin 1 attenuates hypoxic pulmonary artery hypertension by suppressing pulmonary artery media smooth muscle expansion.
Zhang L, Zeng XX, Li YM, Chen SK, Tang LY, Wang N, Yang X, Lin MJ
Acta physiologica (Oxford, England) 2021 Feb;231(2):e13558
Acta physiologica (Oxford, England) 2021 Feb;231(2):e13558
BRG1 Stimulates Endothelial Derived Alarmin MRP8 to Promote Macrophage Infiltration in an Animal Model of Cardiac Hypertrophy.
Li Z, Zhang Y, Zhang Y, Yu L, Xiao B, Li T, Kong X, Xu Y
Frontiers in cell and developmental biology 2020;8:569
Frontiers in cell and developmental biology 2020;8:569
Human Isogenic Cell Line Models for Neutrophils and Myeloid-Derived Suppressor Cells.
Zhang Y, Wilt E, Lu X
International journal of molecular sciences 2020 Oct 18;21(20)
International journal of molecular sciences 2020 Oct 18;21(20)
Curcumin increases the sensitivity of K562/DOX cells to doxorubicin by targeting S100 calcium-binding protein A8 and P-glycoprotein.
Yang L, Li D, Tang P, Zuo Y
Oncology letters 2020 Jan;19(1):83-92
Oncology letters 2020 Jan;19(1):83-92
Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation.
Duan X, Liu X, Liu N, Huang Y, Jin Z, Zhang S, Ming Z, Chen H
Cell death & disease 2020 Feb 19;11(2):134
Cell death & disease 2020 Feb 19;11(2):134
Global Proteome and Phosphoproteome Characterization of Sepsis-induced Kidney Injury.
Lin YH, Platt MP, Fu H, Gui Y, Wang Y, Gonzalez-Juarbe N, Zhou D, Yu Y
Molecular & cellular proteomics : MCP 2020 Dec;19(12):2030-2047
Molecular & cellular proteomics : MCP 2020 Dec;19(12):2030-2047
KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.
Liao W, Overman MJ, Boutin AT, Shang X, Zhao D, Dey P, Li J, Wang G, Lan Z, Li J, Tang M, Jiang S, Ma X, Chen P, Katkhuda R, Korphaisarn K, Chakravarti D, Chang A, Spring DJ, Chang Q, Zhang J, Maru DM, Maeda DY, Zebala JA, Kopetz S, Wang YA, DePinho RA
Cancer cell 2019 Apr 15;35(4):559-572.e7
Cancer cell 2019 Apr 15;35(4):559-572.e7
Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation.
Yu Z, Zhao S, Ren L, Wang L, Chen Z, Hoffman RM, Zhou J
Oncotarget 2017 Sep 8;8(38):63461-63483
Oncotarget 2017 Sep 8;8(38):63461-63483
HRD1 sensitizes breast cancer cells to Tamoxifen by promoting S100A8 degradation.
Wang Y, Guo A, Liang X, Li M, Shi M, Li Y, Jenkins G, Lin X, Wei X, Jia Z, Feng X, Su D, Guo W
Oncotarget 2017 Apr 4;8(14):23564-23574
Oncotarget 2017 Apr 4;8(14):23564-23574
Protein profiling the differences between diabetic and normal mouse cumulus cells.
Jiang GJ, Ma JY, Zhang GL, Mo FF, Zhang DW, Gao SH, Li XL
Molecular reproduction and development 2014 Dec;81(12):1080-5
Molecular reproduction and development 2014 Dec;81(12):1080-5
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 15792-1-AP(S100A8 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human stomach cancer using 15792-1-AP(S100A8 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The S100A8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human S100A8. This antibody recognizes human, mouse antigen. The S100A8 antibody has been validated for the following applications: ELISA, WB, IHC analysis.